{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:23:29Z","timestamp":1782840209940,"version":"3.54.5"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"DOI":"10.7759\/cureus.59444","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T13:24:00Z","timestamp":1714569840000},"source":"Crossref","is-referenced-by-count":1,"title":["Cardiovascular Autonomic Deficits in Different Types of Achalasia"],"prefix":"10.7759","author":[{"given":"Abhijith","family":"Anil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh K","family":"Netam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atanu","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinu S","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Jaryal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind K","family":"Makharia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajinder","family":"Parshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore K","family":"Deepak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000731","article-title":"ACG clinical guideline: diagnosis and management of achalasia","volume":"115","author":"Vaezi MF","year":"2020","unstructured":"Vaezi MF, Pandolfino JE, Yadlapati RH, Greer KB, Kavitt RT. ACG clinical guideline: diagnosis and management of achalasia. Am J Gastroenterol. 2020, 115:1393-411. 10.14309\/ajg.0000000000000731","journal-title":"Am J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058","article-title":"Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0(\u00a9)","volume":"33","author":"Yadlapati R","year":"2021","unstructured":"Yadlapati R, Kahrilas PJ, Fox MR, et al.. Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0(\u00a9). Neurogastroenterol Motil. 2021, 33:e14058. 10.1111\/nmo.14058","journal-title":"Neurogastroenterol Motil"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01532.x","article-title":"Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls","volume":"103","author":"Pandolfino JE","year":"2008","unstructured":"Pandolfino JE, Ghosh SK, Rice J, Clarke JO, Kwiatek MA, Kahrilas PJ. Classifying esophageal motility by pressure topography characteristics: a study of 400 patients and 75 controls. Am J Gastroenterol. 2008, 103:27-37. 10.1111\/j.1572-0241.2007.01532.x","journal-title":"Am J Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41775.x","article-title":"Etiology and pathogenesis of achalasia: the current understanding","volume":"100","author":"Park W","year":"2005","unstructured":"Park W, Vaezi MF. Etiology and pathogenesis of achalasia: the current understanding. Am J Gastroenterol. 2005, 100:1404-14. 10.1111\/j.1572-0241.2005.41775.x","journal-title":"Am J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196409000-00010","article-title":"Achalasia of the esophagus: pathologic and etiologic considerations","volume":"160","author":"Cassella RR","year":"1964","unstructured":"Cassella RR, Brown AL, Sayre GP, Ellis FH. Achalasia of the esophagus: pathologic and etiologic considerations. Ann Surg. 1964, 160:474-87. 10.1097\/00000658-196409000-00010","journal-title":"Ann Surg"},{"key":"ref6","article-title":"Fine-structure changes in achalasia of the esophagus. I. vagus nerves","volume":"46","author":"Cassella RR","year":"1965","unstructured":"Cassella RR, Ellis FH Jr, Brown AL Jr. Fine-structure changes in achalasia of the esophagus. I. vagus nerves. Am J Pathol. 1965, 46:279-88.","journal-title":"Am J Pathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00044","article-title":"Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders","volume":"9","author":"Breit S","year":"2018","unstructured":"Breit S, Kupferberg A, Rogler G, Hasler G. Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders. Front Psychiatry. 2018, 9:44-5. 10.3389\/fpsyt.2018.00044","journal-title":"Front Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248106","article-title":"Cardiovascular dysautonomia in achalasia patients: blood pressure and heart rate variability alterations","volume":"16","author":"Rivera AL","year":"2021","unstructured":"Rivera AL, Esta\u00f1ol B, Macias-Gallardo JJ, Delgado-Garcia G, Fossion R, Frank A, Torres-Villalobos GM. Cardiovascular dysautonomia in achalasia patients: blood pressure and heart rate variability alterations. PLoS One. 2021, 16:e0248106. 10.1371\/journal.pone.0248106","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.21037\/atm.2020.03.149","article-title":"Manometric pattern progression in esophageal achalasia in the era of high-resolution manometry","volume":"9","author":"Salvador R","year":"2021","unstructured":"Salvador R, Costantini M, Tolone S. Manometric pattern progression in esophageal achalasia in the era of high-resolution manometry. Ann Transl Med. 2021, 9:906-7.","journal-title":"Ann Transl Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20014","article-title":"2019 Seoul Consensus on esophageal achalasia guidelines","volume":"26","author":"Jung HK","year":"2020","unstructured":"Jung HK, Hong SJ, Lee OY, et al.. 2019 Seoul Consensus on esophageal achalasia guidelines. J Neurogastroenterol Motil. 2020, 26:180-203. 10.5056\/jnm20014","journal-title":"J Neurogastroenterol Motil"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1998.00120.x","article-title":"Autonomic dysfunction in patients with achalasia of the oesophagus","volume":"10","author":"von Herbay A","year":"1998","unstructured":"von Herbay A, Heyer T, Olk W, et al.. Autonomic dysfunction in patients with achalasia of the oesophagus. Neurogastroenterol Motil. 1998, 10:387-93. 10.1046\/j.1365-2982.1998.00120.x","journal-title":"Neurogastroenterol Motil"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1023\/a:1026638822259","article-title":"Extraesophageal autonomic dysfunction in patients with achalasia","volume":"44","author":"Olk W","year":"1999","unstructured":"Olk W, Kiesewalter B, Auer P, et al.. Extraesophageal autonomic dysfunction in patients with achalasia. Dig Dis Sci. 1999, 44:2088-93. 10.1023\/a:1026638822259","journal-title":"Dig Dis Sci"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410004460","article-title":"Achalasia: a vagal disease","volume":"39","author":"Ohlsson B","year":"2004","unstructured":"Ohlsson B, Ekberg O, Sundkvist G. Achalasia: a vagal disease. Scand J Gastroenterol. 2004, 39:527-30. 10.1080\/00365520410004460","journal-title":"Scand J Gastroenterol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.4.1563","article-title":"Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure","volume":"71","author":"Sandroni P","year":"1991","unstructured":"Sandroni P, Benarroch EE, Low PA. Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure. J Appl Physiol (1985). 1991, 71:1563-7. 10.1152\/jappl.1991.71.4.1563","journal-title":"J Appl Physiol (1985)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1970.218.4.1030","article-title":"Cardiac vagal efferent activity and heart period in the carotid sinus reflex","volume":"218","author":"Katona PG","year":"1970","unstructured":"Katona PG, Poitras JW, Barnett GO, Terry BS. Cardiac vagal efferent activity and heart period in the carotid sinus reflex. Am J Physiol. 1970, 218:1030-7. 10.1152\/ajplegacy.1970.218.4.1030","journal-title":"Am J Physiol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-157","article-title":"A comparative study of 22-channel water-perfusion system and solid-state system with 36-sensors in esophageal manometery","volume":"12","author":"Wang K","year":"2012","unstructured":"Wang K, Duan LP, Ge Y, Xia ZW, Xu ZJ. A comparative study of 22-channel water-perfusion system and solid-state system with 36-sensors in esophageal manometery. BMC Gastroenterol. 2012, 12:157. 10.1186\/1471-230X-12-157","journal-title":"BMC Gastroenterol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12639","article-title":"The Valsalva manoeuvre: physiology and clinical examples","volume":"217","author":"Pstras L","year":"2016","unstructured":"Pstras L, Thomaseth K, Waniewski J, Balzani I, Bellavere F. The Valsalva manoeuvre: physiology and clinical examples. Acta Physiol (Oxf). 2016, 217:103-19. 10.1111\/apha.12639","journal-title":"Acta Physiol (Oxf)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012469","article-title":"The baroreceptor input to cardiac vagal motoneurones","volume":"282","author":"McAllen RM","year":"1978","unstructured":"McAllen RM, Spyer KM. The baroreceptor input to cardiac vagal motoneurones. J Physiol. 1978, 282:365-74. 10.1113\/jphysiol.1978.sp012469","journal-title":"J Physiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1139\/h05-018","article-title":"Cold pressor test protocol to evaluate cardiac autonomic function","volume":"31","author":"Wirch JL","year":"2006","unstructured":"Wirch JL, Wolfe LA, Weissgerber TL, Davies GA. Cold pressor test protocol to evaluate cardiac autonomic function. Appl Physiol Nutr Metab. 2006, 31:235-43. 10.1139\/h05-018","journal-title":"Appl Physiol Nutr Metab"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1995.tb00209.x","article-title":"Autonomic dysfunction in patients with achalasia","volume":"7","author":"Eckardt VF","year":"1995","unstructured":"Eckardt VF, Stenner F, Liewen H, R\u00f6der R, Koop H, Bernhard G. Autonomic dysfunction in patients with achalasia. Neurogastroenterol Motil. 1995, 7:55-61. 10.1111\/j.1365-2982.1995.tb00209.x","journal-title":"Neurogastroenterol Motil"},{"key":"ref21","article-title":"Achalasia of the cardia: pharmacology and histopathology of isolated cardiac sphincteric muscle from patients with and without achalasia","volume":"38","author":"Misiewicz JJ","year":"1969","unstructured":"Misiewicz JJ, Waller SL, Anthony PP, Gummer JW. Achalasia of the cardia: pharmacology and histopathology of isolated cardiac sphincteric muscle from patients with and without achalasia. Q J Med. 1969, 38:17-30.","journal-title":"Q J Med"},{"key":"ref22","article-title":"An overview of heart rate variability metrics and norms","volume":"28","author":"Shaffer F","year":"2017","unstructured":"Shaffer F, Ginsberg JP. An overview of heart rate variability metrics and norms. Front Public Health. 2017, 28:2023-15.","journal-title":"Front Public Health"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199912000-00002","article-title":"Studies of autonomic function in patients with achalasia and nutcracker oesophagus","volume":"11","author":"Trudgill NJ","year":"1999","unstructured":"Trudgill NJ, Hussain FN, Smith LF, Riley SA. Studies of autonomic function in patients with achalasia and nutcracker oesophagus. Eur J Gastroenterol Hepatol. 1999, 11:1349-54. 10.1097\/00042737-199912000-00002","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1023\/a:1005472400263","article-title":"Cardiovascular autonomic function in patients with primary achalasia","volume":"45","author":"Rinaldi R","year":"2000","unstructured":"Rinaldi R, Cortelli P, Di Simone MP, Pierangeli G, D'Alessandro R, Mattioli S. Cardiovascular autonomic function in patients with primary achalasia. Dig Dis Sci. 2000, 45:825-9. 10.1023\/a:1005472400263","journal-title":"Dig Dis Sci"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00920.x","article-title":"Absence of cardiovascular autonomic dysfunction and vagal pancreatic impairment in idiopathic achalasia of the oesophagus","volume":"19","author":"Herreros B","year":"2007","unstructured":"Herreros B, Ascaso JF, Mora F, Costa AJ, Sanchiz V, Minguez M, Benages A. Absence of cardiovascular autonomic dysfunction and vagal pancreatic impairment in idiopathic achalasia of the oesophagus. Neurogastroenterol Motil. 2007, 19:646-52. 10.1111\/j.1365-2982.2007.00920.x","journal-title":"Neurogastroenterol Motil"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/ng1885","article-title":"A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC","volume":"38","author":"de Bakker PI","year":"2006","unstructured":"de Bakker PI, McVean G, Sabeti PC, et al.. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet. 2006, 38:1166-72. 10.1038\/ng1885","journal-title":"Nat Genet"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12711","article-title":"Histopathologic patterns among achalasia subtypes","volume":"28","author":"Sodikoff JB","year":"2016","unstructured":"Sodikoff JB, Lo AA, Shetuni BB, Kahrilas PJ, Yang GY, Pandolfino JE. Histopathologic patterns among achalasia subtypes. Neurogastroenterol Motil. 2016, 28:139-45. 10.1111\/nmo.12711","journal-title":"Neurogastroenterol Motil"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/235183-cardiovascular-autonomic-deficits-in-different-types-of-achalasia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T13:24:23Z","timestamp":1714569863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/235183-cardiovascular-autonomic-deficits-in-different-types-of-achalasia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.59444","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,1]]}}}