{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:52:06Z","timestamp":1787644326537,"version":"build-2736575974"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,8]]},"DOI":"10.7759\/cureus.57803","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T07:45:40Z","timestamp":1712562340000},"source":"Crossref","is-referenced-by-count":4,"title":["Unraveling the Enigma of Aortic Dissection: From Genetics to Innovative Therapies"],"prefix":"10.7759","author":[{"given":"Swathi","family":"Godugu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendrarajah","family":"Pradeepan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Eze-odurukwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Faqeer Hussain","family":"Bokhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyal","family":"Bakht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Farhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Aortic dissection","author":"Levy D","year":"2024","unstructured":"Levy D, Goyal A, Grigorova Y, Farci F, Le JK. Aortic dissection. StatPearls. StatPearls Publishing, Treasure Island; 2024."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/life12101511","article-title":"Chronic thoracic aortic dissection: how to treat, when to intervene","volume":"12","author":"Papakonstantinou PE","year":"2022","unstructured":"Papakonstantinou PE, Benia D, Polyzos D, et al.. Chronic thoracic aortic dissection: how to treat, when to intervene. Life (Basel). 2022, 12:10.3390\/life12101511","journal-title":"Life (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.05.232","article-title":"Current evidence in predictors of aortic growth and events in acute type B aortic dissection","volume":"68","author":"Spinelli D","year":"2018","unstructured":"Spinelli D, Benedetto F, Donato R, et al.. Current evidence in predictors of aortic growth and events in acute type B aortic dissection. J Vasc Surg. 2018, 68:1925-1935.e8. 10.1016\/j.jvs.2018.05.232","journal-title":"J Vasc Surg"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2018.07.018","article-title":"Surgery for acute presentation of thoracoabdominal aortic disease","volume":"31","author":"Lau C","year":"2019","unstructured":"Lau C, Leonard JR, Iannacone E, Gaudino M, Girardi LN. Surgery for acute presentation of thoracoabdominal aortic disease. Semin Thorac Cardiovasc Surg. 2019, 31:11-6. 10.1053\/j.semtcvs.2018.07.018","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.07.047","article-title":"The pathogenesis of thoracic aortic aneurysm from hereditary perspective","volume":"677","author":"Wu L","year":"2018","unstructured":"Wu L. The pathogenesis of thoracic aortic aneurysm from hereditary perspective. Gene. 2018, 677:77-82. 10.1016\/j.gene.2018.07.047","journal-title":"Gene"},{"key":"ref6","article-title":"Risk factors for aortic dissection","author":"Kano HD","year":"2023","unstructured":"Kano HD, Sun W. Risk factors for aortic dissection. US Cardiol Rev. 2023,","journal-title":"US Cardiol Rev"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.01.006","article-title":"Inherited diseases and syndromes leading to aortic aneurysms and dissections","volume":"35","author":"Caglayan AO","year":"2009","unstructured":"Caglayan AO, Dundar M. Inherited diseases and syndromes leading to aortic aneurysms and dissections. Eur J Cardiothorac Surg. 2009, 35:931-40. 10.1016\/j.ejcts.2009.01.006","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-020-01124-7","article-title":"Genetic screening in heritable thoracic aortic disease-rationale, potentials and pitfalls","volume":"38","author":"Acharya M","year":"2022","unstructured":"Acharya M, Maselli D, Mariscalco G. Genetic screening in heritable thoracic aortic disease-rationale, potentials and pitfalls. Indian J Thorac Cardiovasc Surg. 2022, 38:24-35. 10.1007\/s12055-020-01124-7","journal-title":"Indian J Thorac Cardiovasc Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2005.06.001","article-title":"Heritable disorders predisposing to aortic dissection","volume":"17","author":"Gleason TG","year":"2005","unstructured":"Gleason TG. Heritable disorders predisposing to aortic dissection. Semin Thorac Cardiovasc Surg. 2005, 17:274-81. 10.1053\/j.semtcvs.2005.06.001","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318756433","article-title":"The role of genetic testing in the prevention of acute aortic dissection","volume":"25","author":"Carino D","year":"2018","unstructured":"Carino D, Agostinelli A, Molardi A, Benassi F, Gherli T, Nicolini F. The role of genetic testing in the prevention of acute aortic dissection. Eur J Prev Cardiol. 2018, 25:15-23. 10.1177\/2047487318756433","journal-title":"Eur J Prev Cardiol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000836","article-title":"Genetics of syndromic and nonsyndromic aortopathies","volume":"31","author":"Rigelsky CM","year":"2019","unstructured":"Rigelsky CM, Moran RT. Genetics of syndromic and nonsyndromic aortopathies. Curr Opin Pediatr. 2019, 31:694-701. 10.1097\/MOP.0000000000000836","journal-title":"Curr Opin Pediatr"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181d4739e","article-title":"2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine","volume":"121","author":"Hiratzka LF","year":"2010","unstructured":"Hiratzka LF, Bakris GL, Beckman JA, et al.. 2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation. 2010, 121:e266-369. 10.1161\/CIR.0b013e3181d4739e","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/life12101606","article-title":"Current understanding of aortic dissection","volume":"12","author":"Yuan X","year":"2022","unstructured":"Yuan X, Mitsis A, Nienaber CA. Current understanding of aortic dissection. Life (Basel). 2022, 12:10.3390\/life12101606","journal-title":"Life (Basel)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkn044","article-title":"Diagnosis and management of aortic dissection","volume":"9","author":"Hebballi R","year":"2009","unstructured":"Hebballi R, Swanevelder J. Diagnosis and management of aortic dissection. BJA Educ. 2009, 9:14-8. 10.1093\/bjaceaccp\/mkn044","journal-title":"BJA Educ"},{"key":"ref15","article-title":"Pathophysiology of aortic dissection and connective tissue disorders","author":"Hamilton M","year":"2011","unstructured":"Hamilton M. Pathophysiology of aortic dissection and connective tissue disorders.  Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists. Fitridge R, Thompson M (ed): University of Adelaide Press, Adelaide; 2011."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.01.020","article-title":"The IRAD classification system for characterizing survival after aortic dissection","volume":"126","author":"Booher AM","year":"2013","unstructured":"Booher AM, Isselbacher EM, Nienaber CA, et al.. The IRAD classification system for characterizing survival after aortic dissection. Am J Med. 2013, 126:730.e19-24. 10.1016\/j.amjmed.2013.01.020","journal-title":"Am J Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivz281","article-title":"Aortic dissection reconsidered: type, entry site, malperfusion classification adding clarity and enabling outcome prediction","volume":"30","author":"Sievers HH","year":"2020","unstructured":"Sievers HH, Rylski B, Czerny M, Baier AL, Kreibich M, Siepe M, Beyersdorf F. Aortic dissection reconsidered: type, entry site, malperfusion classification adding clarity and enabling outcome prediction. Interact Cardiovasc Thorac Surg. 2020, 30:451-7. 10.1093\/icvts\/ivz281","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.11.013","article-title":"Society for Vascular Surgery (SVS) and Society of Thoracic Surgeons (STS) reporting standards for type B aortic dissections","volume":"71","author":"Lombardi JV","year":"2020","unstructured":"Lombardi JV, Hughes GC, Appoo JJ, et al.. Society for Vascular Surgery (SVS) and Society of Thoracic Surgeons (STS) reporting standards for type B aortic dissections. J Vasc Surg. 2020, 71:723-47. 10.1016\/j.jvs.2019.11.013","journal-title":"J Vasc Surg"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult","volume":"35","author":"Erbel R","year":"2014","unstructured":"Erbel R, Aboyans V, Boileau C, et al.. 2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. Eur Heart J. 2014, 35:2873-926. 10.1093\/eurheartj\/ehu281","journal-title":"Eur Heart J"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39757","article-title":"A devastating tear: atypical presentation of aortic dissection discovered on echocardiography","volume":"15","author":"Alhalaseh S","year":"2023","unstructured":"Alhalaseh S, Chamay S, Barrera N, Zaremski L, Baghdadi S. A devastating tear: atypical presentation of aortic dissection discovered on echocardiography. Cureus. 2023, 15:e39757. 10.7759\/cureus.39757","journal-title":"Cureus"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14355","article-title":"Atypical presentation of fatal disease: painless aortic dissection","volume":"13","author":"Bedanie G","year":"2021","unstructured":"Bedanie G, Abaleka FI, Tikue A, Thongtan T, Ansari MM. Atypical presentation of fatal disease: painless aortic dissection. Cureus. 2021, 13:e14355. 10.7759\/cureus.14355","journal-title":"Cureus"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.11.032","article-title":"Acute aortic dissection: perspectives from the International Registry of Acute Aortic Dissection (IRAD)","volume":"37","author":"Tsai TT","year":"2009","unstructured":"Tsai TT, Trimarchi S, Nienaber CA. Acute aortic dissection: perspectives from the International Registry of Acute Aortic Dissection (IRAD). Eur J Vasc Endovasc Surg. 2009, 37:149-59. 10.1016\/j.ejvs.2008.11.032","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-316322","article-title":"The risk of misdiagnosis in acute thoracic aortic dissection: a review of current guidelines","volume":"106","author":"Salmasi MY","year":"2020","unstructured":"Salmasi MY, Al-Saadi N, Hartley P, et al.. The risk of misdiagnosis in acute thoracic aortic dissection: a review of current guidelines. Heart. 2020, 106:885-91. 10.1136\/heartjnl-2019-316322","journal-title":"Heart"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-015-0008-5","article-title":"Feasibility and accuracy of bedside transthoracic echocardiography in diagnosis of acute proximal aortic dissection","volume":"13","author":"Sobczyk D","year":"2015","unstructured":"Sobczyk D, Nycz K. Feasibility and accuracy of bedside transthoracic echocardiography in diagnosis of acute proximal aortic dissection. Cardiovasc Ultrasound. 2015, 13:15. 10.1186\/s12947-015-0008-5","journal-title":"Cardiovasc Ultrasound"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.192623","article-title":"Transesophageal echocardiography evaluation of the thoracic aorta","volume":"19","author":"Patil TA","year":"2016","unstructured":"Patil TA, Nierich A. Transesophageal echocardiography evaluation of the thoracic aorta. Ann Card Anaesth. 2016, 19:S44-55. 10.4103\/0971-9784.192623","journal-title":"Ann Card Anaesth"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2015.09.005","article-title":"Use of multi-detector CT angiography in identification and classification of aorto-iliac diseases; clinical and surgical application","volume":"47","author":"Alarabawy RA","year":"2016","unstructured":"Alarabawy RA, El Ahwal HM, Elwagih MM, Ismail A, Khattab MA. Use of multi-detector CT angiography in identification and classification of aorto-iliac diseases; clinical and surgical application. Egypt J Radiol Nucl Med. 2016, 47:169-78. 10.1016\/j.ejrnm.2015.09.005","journal-title":"Egypt J Radiol Nucl Med"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2016.11.039","article-title":"MR angiography can guide ED management of suspected acute aortic dissection","volume":"35","author":"Wang GX","year":"2017","unstructured":"Wang GX, Hedgire SS, Le TQ, et al.. MR angiography can guide ED management of suspected acute aortic dissection. Am J Emerg Med. 2017, 35:527-30. 10.1016\/j.ajem.2016.11.039","journal-title":"Am J Emerg Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1053\/j.ro.2022.07.001","article-title":"Artificial intelligence applications in aortic dissection imaging","volume":"57","author":"Mastrodicasa D","year":"2022","unstructured":"Mastrodicasa D, Codari M, B\u00e4umler K, et al.. Artificial intelligence applications in aortic dissection imaging. Semin Roentgenol. 2022, 57:357-63. 10.1053\/j.ro.2022.07.001","journal-title":"Semin Roentgenol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1137949","article-title":"Editorial: advances in aortic imaging","volume":"10","author":"Leach JR","year":"2023","unstructured":"Leach JR, Zhu C, Burris N, Hope MD. Editorial: advances in aortic imaging. Front Cardiovasc Med. 2023, 10:1137949. 10.3389\/fcvm.2023.1137949","journal-title":"Front Cardiovasc Med"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002719","article-title":"Biomarkers in aortic dissection: diagnostic and prognostic value from clinical research","volume":"137","author":"Zhao Y","year":"2024","unstructured":"Zhao Y, Fu W, Wang L. Biomarkers in aortic dissection: diagnostic and prognostic value from clinical research. Chin Med J (Engl). 2024, 137:257-69. 10.1097\/CM9.0000000000002719","journal-title":"Chin Med J (Engl)"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-021-00706-1","article-title":"Angiotensin receptor-neprilysin inhibitors: comprehensive review and implications in hypertension treatment","volume":"44","author":"Yamamoto K","year":"2021","unstructured":"Yamamoto K, Rakugi H. Angiotensin receptor-neprilysin inhibitors: comprehensive review and implications in hypertension treatment. Hypertens Res. 2021, 44:1239-50. 10.1038\/s41440-021-00706-1","journal-title":"Hypertens Res"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115263","article-title":"Endothelial and vascular smooth muscle dysfunction in hypertension","volume":"205","author":"de Oliveira MG","year":"2022","unstructured":"de Oliveira MG, Nadruz W Jr, M\u00f3nica FZ. Endothelial and vascular smooth muscle dysfunction in hypertension. Biochem Pharmacol. 2022, 205:115263. 10.1016\/j.bcp.2022.115263","journal-title":"Biochem Pharmacol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.01.006","article-title":"Vasodilator therapy in patients with aortic insufficiency: a systematic review","volume":"153","author":"Mahajerin A","year":"2007","unstructured":"Mahajerin A, Gurm HS, Tsai TT, Chan PS, Nallamothu BK. Vasodilator therapy in patients with aortic insufficiency: a systematic review. Am Heart J. 2007, 153:454-61. 10.1016\/j.ahj.2007.01.006","journal-title":"Am Heart J"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2008.08.001","article-title":"Inflammatory response is associated with aortic dissection","volume":"8","author":"Luo F","year":"2009","unstructured":"Luo F, Zhou XL, Li JJ, Hui RT. Inflammatory response is associated with aortic dissection. Ageing Res Rev. 2009, 8:31-5. 10.1016\/j.arr.2008.08.001","journal-title":"Ageing Res Rev"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175693","article-title":"Hybrid treatment of complex diseases of the aortic arch and descending thoracic aorta by frozen elephant trunk technique","volume":"12","author":"Porterie J","year":"2023","unstructured":"Porterie J, Hostalrich A, Dagenais F, Marcheix B, Chaufour X, Ricco JB. Hybrid treatment of complex diseases of the aortic arch and descending thoracic aorta by frozen elephant trunk technique. J Clin Med. 2023, 12:10.3390\/jcm12175693","journal-title":"J Clin Med"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.21037\/jovs.2019.01.11","article-title":"Valve sparing aortic root surgery: from revolution to evolution?","volume":"5","author":"Harky A","year":"2019","unstructured":"Harky A, Antoniou A, Howard C, Rimmer L, Ahmad MU, Bashir M. Valve sparing aortic root surgery: from revolution to evolution?. J Visual Surg. 2019, 5:10.21037\/jovs.2019.01.11","journal-title":"J Visual Surg"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.03.410","article-title":"Branched versus fenestrated endografts for endovascular repair of aortic arch lesions","volume":"64","author":"Tsilimparis N","year":"2016","unstructured":"Tsilimparis N, Debus ES, von Kodolitsch Y, et al.. Branched versus fenestrated endografts for endovascular repair of aortic arch lesions. J Vasc Surg. 2016, 64:592-9. 10.1016\/j.jvs.2016.03.410","journal-title":"J Vasc Surg"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905203402004","article-title":"Endovascular stent-graft placement for the treatment of acute aortic dissection","volume":"340","author":"Dake MD","year":"1999","unstructured":"Dake MD, Kato N, Mitchell RS, et al.. Endovascular stent-graft placement for the treatment of acute aortic dissection. N Engl J Med. 1999, 340:1546-52. 10.1056\/NEJM199905203402004","journal-title":"N Engl J Med"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.817675","article-title":"Clinical results and aortic remodeling after endovascular treatment for complicated type b aortic dissection with the \u201cfabulous\u201d stent system","volume":"9","author":"Wang R","year":"2022","unstructured":"Wang R, Kan Y, Yang M, et al.. Clinical results and aortic remodeling after endovascular treatment for complicated type b aortic dissection with the \u201cfabulous\u201d stent system. Front Cardiovasc Med. 2022, 9:817675. 10.3389\/fcvm.2022.817675","journal-title":"Front Cardiovasc Med"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.0711","article-title":"Review on laser technology in intravascular imaging and treatment","volume":"13","author":"Li J","year":"2022","unstructured":"Li J, Shang C, Rong Y, et al.. Review on laser technology in intravascular imaging and treatment. Aging Dis. 2022, 13:246-66. 10.14336\/AD.2021.0711","journal-title":"Aging Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/242782-unraveling-the-enigma-of-aortic-dissection-from-genetics-to-innovative-therapies","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T07:45:43Z","timestamp":1712562343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/242782-unraveling-the-enigma-of-aortic-dissection-from-genetics-to-innovative-therapies"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":40,"URL":"https:\/\/doi.org\/10.7759\/cureus.57803","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,8]]}}}