{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:19:08Z","timestamp":1791047948429,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,22]]},"DOI":"10.7759\/cureus.58772","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T23:04:58Z","timestamp":1713827098000},"source":"Crossref","is-referenced-by-count":2,"title":["A Case of Thrombocytopenia, Anasarca (Edema, Pleural Effusion, and Ascites), Fever, Reticulin Fibrosis\/Renal Dysfunction, and Organomegaly (TAFRO) Syndrome Initially Not Presenting With Thrombocytopenia: A Role of Immature Platelet Fraction"],"prefix":"10.7759","author":[{"given":"Mutsuo","family":"Kanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.11406\/rinketsu.51.320","article-title":"[Thrombocytopenia with mild bone marrow fibrosis accompanied by fever, pleural effusion, ascites and hepatosplenomegaly] (Article in Japanese)","volume":"51","author":"Takai K","year":"2010","unstructured":"Takai K, Nikkuni K, Shibuya H, Hashidate H. [Thrombocytopenia with mild bone marrow fibrosis accompanied by fever, pleural effusion, ascites and hepatosplenomegaly] (Article in Japanese). Rinsho Ketsueki. 2010, 51:320-5. 10.11406\/rinketsu.51.320","journal-title":"Rinsho Ketsueki"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24242","article-title":"Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease","volume":"91","author":"Iwaki N","year":"2016","unstructured":"Iwaki N, Fajgenbaum DC, Nabel CS, et al.. Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease. Am J Hematol. 2016, 91:220-6. 10.1002\/ajh.24242","journal-title":"Am J Hematol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2020.10.011","article-title":"TAFRO syndrome with kidney involvement: a case series of patients with kidney biopsies","volume":"3","author":"Shimada K","year":"2021","unstructured":"Shimada K, Sasaki T, Okabe M, et al.. TAFRO syndrome with kidney involvement: a case series of patients with kidney biopsies. Kidney Med. 2021, 3:286-93. 10.1016\/j.xkme.2020.10.011","journal-title":"Kidney Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-019-02780-1","article-title":"2019 updated diagnostic criteria and disease severity classification for TAFRO syndrome","volume":"111","author":"Masaki Y","year":"2020","unstructured":"Masaki Y, Kawabata H, Takai K, et al.. 2019 updated diagnostic criteria and disease severity classification for TAFRO syndrome. Int J Hematol. 2020, 111:155-8. 10.1007\/s12185-019-02780-1","journal-title":"Int J Hematol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.53.87","article-title":"Atypical hyaline vascular-type castleman's disease with thrombocytopenia, anasarca, fever, and systemic lymphadenopathy","volume":"53","author":"Iwaki N","year":"2013","unstructured":"Iwaki N, Sato Y, Takata K, et al.. Atypical hyaline vascular-type castleman's disease with thrombocytopenia, anasarca, fever, and systemic lymphadenopathy. J Clin Exp Hematop. 2013, 53:87-93. 10.3960\/jslrt.53.87","journal-title":"J Clin Exp Hematop"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.53.101","article-title":"A case of multicentric castleman's disease of mixed-type, which showed constellation of symptoms, i.e., thrombocytopenia, anasarca, anemia, fever, myelofibrosis, and lymphadenopathy","volume":"53","author":"Awano N","year":"2013","unstructured":"Awano N, Inomata M, Sonoda Y, et al.. A case of multicentric castleman's disease of mixed-type, which showed constellation of symptoms, i.e., thrombocytopenia, anasarca, anemia, fever, myelofibrosis, and lymphadenopathy. J Clin Exp Hematop. 2013, 53:101-5. 10.3960\/jslrt.53.101","journal-title":"J Clin Exp Hematop"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1059982","article-title":"TAFRO syndrome: 2 cases and review of the literature","volume":"27","author":"Kawashima M","year":"2017","unstructured":"Kawashima M, Usui T, Okada H, et al.. TAFRO syndrome: 2 cases and review of the literature. Mod Rheumatol. 2017, 27:1093-7. 10.3109\/14397595.2015.1059982","journal-title":"Mod Rheumatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1206243","article-title":"A case of TAFRO syndrome, a variant of multicentric Castleman's disease, successfully treated with corticosteroid and cyclosporine A","volume":"29","author":"Takasawa N","year":"2019","unstructured":"Takasawa N, Sekiguchi Y, Takahashi T, Muryoi A, Satoh J, Sasaki T. A case of TAFRO syndrome, a variant of multicentric Castleman's disease, successfully treated with corticosteroid and cyclosporine A. Mod Rheumatol. 2019, 29:198-202. 10.1080\/14397595.2016.1206243","journal-title":"Mod Rheumatol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.11406\/rinketsu.57.2490","article-title":"[TAFRO syndrome showing cholangitis on liver biopsy] (Article in Japanese)","volume":"57","author":"Nagai Y","year":"2016","unstructured":"Nagai Y, Ando S, Honda N, Noguchi H, Maemori M, Hayashi T, Sakai H. [TAFRO syndrome showing cholangitis on liver biopsy] (Article in Japanese). Rinsho Ketsueki. 2016, 57:2490-5. 10.11406\/rinketsu.57.2490","journal-title":"Rinsho Ketsueki"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.11406\/rinketsu.59.991","article-title":"[Clinical significance of chronologic immature platelet fraction analysis in TAFRO syndrome] (Article in Japanese)","volume":"59","author":"Saga T","year":"2018","unstructured":"Saga T, Ishihara T, Kanagawa M, Hiratsuka Y, Matsuura T, Yashiro S, Kano S. [Clinical significance of chronologic immature platelet fraction analysis in TAFRO syndrome] (Article in Japanese). Rinsho Ketsueki. 2018, 59:991-6. 10.11406\/rinketsu.59.991","journal-title":"Rinsho Ketsueki"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.09.007","article-title":"A simple technique to determine thrombopoiesis level using immature platelet fraction (IPF)","volume":"118","author":"Abe Y","year":"2006","unstructured":"Abe Y, Wada H, Tomatsu H, et al.. A simple technique to determine thrombopoiesis level using immature platelet fraction (IPF). Thromb Res. 2006, 118:463-9. 10.1016\/j.thromres.2005.09.007","journal-title":"Thromb Res"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051172","article-title":"Reticulated platelets-which functions have been established by in vivo and in vitro data?","volume":"10","author":"Hamad MA","year":"2021","unstructured":"Hamad MA, Schanze N, Schommer N, N\u00fchrenberg T, Duerschmied D. Reticulated platelets-which functions have been established by in vivo and in vitro data?. Cells. 2021, 10:1172. 10.3390\/cells10051172","journal-title":"Cells"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019096","article-title":"Immature platelet fraction: a useful marker for identifying the cause of thrombocytopenia and predicting platelet recovery","volume":"99","author":"Jeon K","year":"2020","unstructured":"Jeon K, Kim M, Lee J, Lee JS, Kim HS, Kang HJ, Lee YK. Immature platelet fraction: a useful marker for identifying the cause of thrombocytopenia and predicting platelet recovery. Medicine (Baltimore). 2020, 99:e19096. 10.1097\/MD.0000000000019096","journal-title":"Medicine (Baltimore)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00146","article-title":"Mean platelet volume and immature platelet fraction in autoimmune disorders","volume":"4","author":"Schmoeller D","year":"2017","unstructured":"Schmoeller D, Picarelli MM, Paz Munhoz T, Poli de Figueiredo CE, Staub HL. Mean platelet volume and immature platelet fraction in autoimmune disorders. Front Med (Lausanne). 2017, 4:146. 10.3389\/fmed.2017.00146","journal-title":"Front Med (Lausanne)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13177","article-title":"Reticulated platelets and immature platelet fraction: clinical applications and method limitations","volume":"42","author":"Buttarello M","year":"2020","unstructured":"Buttarello M, Mezzapelle G, Freguglia F, Plebani M. Reticulated platelets and immature platelet fraction: clinical applications and method limitations. Int J Lab Hematol. 2020, 42:363-70. 10.1111\/ijlh.13177","journal-title":"Int J Lab Hematol"},{"key":"ref16","article-title":"Significance of platelet most frequent volume for platelet size evaluation","volume":"58","author":"Isono S","year":"2012","unstructured":"Isono S, Tatsuta M, Nagata K, et al.. Significance of platelet most frequent volume for platelet size evaluation. Clin Lab. 2012, 58:857-60.","journal-title":"Clin Lab"},{"key":"ref17","article-title":"[Usefulness of platelet volume mode (P-MFV) as a platelet size indicator during thrombocytopenia] (Article in Japanese)","volume":"13","author":"Isono S","year":"2012","unstructured":"Isono S, Tatsuta M, Nagata K, et al.. [Usefulness of platelet volume mode (P-MFV) as a platelet size indicator during thrombocytopenia] (Article in Japanese). Sysmex J Web. 2012, 13:","journal-title":"Sysmex J Web"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/mrcr\/rxac007","article-title":"A case of TAFRO syndrome maintained in remission for 5 years after discontinuation of tocilizumab","volume":"7","author":"Yamagami K","year":"2023","unstructured":"Yamagami K, Hanioka Y, Yao S, Nakamura R, Nakamura T, Ishii N, Goto H. A case of TAFRO syndrome maintained in remission for 5 years after discontinuation of tocilizumab. Mod Rheumatol Case Rep. 2023, 7:205-10. 10.1093\/mrcr\/rxac007","journal-title":"Mod Rheumatol Case Rep"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1266187","article-title":"Case report: a case of TAFRO syndrome with severe and prolonged thrombocytopenia: diagnostic pitfalls","volume":"14","author":"Sato H","year":"2023","unstructured":"Sato H, Kanno A, Sato M, et al.. Case report: a case of TAFRO syndrome with severe and prolonged thrombocytopenia: diagnostic pitfalls. Front Immunol. 2023, 14:1266187. 10.3389\/fimmu.2023.1266187","journal-title":"Front Immunol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/232758-a-case-of-thrombocytopenia-anasarca-edema-pleural-effusion-and-ascites-fever-reticulin-fibrosisrenal-dysfunction-and-organomegaly-tafro-syndrome-initially-not-presenting-with-thrombocytopenia-a-role-of-immature-platelet-fraction","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T23:05:07Z","timestamp":1713827107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/232758-a-case-of-thrombocytopenia-anasarca-edema-pleural-effusion-and-ascites-fever-reticulin-fibrosisrenal-dysfunction-and-organomegaly-tafro-syndrome-initially-not-presenting-with-thrombocytopenia-a-role-of-immature-platelet-fraction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.58772","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,22]]}}}