{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:28:02Z","timestamp":1713572882951},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,19]]},"DOI":"10.7759\/cureus.58602","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T16:47:50Z","timestamp":1713545270000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Therapeutic Characteristics of Hospitalized Patients with Advanced Lung Cancer in Najran, Saudi Arabia: A Retrospective Study"],"prefix":"10.7759","author":[{"given":"Ahmed M","family":"Badheeb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamoud  Y","family":"Obied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Al Suleiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed  A","family":"Qurayshah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad A","family":"Awad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Abu Bakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batool","family":"Alwadai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah M","family":"Nasher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam  A","family":"Seada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasher  H","family":"Alyami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelaziz A","family":"Aman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman","family":"Al Qasim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Badheeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jegh.2017.09.004","article-title":"An overview of mortality & predictors of small-cell and non-small cell lung cancer among Saudi patients","volume":"7 Suppl 1","author":"Alghamdi HI","year":"2018","unstructured":"Alghamdi HI, Alshehri AF, Farhat GN. An overview of mortality & predictors of small-cell and non-small cell lung cancer among Saudi patients. J Epidemiol Glob Health. 2018, 7 Suppl 1:S1-6. 10.1016\/j.jegh.2017.09.004","journal-title":"J Epidemiol Glob Health"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1715907","article-title":"Higher lung cancer incidence in young women than young men in the United States","volume":"378","author":"Jemal A","year":"2018","unstructured":"Jemal A, Miller KD, Ma J, et al.. Higher lung cancer incidence in young women than young men in the United States. N Engl J Med. 2018, 378:1999-2009. 10.1056\/NEJMoa1715907","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4065\/83.5.584","article-title":"Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship","volume":"83","author":"Molina JR","year":"2008","unstructured":"Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008, 83:584-94. 10.4065\/83.5.584","journal-title":"Mayo Clin Proc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30030239","article-title":"Stage III non-small-cell lung cancer: an overview of treatment options","volume":"30","author":"Petrella F","year":"2023","unstructured":"Petrella F, Rizzo S, Attili I, et al.. Stage III non-small-cell lung cancer: an overview of treatment options. Curr Oncol. 2023, 30:3160-75. 10.3390\/curroncol30030239","journal-title":"Curr Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1281888","article-title":"Efficacy and safety of definitive chemoradiotherapy with or without induction immune checkpoint inhibitors in patients with stage III non-small cell lung cancer","volume":"14","author":"Yang Y","year":"2023","unstructured":"Yang Y, Wang J, Zhang T, et al.. Efficacy and safety of definitive chemoradiotherapy with or without induction immune checkpoint inhibitors in patients with stage III non-small cell lung cancer. Front Immunol. 2023, 14:1281888. 10.3389\/fimmu.2023.1281888","journal-title":"Front Immunol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.58957","article-title":"Lung cancer at a University Hospital in Saudi Arabia: a four-year prospective study of clinical, pathological, radiological, bronchoscopic, and biochemical parameters","volume":"5","author":"Alamoudi OS","year":"2010","unstructured":"Alamoudi OS. Lung cancer at a University Hospital in Saudi Arabia: a four-year prospective study of clinical, pathological, radiological, bronchoscopic, and biochemical parameters. Ann Thorac Med. 2010, 5:30-6. 10.4103\/1817-1737.58957","journal-title":"Ann Thorac Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003218","article-title":"Applying what we know to accelerate cancer prevention","volume":"4","author":"Colditz GA","year":"2012","unstructured":"Colditz GA, Wolin KY, Gehlert S. Applying what we know to accelerate cancer prevention. Sci Transl Med. 2012, 4:127rv4. 10.1126\/scitranslmed.3003218","journal-title":"Sci Transl Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1295847","article-title":"A population-based study of 15,000 people on knowledge and awareness of lung cancer symptoms and risk factors in Saudi Arabia","volume":"14","author":"AlRabeeah SM","year":"2024","unstructured":"AlRabeeah SM, Alzahrani EM, Aldhahir AM, et al.. A population-based study of 15,000 people on knowledge and awareness of lung cancer symptoms and risk factors in Saudi Arabia. Front Oncol. 2024, 14:1295847. 10.3389\/fonc.2024.1295847","journal-title":"Front Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2023.102439","article-title":"Tobacco control policies implementation and future lung cancer incidence in Saudi Arabia. A population-based study","volume":"36","author":"Ramadan M","year":"2023","unstructured":"Ramadan M, Alhusseini N, Samhan L, Samhan S, Abbad T. Tobacco control policies implementation and future lung cancer incidence in Saudi Arabia. A population-based study. Prev Med Rep. 2023, 36:102439. 10.1016\/j.pmedr.2023.102439","journal-title":"Prev Med Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.00275301","article-title":"The new World Health Organization classification of lung tumours","volume":"18","author":"Brambilla E","year":"2001","unstructured":"Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y. The new World Health Organization classification of lung tumours. Eur Respir J. 2001, 18:1059-68. 10.1183\/09031936.01.00275301","journal-title":"Eur Respir J"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7150\/jca.92624","article-title":"Efficacy and safety assessment of intrathoracic perfusion chemotherapy combined with immunological factor interleukin-2 in the treatment of advanced non-small cell lung cancer: a retrospective cohort study","volume":"15","author":"Cao Q","year":"2024","unstructured":"Cao Q, Zhu J, Wu X, et al.. Efficacy and safety assessment of intrathoracic perfusion chemotherapy combined with immunological factor interleukin-2 in the treatment of advanced non-small cell lung cancer: a retrospective cohort study. J Cancer. 2024, 15:2024-32. 10.7150\/jca.92624","journal-title":"J Cancer"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104633","article-title":"Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1\/PD-L1 immunotherapy in non-small cell lung cancer","volume":"92","author":"Ghiringhelli F","year":"2023","unstructured":"Ghiringhelli F, Bibeau F, Greillier L, et al.. Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1\/PD-L1 immunotherapy in non-small cell lung cancer. EBioMedicine. 2023, 92:104633. 10.1016\/j.ebiom.2023.104633","journal-title":"EBioMedicine"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.31729\/jnma.7330","article-title":"Adenocarcinoma among patients diagnosed with lung cancer in a tertiary care centre: a descriptive cross-sectional study","volume":"60","author":"Ansari F","year":"2022","unstructured":"Ansari F, Ghimire RH, Shrestha N, Yadav S. Adenocarcinoma among patients diagnosed with lung cancer in a tertiary care centre: a descriptive cross-sectional study. JNMA J Nepal Med Assoc. 2022, 60:377-80. 10.31729\/jnma.7330","journal-title":"JNMA J Nepal Med Assoc"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.14744\/ejmi.2023.29049","article-title":"Survival evaluation in patients over 70 years of age with advanced stage non-small cell lung cancer","volume":"7","author":"Ozturk A","year":"2023","unstructured":"Ozturk A. Survival evaluation in patients over 70 years of age with advanced stage non-small cell lung cancer. Eurasian J Med Invest. 2023, 7:501-8. 10.14744\/ejmi.2023.29049","journal-title":"Eurasian J Med Invest"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2019.5.24112","article-title":"A histopathological analysis of lung cancers. An 11-year retrospective study from Al-Madinah Al-Munawwarah, Saudi Arabia","volume":"40","author":"Albasri AM","year":"2019","unstructured":"Albasri AM. A histopathological analysis of lung cancers. An 11-year retrospective study from Al-Madinah Al-Munawwarah, Saudi Arabia. Saudi Med J. 2019, 40:503-6. 10.15537\/smj.2019.5.24112","journal-title":"Saudi Med J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182211827","article-title":"A retrospective cohort study of lung cancer incidences and epidemiological analysis in Saudi Arabian population from 2006-2016","volume":"18","author":"Almatroudi A","year":"2021","unstructured":"Almatroudi A. A retrospective cohort study of lung cancer incidences and epidemiological analysis in Saudi Arabian population from 2006-2016. Int J Environ Res Public Health. 2021, 18:10.3390\/ijerph182211827","journal-title":"Int J Environ Res Public Health"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/atm.ATM_92_17","article-title":"Saudi lung cancer management guidelines 2017","volume":"12","author":"Jazieh AR","year":"2017","unstructured":"Jazieh AR, Al Kattan K, Bamousa A, et al.. Saudi lung cancer management guidelines 2017. Ann Thorac Med. 2017, 12:221-46. 10.4103\/atm.ATM_92_17","journal-title":"Ann Thorac Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774","article-title":"Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer","volume":"375","author":"Reck M","year":"2016","unstructured":"Reck M, Rodr\u00edguez-Abreu D, Robinson AG, et al.. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med. 2016, 375:1823-33. 10.1056\/NEJMoa1606774","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2023.05.005","article-title":"Chemoimmunotherapy as the first-line treatment for patients with extensive-stage small-cell lung cancer and an ECOG performance status 2 or 3","volume":"24","author":"Agarwal M","year":"2023","unstructured":"Agarwal M, Liu A, Langlais BT, et al.. Chemoimmunotherapy as the first-line treatment for patients with extensive-stage small-cell lung cancer and an ECOG performance status 2 or 3. Clin Lung Cancer. 2023, 24:591-7. 10.1016\/j.cllc.2023.05.005","journal-title":"Clin Lung Cancer"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099314","article-title":"EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy","volume":"304","author":"Paez JG","year":"2004","unstructured":"Paez JG, J\u00e4nne PA, Lee JC, et al.. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004, 304:1497-500. 10.1126\/science.1099314","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji055","article-title":"Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers","volume":"97","author":"Shigematsu H","year":"2005","unstructured":"Shigematsu H, Lin L, Takahashi T, et al.. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 2005, 97:339-46. 10.1093\/jnci\/dji055","journal-title":"J Natl Cancer Inst"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.043","article-title":"EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment","volume":"23","author":"Marchetti A","year":"2005","unstructured":"Marchetti A, Martella C, Felicioni L, et al.. EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol. 2005, 23:857-65. 10.1200\/JCO.2005.08.043","journal-title":"J Clin Oncol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2018.10.007","article-title":"Reduced area of the normal lung on high-resolution computed tomography predicts poor survival in patients with lung cancer and combined pulmonary fibrosis and emphysema","volume":"57","author":"Miyamoto A","year":"2019","unstructured":"Miyamoto A, Kurosaki A, Moriguchi S, et al.. Reduced area of the normal lung on high-resolution computed tomography predicts poor survival in patients with lung cancer and combined pulmonary fibrosis and emphysema. Respir Investig. 2019, 57:140-9. 10.1016\/j.resinv.2018.10.007","journal-title":"Respir Investig"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31816de2b8","article-title":"The impact of additional prognostic factors on survival and their relationship with the anatomical extent of disease expressed by the 6th edition of the TNM classification of malignant tumors and the proposals for the 7th edition","volume":"3","author":"Sculier JP","year":"2008","unstructured":"Sculier JP, Chansky K, Crowley JJ, Van Meerbeeck J, Goldstraw P. The impact of additional prognostic factors on survival and their relationship with the anatomical extent of disease expressed by the 6th edition of the TNM classification of malignant tumors and the proposals for the 7th edition. J Thorac Oncol. 2008, 3:457-66. 10.1097\/JTO.0b013e31816de2b8","journal-title":"J Thorac Oncol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000652","article-title":"Refining prognosis in lung cancer: a report on the quality and relevance of clinical prognostic tools","volume":"10","author":"Mahar AL","year":"2015","unstructured":"Mahar AL, Compton C, McShane LM, Halabi S, Asamura H, Rami-Porta R, Groome PA. Refining prognosis in lung cancer: a report on the quality and relevance of clinical prognostic tools. J Thorac Oncol. 2015, 10:1576-89. 10.1097\/JTO.0000000000000652","journal-title":"J Thorac Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/245123-clinical-and-therapeutic-characteristics-of-hospitalized-patients-with-advanced-lung-cancer-in-najran-saudi-arabia-a-retrospective-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T16:47:53Z","timestamp":1713545273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/245123-clinical-and-therapeutic-characteristics-of-hospitalized-patients-with-advanced-lung-cancer-in-najran-saudi-arabia-a-retrospective-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,19]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.58602","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,19]]}}}