{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:26:02Z","timestamp":1785795962884,"version":"3.56.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,17]]},"DOI":"10.7759\/cureus.54365","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T19:15:30Z","timestamp":1708197330000},"source":"Crossref","is-referenced-by-count":2,"title":["Focal Neurotoxicity Associated With Topical 5-Fluorouracil"],"prefix":"10.7759","author":[{"given":"Ryan M","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Mobilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack B","family":"Newcomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase L","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Actinic keratosis: current therapies and insights into new treatments","volume":"18","author":"Hashim PW","year":"2019","unstructured":"Hashim PW, Chen T, Rigel D, Bhatia N, Kircik LH. Actinic keratosis: current therapies and insights into new treatments. J Drugs Dermatol. 2019, 18:s161-s166.","journal-title":"J Drugs Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley DB","year":"2003","unstructured":"Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003, 3:330-338. 10.1038\/nrc1074","journal-title":"Nat Rev Cancer"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2002.17.1.73","article-title":"A case of neurotoxicity following 5-fluorouracil-based chemotherapy","volume":"17","author":"Ki SS","year":"2002","unstructured":"Ki SS, Jeong JM, Kim SH, et al.. A case of neurotoxicity following 5-fluorouracil-based chemotherapy. Korean J Intern Med. 2002, 17:73-77. 10.3904\/kjim.2002.17.1.73","journal-title":"Korean J Intern Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.cad.0000231479.30524.0e","article-title":"Peripheral neuropathy exacerbation associated with topical 5-fluorouracil","volume":"17","author":"Saif MW","year":"2006","unstructured":"Saif MW, Hashmi S, Mattison L, Donovan WB, Diasio RB. Peripheral neuropathy exacerbation associated with topical 5-fluorouracil. Anticancer Drugs. 2006, 17:1095-1098. 10.1097\/01.cad.0000231479.30524.0e","journal-title":"Anticancer Drugs"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-021-04318-x","article-title":"Pharmacokinetics of preoperative intraperitoneal 5-FU in patients with pancreatic ductal adenocarcinoma","volume":"88","author":"\u00d6man M","year":"2021","unstructured":"\u00d6man M, Wettergren Y, Odin E, Westermark S, Naredi P, Hemmingsson O, Taflin H. Pharmacokinetics of preoperative intraperitoneal 5-FU in patients with pancreatic ductal adenocarcinoma. Cancer Chemother Pharmacol. 2021, 88:619-631. 10.1007\/s00280-021-04318-x","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12877","article-title":"Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment","volume":"81","author":"Derissen EJ","year":"2016","unstructured":"Derissen EJ, Jacobs BA, Huitema AD, Rosing H, Schellens JH, Beijnen JH. Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment. Br J Clin Pharmacol. 2016, 81:949-957. 10.1111\/bcp.12877","journal-title":"Br J Clin Pharmacol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2018_138","article-title":"Dihydropyrimidine dehydrogenase deficiency: homozygosity for an extremely rare variant in DPYD due to uniparental isodisomy of chromosome 1","volume":"45","author":"van Kuilenburg AB","year":"2019","unstructured":"van Kuilenburg AB, Meijer J, Meinsma R, et al.. Dihydropyrimidine dehydrogenase deficiency: homozygosity for an extremely rare variant in DPYD due to uniparental isodisomy of chromosome 1. JIMD Rep. 2019, 45:65-69. 10.1007\/8904_2018_138","journal-title":"JIMD Rep"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2018.049","article-title":"Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity","volume":"8","author":"Fidai SS","year":"2018","unstructured":"Fidai SS, Sharma AE, Johnson DN, Segal JP, Lastra RR. Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity. Autops Case Rep. 2018, 8:e2018049. 10.4322\/acr.2018.049","journal-title":"Autops Case Rep"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.4197\/Med.20-2.9","article-title":"Rare case of motor neuropathy with 5-fluorouracil chemotherapy: a case report","volume":"20","author":"Alkhayyat SS","year":"2013","unstructured":"Alkhayyat SS. Rare case of motor neuropathy with 5-fluorouracil chemotherapy: a case report. JKAU Med Sci. 2013, 20:111-119.","journal-title":"JKAU Med Sci"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200409000-00005","article-title":"Peripheral neuropathy associated with capecitabine","volume":"15","author":"Saif MW","year":"2004","unstructured":"Saif MW, Wood TE, McGee PJ, Diasio RB. Peripheral neuropathy associated with capecitabine. Anticancer Drugs. 2004, 15:767-771. 10.1097\/00001813-200409000-00005","journal-title":"Anticancer Drugs"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200107000-00006","article-title":"Peripheral neuropathy associated with weekly oral 5-fluorouracil, leucovorin and eniluracil","volume":"12","author":"Saif MW","year":"2001","unstructured":"Saif MW, Wilson RH, Harold N, Keith B, Dougherty DS, Grem JL. Peripheral neuropathy associated with weekly oral 5-fluorouracil, leucovorin and eniluracil. Anticancer Drugs. 2001, 12:525-531. 10.1097\/00001813-200107000-00006","journal-title":"Anticancer Drugs"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1188\/14.CJON.581-585","article-title":"5-Fluorouracil toxicity and dihydropyrimidine dehydrogenase enzyme: implications for practice","volume":"18","author":"Latchman J","year":"2014","unstructured":"Latchman J, Guastella A, Tofthagen C. 5-Fluorouracil toxicity and dihydropyrimidine dehydrogenase enzyme: implications for practice. Clin J Oncol Nurs. 2014, 18:581-585. 10.1188\/14.CJON.581-585","journal-title":"Clin J Oncol Nurs"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2016.11.038","article-title":"The successful treatment of 5-fluorouracil (5-FU) overdose in a patient with malignancy and HIV\/AIDS with uridine triacetate","volume":"35","author":"Santos C","year":"2017","unstructured":"Santos C, Morgan BW, Geller RJ. The successful treatment of 5-fluorouracil (5-FU) overdose in a patient with malignancy and HIV\/AIDS with uridine triacetate. Am J Emerg Med. 2017, 35:802.e7-802.e8. 10.1016\/j.ajem.2016.11.038","journal-title":"Am J Emerg Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/203127-focal-neurotoxicity-associated-with-topical-5-fluorouracil","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T19:15:35Z","timestamp":1708197335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/203127-focal-neurotoxicity-associated-with-topical-5-fluorouracil"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,17]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.54365","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,17]]}}}