{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:28:55Z","timestamp":1785896935937,"version":"3.56.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,10]]},"DOI":"10.7759\/cureus.55902","type":"journal-article","created":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T17:59:16Z","timestamp":1710093556000},"source":"Crossref","is-referenced-by-count":23,"title":["Gastric Cancer: A Comprehensive Literature Review"],"prefix":"10.7759","author":[{"given":"Reda H","family":"Mithany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Hasaan","family":"Shahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Manasseh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Talha","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samana","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesma","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.045","article-title":"Burden of gastric cancer","volume":"18","author":"Thrift AP","year":"2020","unstructured":"Thrift AP, El-Serag HB. Burden of gastric cancer. Clin Gastroenterol Hepatol. 2020, 18:534-42. 10.1016\/j.cgh.2019.07.045","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4586","article-title":"Gastric and esophageal cancer in China 2000 to 2030: recent trends and short-term predictions of the future burden","volume":"11","author":"Zhou J","year":"2022","unstructured":"Zhou J, Zheng R, Zhang S, et al.. Gastric and esophageal cancer in China 2000 to 2030: recent trends and short-term predictions of the future burden. Cancer Med. 2022, 11:1902-12. 10.1002\/cam4.4586","journal-title":"Cancer Med"},{"key":"ref3","article-title":"Anatomy, abdomen and pelvis: stomach","author":"Chaudhry SR","year":"2022","unstructured":"Chaudhry SR, Liman MN, Peterson DC. Anatomy, abdomen and pelvis: stomach. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2022."},{"key":"ref4","article-title":"Intestinal architecture and development","author":"Rao JN","year":"2010","unstructured":"Rao JN, Wang JY. Intestinal architecture and development. Regulation of Gastrointestinal Mucosal Growth. Morgan &amp; Claypool Life Sciences, San Rafael (CA); 2010."},{"key":"ref5","article-title":"Anatomy, abdomen and pelvis: celiac trunk","author":"Ahluwalia N","year":"2024","unstructured":"Ahluwalia N, Nassereddin A, Futterman B. Anatomy, abdomen and pelvis: celiac trunk. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2024."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2018.80001","article-title":"Epidemiology of gastric cancer: global trends, risk factors and prevention","volume":"14","author":"Rawla P","year":"2019","unstructured":"Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019, 14:26-38. 10.5114\/pg.2018.80001","journal-title":"Prz Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.15165","article-title":"Association between Helicobacter pylori and gastric carcinoma","volume":"13","author":"Padda J","year":"2021","unstructured":"Padda J, Khalid K, Cooper AC, Jean-Charles G. Association between Helicobacter pylori and gastric carcinoma. Cureus. 2021, 13:e15165. 10.7759\/cureus.15165","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.892468","article-title":"Risk factors for gastric cancer: a comprehensive analysis of observational studies","volume":"10","author":"Hui Y","year":"2022","unstructured":"Hui Y, Tu C, Liu D, Zhang H, Gong X. Risk factors for gastric cancer: a comprehensive analysis of observational studies. Front Public Health. 2022, 10:892468. 10.3389\/fpubh.2022.892468","journal-title":"Front Public Health"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30219-9","article-title":"Hereditary diffuse gastric cancer: updated clinical practice guidelines","volume":"21","author":"Blair VR","year":"2020","unstructured":"Blair VR, McLeod M, Carneiro F, et al.. Hereditary diffuse gastric cancer: updated clinical practice guidelines. Lancet Oncol. 2020, 21:e386-97. 10.1016\/S1470-2045(20)30219-9","journal-title":"Lancet Oncol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2022.101800","article-title":"Familial and hereditary gastric cancer, an overview","volume":"58-59","author":"Carneiro F","year":"2022","unstructured":"Carneiro F. Familial and hereditary gastric cancer, an overview. Best Pract Res Clin Gastroenterol. 2022, 58-59:101800. 10.1016\/j.bpg.2022.101800","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00658-5","article-title":"Inflammation and tumor progression: signaling pathways and targeted intervention","volume":"6","author":"Zhao H","year":"2021","unstructured":"Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y, Li Y. Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther. 2021, 6:263. 10.1038\/s41392-021-00658-5","journal-title":"Signal Transduct Target Ther"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13235915","article-title":"Early TP53 alterations shape gastric and esophageal cancer development","volume":"13","author":"Sahgal P","year":"2021","unstructured":"Sahgal P, Huffman BM, Patil DT, Chatila WK, Yaeger R, Cleary JM, Sethi NS. Early TP53 alterations shape gastric and esophageal cancer development. Cancers (Basel). 2021, 13:5915. 10.3390\/cancers13235915","journal-title":"Cancers (Basel)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.47162\/RJME.64.3.03","article-title":"Tumor angiogenesis in gastric cancer","volume":"64","author":"Giubelan A","year":"2023","unstructured":"Giubelan A, Stancu MI, Hon\u0163aru SO, M\u0103l\u0103escu GD, Badea-Voiculescu O, Firoiu C, Mogoant\u0103 S\u015e. Tumor angiogenesis in gastric cancer. Rom J Morphol Embryol. 2023, 64:311-8. 10.47162\/RJME.64.3.03","journal-title":"Rom J Morphol Embryol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9050052","article-title":"Epidermal growth factor receptor cell proliferation signaling pathways","volume":"9","author":"Wee P","year":"2017","unstructured":"Wee P, Wang Z. Epidermal growth factor receptor cell proliferation signaling pathways. Cancers (Basel). 2017, 9:52. 10.3390\/cancers9050052","journal-title":"Cancers (Basel)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13235930","article-title":"Proteomic signatures of diffuse and intestinal subtypes of gastric cancer","volume":"13","author":"Singh S","year":"2021","unstructured":"Singh S, Bhat MY, Sathe G, et al.. Proteomic signatures of diffuse and intestinal subtypes of gastric cancer. Cancers (Basel). 2021, 13:5930. 10.3390\/cancers13235930","journal-title":"Cancers (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3399\/bjgpopen20X101001","article-title":"Patient symptom experience prior to a diagnosis of oesophageal or gastric cancer: a multi-methods study","volume":"4","author":"Humphrys E","year":"2020","unstructured":"Humphrys E, Walter FM, Rubin G, et al.. Patient symptom experience prior to a diagnosis of oesophageal or gastric cancer: a multi-methods study. BJGP Open. 2020, 4:10.3399\/bjgpopen20X101001","journal-title":"BJGP Open"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2021.03.005","article-title":"Improving the early diagnosis of gastric cancer","volume":"31","author":"Huang RJ","year":"2021","unstructured":"Huang RJ, Hwang JH. Improving the early diagnosis of gastric cancer. Gastrointest Endosc Clin N Am. 2021, 31:503-17. 10.1016\/j.giec.2021.03.005","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"ref18","article-title":"Gastric cancer","author":"Mukkamalla SK","year":"2023","unstructured":"Mukkamalla SK, Recio-Boiles A, Babiker HM. Gastric cancer. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33294","article-title":"Value of upper gastrointestinal endoscopy for gastric cancer surveillance in patients with Lynch syndrome","volume":"148","author":"Ladigan-Badura S","year":"2021","unstructured":"Ladigan-Badura S, Vangala DB, Engel C, et al.. Value of upper gastrointestinal endoscopy for gastric cancer surveillance in patients with Lynch syndrome. Int J Cancer. 2021, 148:106-14. 10.1002\/ijc.33294","journal-title":"Int J Cancer"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13071276","article-title":"Imaging in gastric cancer: current practice and future perspectives","volume":"13","author":"Giandola T","year":"2023","unstructured":"Giandola T, Maino C, Marrapodi G, et al.. Imaging in gastric cancer: current practice and future perspectives. Diagnostics (Basel). 2023, 13:1276. 10.3390\/diagnostics13071276","journal-title":"Diagnostics (Basel)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061402","article-title":"Gastric cancer staging: is it time for magnetic resonance imaging?","volume":"12","author":"Renzulli M","year":"2020","unstructured":"Renzulli M, Clemente A, Spinelli D, et al.. Gastric cancer staging: is it time for magnetic resonance imaging?. Cancers (Basel). 2020, 12:1402. 10.3390\/cancers12061402","journal-title":"Cancers (Basel)"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0703-1","article-title":"Molecular profiling for precision cancer therapies","volume":"12","author":"Malone ER","year":"2020","unstructured":"Malone ER, Oliva M, Sabatini PJ, Stockley TL, Siu LL. Molecular profiling for precision cancer therapies. Genome Med. 2020, 12:8. 10.1186\/s13073-019-0703-1","journal-title":"Genome Med"},{"key":"ref23","article-title":"TNM classification","author":"Rosen RD","year":"2023","unstructured":"Rosen RD, Sapra A. TNM classification. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref24","unstructured":"TNM staging for stomach cancer. (2022). Accessed. November 10, 2023: https:\/\/www.cancerresearchuk.org\/about-cancer\/stomach-cancer\/stages\/tnm-staging."},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.06.006","article-title":"Clinical and pathological staging of gastric cancer: current perspectives and implications","volume":"46","author":"Zhu Z","year":"2020","unstructured":"Zhu Z, Gong Y, Xu H. Clinical and pathological staging of gastric cancer: current perspectives and implications. Eur J Surg Oncol. 2020, 46:e14-9. 10.1016\/j.ejso.2020.06.006","journal-title":"Eur J Surg Oncol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21657","article-title":"Current treatment and recent progress in gastric cancer","volume":"71","author":"Joshi SS","year":"2021","unstructured":"Joshi SS, Badgwell BD. Current treatment and recent progress in gastric cancer. CA Cancer J Clin. 2021, 71:264-79. 10.3322\/caac.21657","journal-title":"CA Cancer J Clin"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/IJ9.0000000000000011","article-title":"The principles of the surgical management of gastric cancer","volume":"2","author":"Weledji EP","year":"2017","unstructured":"Weledji EP. The principles of the surgical management of gastric cancer. Int J Surg Oncol (N Y). 2017, 2:e11. 10.1097\/IJ9.0000000000000011","journal-title":"Int J Surg Oncol (N Y)"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.744839","article-title":"Recent advances in the diagnosis, staging, treatment, and prognosis of advanced gastric cancer: a literature review","volume":"8","author":"Chen ZD","year":"2021","unstructured":"Chen ZD, Zhang PF, Xi HQ, Wei B, Chen L, Tang Y. Recent advances in the diagnosis, staging, treatment, and prognosis of advanced gastric cancer: a literature review. Front Med (Lausanne). 2021, 8:744839. 10.3389\/fmed.2021.744839","journal-title":"Front Med (Lausanne)"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i38.13667","article-title":"Subtotal gastrectomy for gastric cancer","volume":"20","author":"Santoro R","year":"2014","unstructured":"Santoro R, Ettorre GM, Santoro E. Subtotal gastrectomy for gastric cancer. World J Gastroenterol. 2014, 20:13667-80. 10.3748\/wjg.v20.i38.13667","journal-title":"World J Gastroenterol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11323-8","article-title":"Cytoreductive surgery with HIPEC is a safe and effective palliative option in chemorefractory symptomatic peritoneal metastasis","volume":"29","author":"Zhang C","year":"2022","unstructured":"Zhang C, Patel A, Hegeholz D, Brown K, Shostrom V, Pottebaum M, Foster JM. Cytoreductive surgery with HIPEC is a safe and effective palliative option in chemorefractory symptomatic peritoneal metastasis. Ann Surg Oncol. 2022, 29:3337-46. 10.1245\/s10434-022-11323-8","journal-title":"Ann Surg Oncol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-022-01004-9","article-title":"Neoadjuvant and adjuvant therapy approaches to gastric cancer","volume":"23","author":"Fong C","year":"2022","unstructured":"Fong C, Johnston E, Starling N. Neoadjuvant and adjuvant therapy approaches to gastric cancer. Curr Treat Options Oncol. 2022, 23:1247-68. 10.1007\/s11864-022-01004-9","journal-title":"Curr Treat Options Oncol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.3635","article-title":"Cancer and radiation therapy: current advances and future directions","volume":"9","author":"Baskar R","year":"2012","unstructured":"Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 2012, 9:193-9. 10.7150\/ijms.3635","journal-title":"Int J Med Sci"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2022.102325","article-title":"Is there still a place for radiotherapy in gastric cancer?","volume":"68","author":"Chong IY","year":"2023","unstructured":"Chong IY, Chau I. Is there still a place for radiotherapy in gastric cancer?. Curr Opin Pharmacol. 2023, 68:102325. 10.1016\/j.coph.2022.102325","journal-title":"Curr Opin Pharmacol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s10353-016-0389-1","article-title":"Targeted therapy in gastric cancer","volume":"48","author":"Jomrich G","year":"2016","unstructured":"Jomrich G, Schoppmann SF. Targeted therapy in gastric cancer. Eur Surg. 2016, 48:278-84. 10.1007\/s10353-016-0389-1","journal-title":"Eur Surg"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29050247","article-title":"Immune checkpoint inhibitors in cancer therapy","volume":"29","author":"Shiravand Y","year":"2022","unstructured":"Shiravand Y, Khodadadi F, Kashani SM, et al.. Immune checkpoint inhibitors in cancer therapy. Curr Oncol. 2022, 29:3044-60. 10.3390\/curroncol29050247","journal-title":"Curr Oncol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-0121","article-title":"Association of tumor mutational burden with efficacy of pembrolizumab\u00b1chemotherapy as first-line therapy for gastric cancer in the phase III KEYNOTE-062 study","volume":"28","author":"Lee KW","year":"2022","unstructured":"Lee KW, Van Cutsem E, Bang YJ, et al.. Association of tumor mutational burden with efficacy of pembrolizumab\u00b1chemotherapy as first-line therapy for gastric cancer in the phase III KEYNOTE-062 study. Clin Cancer Res. 2022, 28:3489-98. 10.1158\/1078-0432.CCR-22-0121","journal-title":"Clin Cancer Res"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00215-2","article-title":"Trastuzumab deruxtecan in patients in the USA and Europe with HER2-positive advanced gastric or gastroesophageal junction cancer with disease progression on or after a trastuzumab-containing regimen (DESTINY-Gastric02): primary and updated analyses from a single-arm, phase 2 study","volume":"24","author":"Van Cutsem E","year":"2023","unstructured":"Van Cutsem E, di Bartolomeo M, Smyth E, et al.. Trastuzumab deruxtecan in patients in the USA and Europe with HER2-positive advanced gastric or gastroesophageal junction cancer with disease progression on or after a trastuzumab-containing regimen (DESTINY-Gastric02): primary and updated analyses from a single-arm, phase 2 study. Lancet Oncol. 2023, 24:744-56. 10.1016\/S1470-2045(23)00215-2","journal-title":"Lancet Oncol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2014.47.6.478","article-title":"Prevention strategies for gastric cancer: a global perspective","volume":"47","author":"Park JY","year":"2014","unstructured":"Park JY, von Karsa L, Herrero R. Prevention strategies for gastric cancer: a global perspective. Clin Endosc. 2014, 47:478-89. 10.5946\/ce.2014.47.6.478","journal-title":"Clin Endosc"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15037","article-title":"Gastric cancer prevention strategies: a global perspective","volume":"35","author":"Eusebi LH","year":"2020","unstructured":"Eusebi LH, Telese A, Marasco G, Bazzoli F, Zagari RM. Gastric cancer prevention strategies: a global perspective. J Gastroenterol Hepatol. 2020, 35:1495-502. 10.1111\/jgh.15037","journal-title":"J Gastroenterol Hepatol"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.06.03","article-title":"Gastric cancer: epidemiology, risk factors and prevention strategies","volume":"32","author":"Yang L","year":"2020","unstructured":"Yang L, Ying X, Liu S, et al.. Gastric cancer: epidemiology, risk factors and prevention strategies. Chin J Cancer Res. 2020, 32:695-704. 10.21147\/j.issn.1000-9604.2020.06.03","journal-title":"Chin J Cancer Res"},{"key":"ref41","unstructured":"Survival for stomach cancer. (2022). Accessed. November 10, 2023: https:\/\/www.cancerresearchuk.org\/about-cancer\/stomach-cancer\/survival."},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1177\/10732748221099227","article-title":"Recent estimates and predictions of 5-year survival in patients with gastric cancer: a model-based period analysis","volume":"29","author":"Li Y","year":"2022","unstructured":"Li Y, Feng A, Zheng S, Chen C, Lyu J. Recent estimates and predictions of 5-year survival in patients with gastric cancer: a model-based period analysis. Cancer Control. 2022, 29:10732748221099227. 10.1177\/10732748221099227","journal-title":"Cancer Control"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/205412-gastric-cancer-a-comprehensive-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T17:59:21Z","timestamp":1710093561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/205412-gastric-cancer-a-comprehensive-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,10]]},"references-count":42,"URL":"https:\/\/doi.org\/10.7759\/cureus.55902","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,10]]}}}