{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:32:49Z","timestamp":1787315569026,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,2]]},"DOI":"10.7759\/cureus.55396","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T11:10:11Z","timestamp":1709377811000},"source":"Crossref","is-referenced-by-count":6,"title":["In Vitro Evaluation of Extracts From Ixora Species for a Potential Phytosomal Formulation"],"prefix":"10.7759","author":[{"given":"Jasmin Sajini","family":"Rajayan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinodhini","family":"Chandrasekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamundeeswari","family":"Duraipandian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Extraction and isolation of active constituents from Ixora chinensis Lam leaves","volume":"7","author":"Sunitha D","year":"2015","unstructured":"Sunitha D, Hemalatha K, Manthripragada BR, Chary N. Extraction and isolation of active constituents from Ixora chinensis Lam leaves. Der Pharma Chemica. 2015, 7:434-41.","journal-title":"Der Pharma Chemica"},{"key":"ref2","article-title":"A review on phytochemical and pharmacological activity of genus Ixora","volume":"3","author":"Kharat AR","year":"2013","unstructured":"Kharat AR, Nambiar VV, Tarkasband YS, Pujari RR. A review on phytochemical and pharmacological activity of genus Ixora. Int J Res Pharm Chem. 2013, 3:628-35.","journal-title":"Int J Res Pharm Chem"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(00)00218-X","article-title":"Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds","volume":"25","author":"Rauha JP","year":"2000","unstructured":"Rauha JP, Remes S, Heinonen M, et al.. Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. Int J Food Microbiol. 2000, 25:3-12. 10.1016\/S0168-1605(00)00218-X","journal-title":"Int J Food Microbiol"},{"key":"ref4","article-title":"Phytochemical studies of Ixora coccinea Linn-an ethnobotanical plant from Karwar District","volume":"6","author":"Damle S","year":"2017","unstructured":"Damle S, Sharon K. Phytochemical studies of Ixora coccinea Linn-an ethnobotanical plant from Karwar District. Int J Bio Pharm Allied Sci . 2017, 6:1403-15.","journal-title":"Int J Bio Pharm Allied Sci"},{"key":"ref5","article-title":"","author":"Srinivasan GV","year":"2015","unstructured":"Srinivasan GV. Phytochemical investigation and biological studies of secondary metabolites from some folk medicinal plants. University of Calicut, Malappuram, India; 2015. https:\/\/shodhganga.inflibnet.ac.in:8443\/jspui\/handle\/10603\/143434."},{"key":"ref6","article-title":"Ixora coccinea Linn.: traditional uses, phytochemistry and pharmacology","volume":"18","author":"Manjeshwar SB","year":"2012","unstructured":"Manjeshwar SB, Poruthukaran JK. Ixora coccinea Linn.: traditional uses, phytochemistry and pharmacology. Chin J Integr Med. 2012, 18:72-9.","journal-title":"Chin J Integr Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/13880200590919483","article-title":"Anti-inflammatory activity of the aqueous leaf extract of Ixora coccinea","volume":"43","author":"Ratnasooriya WD","year":"2005","unstructured":"Ratnasooriya WD, Deraniyagala SA, Galhena G, Liyanage SS, Bathige SD, Jayakody JR. Anti-inflammatory activity of the aqueous leaf extract of Ixora coccinea. Pharm Bio. 2005, 43:147-52. 10.1080\/13880200590919483","journal-title":"Pharm Bio"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1099-1573(199909)13:6<517::aid-ptr524>3.0.co;2-y","article-title":"Modulatory effects of ixora coccinea flower on cyclophosphamide-induced toxicity in mice","volume":"13","author":"Latha PG","year":"1999","unstructured":"Latha PG, Panikkar KR. Modulatory effects of ixora coccinea flower on cyclophosphamide-induced toxicity in mice. Phytother Res. 1999, 13:517-20. 10.1002\/(sici)1099-1573(199909)13:6&lt;517::aid-ptr524&gt;3.0.co;2-y","journal-title":"Phytother Res"},{"key":"ref9","article-title":"Occurrence of camptothecin an anticancer drug from Ixora coccinea Linn","volume":"2","author":"Saravanan P","year":"2011","unstructured":"Saravanan P, Boopalan E. Occurrence of camptothecin an anticancer drug from Ixora coccinea Linn. Int J Appl Biol. 2011, 2:30-4.","journal-title":"Int J Appl Biol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3835(98)00140-2","article-title":"Cytotoxic and antitumour principles from Ixora coccinea flowers","volume":"14","author":"Latha PG","year":"1998","unstructured":"Latha PG, Panikkar KR. Cytotoxic and antitumour principles from Ixora coccinea flowers. Cancer Lett. 1998, 14:197-202. 10.1016\/s0304-3835(98)00140-2","journal-title":"Cancer Lett"},{"key":"ref11","article-title":"Pharmacognostic & phytochemical characterization of Ixora alba L","volume":"5","author":"Talpade MB","year":"2016","unstructured":"Talpade MB, Chachad D. Pharmacognostic &amp; phytochemical characterization of Ixora alba L. World J Pharm Res. 2016, 5:1015-22.","journal-title":"World J Pharm Res"},{"key":"ref12","article-title":"In-vitro free radical scavenging activity of Ixora coccinea L","volume":"15","author":"Saha MR","year":"2008","unstructured":"Saha MR, Alam MA, Akter R, Jahangir R. In-vitro free radical scavenging activity of Ixora coccinea L. Bangladesh J Pharmacol. 2008, 15:90-6.","journal-title":"Bangladesh J Pharmacol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.02.095","article-title":"Inductively coupled plasma-mass spectrometry (ICP-MS) and -optical emission spectroscopy (ICP-OES) for determination of essential minerals in closed acid digestates of peanuts (Arachis hypogaea L.)","volume":"1","author":"Phan-Thien KY","year":"2012","unstructured":"Phan-Thien KY, Wright GC, Lee NA. Inductively coupled plasma-mass spectrometry (ICP-MS) and -optical emission spectroscopy (ICP-OES) for determination of essential minerals in closed acid digestates of peanuts (Arachis hypogaea L.). Food Chem. 2012, 1:453-60. 10.1016\/j.foodchem.2012.02.095","journal-title":"Food Chem"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-011-0881-3","article-title":"Ixora coccinea Linn.: traditional uses, phytochemistry and pharmacology","volume":"18","author":"Baliga MS","year":"2012","unstructured":"Baliga MS, Kurian PJ. Ixora coccinea Linn.: traditional uses, phytochemistry and pharmacology. Chin J Integr Med. 2012, 18:72-9. 10.1007\/s11655-011-0881-3","journal-title":"Chin J Integr Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-2423(03)37010-6","article-title":"Total antioxidant capacity","volume":"37","author":"Bartosz G","year":"2003","unstructured":"Bartosz G. Total antioxidant capacity. Adv Clin Chem. 2003, 37:219-92. 10.1016\/s0065-2423(03)37010-6","journal-title":"Adv Clin Chem"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-221","article-title":"Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L","volume":"12","author":"Saeed N","year":"2012","unstructured":"Saeed N, Khan MR, Shabbir M. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. BMC Complement Altern Med. 2012, 12:221. 10.1186\/1472-6882-12-221","journal-title":"BMC Complement Altern Med"},{"key":"ref17","article-title":"Study of antimicrobial properties of Catharanthus roseus by Agar well diffusion method","volume":"31","author":"Chaman S","year":"2013","unstructured":"Chaman S, Sharma G, Reshi AK, Shalini. Study of antimicrobial properties of Catharanthus roseus by Agar well diffusion method. Int J Pharm Sci Res. 2013, 31:65-8.","journal-title":"Int J Pharm Sci Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand I","year":"2008","unstructured":"Wiegand I, Hilpert K, Hancock RE. Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nat Protoc. 2008, 3:163-75. 10.1038\/nprot.2007.521","journal-title":"Nat Protoc"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3109\/13880200903490505","article-title":"Antioxidant activity and total phenolic content of methanol extracts of Ixora coccinea","volume":"48","author":"Torey A","year":"2010","unstructured":"Torey A, Sasidharan S, Latha LY, Sudhakaran S, Ramanathan S. Antioxidant activity and total phenolic content of methanol extracts of Ixora coccinea. Pharm Biol. 2010, 48:1119-23. 10.3109\/13880200903490505","journal-title":"Pharm Biol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200700066","article-title":"A rapid RP-HPTLC densitometry method for simultaneous determination of major flavonoids in important medicinal plants","volume":"30","author":"Bhandari P","year":"2007","unstructured":"Bhandari P, Kumar N, Gupta AP, Singh B, Kaul VK. A rapid RP-HPTLC densitometry method for simultaneous determination of major flavonoids in important medicinal plants. J Sep Sci. 2007, 30:2092-6. 10.1002\/jssc.200700066","journal-title":"J Sep Sci"},{"key":"ref21","article-title":"In-vitro cytotoxicity activity of Solanum nigrum extract against HeLa cell line and Vero cell line","volume":"1","author":"Patel S","year":"2009","unstructured":"Patel S, Gheewala N, Suthar A, Shah A, Patel SK. In-vitro cytotoxicity activity of Solanum nigrum extract against HeLa cell line and Vero cell line. Int J Pharm Pharm Sci. 2009, 1:38-46.","journal-title":"Int J Pharm Pharm Sci"},{"key":"ref22","article-title":"Comparative analysis of three leaf extracts of Ixora Coccinea linn. for their protective and anti-oxidant potentials and correlation with analytical data","volume":"4","author":"Shyam P","year":"2013","unstructured":"Shyam P, Suresh PK. Comparative analysis of three leaf extracts of Ixora Coccinea linn. for their protective and anti-oxidant potentials and correlation with analytical data. Int J Pharma Bio Sci. 2013, 4:937-49.","journal-title":"Int J Pharma Bio Sci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2020.08.012","article-title":"Antioxidant and antimicrobial activities of Ixora coccinea root and quantification of phenolic compounds using HPLC","volume":"135","author":"Muhammad H","year":"2020","unstructured":"Muhammad H, Qasim M,  Ikram A, et al.. Antioxidant and antimicrobial activities of Ixora coccinea root and quantification of phenolic compounds using HPLC. S Afr J Bot. 2020, 135:71-9. 10.1016\/j.sajb.2020.08.012","journal-title":"S Afr J Bot"},{"key":"ref24","article-title":"Anti - tumour activity of an ayurvedic oil preparation","volume":"6","author":"Panikar KR","year":"1986","unstructured":"Panikar KR, Bhanumathy P, Raghunath PN. Anti - tumour activity of an ayurvedic oil preparation. Anc Sci Life. 1986, 6:107-8.","journal-title":"Anc Sci Life"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1076\/1388-0209(200004)3821-1FT152","article-title":"Inhibition of chemical carcinogenesis in mice by ixora coccinea flowers","volume":"38","author":"Latha PG","year":"2000","unstructured":"Latha PG, Panikkar KR. Inhibition of chemical carcinogenesis in mice by ixora coccinea flowers. Pharm Biol. 2000, 38:152-6. 10.1076\/1388-0209(200004)3821-1FT152","journal-title":"Pharm Biol"},{"key":"ref26","article-title":"GC-MS analysis of bioactive compounds present in the petroleum ether, chloroform and methanol extract of Ixora coccinea\u2019s flower and in-vitro cytotoxic activity of methanolic extract against DLA and EAC cancer cell lines","volume":"5","author":"Prabhu V","year":"2018","unstructured":"Prabhu V, Poonkodi K, Mini R, Vimala Devi K, Karthigai Priya M. GC-MS analysis of bioactive compounds present in the petroleum ether, chloroform and methanol extract of Ixora coccinea\u2019s flower and in-vitro cytotoxic activity of methanolic extract against DLA and EAC cancer cell lines. Int J Res Anal Rev. 2018, 5:801-7.","journal-title":"Int J Res Anal Rev"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/229790-in-vitro-evaluation-of-extracts-from-ixora-species-for-a-potential-phytosomal-formulation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T11:10:17Z","timestamp":1709377817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/229790-in-vitro-evaluation-of-extracts-from-ixora-species-for-a-potential-phytosomal-formulation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,2]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.55396","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,2]]}}}