{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:36:08Z","timestamp":1777721768704,"version":"3.51.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,11]]},"DOI":"10.7759\/cureus.55972","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T21:12:33Z","timestamp":1710191553000},"source":"Crossref","is-referenced-by-count":3,"title":["Pneumatosis Intestinalis, Pneumoperitoneum, Pneumoretroperitoneum, Pneumomediastinum, and Pneumobilia After Pembrolizumab Therapy: A Case Report"],"prefix":"10.7759","author":[{"given":"Charles D","family":"Calenda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron R","family":"Toohey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AyJy","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaspreet","family":"Ubhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunima","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fady","family":"Abou Rizk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.01.011","article-title":"Management and outcome of pneumatosis intestinalis","volume":"195","author":"Morris MS","year":"2008","unstructured":"Morris MS, Gee AC, Cho SD, Limbaugh K, Underwood S, Ham B, Schreiber MA. Management and outcome of pneumatosis intestinalis. Am J Surg. 2008, 195:679-82. 10.1016\/j.amjsurg.2008.01.011","journal-title":"Am J Surg"},{"key":"ref2","article-title":"Pneumatosis intestinalis","author":"Goldberg E","year":"2023","unstructured":"Goldberg E, Thomas Lamont MDJ. Pneumatosis intestinalis. UpToDate. Post TW (ed): UpToDate, Waltham, MA; 2023."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4348-9","article-title":"Clinical significance of pneumatosis intestinalis - correlation of MDCT-findings with treatment and outcome","volume":"27","author":"Treyaud MO","year":"2017","unstructured":"Treyaud MO, Duran R, Zins M, Knebel JF, Meuli RA, Schmidt S. Clinical significance of pneumatosis intestinalis - correlation of MDCT-findings with treatment and outcome. Eur Radiol. 2017, 27:70-9. 10.1007\/s00330-016-4348-9","journal-title":"Eur Radiol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14071666","article-title":"Pneumatosis intestinalis induced by anticancer treatment: a systematic review","volume":"14","author":"Gazzaniga G","year":"2022","unstructured":"Gazzaniga G, Villa F, Tosi F, et al.. Pneumatosis intestinalis induced by anticancer treatment: a systematic review. Cancers (Basel). 2022, 14:10.3390\/cancers14071666","journal-title":"Cancers (Basel)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05461-z","article-title":"Pneumatosis intestinalis in cancer patients who received immune checkpoint inhibitors","volume":"149","author":"Sperling G","year":"2023","unstructured":"Sperling G, Shatila M, Varatharajalu K, et al.. Pneumatosis intestinalis in cancer patients who received immune checkpoint inhibitors. J Cancer Res Clin Oncol. 2023, 149:17597-605. 10.1007\/s00432-023-05461-z","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06768-4","article-title":"Gas bubbles: a persistent problem with immunotherapy","volume":"66","author":"Yik B","year":"2021","unstructured":"Yik B, Shah N. Gas bubbles: a persistent problem with immunotherapy. Dig Dis Sci. 2021, 66:2542-4. 10.1007\/s10620-020-06768-4","journal-title":"Dig Dis Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1133551","article-title":"Pneumatosis intestinalis post steroid use in a patient with immune-related adverse events: case report, literature review and FAERS analysis","volume":"14","author":"Zhang T","year":"2023","unstructured":"Zhang T, Cao M, Zhao B, et al.. Pneumatosis intestinalis post steroid use in a patient with immune-related adverse events: case report, literature review and FAERS analysis. Front Pharmacol. 2023, 14:10.3389\/fphar.2023.1133551","journal-title":"Front Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1190850","article-title":"An updated review of gastrointestinal toxicity induced by PD-1 inhibitors: from mechanisms to management","volume":"14","author":"Cheng Y","year":"2023","unstructured":"Cheng Y, Ling F, Li J, Chen Y, Xu M, Li S, Zhu L. An updated review of gastrointestinal toxicity induced by PD-1 inhibitors: from mechanisms to management. Front Immunol. 2023, 14:10.3389\/fimmu.2023.1190850","journal-title":"Front Immunol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.1.68","article-title":"The spectrum of pneumatosis intestinalis","volume":"138","author":"St Peter SD","year":"2003","unstructured":"St Peter SD, Abbas MA, Kelly KA. The spectrum of pneumatosis intestinalis. Arch Surg. 2003, 138:68-75. 10.1001\/archsurg.138.1.68","journal-title":"Arch Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/1756284819870911","article-title":"Impact of the gut microbiota on immune checkpoint inhibitor-associated toxicities","volume":"12","author":"Pezo RC","year":"2019","unstructured":"Pezo RC, Wong M, Martin A. Impact of the gut microbiota on immune checkpoint inhibitor-associated toxicities. Therap Adv Gastroenterol. 2019, 12:10.1177\/1756284819870911","journal-title":"Therap Adv Gastroenterol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.07.010","article-title":"Pneumatosis intestinalis and pneumoperitoneum during treatment by paclitaxel","volume":"149","author":"Guiu S","year":"2011","unstructured":"Guiu S, Ortega-Deballon P, Guiu B. Pneumatosis intestinalis and pneumoperitoneum during treatment by paclitaxel. Surgery. 2011, 149:297-8. 10.1016\/j.surg.2009.07.010","journal-title":"Surgery"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.51821\/84.3.015","article-title":"Pneumatosis intestinalis and spontaneous perforation associated with drug toxicity in oncologic patients: a case series","volume":"84","author":"Brocchi S","year":"2021","unstructured":"Brocchi S, Parmeggiani A, Gaudiano C, et al.. Pneumatosis intestinalis and spontaneous perforation associated with drug toxicity in oncologic patients: a case series. Acta Gastroenterol Belg. 2021, 84:497-9. 10.51821\/84.3.015","journal-title":"Acta Gastroenterol Belg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S150960","article-title":"Comparative effectiveness of early-line nab-paclitaxel vs. paclitaxel in patients with metastatic breast cancer: a US community-based real-world analysis","volume":"10","author":"Mahtani RL","year":"2018","unstructured":"Mahtani RL, Parisi M, Gl\u00fcck S, et al.. Comparative effectiveness of early-line nab-paclitaxel vs. paclitaxel in patients with metastatic breast cancer: a US community-based real-world analysis. Cancer Manag Res. 2018, 10:249-56. 10.2147\/CMAR.S150960","journal-title":"Cancer Manag Res"},{"key":"ref14","article-title":"Pneumatosis intestinalis","author":"Im J","year":"2023","unstructured":"Im J, Anjum F. Pneumatosis intestinalis. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL); 2023."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000236596","article-title":"Pneumatosis intestinalis: can we avoid surgical intervention in nonsurgical patients?","volume":"3","author":"Al-Talib A","year":"2009","unstructured":"Al-Talib A, Al-Ghtani F, Munk R. Pneumatosis intestinalis: can we avoid surgical intervention in nonsurgical patients?. Case Rep Gastroenterol. 2009, 3:286-92. 10.1159\/000236596","journal-title":"Case Rep Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783x-14-6-231","article-title":"Natural history, clinical pattern, and surgical considerations of pneumatosis intestinalis","volume":"14","author":"Khalil PN","year":"2009","unstructured":"Khalil PN, Huber-Wagner S, Ladurner R, et al.. Natural history, clinical pattern, and surgical considerations of pneumatosis intestinalis. Eur J Med Res. 2009, 14:231-9. 10.1186\/2047-783x-14-6-231","journal-title":"Eur J Med Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/222608-pneumatosis-intestinalis-pneumoperitoneum-pneumoretroperitoneum-pneumomediastinum-and-pneumobilia-after-pembrolizumab-therapy-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T21:12:35Z","timestamp":1710191555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/222608-pneumatosis-intestinalis-pneumoperitoneum-pneumoretroperitoneum-pneumomediastinum-and-pneumobilia-after-pembrolizumab-therapy-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.55972","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,11]]}}}