{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:18:15Z","timestamp":1790777895435,"version":"4.1.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,18]]},"DOI":"10.7759\/cureus.58544","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T16:56:31Z","timestamp":1713459391000},"source":"Crossref","is-referenced-by-count":10,"title":["A Comprehensive Narrative Review of Nanomaterial Applications in Restorative Dentistry: Demineralization Inhibition and Remineralization Applications (Part I)"],"prefix":"10.7759","author":[{"given":"Sahar M","family":"Elmarsafy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390%2Fmedicina56020055","article-title":"Antibacterial properties of nanoparticles in dental restorative materials. A systematic review and meta-analysis","volume":"56","author":"Ferrando-Magraner E","year":"2020","unstructured":"Ferrando-Magraner E, Bellot-Arc\u00eds C, Paredes-Gallardo V, Almerich-Silla JM, Garc\u00eda-Sanz V, Fern\u00e1ndez-Alonso M, Montiel-Company JM. Antibacterial properties of nanoparticles in dental restorative materials. A systematic review and meta-analysis. Medicina (Kaunas). 2020, 56:55. 10.3390%2Fmedicina56020055","journal-title":"Medicina (Kaunas)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2020.08.006","article-title":"Nanotechnology in dentistry: present and future perspectives on dental nanomaterials","volume":"36","author":"Jandt KD","year":"2020","unstructured":"Jandt KD, Watts DC. Nanotechnology in dentistry: present and future perspectives on dental nanomaterials. Dent Mater. 2020, 36:1365-78. 10.1016\/j.dental.2020.08.006","journal-title":"Dent Mater"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ksujds.2012.11.004","article-title":"Mechanical behavior of water-aged nano-filled hybrid composite restoratives","volume":"4","author":"Ateyah N","year":"2013","unstructured":"Ateyah N. Mechanical behavior of water-aged nano-filled hybrid composite restoratives. Saud Univ J Dent Sci. 2013, 4:21-5. 10.1016\/j.ksujds.2012.11.004","journal-title":"Saud Univ J Dent Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2021.vol35.0120","article-title":"Synthesis, characterization, and incorporation of upconverting nanoparticles into a dental adhesive","volume":"35","author":"Pacheco RR","year":"2021","unstructured":"Pacheco RR, Garcia-Flores AF, Soto-Montero JR, et al.. Synthesis, characterization, and incorporation of upconverting nanoparticles into a dental adhesive. Braz Oral Res. 2021, 35:10.1590\/1807-3107bor-2021.vol35.0120","journal-title":"Braz Oral Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2022.102231","article-title":"Current trends and future perspectives on dental nanomaterials - an overview of nanotechnology strategies in dentistry","volume":"34","author":"Umapathy V R","year":"2022","unstructured":"Umapathy V R, Natarajan P M, SumathiJones C, Swamikannu B, Johnson W, Alagarsamy V, Milon A. Current trends and future perspectives on dental nanomaterials - an overview of nanotechnology strategies in dentistry. J King Saud Univ Sci. 2022, 34:10.1016\/j.jksus.2022.102231","journal-title":"J King Saud Univ Sci"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ceramint.2017.04.105","article-title":"Nanostructured insulators - a review of nanotechnology concepts for outdoor ceramic insulators","volume":"43","author":"Contreras JE","year":"2017","unstructured":"Contreras JE, Rodr\u00edguez EA. Nanostructured insulators - a review of nanotechnology concepts for outdoor ceramic insulators. Ceram Int. 2017, 43:8545-50. 10.1016%2Fj.ceramint.2017.04.105","journal-title":"Ceram Int"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8100146","article-title":"Metal oxide nanoparticles and nanotubes: ultrasmall nanostructures to engineer antibacterial and improved dental adhesives and composites","volume":"8","author":"Balhaddad AA","year":"2021","unstructured":"Balhaddad AA, Garcia IM, Mokeem L, Alsahafi R, Collares FM, Sampaio de Melo MA. Metal oxide nanoparticles and nanotubes: ultrasmall nanostructures to engineer antibacterial and improved dental adhesives and composites. Bioengineering (Basel). 2021, 8:146. 10.3390\/bioengineering8100146","journal-title":"Bioengineering (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.33779","article-title":"Application of nanomaterials in restorative dentistry","volume":"15","author":"Mandhalkar R","year":"2023","unstructured":"Mandhalkar R, Paul P, Reche A. Application of nanomaterials in restorative dentistry. Cureus. 2023, 15:10.7759\/cureus.33779","journal-title":"Cureus"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S389038","article-title":"Caries management with non-metallic nanomaterials: a systematic review","volume":"17","author":"Xu VW","year":"2022","unstructured":"Xu VW, Nizami MZ, Yin IX, Lung CY, Yu OY, Chu CH. Caries management with non-metallic nanomaterials: a systematic review. Int J Nanomedicine. 2022, 17:5809-24. 10.2147\/IJN.S389038","journal-title":"Int J Nanomedicine"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1515\/rams-2020-0052","article-title":"Nanotechnology-based materials as emerging trends for dental applications","volume":"60","author":"Barot","year":"2021","unstructured":"Barot, T, Rawtani D, Kulkarni P. Nanotechnology-based materials as emerging trends for dental applications. Rev Adv Mater Sci. 2021, 60:173-89. 10.1515\/rams-2020-0052","journal-title":"Rev Adv Mater Sci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9132714","article-title":"Antimicrobial properties of silver nitrate nanoparticle and its application in endodontics and dentistry: a review of literature","volume":"2021","author":"Thangavelu L","year":"2021","unstructured":"Thangavelu L, Adil AH, Arshad S, et al.. Antimicrobial properties of silver nitrate nanoparticle and its application in endodontics and dentistry: a review of literature. J Nanomater. 2021, 2021:1-12. 10.1155\/2021\/9132714","journal-title":"J Nanomater"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4317\/jced.53620","article-title":"Tensile strength and impact strength of color modified acrylic resin reinforced with titanium dioxide nanoparticles","volume":"9","author":"Ghahremani L","year":"2017","unstructured":"Ghahremani L, Shirkavand S, Akbari F, Sabzikari N. Tensile strength and impact strength of color modified acrylic resin reinforced with titanium dioxide nanoparticles. J Clin Exp Dent. 2017, 9:e661-5. 10.4317\/jced.53620","journal-title":"J Clin Exp Dent"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2018.03.022","article-title":"Evaluation of the filler packing structures in dental resin composites: from theory to practice","volume":"34","author":"Wang R","year":"2018","unstructured":"Wang R, Habib E, Zhu XX. Evaluation of the filler packing structures in dental resin composites: from theory to practice. Dent Mater. 2018, 34:1014-23. 10.1016\/j.dental.2018.03.022","journal-title":"Dent Mater"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/ma10010089","article-title":"Combining bioactive multifunctional dental composite with PAMAM for root dentin remineralization","volume":"10","author":"Xiao S","year":"2017","unstructured":"Xiao S, Liang K, Weir MD, et al.. Combining bioactive multifunctional dental composite with PAMAM for root dentin remineralization. Materials (Basel). 2017, 10:89. 10.3390\/ma10010089","journal-title":"Materials (Basel)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000026128","article-title":"Attitudes of general practitioners and pediatricians to management of acute pyelonephritis in children","volume":"9","author":"Al-Eisa A","year":"2000","unstructured":"Al-Eisa A, Al-Mosawi M, Gupta R, D\u2019Souza TM, Sharma PN. Attitudes of general practitioners and pediatricians to management of acute pyelonephritis in children. Med Princ Pract. 2000, 9:119-24. 10.1159\/000026128","journal-title":"Med Princ Pract"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000314699","article-title":"Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds","volume":"23","author":"H\u00fcbner NO","year":"2010","unstructured":"H\u00fcbner NO, Siebert J, Kramer A. Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds. Skin Pharmacol Physiol. 2010, 23:244-58. 10.1159\/000314699","journal-title":"Skin Pharmacol Physiol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-13575-5_8","article-title":"Nanoparticles in restorative materials","author":"De Souza GM","year":"2015","unstructured":"De Souza GM. Nanoparticles in restorative materials. Nanotechnology in Endodontics. Kishen A (ed): Springer, Cham, Switzerland; 2015. 139-71. 10.1007\/978-3-319-13575-5_8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2018.05.009","article-title":"Novel dental adhesive resin with crack self-healing, antimicrobial and remineralization properties","volume":"75","author":"Yue S","year":"2018","unstructured":"Yue S, Wu J, Zhang Q, et al.. Novel dental adhesive resin with crack self-healing, antimicrobial and remineralization properties. J Dent. 2018, 75:48-57. 10.1016\/j.jdent.2018.05.009","journal-title":"J Dent"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2017.03.002","article-title":"Novel dental adhesive with triple benefits of calcium phosphate recharge, protein-repellent and antibacterial functions","volume":"33","author":"Xie X","year":"2017","unstructured":"Xie X, Wang L, Xing D, et al.. Novel dental adhesive with triple benefits of calcium phosphate recharge, protein-repellent and antibacterial functions. Dent Mater. 2017, 33:553-63. 10.1016\/j.dental.2017.03.002","journal-title":"Dent Mater"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-67132-1_12","article-title":"Application of nanomaterials in dentistry","author":"Qasim SB","year":"2017","unstructured":"Qasim SB, Rehman IU. Application of nanomaterials in dentistry. Micro and Nanomanufacturing Volume II. Jackson M, Ahmed W (ed): Springer, Cham, Switzerland; 2017. II:319-36. 10.1007\/978-3-319-67132-1_12"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/ma14216260","article-title":"Effect of nanostructures on the properties of glass ionomer dental restoratives\/cements: a comprehensive narrative review","volume":"14","author":"Amin F","year":"2021","unstructured":"Amin F, Rahman S, Khurshid Z, Zafar MS, Sefat F, Kumar N. Effect of nanostructures on the properties of glass ionomer dental restoratives\/cements: a comprehensive narrative review. Materials (Basel). 2021, 14:6260. 10.3390\/ma14216260","journal-title":"Materials (Basel)"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.12.003","article-title":"Antibacterial properties and compressive strength of new one-step preparation silver nanoparticles in glass ionomer cements (NanoAg-GIC)","volume":"69","author":"Paiva L","year":"2018","unstructured":"Paiva L, Fidalgo TK, da Costa LP, et al.. Antibacterial properties and compressive strength of new one-step preparation silver nanoparticles in glass ionomer cements (NanoAg-GIC). J Dent. 2018, 69:102-9. 10.1016\/j.jdent.2017.12.003","journal-title":"J Dent"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1799-y","article-title":"Antibacterial properties of copper iodide-doped glass ionomer-based materials and effect of copper iodide nanoparticles on collagen degradation","volume":"21","author":"Renn\u00e9 WG","year":"2017","unstructured":"Renn\u00e9 WG, Lindner A, Mennito AS, et al.. Antibacterial properties of copper iodide-doped glass ionomer-based materials and effect of copper iodide nanoparticles on collagen degradation. Clin Oral Investig. 2017, 21:369-79. 10.1007\/s00784-016-1799-y","journal-title":"Clin Oral Investig"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2018.01.010","article-title":"Influence of hydroxyapatite nanoparticles on the properties of glass ionomer cement","volume":"8","author":"Alatawi RA","year":"2019","unstructured":"Alatawi RA, Elsayed NH, Mohamed WS. Influence of hydroxyapatite nanoparticles on the properties of glass ionomer cement. J Mater Res Technol. 2019, 8:344-9. 10.1016\/j.jmrt.2018.01.010","journal-title":"J Mater Res Technol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2008.10.004","article-title":"New nano-sized Al2O3-BN coating 3Y-TZP ceramic composites for CAD\/CAM-produced all-ceramic dental restorations. Part I. Fabrication of powders","volume":"5","author":"Yang SF","year":"2009","unstructured":"Yang SF, Yang LQ, Jin ZH, Guo TW, Wang L, Liu HC. New nano-sized Al2O3-BN coating 3Y-TZP ceramic composites for CAD\/CAM-produced all-ceramic dental restorations. Part I. Fabrication of powders. Nanomedicine. 2009, 5:232-9. 10.1016\/j.nano.2008.10.004","journal-title":"Nanomedicine"},{"key":"ref26","article-title":"The effect of adding TiO2 nanoparticles on dental amalgam properties","volume":"10","author":"Fathi MH","year":"2013","unstructured":"Fathi MH. The effect of adding TiO2 nanoparticles on dental amalgam properties. Dent Res J (Isfahan). 2013, 10:29-39.","journal-title":"Dent Res J (Isfahan)"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1088\/2053-1591\/aadb45","article-title":"Fabrication and evaluation of amalgam\/nano hydroxyapatite composites for dental restoration","volume":"5","author":"Khodaei M","year":"2018","unstructured":"Khodaei M, Amini K, Mahdavian P. Fabrication and evaluation of amalgam\/nano hydroxyapatite composites for dental restoration. Materials Research Express. 2018, 5:10.1088\/2053-1591\/aadb45","journal-title":"Materials Research Express"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1021\/nn505015e","article-title":"Review of nanomaterials in dentistry: interactions with the oral microenvironment, clinical applications, hazards, and benefits","volume":"9","author":"Besinis A","year":"2015","unstructured":"Besinis A, De Peralta T, Tredwin CJ, Handy RD. Review of nanomaterials in dentistry: interactions with the oral microenvironment, clinical applications, hazards, and benefits. ACS Nano. 2015, 9:2255-89. 10.1021\/nn505015e","journal-title":"ACS Nano"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2311910","article-title":"The potential application of green-synthesized metal nanoparticles in dentistry: a comprehensive review","volume":"2022","author":"Yazdanian M","year":"2022","unstructured":"Yazdanian M, Rostamzadeh P, Rahbar M, et al.. The potential application of green-synthesized metal nanoparticles in dentistry: a comprehensive review. Bioinorg Chem Appl. 2022, 2022:10.1155\/2022\/2311910","journal-title":"Bioinorg Chem Appl"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020380","article-title":"Plant extract-synthesized silver nanoparticles for application in dental therapy","volume":"14","author":"Ahmed O","year":"2022","unstructured":"Ahmed O, Sibuyi NR, Fadaka AO, Madiehe MA, Maboza E, Meyer M, Geerts G. Plant extract-synthesized silver nanoparticles for application in dental therapy. Pharmaceutics. 2022, 14:10.3390\/pharmaceutics14020380","journal-title":"Pharmaceutics"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S246764","article-title":"The antibacterial mechanism of silver nanoparticles and its application in dentistry","volume":"15","author":"Yin IX","year":"2020","unstructured":"Yin IX, Zhang J, Zhao IS, Mei ML, Li Q, Chu CH. The antibacterial mechanism of silver nanoparticles and its application in dentistry. Int J Nanomedicine. 2020, 15:2555-62. 10.2147\/IJN.S246764","journal-title":"Int J Nanomedicine"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2014.05.017","article-title":"A new \"silver-bullet\" to treat caries in children - nano silver fluoride: a randomised clinical trial","volume":"42","author":"Santos VE Jr","year":"2014","unstructured":"Santos VE Jr, Vasconcelos Filho A, Targino AG, Flores MA, Galembeck A, Caldas AF Jr, Rosenblatt A. A new \"silver-bullet\" to treat caries in children - nano silver fluoride: a randomised clinical trial. J Dent. 2014, 42:945-51. 10.1016\/j.jdent.2014.05.017","journal-title":"J Dent"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2015.09.005","article-title":"Advances in dental materials through nanotechnology: facts, perspectives and toxicological aspects","volume":"33","author":"Padovani GC","year":"2015","unstructured":"Padovani GC, Feitosa VP, Sauro S, Tay FR, Dur\u00e1n G, Paula AJ, Dur\u00e1n N. Advances in dental materials through nanotechnology: facts, perspectives and toxicological aspects. Trends Biotechnol. 2015, 33:621-36. 10.1016\/j.tibtech.2015.09.005","journal-title":"Trends Biotechnol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2018.03.016","article-title":"Does the size matter? Evaluation of effect of incorporation of silver nanoparticles of varying particle size on the antimicrobial activity and properties of irreversible hydrocolloid impression material","volume":"34","author":"Ginjupalli K","year":"2018","unstructured":"Ginjupalli K, Shaw T, Tellapragada C, Alla R, Gupta L, Perampalli NU. Does the size matter? Evaluation of effect of incorporation of silver nanoparticles of varying particle size on the antimicrobial activity and properties of irreversible hydrocolloid impression material. Dent Mater. 2018, 34:e158-65. 10.1016\/j.dental.2018.03.016","journal-title":"Dent Mater"},{"key":"ref35","article-title":"Evaluation of resin composites modified with nanogold and nanosilver","volume":"16","author":"\u0141Soko\u0142owski J","year":"2014","unstructured":"\u0141Soko\u0142owski J, Szynkowska MI, Kleczewska J, et al.. Evaluation of resin composites modified with nanogold and nanosilver. Acta Bioeng Biomech. 2014, 16:51-61.","journal-title":"Acta Bioeng Biomech"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27062007","article-title":"Synthesis of silver nanoparticles from extracts of wild ginger (Zingiber zerumbet) with antibacterial activity against selective multidrug resistant oral bacteria","volume":"27","author":"Ramzan M","year":"2022","unstructured":"Ramzan M, Karobari MI, Heboyan A, et al.. Synthesis of silver nanoparticles from extracts of wild ginger (Zingiber zerumbet) with antibacterial activity against selective multidrug resistant oral bacteria. Molecules. 2022, 27:2007. 10.3390\/molecules27062007","journal-title":"Molecules"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.2174\/2210681213666230411102645","article-title":"Antimicrobial efficacy of various nanoparticles on addition to orthodontic materials - a systematic review and meta-analysis","volume":"13","author":"Kumari D","year":"2023","unstructured":"Kumari D, Soans CR, Shersha S, Mansoor R, Ravi MS. Antimicrobial efficacy of various nanoparticles on addition to orthodontic materials - a systematic review and meta-analysis. Nanoscience &amp; Nanotechnology-Asia. 2023, 13:1-12. 10.2174\/2210681213666230411102645","journal-title":"Nanoscience & Nanotechnology-Asia"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2023.104411","article-title":"Antibacterial one-step self-etching dental adhesive with silver nanoparticles synthesized in situ","volume":"129","author":"Wang Y","year":"2023","unstructured":"Wang Y, Ding Y, Deng J, Nie R, Meng X. Antibacterial one-step self-etching dental adhesive with silver nanoparticles synthesized in situ. J Dent. 2023, 129:10.1016\/j.jdent.2023.104411","journal-title":"J Dent"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14020077","article-title":"Developing a novel enamel adhesive with amorphous calcium phosphate and silver nanoparticles to prevent demineralization during orthodontic treatment","volume":"14","author":"Jia A","year":"2023","unstructured":"Jia A, Wang P, Tong F, et al.. Developing a novel enamel adhesive with amorphous calcium phosphate and silver nanoparticles to prevent demineralization during orthodontic treatment. J Funct Biomater. 2023, 14:77. 10.3390\/jfb14020077","journal-title":"J Funct Biomater"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.22037\/jds.v32i4.24781","article-title":"Applications of nanotechnology in dentistry: a review","volume":"32","author":"Vahabi S","year":"2019","unstructured":"Vahabi S, Mardanifar F. Applications of nanotechnology in dentistry: a review. Shahid Beheshti University Dental Journal. 2019, 32:228-39. 10.22037\/jds.v32i4.24781","journal-title":"Shahid Beheshti University Dental Journal"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/polym15030529","article-title":"Effect of zinc oxide incorporation on the antibacterial, physicochemical, and mechanical properties of pit and fissure sealants","volume":"15","author":"Choi JW","year":"2023","unstructured":"Choi JW, Yang SY. Effect of zinc oxide incorporation on the antibacterial, physicochemical, and mechanical properties of pit and fissure sealants. Polymers (Basel). 2023, 15:529. 10.3390\/polym15030529","journal-title":"Polymers (Basel)"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3477886","article-title":"Adhesive bond integrity of experimental zinc oxide nanoparticles incorporated dentin adhesive: an SEM, EDX, \u039cTBS, and rheometric analysis","volume":"2022","author":"Alfaawaz YF","year":"2022","unstructured":"Alfaawaz YF, Alamri R, Almohsen F, et al.. Adhesive bond integrity of experimental zinc oxide nanoparticles incorporated dentin adhesive: an SEM, EDX, \u039cTBS, and rheometric analysis. Scanning. 2022, 2022:10.1155\/2022\/3477886","journal-title":"Scanning"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.2319\/011408-19.1","article-title":"Antimicrobial effects of zinc oxide in an orthodontic bonding agent","volume":"79","author":"Spencer CG","year":"2009","unstructured":"Spencer CG, Campbell PM, Buschang PH, Cai J, Honeyman AL. Antimicrobial effects of zinc oxide in an orthodontic bonding agent. Angle Orthod. 2009, 79:317-22. 10.2319\/011408-19.1","journal-title":"Angle Orthod"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1743019","article-title":"Influence of the physical inclusion of ZRO2\/TIO2 nanoparticles on physical, mechanical, and morphological characteristics of PMMA-based interim restorative material [RETRACTED]","volume":"2022","author":"Alrahlah A","year":"2022","unstructured":"Alrahlah A, Khan R, Vohra F, et al.. Influence of the physical inclusion of ZRO2\/TIO2 nanoparticles on physical, mechanical, and morphological characteristics of PMMA-based interim restorative material [RETRACTED]. Biomed Res Int. 2022, 2022:1743019. 10.1155\/2022\/1743019","journal-title":"Biomed Res Int"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S86033","article-title":"Nanotechnology in dentistry: prevention, diagnosis, and therapy","volume":"10","author":"Abou Neel EA","year":"2015","unstructured":"Abou Neel EA, Bozec L, Perez RA, Kim HW, Knowles JC. Nanotechnology in dentistry: prevention, diagnosis, and therapy. Int J Nanomedicine. 2015, 10:6371-94. 10.2147\/IJN.S86033","journal-title":"Int J Nanomedicine"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2010.01.008","article-title":"Dental adhesives with bioactive and on-demand bactericidal properties","volume":"26","author":"Welch K","year":"2010","unstructured":"Welch K, Cai Y, Engqvist H, Str\u00f8mme M. Dental adhesives with bioactive and on-demand bactericidal properties. Dent Mater. 2010, 26:491-9. 10.1016\/j.dental.2010.01.008","journal-title":"Dent Mater"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_308_18","article-title":"The antibacterial effect of two cavity disinfectants against one of cariogenic pathogen: an in vitro comparative study","volume":"9","author":"Elgamily HM","year":"2018","unstructured":"Elgamily HM, El-Sayed HS, Abdelnabi A. The antibacterial effect of two cavity disinfectants against one of cariogenic pathogen: an in vitro comparative study. Contemp Clin Dent. 2018, 9:457-62. 10.4103\/ccd.ccd_308_18","journal-title":"Contemp Clin Dent"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2022.119824","article-title":"Evaluation of antibacterial and mechanical features of dental adhesives containing colloidal gold nanoparticles","volume":"365","author":"Dadkan S","year":"2022","unstructured":"Dadkan S, Khakbiz M, Ghazanfari L, Chen M, Lee K. Evaluation of antibacterial and mechanical features of dental adhesives containing colloidal gold nanoparticles. J Mol Liq. 2022, 365:10.1016\/j.molliq.2022.119824","journal-title":"J Mol Liq"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.191","article-title":"Nanotechnology strategies for antibacterial and remineralizing composites and adhesives to tackle dental caries","volume":"10","author":"Cheng L","year":"2015","unstructured":"Cheng L, Zhang K, Weir MD, Melo MA, Zhou X, Xu HH. Nanotechnology strategies for antibacterial and remineralizing composites and adhesives to tackle dental caries. Nanomedicine (Lond). 2015, 10:627-41. 10.2217\/nnm.14.191","journal-title":"Nanomedicine (Lond)"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3390\/nano12101676","article-title":"Nanomaterials in dentistry: current applications and future scope","volume":"12","author":"Sreenivasalu PK","year":"2022","unstructured":"Sreenivasalu PK, Dora CP, Swami R, et al.. Nanomaterials in dentistry: current applications and future scope. Nanomaterials (Basel). 2022, 12:1676. 10.3390\/nano12101676","journal-title":"Nanomaterials (Basel)"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2013.05.010","article-title":"Nanotechnology-based restorative materials for dental caries management","volume":"31","author":"Melo MA","year":"2013","unstructured":"Melo MA, Guedes SF, Xu HH, Rodrigues LK. Nanotechnology-based restorative materials for dental caries management. Trends Biotechnol. 2013, 31:459-67. 10.1016\/j.tibtech.2013.05.010","journal-title":"Trends Biotechnol"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.a38525","article-title":"Antibacterial orthodontic adhesive incorporating polyethyleneimine nanoparticles","volume":"15","author":"Zaltsman N","year":"2017","unstructured":"Zaltsman N, Kesler Shvero D, Polak D, Weiss EI, Beyth N. Antibacterial orthodontic adhesive incorporating polyethyleneimine nanoparticles. Oral Health Prev Dent. 2017, 15:245-50. 10.3290\/j.ohpd.a38525","journal-title":"Oral Health Prev Dent"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.3233\/THC-181568","article-title":"Evaluating antibacterial and surface mechanical properties of chitosan modified dental resin composites","volume":"28","author":"Ali S","year":"2020","unstructured":"Ali S, Sangi L, Kumar N, Kumar B, Khurshid Z, Zafar MS. Evaluating antibacterial and surface mechanical properties of chitosan modified dental resin composites. Technol Health Care. 2020, 28:165-73. 10.3233\/THC-181568","journal-title":"Technol Health Care"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500807","article-title":"Nano DCPA-whisker composites with high strength and Ca and PO4 Release","volume":"85","author":"Xu HH","year":"2006","unstructured":"Xu HH, Sun L, Weir MD, Antonucci JM, Takagi S, Chow LC, Peltz M. Nano DCPA-whisker composites with high strength and Ca and PO4 Release. J Dent Res. 2006, 85:722-7. 10.1177\/154405910608500807","journal-title":"J Dent Res"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.3390\/nano10091770","article-title":"Nanomaterials in dentistry: state of the art and future challenges","volume":"10","author":"Bonilla-Represa V","year":"2020","unstructured":"Bonilla-Represa V, Abalos-Labruzzi C, Herrera-Martinez M, Guerrero-P\u00e9rez MO. Nanomaterials in dentistry: state of the art and future challenges. Nanomaterials (Basel). 2020, 10:10.3390\/nano10091770","journal-title":"Nanomaterials (Basel)"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00333","article-title":"Remineralization and repair of enamel surface by biomimetic Zn-carbonate hydroxyapatite containing toothpaste: a comparative in vivo study","volume":"5","author":"Lelli M","year":"2014","unstructured":"Lelli M, Putignano A, Marchetti M, et al.. Remineralization and repair of enamel surface by biomimetic Zn-carbonate hydroxyapatite containing toothpaste: a comparative in vivo study. Front Physiol. 2014, 5:333. 10.3389\/fphys.2014.00333","journal-title":"Front Physiol"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.14693\/jdi.v27i2.1154","article-title":"Nanomaterials and nanorobotics in dentistry: a review","volume":"27","author":"Kasimoglu Y","year":"2020","unstructured":"Kasimoglu Y, Tabakcilar D, Guclu ZA, et al.. Nanomaterials and nanorobotics in dentistry: a review. J Dent Indones. 2020, 27:77-84. 10.14693\/jdi.v27i2.1154","journal-title":"J Dent Indones"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2014.04.014","article-title":"Physical chemical effects of zinc on in vitro enamel demineralization","volume":"42","author":"Mohammed NR","year":"2014","unstructured":"Mohammed NR, Mneimne M, Hill RG, Al-Jawad M, Lynch RJ, Anderson P. Physical chemical effects of zinc on in vitro enamel demineralization. J Dent. 2014, 42:1096-104. 10.1016\/j.jdent.2014.04.014","journal-title":"J Dent"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3390\/cryst11060674","article-title":"Dental applications of systems based on hydroxyapatite nanoparticles-an evidence-based update","volume":"11","author":"Balhuc S","year":"2021","unstructured":"Balhuc S, Campian R, Labunet A, Negucioiu M, Buduru S, Kui A. Dental applications of systems based on hydroxyapatite nanoparticles-an evidence-based update. Crystals. 2021, 11:674. 10.3390\/cryst11060674","journal-title":"Crystals"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2023.2217689","article-title":"Effect of experimental toothpaste containing hydroxyapatite nanoparticles and propolis, with and without fluoride, on the microcosm biofilm and enamel demineralization","volume":"39","author":"da Silva Ribeiro CF","year":"2023","unstructured":"da Silva Ribeiro CF, Dionizio A, Teodoro Ara\u00fajo T, et al.. Effect of experimental toothpaste containing hydroxyapatite nanoparticles and propolis, with and without fluoride, on the microcosm biofilm and enamel demineralization. Biofouling. 2023, 39:339-48. 10.1080\/08927014.2023.2217689","journal-title":"Biofouling"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2016.09.038","article-title":"Composite resin reinforced with silver nanoparticles-laden hydroxyapatite nanowires for dental application","volume":"33","author":"Ai M","year":"2017","unstructured":"Ai M, Du Z, Zhu S, Geng H, Zhang X, Cai Q, Yang X. Composite resin reinforced with silver nanoparticles-laden hydroxyapatite nanowires for dental application. Dent Mater. 2017, 33:12-22. 10.1016\/j.dental.2016.09.038","journal-title":"Dent Mater"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2017.01.018","article-title":"The innovative applications of therapeutic nanostructures in dentistry","volume":"13","author":"Elkassas D","year":"2017","unstructured":"Elkassas D, Arafa A. The innovative applications of therapeutic nanostructures in dentistry. Nanomedicine. 2017, 13:1543-62. 10.1016\/j.nano.2017.01.018","journal-title":"Nanomedicine"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02549-9","article-title":"Synthesis and characterization of nano bioactive glass for improving enamel remineralization ability of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)","volume":"22","author":"Akbarzade T","year":"2022","unstructured":"Akbarzade T, Farmany A, Farhadian M, Khamverdi Z, Dastgir R. Synthesis and characterization of nano bioactive glass for improving enamel remineralization ability of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). BMC Oral Health. 2022, 22:525. 10.1186\/s12903-022-02549-9","journal-title":"BMC Oral Health"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2019.103193","article-title":"Dentin remineralization via adhesive containing amorphous calcium phosphate nanoparticles in a biofilm-challenged environment","volume":"89","author":"Tao S","year":"2019","unstructured":"Tao S, He L, Xu HH, et al.. Dentin remineralization via adhesive containing amorphous calcium phosphate nanoparticles in a biofilm-challenged environment. J Dent. 2019, 89:10.1016\/j.jdent.2019.103193","journal-title":"J Dent"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.37983\/IJDM.2019.1202","article-title":"Recent advances in dental composites: an overview","volume":"1","author":"Dara L","year":"2019","unstructured":"Dara L, Buchi D, Mantena SR, K MV, Rao DB, Chandrappa V. Recent advances in dental composites: an overview. Int J Dent Mater. 2019, 1:48-54. 10.37983\/IJDM.2019.1202","journal-title":"Int J Dent Mater"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37580-w","article-title":"Self-assembly of dental surface nanofilaments and remineralisation by SnF2 and CPP-ACP nanocomplexes","volume":"9","author":"Fernando JR","year":"2019","unstructured":"Fernando JR, Shen P, Sim CP, et al.. Self-assembly of dental surface nanofilaments and remineralisation by SnF2 and CPP-ACP nanocomplexes. Sci Rep. 2019, 9:1285. 10.1038\/s41598-018-37580-w","journal-title":"Sci Rep"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-022-00404-9","article-title":"Casein phosphopeptide amorphous calcium phosphate and universal adhesive resin as a complementary approach for management of white spot lesions: an in-vitro study","volume":"23","author":"Aref NS","year":"2022","unstructured":"Aref NS, Alrasheed MK. Casein phosphopeptide amorphous calcium phosphate and universal adhesive resin as a complementary approach for management of white spot lesions: an in-vitro study. Prog Orthod. 2022, 23:10. 10.1186\/s40510-022-00404-9","journal-title":"Prog Orthod"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1177\/03015742221076915","article-title":"Assessment of white spot lesion and enamel demineralization in orthodontic patients with fixed brackets\u2014a clinical appraisal using fluoride mouth rinse, fluoride varnish containing CPP-ACP, and CPP-ACFP","volume":"57","author":"Mishra S","year":"2023","unstructured":"Mishra S, Mani S, Sonawane A, Viragi P, Toshniwal NG, Manerikar R. Assessment of white spot lesion and enamel demineralization in orthodontic patients with fixed brackets\u2014a clinical appraisal using fluoride mouth rinse, fluoride varnish containing CPP-ACP, and CPP-ACFP. J Indian Orthod Soc. 2023, 57:91-7. 10.1177\/03015742221076915","journal-title":"J Indian Orthod Soc"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.24941\/ijcr.41773.06.2021","article-title":"Remineralizing agents in pediatric dentistry: a review of literature","volume":"13","author":"Anjali","year":"2021","unstructured":"Anjali, Anuradha P, Tiwana JK. Remineralizing agents in pediatric dentistry: a review of literature. Int J Curr Res. 2021, 13:18067-70. 10.24941\/ijcr.41773.06.2021","journal-title":"Int J Curr Res"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15326","article-title":"Recent advances in the use of inorganic nanomaterials as anti caries agents","volume":"9","author":"Al-Hijazi AY","year":"2023","unstructured":"Al-Hijazi AY, Hasan N, Nasr BK, Jasim Al-Khafaji HH, Al-Khafaji B, Abdah Alanssari BF, Jalil AT. Recent advances in the use of inorganic nanomaterials as anti caries agents. Heliyon. 2023, 9:10.1016\/j.heliyon.2023.e15326","journal-title":"Heliyon"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.3390\/jfb11030056","article-title":"Novel CaF2 nanocomposites with antibacterial function and fluoride and calcium ion release to inhibit oral biofilm and protect teeth","volume":"11","author":"Mitwalli H","year":"2020","unstructured":"Mitwalli H, Balhaddad AA, AlSahafi R, Oates TW, Melo MA, Xu HH, Weir MD. Novel CaF2 nanocomposites with antibacterial function and fluoride and calcium ion release to inhibit oral biofilm and protect teeth. J Funct Biomater. 2020, 11:56. 10.3390\/jfb11030056","journal-title":"J Funct Biomater"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.4103\/jispcd.JISPCD_223_19","article-title":"Role of nanotechnology in dentistry: systematic review","volume":"9","author":"Moothedath M","year":"2019","unstructured":"Moothedath M, Moothedath M, Jairaj A, Harshitha B, Baba SM, Khateeb SU. Role of nanotechnology in dentistry: systematic review. J Int Soc Prev Community Dent. 2019, 9:535-41. 10.4103\/jispcd.JISPCD_223_19","journal-title":"J Int Soc Prev Community Dent"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/247440-a-comprehensive-narrative-review-of-nanomaterial-applications-in-restorative-dentistry-demineralization-inhibition-and-remineralization-applications-part-i","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T16:56:36Z","timestamp":1713459396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/247440-a-comprehensive-narrative-review-of-nanomaterial-applications-in-restorative-dentistry-demineralization-inhibition-and-remineralization-applications-part-i"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":72,"URL":"https:\/\/doi.org\/10.7759\/cureus.58544","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,18]]}}}