{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:01:41Z","timestamp":1771257701982,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"DOI":"10.7759\/cureus.57539","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T15:43:32Z","timestamp":1712159012000},"source":"Crossref","is-referenced-by-count":2,"title":["Exosomes for the Management of Low Back Pain: A Review of Current Clinical Evidence"],"prefix":"10.7759","author":[{"given":"Ashim","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205327","article-title":"Musculoskeletal disorders and the Global Burden of Disease study","volume":"73","author":"Storheim K","year":"2014","unstructured":"Storheim K, Zwart JA. Musculoskeletal disorders and the Global Burden of Disease study. Ann Rheum Dis. 2014, 73:949-50. 10.1136\/annrheumdis-2014-205327","journal-title":"Ann Rheum Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-04241-2","article-title":"Amniotic membrane and\/or umbilical cord tissue for treatment of facet joint syndrome: A narrative review","volume":"18","author":"Gupta A","year":"2023","unstructured":"Gupta A, Maffulli N. Amniotic membrane and\/or umbilical cord tissue for treatment of facet joint syndrome: A narrative review. J Orthop Surg Res. 2023, 18:744. 10.1186\/s13018-023-04241-2","journal-title":"J Orthop Surg Res"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00133-9","article-title":"The global epidemic of low back pain","volume":"5","author":"The Lancet Rheumatology","year":"2023","unstructured":"The Lancet Rheumatology. The global epidemic of low back pain. Lancet Rheumatol. 2023, 5:305. 10.1016\/S2665-9913(23)00133-9","journal-title":"Lancet Rheumatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-064119","article-title":"Clinical and economic burden of low back pain in low- and middle-income countries: A systematic review","volume":"13","author":"Fatoye F","year":"2023","unstructured":"Fatoye F, Gebrye T, Mbada CE, Useh U. Clinical and economic burden of low back pain in low- and middle-income countries: A systematic review. BMJ Open. 2023, 13:e064119. 10.1136\/bmjopen-2022-064119","journal-title":"BMJ Open"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1098100","article-title":"Global and regional estimates of clinical and economic burden of low back pain in high-income countries: A systematic review and meta-analysis","volume":"11","author":"Fatoye F","year":"2023","unstructured":"Fatoye F, Gebrye T, Ryan CG, Useh U, Mbada C. Global and regional estimates of clinical and economic burden of low back pain in high-income countries: A systematic review and meta-analysis. Front Public Health. 2023, 11:1098100. 10.3389\/fpubh.2023.1098100","journal-title":"Front Public Health"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-023-00570-6","article-title":"H-wave(\u00ae) device stimulation for chronic low back pain: a patient-reported outcome measures (PROMs) study","volume":"13","author":"Norwood SM","year":"2024","unstructured":"Norwood SM, Han D, Gupta A. H-wave(\u00ae) device stimulation for chronic low back pain: a patient-reported outcome measures (PROMs) study. Pain Ther. 2024, 13:113-26. 10.1007\/s40122-023-00570-6","journal-title":"Pain Ther"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-283","article-title":"Prevalence of low back pain by anatomic location and intensity in an occupational population","volume":"15","author":"Thiese MS","year":"2014","unstructured":"Thiese MS, Hegmann KT, Wood EM, et al.. Prevalence of low back pain by anatomic location and intensity in an occupational population. BMC Musculoskelet Disord. 2014, 15:283. 10.1186\/1471-2474-15-283","journal-title":"BMC Musculoskelet Disord"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13040974","article-title":"Non-surgical approaches to the management of lumbar disc herniation associated with radiculopathy: A narrative review","volume":"13","author":"El Melhat AM","year":"2024","unstructured":"El Melhat AM, Youssef AS, Zebdawi MR, Hafez MA, Khalil LH, Harrison DE. Non-surgical approaches to the management of lumbar disc herniation associated with radiculopathy: A narrative review. J Clin Med. 2024, 13:974. 10.3390\/jcm13040974","journal-title":"J Clin Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-018-0638-x","article-title":"Facet joint syndrome: From diagnosis to interventional management","volume":"9","author":"Perolat R","year":"2018","unstructured":"Perolat R, Kastler A, Nicot B, et al.. Facet joint syndrome: From diagnosis to interventional management. Insights Imaging. 2018, 9:773-89. 10.1007\/s13244-018-0638-x","journal-title":"Insights Imaging"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-010-0983-4","article-title":"The lumbar facet joint: A review of current knowledge: Part 1: Anatomy, biomechanics, and grading","volume":"40","author":"Varlotta GP","year":"2011","unstructured":"Varlotta GP, Lefkowitz TR, Schweitzer M, Errico TJ, Spivak J, Bendo JA, Rybak L. The lumbar facet joint: A review of current knowledge: Part 1: Anatomy, biomechanics, and grading. Skeletal Radiol. 2011, 40:13-23. 10.1007\/s00256-010-0983-4","journal-title":"Skeletal Radiol"},{"key":"ref11","article-title":"Lumbosacral Facet Syndrome","author":"Alexander CE","year":"2024","unstructured":"Alexander CE, Cascio MA, Varacallo M. Lumbosacral Facet Syndrome. StatPearls Publishing, Treasure Island (FL); 2024."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000141265.55411.30","article-title":"Inflammatory cytokines released from the facet joint tissue in degenerative lumbar spinal disorders","volume":"29","author":"Igarashi A","year":"2004","unstructured":"Igarashi A, Kikuchi S, Konno S, Olmarker K. Inflammatory cytokines released from the facet joint tissue in degenerative lumbar spinal disorders. Spine (Phila Pa 1976). 2004, 29:2091-5. 10.1097\/01.brs.0000141265.55411.30","journal-title":"Spine (Phila Pa 1976)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.46255","article-title":"Cooled radiofrequency treatment for radicular pain related to lumbar disc herniation","volume":"15","author":"Medina-P\u00e9rez JJ","year":"2023","unstructured":"Medina-P\u00e9rez JJ, Vega-Rosas A, Coubert-Pelayo SG, Rosas-Barcelo LS. Cooled radiofrequency treatment for radicular pain related to lumbar disc herniation. Cureus. 2023, 15:e46255. 10.7759\/cureus.46255","journal-title":"Cureus"},{"key":"ref14","article-title":"Radicular Back Pain","author":"Dydyk AM","year":"2022","unstructured":"Dydyk AM, Khan MZ, Singh P. Radicular Back Pain. StatPearls Publishing, Treasure Island (FL); 2022."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-5-15","article-title":"Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions","volume":"5","author":"Manchikanti L","year":"2004","unstructured":"Manchikanti L, Boswell MV, Singh V, Pampati V, Damron KS, Beyer CD. Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions. BMC Musculoskelet Disord. 2004, 5:15. 10.1186\/1471-2474-5-15","journal-title":"BMC Musculoskelet Disord"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.130","article-title":"Chronic low back pain: Pharmacological, interventional and surgical strategies","volume":"9","author":"Morlion B","year":"2013","unstructured":"Morlion B. Chronic low back pain: Pharmacological, interventional and surgical strategies. Nat Rev Neurol. 2013, 9:462-73. 10.1038\/nrneurol.2013.130","journal-title":"Nat Rev Neurol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2014.23.10.465","article-title":"Comparison of cryopreserved amniotic membrane and umbilical cord tissue with dehydrated amniotic membrane\/chorion tissue","volume":"23","author":"Cooke M","year":"2014","unstructured":"Cooke M, Tan EK, Mandrycky C, He H, O'Connell J, Tseng SCG. Comparison of cryopreserved amniotic membrane and umbilical cord tissue with dehydrated amniotic membrane\/chorion tissue. J Wound Care. 2014, 23:476. 10.12968\/jowc.2014.23.10.465","journal-title":"J Wound Care"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-04657-4","article-title":"Management of rotator cuff injuries using allogenic platelet-rich plasma","volume":"19","author":"Gupta A","year":"2024","unstructured":"Gupta A, Migliorini F, Maffulli N. Management of rotator cuff injuries using allogenic platelet-rich plasma. J Orthop Surg Res. 2024, 19:165. 10.1186\/s13018-024-04657-4","journal-title":"J Orthop Surg Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.52693","article-title":"Autologous conditioned plasma (ACP) and osteoarthritis of the knee: A review of current clinical evidence","volume":"16","author":"Gupta A","year":"2024","unstructured":"Gupta A, Jain V. Autologous conditioned plasma (ACP) and osteoarthritis of the knee: A review of current clinical evidence. Cureus. 2024, 16:e52693. 10.7759\/cureus.52693","journal-title":"Cureus"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.53118","article-title":"Hyperacute serum and knee osteoarthritis","volume":"16","author":"Gupta A","year":"2024","unstructured":"Gupta A, Aratikatla A. Hyperacute serum and knee osteoarthritis. Cureus. 2024, 16:e53118. 10.7759\/cureus.53118","journal-title":"Cureus"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.53579","article-title":"Autologous protein solution (APS) and osteoarthritis of the knee: A scoping review of current clinical evidence","volume":"16","author":"Gupta A","year":"2024","unstructured":"Gupta A. Autologous protein solution (APS) and osteoarthritis of the knee: A scoping review of current clinical evidence. Cureus. 2024, 16:e53579. 10.7759\/cureus.53579","journal-title":"Cureus"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030738","article-title":"Factors influencing the yield of progenitor cells in bone marrow aspiration concentrate-A retrospective analysis of 58 patients","volume":"11","author":"Muthu S","year":"2023","unstructured":"Muthu S, Jeyaraman M, Narula A, et al.. Factors influencing the yield of progenitor cells in bone marrow aspiration concentrate-A retrospective analysis of 58 patients. Biomedicines. 2023, 11:738. 10.3390\/biomedicines11030738","journal-title":"Biomedicines"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2023.07.055","article-title":"Arthroscopy with lipoaspirate and plasma infiltration using adipose-derived stem cells plus platelet-rich plasma: Harvesting and injection for arthroscopic treatment of cartilage defects of the knee","volume":"12","author":"Weninger P","year":"2023","unstructured":"Weninger P, Feichtinger X, Steffel C, Kerschbaumer C, Duscher D. Arthroscopy with lipoaspirate and plasma infiltration using adipose-derived stem cells plus platelet-rich plasma: Harvesting and injection for arthroscopic treatment of cartilage defects of the knee. Arthrosc Tech. 2023, 12:e2265-71. 10.1016\/j.eats.2023.07.055","journal-title":"Arthrosc Tech"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-03197-z","article-title":"Allogenic perinatal tissue for musculoskeletal regenerative medicine applications: A systematic review protocol","volume":"17","author":"Aratikatla A","year":"2022","unstructured":"Aratikatla A, Maffulli N, Rodriguez HC, Gupta M, Potty AG, El-Amin SF 3rd, Gupta A. Allogenic perinatal tissue for musculoskeletal regenerative medicine applications: A systematic review protocol. J Orthop Surg Res. 2022, 17:307. 10.1186\/s13018-022-03197-z","journal-title":"J Orthop Surg Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.29245\/2767-5130\/2022\/1.1157","article-title":"Commentary: Cell-free stem cell-derived extract formulation for treatment of knee osteoarthritis","volume":"3","author":"Gupta A","year":"2022","unstructured":"Gupta A. Commentary: Cell-free stem cell-derived extract formulation for treatment of knee osteoarthritis. J Orthopedics & Orthopedic Surg. 2022, 3:23-2. 10.29245\/2767-5130\/2022\/1.1157","journal-title":"J Orthopedics & Orthopedic Surg"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.30574\/ijsra.2021.4.1.0178","article-title":"One month safety study of ExoFlo injection for the treatment of lumbar or cervical radiculopathy in the epidural space","volume":"4","author":"Phillips A","year":"2021","unstructured":"Phillips A, Wong A, Chen G, LaSalle J, Kuo J. One month safety study of ExoFlo injection for the treatment of lumbar or cervical radiculopathy in the epidural space. IJSRA. 2021, 4:119-124. 10.30574\/ijsra.2021.4.1.0178","journal-title":"IJSRA"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2023-0110","article-title":"Safety of bone marrow derived mesenchymal stem cell extracellular vesicle injection for lumbar facet joint pain","volume":"19","author":"Wilson JE","year":"2024","unstructured":"Wilson JE, Today BA, Salazar M, et al.. Safety of bone marrow derived mesenchymal stem cell extracellular vesicle injection for lumbar facet joint pain. Regen Med. 2024, 19:19-26. 10.2217\/rme-2023-0110","journal-title":"Regen Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1019437","article-title":"Application of mesenchymal stem cell-derived exosomes from different sources in intervertebral disc degeneration","volume":"10","author":"Xia Y","year":"2022","unstructured":"Xia Y, Yang R, Hou Y, Wang H, Li Y, Zhu J, Fu C. Application of mesenchymal stem cell-derived exosomes from different sources in intervertebral disc degeneration. Front Bioeng Biotechnol. 2022, 10:1019437. 10.3389\/fbioe.2022.1019437","journal-title":"Front Bioeng Biotechnol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1609206","article-title":"Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications","volume":"8","author":"Witwer KW","year":"2019","unstructured":"Witwer KW, Van Balkom BW, Bruno S, et al.. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. J Extracell Vesicles. 2019, 8:1609206. 10.1080\/20013078.2019.1609206","journal-title":"J Extracell Vesicles"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107823","article-title":"Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes","volume":"97","author":"Arabpour M","year":"2021","unstructured":"Arabpour M, Saghazadeh A, Rezaei N. Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes. Int Immunopharmacol. 2021, 97:107823. 10.1016\/j.intimp.2021.107823","journal-title":"Int Immunopharmacol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3061","article-title":"Preclinical translation of exosomes derived from mesenchymal stem\/stromal cells","volume":"38","author":"Elahi FM","year":"2020","unstructured":"Elahi FM, Farwell DG, Nolta JA, Anderson JD. Preclinical translation of exosomes derived from mesenchymal stem\/stromal cells. Stem Cells. 2020, 38:15-21. 10.1002\/stem.3061","journal-title":"Stem Cells"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldad008","article-title":"Stem cells and discogenic back pain","volume":"146","author":"Miranda L","year":"2023","unstructured":"Miranda L, Quaranta M, Oliva F, Maffulli N. Stem cells and discogenic back pain. Br Med Bull. 2023, 146:73-87. 10.1093\/bmb\/ldad008","journal-title":"Br Med Bull"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2021.07.015","article-title":"The effectiveness of intradiscal biologic treatments for discogenic low back pain: A systematic review","volume":"22","author":"Schneider BJ","year":"2022","unstructured":"Schneider BJ, Hunt C, Conger A, et al.. The effectiveness of intradiscal biologic treatments for discogenic low back pain: A systematic review. Spine J. 2022, 22:226-37. 10.1016\/j.spinee.2021.07.015","journal-title":"Spine J"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9149315","article-title":"Clinical efficacy and safety of human mesenchymal stem cell therapy for degenerative disc disease: A systematic review and meta-analysis of randomized controlled trials","volume":"2021","author":"Xie B","year":"2021","unstructured":"Xie B, Chen S, Xu Y, et al.. Clinical efficacy and safety of human mesenchymal stem cell therapy for degenerative disc disease: A systematic review and meta-analysis of randomized controlled trials. Stem Cells Int. 2021, 2021:9149315. 10.1155\/2021\/9149315","journal-title":"Stem Cells Int"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/242954-exosomes-for-the-management-of-low-back-pain-a-review-of-current-clinical-evidence","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T15:43:36Z","timestamp":1712159016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/242954-exosomes-for-the-management-of-low-back-pain-a-review-of-current-clinical-evidence"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":34,"URL":"https:\/\/doi.org\/10.7759\/cureus.57539","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,3]]}}}