{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:56:15Z","timestamp":1785873375953,"version":"3.56.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,19]]},"DOI":"10.7759\/cureus.58586","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T13:17:01Z","timestamp":1713532621000},"source":"Crossref","is-referenced-by-count":4,"title":["Metastatic Occult Primary Lobular Breast Cancer: A Case Report"],"prefix":"10.7759","author":[{"given":"Athanasios","family":"Pouptsis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Cano Gimeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Martinez Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ba\u00f1uls Marrades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Olivan Sasot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.11.1421","article-title":"Trends in incidence rates of invasive lobular and ductal breast carcinoma","volume":"289","author":"Li CI","year":"2003","unstructured":"Li CI, Anderson BO, Daling JR, Moe RE. Trends in incidence rates of invasive lobular and ductal breast carcinoma. JAMA. 2003, 289:1421-4. 10.1001\/jama.289.11.1421","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-06-0060","article-title":"Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment","volume":"14","author":"Biglia N","year":"2007","unstructured":"Biglia N, Mariani L, Sgro L, Mininanni P, Moggio G, Sismondi P. Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment. Endocr Relat Cancer. 2007, 14:549-67. 10.1677\/ERC-06-0060","journal-title":"Endocr Relat Cancer"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1148\/rg.291085100","article-title":"Invasive lobular carcinoma of the breast: spectrum of mammographic, US, and MR imaging findings","volume":"29","author":"Lopez JK","year":"2009","unstructured":"Lopez JK, Bassett LW. Invasive lobular carcinoma of the breast: spectrum of mammographic, US, and MR imaging findings. Radiographics. 2009, 29:165-76. 10.1148\/rg.291085100","journal-title":"Radiographics"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-015-0546-7","article-title":"Lobular breast cancer: incidence and genetic and non-genetic risk factors","volume":"17","author":"Dossus L","year":"2015","unstructured":"Dossus L, Benusiglio PR. Lobular breast cancer: incidence and genetic and non-genetic risk factors. Breast Cancer Res. 2015, 17:37. 10.1186\/s13058-015-0546-7","journal-title":"Breast Cancer Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.09.004","article-title":"Surgical management of lobular carcinoma from a national screening program: a retrospective analysis","volume":"41","author":"Sharma SD","year":"2015","unstructured":"Sharma SD, Barry M, O'Reilly EA, Kell MR. Surgical management of lobular carcinoma from a national screening program: a retrospective analysis. Eur J Surg Oncol. 2015, 41:79-85. 10.1016\/j.ejso.2014.09.004","journal-title":"Eur J Surg Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02314-w","article-title":"Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer","volume":"41","author":"R\u00e4tze MA","year":"2022","unstructured":"R\u00e4tze MA, Koorman T, Sijnesael T, et al.. Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer. Oncogene. 2022, 41:2932-44. 10.1038\/s41388-022-02314-w","journal-title":"Oncogene"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3065","article-title":"The role and function of cadherins in the mammary gland","volume":"14","author":"Andrews JL","year":"2012","unstructured":"Andrews JL, Kim AC, Hens JR. The role and function of cadherins in the mammary gland. Breast Cancer Res. 2012, 14:203. 10.1186\/bcr3065","journal-title":"Breast Cancer Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.0334","article-title":"Genomic characterization of primary invasive lobular breast cancer","volume":"34","author":"Desmedt C","year":"2016","unstructured":"Desmedt C, Zoppoli G, Gundem G, et al.. Genomic characterization of primary invasive lobular breast cancer. J Clin Oncol. 2016, 34:1872-81. 10.1200\/JCO.2015.64.0334","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.08.007","article-title":"Wide metastatic spreading in infiltrating lobular carcinoma of the breast","volume":"40","author":"Ferlicot S","year":"2004","unstructured":"Ferlicot S, Vincent-Salomon A, M\u00e9dioni J, et al.. Wide metastatic spreading in infiltrating lobular carcinoma of the breast. Eur J Cancer. 2004, 40:336-41. 10.1016\/j.ejca.2003.08.007","journal-title":"Eur J Cancer"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3233\/BD-201027","article-title":"Primary ectopic breast carcinoma in the axilla: a rare presentation and review of the literature","volume":"40","author":"Salemis NS","year":"2021","unstructured":"Salemis NS. Primary ectopic breast carcinoma in the axilla: a rare presentation and review of the literature. Breast Dis. 2021, 40:109-14. 10.3233\/BD-201027","journal-title":"Breast Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4714708","article-title":"Gastric linitis plastica and peritoneal carcinomatosis as first manifestations of occult breast carcinoma: a case report and literature review","volume":"2018","author":"Mantiero M","year":"2018","unstructured":"Mantiero M, Faggioni G, Menichetti A, Fassan M, Guarneri V, Conte P. Gastric linitis plastica and peritoneal carcinomatosis as first manifestations of occult breast carcinoma: a case report and literature review. Case Rep Oncol Med. 2018, 2018:4714708. 10.1155\/2018\/4714708","journal-title":"Case Rep Oncol Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2147\/BCTT.S366785","article-title":"Occult invasive lobular carcinoma presenting as an axillary skin metastatic lesion underwent neoadjuvant endocrine therapy and surgical resection: a case report and review of literature","volume":"14","author":"Busbait S","year":"2022","unstructured":"Busbait S, Alkhalifa AM, Aljohani S, Alhaddad H. Occult invasive lobular carcinoma presenting as an axillary skin metastatic lesion underwent neoadjuvant endocrine therapy and surgical resection: a case report and review of literature. Breast Cancer (Dove Med Press). 2022, 14:145-52. 10.2147\/BCTT.S366785","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/135684","article-title":"Occult breast lobular carcinoma with numerous circulating tumor cells in peripheral blood","volume":"2015","author":"Ogura K","year":"2015","unstructured":"Ogura K, Amano M, Matsumoto T, Sakaguchi A, Kosaka T, Kitabatake T, Kojima K. Occult breast lobular carcinoma with numerous circulating tumor cells in peripheral blood. Case Rep Pathol. 2015, 2015:135684. 10.1155\/2015\/135684","journal-title":"Case Rep Pathol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11050746","article-title":"Invasive lobular carcinoma: A review of imaging modalities with special focus on pathology concordance","volume":"11","author":"Pereslucha AM","year":"2023","unstructured":"Pereslucha AM, Wenger DM, Morris MF, Aydi ZB. Invasive lobular carcinoma: A review of imaging modalities with special focus on pathology concordance. Healthcare (Basel). 2023, 11:746. 10.3390\/healthcare11050746","journal-title":"Healthcare (Basel)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.07.003","article-title":"Invasive lobular breast cancer and its variants: how special are they for systemic therapy decisions?","volume":"92","author":"Guiu S","year":"2014","unstructured":"Guiu S, Wolfer A, Jacot W, Fumoleau P, Romieu G, Bonnetain F, Fiche M. Invasive lobular breast cancer and its variants: how special are they for systemic therapy decisions?. Crit Rev Oncol Hematol. 2014, 92:235-57. 10.1016\/j.critrevonc.2014.07.003","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-109374","article-title":"Distinct pattern of metastases in patients with invasive lobular carcinoma of the breast","volume":"77","author":"Mathew A","year":"2017","unstructured":"Mathew A, Rajagopal PS, Villgran V, et al.. Distinct pattern of metastases in patients with invasive lobular carcinoma of the breast. Geburtshilfe Frauenheilkd. 2017, 77:660-6. 10.1055\/s-0043-109374","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.247882","article-title":"Head-to-head evaluation of (18)f-FES and (18)f-FDG PET\/CT in metastatic invasive lobular breast cancer","volume":"62","author":"Ulaner GA","year":"2021","unstructured":"Ulaner GA, Jhaveri K, Chandarlapaty S, Hatzoglou V, Riedl CC, Lewis JS, Mauguen A. Head-to-head evaluation of (18)f-FES and (18)f-FDG PET\/CT in metastatic invasive lobular breast cancer. J Nucl Med. 2021, 62:326-31. 10.2967\/jnumed.120.247882","journal-title":"J Nucl Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30804-6","article-title":"CDK4\/6 inhibitor treatment for patients with hormone receptor-positive, HER2-negative, advanced or metastatic breast cancer: a US Food and Drug Administration pooled analysis","volume":"21","author":"Gao JJ","year":"2020","unstructured":"Gao JJ, Cheng J, Bloomquist E, et al.. CDK4\/6 inhibitor treatment for patients with hormone receptor-positive, HER2-negative, advanced or metastatic breast cancer: a US Food and Drug Administration pooled analysis. Lancet Oncol. 2020, 21:250-60. 10.1016\/S1470-2045(19)30804-6","journal-title":"Lancet Oncol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5367","article-title":"Peritoneal metastases from breast cancer: a scoping review","volume":"11","author":"Beniey M","year":"2019","unstructured":"Beniey M. Peritoneal metastases from breast cancer: a scoping review. Cureus. 2019, 11:e5367. 10.7759\/cureus.5367","journal-title":"Cureus"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.sabcs22-gs1-10","article-title":"Abstract GS1- 10: Primary results from the randomized phase II RIGHT Choice trial of premenopausal patients with aggressive HR+\/HER2\u2212 advanced breast cancer treated with ribociclib + endocrine therapy vs physician\u2019s choice combination chemotherapy","volume":"83","author":"Lu Y-S","year":"2023","unstructured":"Lu Y-S, Mahidin EIBM, Azim H, et al.. Abstract GS1- 10: Primary results from the randomized phase II RIGHT Choice trial of premenopausal patients with aggressive HR+\/HER2\u2212 advanced breast cancer treated with ribociclib + endocrine therapy vs physician\u2019s choice combination chemotherapy. Cancer Res. 2023, 83:1-10. 10.1158\/1538-7445.sabcs22-gs1-10","journal-title":"Cancer Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/214940-metastatic-occult-primary-lobular-breast-cancer-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T13:17:04Z","timestamp":1713532624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/214940-metastatic-occult-primary-lobular-breast-cancer-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,19]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.58586","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,19]]}}}