{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:01:19Z","timestamp":1787032879473,"version":"build-2736575974"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,21]]},"DOI":"10.7759\/cureus.54660","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T01:25:59Z","timestamp":1708565159000},"source":"Crossref","is-referenced-by-count":1,"title":["Anti-MDA5 Antibody-Positive Clinically Amyopathic Dermatomyositis Associated With Multiple Heterologous Carcinomas: A Case Report"],"prefix":"10.7759","author":[{"given":"Yoshio","family":"Nakano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Gohma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Yasuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-84-1-68","article-title":"Dermatomyositis and malignancy. A review of the literature","volume":"84","author":"Barnes BE","year":"1976","unstructured":"Barnes BE, Mawr B. Dermatomyositis and malignancy. A review of the literature. Ann Intern Med. 1976, 84:68-76. 10.7326\/0003-4819-84-1-68","journal-title":"Ann Intern Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker518","article-title":"The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM","volume":"51","author":"Koga T","year":"2012","unstructured":"Koga T, Fujikawa K, Horai Y, et al.. The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM. Rheumatology (Oxford). 2012, 51:1278-84. 10.1093\/rheumatology\/ker518","journal-title":"Rheumatology (Oxford)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316651748","article-title":"Clinical significance and new detection system of autoantibodies in myositis with interstitial lung disease","volume":"25","author":"Nakashima R","year":"2016","unstructured":"Nakashima R, Hosono Y, Mimori T. Clinical significance and new detection system of autoantibodies in myositis with interstitial lung disease. Lupus. 2016, 25:925-33. 10.1177\/0961203316651748","journal-title":"Lupus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq153","article-title":"Anti-MDA5 and anti-TIF1-gamma antibodies have clinical significance for patients with dermatomyositis","volume":"49","author":"Hoshino K","year":"2010","unstructured":"Hoshino K, Muro Y, Sugiura K, Tomita Y, Nakashima R, Mimori T. Anti-MDA5 and anti-TIF1-gamma antibodies have clinical significance for patients with dermatomyositis. Rheumatology (Oxford). 2010, 49:1726-33. 10.1093\/rheumatology\/keq153","journal-title":"Rheumatology (Oxford)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/art.42311","article-title":"Subsets of idiopathic inflammatory myositis enriched for contemporaneous cancer relative to the general population","volume":"75","author":"Mecoli CA","year":"2023","unstructured":"Mecoli CA, Igusa T, Chen M, et al.. Subsets of idiopathic inflammatory myositis enriched for contemporaneous cancer relative to the general population. Arthritis Rheumatol. 2023, 75:620-9. 10.1002\/art.42311","journal-title":"Arthritis Rheumatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/ar2987","article-title":"Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan","volume":"12","author":"Chen YJ","year":"2010","unstructured":"Chen YJ, Wu CY, Huang YL, Wang CB, Shen JL, Chang YT. Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan. Arthritis Res Ther. 2010, 12:R70. 10.1186\/ar2987","journal-title":"Arthritis Res Ther"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.0569-22","article-title":"A case in which breast cancer developed at the same time as dermatomyositis, and the onset of new cancer was able to be predicted by the exacerbating skin symptoms and parallel increase in the anti-TiF1-\u03b3 antibody levels","volume":"62","author":"Akagi H","year":"2023","unstructured":"Akagi H, Wada T. A case in which breast cancer developed at the same time as dermatomyositis, and the onset of new cancer was able to be predicted by the exacerbating skin symptoms and parallel increase in the anti-TiF1-\u03b3 antibody levels. Intern Med. 2023, 62:3057-62. 10.2169\/internalmedicine.0569-22","journal-title":"Intern Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2177\/jsci.27.427","article-title":"A case of dermatomyositis associated with different types of cancers at intervals of six years [article in Japanese]","volume":"27","author":"Hashimoto M","year":"2004","unstructured":"Hashimoto M, Yoshifuji H, Mimori T. A case of dermatomyositis associated with different types of cancers at intervals of six years [article in Japanese]. Nihon Rinsho Meneki Gakkai Kaishi. 2004, 27:427-30. 10.2177\/jsci.27.427","journal-title":"Nihon Rinsho Meneki Gakkai Kaishi"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2016.11.015","article-title":"Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy","volume":"20","author":"Ichiyasu H","year":"2017","unstructured":"Ichiyasu H, Sakamoto Y, Yoshida C, et al.. Rapidly progressive interstitial lung disease due to anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis complicated with cervical cancer: Successful treatment with direct hemoperfusion using polymyxin B-immobilized fiber column therapy. Respir Med Case Rep. 2017, 20:51-4. 10.1016\/j.rmcr.2016.11.015","journal-title":"Respir Med Case Rep"},{"key":"ref10","article-title":"Acute exacerbation of dermatomyositis-associated interstitial pneumonia after resection of the descending colon cancer requiring differential diagnosis from anastomotic leakage","volume":"51","author":"Hashimoto S","year":"2018","unstructured":"Hashimoto S, Nonaka T, Tominaga T, et al.. Acute exacerbation of dermatomyositis-associated interstitial pneumonia after resection of the descending colon cancer requiring differential diagnosis from anastomotic leakage. J Jpn Soc Gastroenterol Surg. 2018, 51:365-72.","journal-title":"J Jpn Soc Gastroenterol Surg"},{"key":"ref11","article-title":"The importance of including amyopathic dermatomyositis in the idiopathic inflammatory myositis spectrum","volume":"31","author":"Ghazi E","year":"2013","unstructured":"Ghazi E, Sontheimer RD, Werth VP. The importance of including amyopathic dermatomyositis in the idiopathic inflammatory myositis spectrum. Clin Exp Rheumatol. 2013, 31:128-34.","journal-title":"Clin Exp Rheumatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041367","article-title":"Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy","volume":"201","author":"Casciola-Rosen L","year":"2005","unstructured":"Casciola-Rosen L, Nagaraju K, Plotz P, et al.. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med. 2005, 201:591-601. 10.1084\/jem.20041367","journal-title":"J Exp Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000831","article-title":"Lymphocyte immunophenotyping in inflammatory myositis: a review","volume":"33","author":"Franco C","year":"2021","unstructured":"Franco C, Gatto M, Iaccarino L, Ghirardello A, Doria A. Lymphocyte immunophenotyping in inflammatory myositis: a review. Curr Opin Rheumatol. 2021, 33:522-8. 10.1097\/BOR.0000000000000831","journal-title":"Curr Opin Rheumatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa819","article-title":"Elevated carcinoembryonic antigen predicts rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis","volume":"60","author":"Zhu D","year":"2021","unstructured":"Zhu D, Qiao J, Tang S, Pan Y, Li S, Yang C, Fang H. Elevated carcinoembryonic antigen predicts rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis. Rheumatology (Oxford). 2021, 60:3896-903. 10.1093\/rheumatology\/keaa819","journal-title":"Rheumatology (Oxford)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/233380-anti-mda5-antibody-positive-clinically-amyopathic-dermatomyositis-associated-with-multiple-heterologous-carcinomas-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T01:26:07Z","timestamp":1708565167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/233380-anti-mda5-antibody-positive-clinically-amyopathic-dermatomyositis-associated-with-multiple-heterologous-carcinomas-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":14,"URL":"https:\/\/doi.org\/10.7759\/cureus.54660","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,21]]}}}