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Bull World Health Organ. 2020, 98:638-40. 10.2471\/BLT.19.242347","journal-title":"Bull World Health Organ"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005769107","article-title":"Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo","volume":"107","author":"Rimoin AW","year":"2010","unstructured":"Rimoin AW, Mulembakani PM, Johnston SC, et al.. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci U S A. 2010, 107:16262-7. 10.1073\/pnas.1005769107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref69","unstructured":"Emergency purchase of monkeypox vaccine on hold. (2022). Accessed. January 12, 2023: https:\/\/www.hindustantimes.com\/india-news\/emergency-purchase-of-monkeypox-vaccine-on-hold-101662317542985.html."},{"key":"ref70","unstructured":"Monkeypox vaccine. when will it be rolled out in India?. (2022). Accessed: January 12, 2023: https:\/\/www.dnaindia.com\/health\/report-monkeypox-vaccine-when-will-it-be-rolled-out-in-india-who-will-get-it-first-29...."},{"key":"ref71","unstructured":"Mpox (monkeypox) vaccines. (2022). Accessed. January 12, 2023: https:\/\/www.health.gov.au\/diseases\/mpox-monkeypox\/vaccines."},{"key":"ref72","unstructured":"Interim clinical considerations for use of JYNNEOS and ACAM2000 vaccines during the 2022 U.S. mpox outbreak. Accessed. January 12, 2023: https:\/\/www.cdc.gov\/poxvirus\/mpox\/clinicians\/vaccines\/vaccine-considerations.html."},{"key":"ref73","unstructured":"JYNNEOS. Accessed. January 12, 2023: https:\/\/www.fda.gov\/vaccines-blood-biologics\/jynneos."},{"key":"ref74","unstructured":"As monkeypox threat grows, scientists debate best vaccine strategy. (2022). Accessed. December 3, 2023: https:\/\/www.science.org\/content\/article\/monkeypox-threat-grows-scientists-debate-best-vaccine-strategy."},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817307","article-title":"Phase 3 efficacy trial of modified vaccinia Ankara as a vaccine against smallpox","volume":"14","author":"Pittman PR","year":"2019","unstructured":"Pittman PR, Hahn M, Lee HS, et al.. Phase 3 efficacy trial of modified vaccinia Ankara as a vaccine against smallpox. N Engl J Med. 2019, 14:1897-908. 10.1056\/NEJMoa1817307","journal-title":"N Engl J Med"},{"key":"ref76","unstructured":"Clinical considerations for mpox in people who are pregnant or breastfeeding. (2023). Accessed. December 3, 2023: https:\/\/www.cdc.gov\/poxvirus\/mpox\/clinicians\/pregnancy.html#:~:text=Mpox%20and%20Pregnancy,-Data%20regarding%20mpox&amp;t...."},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00270-0","article-title":"Early evaluation of the safety, reactogenicity, and immune response after a single dose of modified vaccinia Ankara-Bavaria Nordic vaccine against mpox in children: a national outbreak response","volume":"23","author":"Ladhani SN","year":"2023","unstructured":"Ladhani SN, Dowell AC, Jones S, et al.. Early evaluation of the safety, reactogenicity, and immune response after a single dose of modified vaccinia Ankara-Bavaria Nordic vaccine against mpox in children: a national outbreak response. Lancet Infect Dis. 2023, 23:1042-50. 10.1016\/S1473-3099(23)00270-0","journal-title":"Lancet Infect Dis"},{"key":"ref78","unstructured":"Notice to readers. newly licensed smallpox vaccine to replace old smallpox vaccine. (2008). Accessed: January 12, 2023: https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm5708a6.htm."},{"key":"ref79","unstructured":"Smallpox. contraindications to vaccination. (2016). Accessed: December 3, 2023: https:\/\/www.cdc.gov\/smallpox\/clinicians\/vaccination-contraindications1.html."},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-022-00527-4","article-title":"Current status of monkeypox vaccines","volume":"7","author":"Gruber MF","year":"2022","unstructured":"Gruber MF. Current status of monkeypox vaccines. NPJ Vaccines. 2022, 7:94. 10.1038\/s41541-022-00527-4","journal-title":"NPJ Vaccines"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2300290","article-title":"Mpox neutralizing antibody response to LC16m8 vaccine in healthy adults","volume":"3","author":"Morino E","year":"2024","unstructured":"Morino E, Mine S, Tomita N, et al.. Mpox neutralizing antibody response to LC16m8 vaccine in healthy adults. NEJM Evid. 2024, 3:EVIDoa2300290. 10.1056\/EVIDoa2300290","journal-title":"NEJM Evid"},{"key":"ref82","unstructured":"Vaccines and immunization for monkeypox. Interim guidance, 16 November 2022. (2022). Accessed: December 3, 2023: https:\/\/www.who.int\/publications\/i\/item\/WHO-MPX-Immunization."},{"key":"ref83","unstructured":"ACIP recommendations. (2023). Accessed. December 10, 2023: https:\/\/www.cdc.gov\/vaccines\/acip\/recommendations.html."},{"key":"ref84","unstructured":"Smallpox\/monkeypox vaccine information statement. (2022). Accessed. April 23, 2024: https:\/\/www.cdc.gov\/vaccines\/hcp\/vis\/vis-statements\/smallpox-monkeypox.html."},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1086\/498155","article-title":"Reemergence of monkeypox: prevalence, diagnostics, and countermeasures","volume":"41","author":"Nalca A","year":"2005","unstructured":"Nalca A, Rimoin AW, Bavari S, Whitehouse CA. Reemergence of monkeypox: prevalence, diagnostics, and countermeasures. Clin Infect Dis. 2005, 41:1765-71. 10.1086\/498155","journal-title":"Clin Infect Dis"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02196","article-title":"Suppression of poxvirus replication by resveratrol","volume":"8","author":"Cao S","year":"2017","unstructured":"Cao S, Realegeno S, Pant A, Satheshkumar PS, Yang Z. Suppression of poxvirus replication by resveratrol. Front Microbiol. 2017, 8:2196. 10.3389\/fmicb.2017.02196","journal-title":"Front Microbiol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/224500-monkeypox-from-emerging-trends-to-therapeutic-concerns","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:09:26Z","timestamp":1713931766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/224500-monkeypox-from-emerging-trends-to-therapeutic-concerns"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":86,"URL":"https:\/\/doi.org\/10.7759\/cureus.58866","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}