{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T09:07:22Z","timestamp":1770714442002,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,23]]},"DOI":"10.7759\/cureus.54768","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T16:40:09Z","timestamp":1708706409000},"source":"Crossref","is-referenced-by-count":2,"title":["Nebulized Versus Intravenously Administered Dexmedetomidine for Obtunding Hemodynamic Responses to Laryngoscopy and Tracheal Intubation: A Randomized Double-Blind Comparative Study"],"prefix":"10.7759","author":[{"given":"Akshita","family":"Singla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajkumar K","family":"Saraswat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avnish","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapna","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.47750\/pnr.2022.13.S06.555","article-title":"Efficacy of preoperative dexmedetomidine nebulization on blunting the hemodynamic response to laryngoscopy and intubation","volume":"13","author":"Suryawanshi DC","year":"2022","unstructured":"Suryawanshi DC, Ravindran DDG, Sathvika DP, Jawale DR. Efficacy of preoperative dexmedetomidine nebulization on blunting the hemodynamic response to laryngoscopy and intubation. J Pharm Negat Results. 2022, 13:10.47750\/pnr.2022.13.S06.555","journal-title":"J Pharm Negat Results"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.7894297","article-title":"Intravenous Dexmedetomidine versus intranasal dexmedetomidine for attenuation of haemodynamic response to laryngoscopy and tracheal intubation: A double blinded RCT from Maharashtra","volume":"4","author":"Chavan SK","year":"2023","unstructured":"Chavan SK, Sikchi SP. Intravenous Dexmedetomidine versus intranasal dexmedetomidine for attenuation of haemodynamic response to laryngoscopy and tracheal intubation: A double blinded RCT from Maharashtra. Int J Med Sci Clin Res Rev. 2023, 4:539-45. 10.5281\/zenodo.7894297","journal-title":"Int J Med Sci Clin Res Rev"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-7094(12)70110-1","article-title":"Dexmedetomidine: current role in anesthesia and intensive care","volume":"62","author":"Afonso J","year":"2012","unstructured":"Afonso J, Reis F. Dexmedetomidine: current role in anesthesia and intensive care. Rev Bras Anestesiol. 2012, 62:118-33. 10.1016\/S0034-7094(12)70110-1","journal-title":"Rev Bras Anestesiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.01.037","article-title":"The efficacy of labetalol vs dexmedetomidine for attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation","volume":"31","author":"El-Shmaa NS","year":"2016","unstructured":"El-Shmaa NS, El-Baradey GF. The efficacy of labetalol vs dexmedetomidine for attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation. J Clin Anesth. 2016, 31:267-73. 10.1016\/j.jclinane.2016.01.037","journal-title":"J Clin Anesth"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2008.08.015","article-title":"Dexmedetomidine suppresses the decrease in blood pressure during anesthetic induction and blunts the cardiovascular response to tracheal intubation","volume":"21","author":"Kunisawa T","year":"2009","unstructured":"Kunisawa T, Nagata O, Nagashima M, et al.. Dexmedetomidine suppresses the decrease in blood pressure during anesthetic induction and blunts the cardiovascular response to tracheal intubation. J Clin Anesth. 2009, 21:194-9. 10.1016\/j.jclinane.2008.08.015","journal-title":"J Clin Anesth"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.04.026","article-title":"Comparison of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response - a randomized controlled trial","volume":"33","author":"Kakkar A","year":"2016","unstructured":"Kakkar A, Tyagi A, Nabi N, Sethi AK, Verma UC. Comparison of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response - a randomized controlled trial. J Clin Anesth. 2016, 33:283-8. 10.1016\/j.jclinane.2016.04.026","journal-title":"J Clin Anesth"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/68.2.126","article-title":"Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and peroperative fentanyl","volume":"68","author":"Scheinin B","year":"1992","unstructured":"Scheinin B, Lindgren L, Randell T, Scheinin H, Scheinin M. Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and peroperative fentanyl. Br J Anaesth. 1992, 68:126-31. 10.1093\/bja\/68.2.126","journal-title":"Br J Anaesth"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.aat.2015.09.003","article-title":"Clinical study to evaluate the role of preoperative dexmedetomidine in attenuation of hemodynamic response to direct laryngoscopy and tracheal intubation","volume":"53","author":"Kumari K","year":"2015","unstructured":"Kumari K, Gombar S, Kapoor D, Sandhu HS. Clinical study to evaluate the role of preoperative dexmedetomidine in attenuation of hemodynamic response to direct laryngoscopy and tracheal intubation. Acta Anaesthesiol Taiwan. 2015, 53:123-30. 10.1016\/j.aat.2015.09.003","journal-title":"Acta Anaesthesiol Taiwan"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_320_19","article-title":"Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: a comparison between intravenous and intranasal route","volume":"63","author":"Niyogi S","year":"2019","unstructured":"Niyogi S, Biswas A, Chakraborty I, Chakraborty S, Acharjee A. Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: a comparison between intravenous and intranasal route. Indian J Anaesth. 2019, 63:915-23. 10.4103\/ija.IJA_320_19","journal-title":"Indian J Anaesth"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154192","article-title":"Intranasal dexmedetomidine as a sedative premedication for patients undergoing suspension laryngoscopy: a randomized double-blind study","volume":"11","author":"Lu C","year":"2016","unstructured":"Lu C, Zhang LM, Zhang Y, Ying Y, Li L, Xu L, Ruan X. Intranasal dexmedetomidine as a sedative premedication for patients undergoing suspension laryngoscopy: a randomized double-blind study. PLoS One. 2016, 11:e0154192. 10.1371\/journal.pone.0154192","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2007.10.004","article-title":"The effectiveness of intramuscular dexmedetomidine on hemodynamic responses during tracheal intubation and anesthesia induction of hypertensive patients: a randomized, double-blind, placebo-controlled study","volume":"68","author":"Dogru K","year":"2007","unstructured":"Dogru K, Arik T, Yildiz K, Bicer C, Madenoglu H, Boyaci A. The effectiveness of intramuscular dexmedetomidine on hemodynamic responses during tracheal intubation and anesthesia induction of hypertensive patients: a randomized, double-blind, placebo-controlled study. Curr Ther Res Clin Exp. 2007, 68:292-302. 10.1016\/j.curtheres.2007.10.004","journal-title":"Curr Ther Res Clin Exp"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000728","article-title":"A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery","volume":"121","author":"Zanaty OM","year":"2015","unstructured":"Zanaty OM, El Metainy SA. A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery. Anesth Analg. 2015, 121:167-71. 10.1213\/ANE.0000000000000728","journal-title":"Anesth Analg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/TheIAForum.TheIAForum_98_19","article-title":"The study of intranasal dexmedetomidine during total intravenous anesthesia for endoscopic retrograde cholangiopancreatography","volume":"8","author":"Prakash D","year":"2021","unstructured":"Prakash D, Parate L, Nagaraj M, Pujari V, Reddy B, Dinesh N. The study of intranasal dexmedetomidine during total intravenous anesthesia for endoscopic retrograde cholangiopancreatography. Indian Anaesth Forum. 2021, 8:129-33. 10.4103\/TheIAForum.TheIAForum_98_19","journal-title":"Indian Anaesth Forum"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.198404","article-title":"Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with intravenous dexmedetomidine: a comparison between two doses","volume":"61","author":"Sebastian B","year":"2017","unstructured":"Sebastian B, Talikoti AT, Krishnamurthy D. Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with intravenous dexmedetomidine: a comparison between two doses. Indian J Anaesth. 2017, 61:48-54. 10.4103\/0019-5049.198404","journal-title":"Indian J Anaesth"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4097\/kja.20153","article-title":"Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial","volume":"74","author":"Misra S","year":"2021","unstructured":"Misra S, Behera BK, Mitra JK, Sahoo AK, Jena SS, Srinivasan A. Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial. Korean J Anesthesiol. 2021, 74:150-7. 10.4097\/kja.20153","journal-title":"Korean J Anesthesiol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5812\/aapm-132607","article-title":"Comparison of intravenous versus nebulized dexmedetomidine for laryngoscopy and intubation-induced sympathoadrenal stress response attenuation","volume":"12","author":"Singh V","year":"2022","unstructured":"Singh V, Pahade A, Mowar A. Comparison of intravenous versus nebulized dexmedetomidine for laryngoscopy and intubation-induced sympathoadrenal stress response attenuation. Anesth Pain Med. 2022, 12:e132607. 10.5812\/aapm-132607","journal-title":"Anesth Pain Med"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.25259\/FH_20230101_43","article-title":"Comparison of intranasal versus intravenous dexmedetomidine to attenuate haemodynamic response of laryngoscopy and endotracheal intubation in elective lumbar spine surgery: a randomized control study","volume":"1","author":"Ankita","year":"2023","unstructured":"Ankita, Kumar H, Kumar M. Comparison of intranasal versus intravenous dexmedetomidine to attenuate haemodynamic response of laryngoscopy and endotracheal intubation in elective lumbar spine surgery: a randomized control study. Future Health. 2023, 1:43-9.","journal-title":"Future Health"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael220","article-title":"Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomized and placebo-controlled study","volume":"97","author":"Tanskanen PE","year":"2006","unstructured":"Tanskanen PE, Kytt\u00e4 JV, Randell TT, Aantaa RE. Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomized and placebo-controlled study. Br J Anaesth. 2006, 97:658-65. 10.1093\/bja\/ael220","journal-title":"Br J Anaesth"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2174\/1874428100701010005","article-title":"The Effects of \u03b12-Adrenergic Receptor Agonist Dexmedetomidine on Hemodynamic Response in Direct Laryngoscopy","volume":"1","author":"Isik B","year":"2007","unstructured":"Isik B, Arslan M, \u00d6zsoylar \u00d6, Ak\u00e7abay M. The Effects of \u03b12-Adrenergic Receptor Agonist Dexmedetomidine on Hemodynamic Response in Direct Laryngoscopy. Open Otorhinolaryngol J. 2007, 1:1-5. 10.2174\/1874428100701010005","journal-title":"Open Otorhinolaryngol J"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.111680","article-title":"A comparative study to evaluate the effect of intranasal dexmedetomidine versus oral alprazolam as a premedication agent in morbidly obese patients undergoing bariatric surgery","volume":"29","author":"Jayaraman L","year":"2013","unstructured":"Jayaraman L, Sinha A, Punhani D. A comparative study to evaluate the effect of intranasal dexmedetomidine versus oral alprazolam as a premedication agent in morbidly obese patients undergoing bariatric surgery. J Anaesthesiol Clin Pharmacol. 2013, 29:179-82. 10.4103\/0970-9185.111680","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"ref21","article-title":"Intranasal delivery: an approach to bypass the blood brain barrier","volume":"36","author":"Talegaonka S","year":"2004","unstructured":"Talegaonka S, Mishra PR. Intranasal delivery: an approach to bypass the blood brain barrier. Indian J Pharmacol. 2004, 36:140.","journal-title":"Indian J Pharmacol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0616","article-title":"Intranasal medication delivery for children: a brief review and update","volume":"126","author":"Wolfe TR","year":"2010","unstructured":"Wolfe TR, Braude DA. Intranasal medication delivery for children: a brief review and update. Pediatrics. 2010, 126:532-7. 10.1542\/peds.2010-0616","journal-title":"Pediatrics"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07309.x","article-title":"A randomised comparison of two intranasal dexmedetomidine doses for premedication in children","volume":"67","author":"Yuen VM","year":"2012","unstructured":"Yuen VM, Hui TW, Irwin MG, et al.. A randomised comparison of two intranasal dexmedetomidine doses for premedication in children. Anaesthesia. 2012, 67:1210-6. 10.1111\/j.1365-2044.2012.07309.x","journal-title":"Anaesthesia"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3181abff90","article-title":"Intranasal dexmedetomidine premedication is comparable with midazolam in burn children undergoing reconstructive surgery","volume":"30","author":"Talon MD","year":"2009","unstructured":"Talon MD, Woodson LC, Sherwood ER, Aarsland A, McRae L, Benham T. Intranasal dexmedetomidine premedication is comparable with midazolam in burn children undergoing reconstructive surgery. J Burn Care Res. 2009, 30:599-605. 10.1097\/BCR.0b013e3181abff90","journal-title":"J Burn Care Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000216293.16613.15","article-title":"Dexmedetomidine for pediatric sedation for computed tomography imaging studies","volume":"103","author":"Mason KP","year":"2006","unstructured":"Mason KP, Zgleszewski SE, Dearden JL, et al.. Dexmedetomidine for pediatric sedation for computed tomography imaging studies. Anesth Analg. 2006, 103:57-62, table of contents. 10.1213\/01.ane.0000216293.16613.15","journal-title":"Anesth Analg"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.02.003","article-title":"Intranasal atomized dexmedetomidine for sedation during third molar extraction","volume":"42","author":"Nooh N","year":"2013","unstructured":"Nooh N, Sheta SA, Abdullah WA, Abdelhalim AA. Intranasal atomized dexmedetomidine for sedation during third molar extraction. Int J Oral Maxillofac Surg. 2013, 42:857-62. 10.1016\/j.ijom.2013.02.003","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1606342","article-title":"A novel use of a novel drug: preoperative nasal preparation with dexmedetomidine for transnasal transsphenoidal neurosurgery approach in skull base neurosurgery","volume":"6","author":"Hrishi A","year":"2017","unstructured":"Hrishi A, Lionel K, Nair P. A novel use of a novel drug: preoperative nasal preparation with dexmedetomidine for transnasal transsphenoidal neurosurgery approach in skull base neurosurgery. Indian J Neurosurg. 2017, 6:170-5. 10.1055\/s-0037-1606342","journal-title":"Indian J Neurosurg"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12284","article-title":"The sedative effects and the attenuation of cardiovascular and arousal responses during anesthesia induction and intubation in pediatric patients: a randomized comparison between two different doses of preoperative intranasal dexmedetomidine","volume":"24","author":"Wang SS","year":"2014","unstructured":"Wang SS, Zhang MZ, Sun Y, et al.. The sedative effects and the attenuation of cardiovascular and arousal responses during anesthesia induction and intubation in pediatric patients: a randomized comparison between two different doses of preoperative intranasal dexmedetomidine. Paediatr Anaesth. 2014, 24:275-81. 10.1111\/pan.12284","journal-title":"Paediatr Anaesth"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/225356-nebulized-versus-intravenously-administered-dexmedetomidine-for-obtunding-hemodynamic-responses-to-laryngoscopy-and-tracheal-intubation-a-randomized-double-blind-comparative-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T17:33:30Z","timestamp":1731432810000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/225356-nebulized-versus-intravenously-administered-dexmedetomidine-for-obtunding-hemodynamic-responses-to-laryngoscopy-and-tracheal-intubation-a-randomized-double-blind-comparative-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.54768","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,23]]}}}