{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:33:36Z","timestamp":1759847616422},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,29]]},"DOI":"10.7759\/cureus.59288","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T15:33:01Z","timestamp":1714404781000},"source":"Crossref","is-referenced-by-count":2,"title":["Role of Molecular Biomarkers in Endometriosis-Related Infertility: A Narrative Review of the Literature"],"prefix":"10.7759","author":[{"given":"Nikoleta","family":"Koutalia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fani","family":"Gkrozou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Vatopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Lentzaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chara","family":"Skentou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minas","family":"Paschopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.04.001","article-title":"Noninvasive diagnosis of endometriosis: review of current peripheral blood and endometrial biomarkers","volume":"50","author":"O DF","year":"2018","unstructured":"O DF, Flores I, Waelkens E, D'Hooghe T. Noninvasive diagnosis of endometriosis: review of current peripheral blood and endometrial biomarkers. Best Pract Res Clin Obstet Gynaecol. 2018, 50:72-83. 10.1016\/j.bpobgyn.2018.04.001","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051750","article-title":"Biomarkers for the noninvasive diagnosis of endometriosis: state of the art and future perspectives","volume":"21","author":"Anastasiu CV","year":"2020","unstructured":"Anastasiu CV, Moga MA, Elena Neculau A, et al.. Biomarkers for the noninvasive diagnosis of endometriosis: state of the art and future perspectives. Int J Mol Sci. 2020, 21:1750. 10.3390\/ijms21051750","journal-title":"Int J Mol Sci"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and pathophysiology of endometriosis","volume":"98","author":"Burney RO","year":"2012","unstructured":"Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012, 98:511-9. 10.1016\/j.fertnstert.2012.06.029","journal-title":"Fertil Steril"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew293","article-title":"World Endometriosis Society consensus on the classification of endometriosis","volume":"32","author":"Johnson NP","year":"2017","unstructured":"Johnson NP, Hummelshoj L, Adamson GD, et al.. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod. 2017, 32:315-24. 10.1093\/humrep\/dew293","journal-title":"Hum Reprod"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2019.1578743","article-title":"Diagnosis of endometriosis in the 21st century","volume":"22","author":"Kiesel L","year":"2019","unstructured":"Kiesel L, Sourouni M. Diagnosis of endometriosis in the 21st century. Climacteric. 2019, 22:296-302. 10.1080\/13697137.2019.1578743","journal-title":"Climacteric"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012179","article-title":"Blood biomarkers for the non-invasive diagnosis of endometriosis","volume":"2016","author":"Nisenblat V","year":"2016","unstructured":"Nisenblat V, Bossuyt PM, Shaikh R, et al.. Blood biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016, 2016:CD012179. 10.1002\/14651858.CD012179","journal-title":"Cochrane Database Syst Rev"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1020827","article-title":"Endometriosis-associated infertility: from pathophysiology to tailored treatment","volume":"13","author":"Bonavina G","year":"2022","unstructured":"Bonavina G, Taylor HS. Endometriosis-associated infertility: from pathophysiology to tailored treatment. Front Endocrinol (Lausanne). 2022, 13:1020827. 10.3389\/fendo.2022.1020827","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56090460","article-title":"Endometriosis associated infertility: a critical review and analysis on etiopathogenesis and therapeutic approaches","volume":"56","author":"Filip L","year":"2020","unstructured":"Filip L, Duic\u0103 F, Pr\u0103datu A, et al.. Endometriosis associated infertility: a critical review and analysis on etiopathogenesis and therapeutic approaches. Medicina (Kaunas). 2020, 56:460. 10.3390\/medicina56090460","journal-title":"Medicina (Kaunas)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116649711","article-title":"Endometrial BCL6 overexpression in eutopic endometrium of women with endometriosis","volume":"23","author":"Evans-Hoeker E","year":"2016","unstructured":"Evans-Hoeker E, Lessey BA, Jeong JW, et al.. Endometrial BCL6 overexpression in eutopic endometrium of women with endometriosis. Reprod Sci. 2016, 23:1234-41. 10.1177\/1933719116649711","journal-title":"Reprod Sci"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11206164","article-title":"Comparison of morphological and digital-assisted analysis for BCL6 endometrial expression in women with endometriosis","volume":"11","author":"Squatrito M","year":"2022","unstructured":"Squatrito M, Blacher S, Henry L, Labied S, Noel A, Nisolle M, Munaut C. Comparison of morphological and digital-assisted analysis for BCL6 endometrial expression in women with endometriosis. J Clin Med. 2022, 11:6164. 10.3390\/jcm11206164","journal-title":"J Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1388-x","article-title":"Medical or surgical treatment before embryo transfer improves outcomes in women with abnormal endometrial BCL6 expression","volume":"36","author":"Likes CE","year":"2019","unstructured":"Likes CE, Cooper LJ, Efird J, Forstein DA, Miller PB, Savaris R, Lessey BA. Medical or surgical treatment before embryo transfer improves outcomes in women with abnormal endometrial BCL6 expression. J Assist Reprod Genet. 2019, 36:483-90. 10.1007\/s10815-018-1388-x","journal-title":"J Assist Reprod Genet"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac027","article-title":"BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis","volume":"28","author":"Louwen F","year":"2022","unstructured":"Louwen F, Kreis NN, Ritter A, Friemel A, Solbach C, Yuan J. BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis. Hum Reprod Update. 2022, 28:890-909. 10.1093\/humupd\/dmac027","journal-title":"Hum Reprod Update"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13296","article-title":"Soluble immune checkpoints CTLA-4, HLA-G, PD-1, and PD-L1 are associated with endometriosis-related infertility","volume":"84","author":"Santoso B","year":"2020","unstructured":"Santoso B, Sa'adi A, Dwiningsih SR, et al.. Soluble immune checkpoints CTLA-4, HLA-G, PD-1, and PD-L1 are associated with endometriosis-related infertility. Am J Reprod Immunol. 2020, 84:e13296. 10.1111\/aji.13296","journal-title":"Am J Reprod Immunol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030487","article-title":"CLTA-4 expression is associated with the maintenance of chronic inflammation in endometriosis and infertility","volume":"10","author":"Abramiuk M","year":"2021","unstructured":"Abramiuk M, B\u0119bnowska D, Hrynkiewicz R, Polak PN, Kotarski J, Roli\u0144ski J, Grywalska E. CLTA-4 expression is associated with the maintenance of chronic inflammation in endometriosis and infertility. Cells. 2021, 10:487. 10.3390\/cells10030487","journal-title":"Cells"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111410","article-title":"Fibronectin molecular status in plasma of women with endometriosis and fertility disorders","volume":"22","author":"Lis-Kuberka J","year":"2021","unstructured":"Lis-Kuberka J, Kubik P, Chrobak A, Paj\u0105k J, Che\u0142mo\u0144ska-Soyta A, Orczyk-Pawi\u0142owicz M. Fibronectin molecular status in plasma of women with endometriosis and fertility disorders. Int J Mol Sci. 2021, 22:11410. 10.3390\/ijms222111410","journal-title":"Int J Mol Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.11.027","article-title":"HOXA-10 gene expression in ectopic and eutopic endometrium tissues: does it differ between fertile and infertile women with endometriosis?","volume":"233","author":"\u00d6zcan C","year":"2019","unstructured":"\u00d6zcan C, \u00d6zdamar \u00d6, G\u00f6kbayrak ME, Do\u011fer E, \u00c7ak\u0131ro\u011flu Y, \u00c7ine N. HOXA-10 gene expression in ectopic and eutopic endometrium tissues: does it differ between fertile and infertile women with endometriosis?. Eur J Obstet Gynecol Reprod Biol. 2019, 233:43-8. 10.1016\/j.ejogrb.2018.11.027","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioz014","article-title":"MicroRNAs in endometriosis: biological function and emerging biomarker candidates","volume":"100","author":"Bjorkman S","year":"2019","unstructured":"Bjorkman S, Taylor HS. MicroRNAs in endometriosis: biological function and emerging biomarker candidates. Biol Reprod. 2019, 100:1135-46. 10.1093\/biolre\/ioz014","journal-title":"Biol Reprod"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-019-00129-x","article-title":"LncRNA H19 overexpression in endometriosis and its utility as a novel biomarker for predicting recurrence","volume":"27","author":"Liu S","year":"2020","unstructured":"Liu S, Xin W, Tang X, Qiu J, Zhang Y, Hua K. LncRNA H19 overexpression in endometriosis and its utility as a novel biomarker for predicting recurrence. Reprod Sci. 2020, 27:1687-97. 10.1007\/s43032-019-00129-x","journal-title":"Reprod Sci"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2076","article-title":"Progesterone resistance in endometriosis is modulated by the altered expression of microRNA-29c and FKBP4","volume":"102","author":"Joshi NR","year":"2017","unstructured":"Joshi NR, Miyadahira EH, Afshar Y, et al.. Progesterone resistance in endometriosis is modulated by the altered expression of microRNA-29c and FKBP4. J Clin Endocrinol Metab. 2017, 102:141-9. 10.1210\/jc.2016-2076","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00374","article-title":"miR-194-3p represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis","volume":"159","author":"Pei T","year":"2018","unstructured":"Pei T, Liu C, Liu T, et al.. miR-194-3p represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis. Endocrinology. 2018, 159:2554-62. 10.1210\/en.2018-00374","journal-title":"Endocrinology"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.11.036","article-title":"Micro-RNA profile and proteins in peritoneal fluid from women with endometriosis: their relationship with sterility","volume":"109","author":"Mar\u00ed-Alexandre J","year":"2018","unstructured":"Mar\u00ed-Alexandre J, Barcel\u00f3-Molina M, Belmonte-L\u00f3pez E, Garc\u00eda-Oms J, Estell\u00e9s A, Braza-Bo\u00efls A, Gilabert-Estell\u00e9s J. Micro-RNA profile and proteins in peritoneal fluid from women with endometriosis: their relationship with sterility. Fertil Steril. 2018, 109:675-84.e2. 10.1016\/j.fertnstert.2017.11.036","journal-title":"Fertil Steril"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2022.09.019","article-title":"Endometriosis-associated infertility diagnosis based on saliva microRNA signatures","volume":"46","author":"Dabi Y","year":"2023","unstructured":"Dabi Y, Suisse S, Puchar A, et al.. Endometriosis-associated infertility diagnosis based on saliva microRNA signatures. Reprod Biomed Online. 2023, 46:138-49. 10.1016\/j.rbmo.2022.09.019","journal-title":"Reprod Biomed Online"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2022.103489","article-title":"Eutopic endometrial immune profile of infertility-patients with and without endometriosis","volume":"150","author":"Freitag N","year":"2022","unstructured":"Freitag N, Baston-Buest DM, Kruessel JS, Markert UR, Fehm TN, Bielfeld AP. Eutopic endometrial immune profile of infertility-patients with and without endometriosis. J Reprod Immunol. 2022, 150:103489. 10.1016\/j.jri.2022.103489","journal-title":"J Reprod Immunol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S232849","article-title":"Systemic inflammatory response markers associated with infertility and endometrioma or uterine leiomyoma in endometriosis","volume":"16","author":"Jing X","year":"2020","unstructured":"Jing X, Li C, Sun J, et al.. Systemic inflammatory response markers associated with infertility and endometrioma or uterine leiomyoma in endometriosis. Ther Clin Risk Manag. 2020, 16:403-12. 10.2147\/TCRM.S232849","journal-title":"Ther Clin Risk Manag"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13384","article-title":"Endometriosis\u00a0with infertility: a comprehensive review on the role of immune deregulation and immunomodulation therapy","volume":"85","author":"Kolanska K","year":"2021","unstructured":"Kolanska K, Alijotas-Reig J, Cohen J, et al.. Endometriosis\u00a0with infertility: a comprehensive review on the role of immune deregulation and immunomodulation therapy. Am J Reprod Immunol. 2021, 85:e13384. 10.1111\/aji.13384","journal-title":"Am J Reprod Immunol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082385","article-title":"Chronic niche inflammation in endometriosis-associated infertility: current understanding and future therapeutic strategies","volume":"19","author":"Lin YH","year":"2018","unstructured":"Lin YH, Chen YH, Chang HY, Au HK, Tzeng CR, Huang YH. Chronic niche inflammation in endometriosis-associated infertility: current understanding and future therapeutic strategies. Int J Mol Sci. 2018, 19:2385. 10.3390\/ijms19082385","journal-title":"Int J Mol Sci"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201805_14899","article-title":"Inflammatory cytokines IL-6, IL-10, IL-13, TNF-\u03b1 and peritoneal fluid flora were associated with infertility in patients with endometriosis","volume":"22","author":"Wang XM","year":"2018","unstructured":"Wang XM, Ma ZY, Song N. Inflammatory cytokines IL-6, IL-10, IL-13, TNF-\u03b1 and peritoneal fluid flora were associated with infertility in patients with endometriosis. Eur Rev Med Pharmacol Sci. 2018, 22:2513-8. 10.26355\/eurrev_201805_14899","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.5603\/GP.2020.0039","article-title":"The role of biological markers in predicting infertility associated with non-obstructive endometriosis","volume":"91","author":"Gica N","year":"2020","unstructured":"Gica N, Panaitescu AM, Iancu G, Botezatu R, Peltecu G, Gica C. The role of biological markers in predicting infertility associated with non-obstructive endometriosis. Ginekol Pol. 2020, 91:189-92. 10.5603\/GP.2020.0039","journal-title":"Ginekol Pol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02500-3","article-title":"Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis","volume":"20","author":"Shih AJ","year":"2022","unstructured":"Shih AJ, Adelson RP, Vashistha H, et al.. Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis. BMC Med. 2022, 20:315. 10.1186\/s12916-022-02500-3","journal-title":"BMC Med"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.102043","article-title":"Deciphering biomarkers of endometriosis by proteomic analysis of eutopic endometrium in infertile patients","volume":"50","author":"Yao Z","year":"2021","unstructured":"Yao Z, Zhang Y, Yan J, Yan L. Deciphering biomarkers of endometriosis by proteomic analysis of eutopic endometrium in infertile patients. J Gynecol Obstet Hum Reprod. 2021, 50:102043. 10.1016\/j.jogoh.2020.102043","journal-title":"J Gynecol Obstet Hum Reprod"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/245597-role-of-molecular-biomarkers-in-endometriosis-related-infertility-a-narrative-review-of-the-literature","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T15:33:06Z","timestamp":1714404786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/245597-role-of-molecular-biomarkers-in-endometriosis-related-infertility-a-narrative-review-of-the-literature"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.59288","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,29]]}}}