{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T07:46:20Z","timestamp":1745480780805},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,12]]},"DOI":"10.7759\/cureus.60162","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:55:00Z","timestamp":1715568900000},"source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Amorolfine Lotion 0.25% w\/v Compared to Amorolfine Cream 0.25% w\/w in Patients With Superficial Fungal Infections of the Skin: A Multi-center, Randomized, Open-Label, Active-Controlled, Non-inferiority Phase III Clinical Trial"],"prefix":"10.7759","author":[{"given":"M Kanaka Prasad","family":"Rao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokesh","family":"Siddananjappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neetu","family":"Sidana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binayak","family":"Diwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indrasish","family":"Podder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavankumar","family":"Daultani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Jaiswal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Chinda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30079-3","article-title":"Emergence of recalcitrant dermatophytosis in India","volume":"18","author":"Bishnoi A","year":"2018","unstructured":"Bishnoi A, Vinay K, Dogra S. Emergence of recalcitrant dermatophytosis in India. Lancet Infect Dis. 2018, 18:250-1. 10.1016\/S1473-3099(18)30079-3","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_206_17","article-title":"The great Indian epidemic of superficial dermatophytosis: An appraisal","volume":"62","author":"Verma S","year":"2017","unstructured":"Verma S, Madhu R. The great Indian epidemic of superficial dermatophytosis: An appraisal. Indian J Dermatol. 2017, 62:227-36. 10.4103\/ijd.IJD_206_17","journal-title":"Indian J Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.185488","article-title":"Clinico-microbiological study of dermatophytosis in a tertiary-care hospital in North Karnataka","volume":"7","author":"Noronha TM","year":"2016","unstructured":"Noronha TM, Tophakhane RS, Nadiger S. Clinico-microbiological study of dermatophytosis in a tertiary-care hospital in North Karnataka. Indian Dermatol Online J. 2016, 7:264-71. 10.4103\/2229-5178.185488","journal-title":"Indian Dermatol Online J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15025","article-title":"Indian irrational skin creams and steroid-modified dermatophytosis - an unholy nexus and alarming situation","volume":"32","author":"Verma SB","year":"2018","unstructured":"Verma SB, Zouboulis C. Indian irrational skin creams and steroid-modified dermatophytosis - an unholy nexus and alarming situation. J Eur Acad Dermatol Venereol. 2018, 32:e426-7. 10.1111\/jdv.15025","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10815.x","article-title":"Efficacy and safety of topical antifungals in the treatment of dermatomycosis: a systematic review","volume":"166","author":"Rotta I","year":"2012","unstructured":"Rotta I, Sanchez A, Gon\u00e7alves PR, Otuki MF, Correr CJ. Efficacy and safety of topical antifungals in the treatment of dermatomycosis: a systematic review. Br J Dermatol. 2012, 166:927-33. 10.1111\/j.1365-2133.2012.10815.x","journal-title":"Br J Dermatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009992.pub2","article-title":"Topical antifungal treatments for tinea cruris and tinea corporis","author":"El-Gohary M","year":"2014","unstructured":"El-Gohary M, van Zuuren EJ, Fedorowicz Z, et al.. Topical antifungal treatments for tinea cruris and tinea corporis. Cochrane Database Syst Rev. 2014, CD009992. 10.1002\/14651858.CD009992.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.178099","article-title":"Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review","volume":"7","author":"Sahoo AK","year":"2016","unstructured":"Sahoo AK, Mahajan R. Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review. Indian Dermatol Online J. 2016, 7:77-86. 10.4103\/2229-5178.178099","journal-title":"Indian Dermatol Online J"},{"key":"ref8","unstructured":"Loceryl 0.25% w\/w Cream. (2024). Accessed. May 11, 2024: https:\/\/www.1mg.com\/drugs\/loceryl-cream-59430."},{"key":"ref9","unstructured":"Electronic Medicines Compendium. Amorolfine 5% w\/v Medicated Nail Lacquer. (2024). Accessed. May 11, 2024: https:\/\/www.medicines.org.uk\/emc\/product\/7413\/smpc#gref."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199549010-00008","article-title":"Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections","volume":"49","author":"Haria M","year":"1995","unstructured":"Haria M, Bryson HM. Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections. Drugs. 1995, 49:103-20. 10.2165\/00003495-199549010-00008","journal-title":"Drugs"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_907_17","article-title":"A randomized, double-blind trial of amorolfine 0.25% cream and sertaconazole 2% cream in limited dermatophytosis","volume":"85","author":"Das A","year":"2019","unstructured":"Das A, Sil A, Sarkar TK, et al.. A randomized, double-blind trial of amorolfine 0.25% cream and sertaconazole 2% cream in limited dermatophytosis. Indian J Dermatol Venereol Leprol. 2019, 85:276-81. 10.4103\/ijdvl.IJDVL_907_17","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.91823","article-title":"Comparative evaluation of effectivity and safety of topical amorolfine and clotrimazole in the treatment of tinea corporis","volume":"56","author":"Banerjee M","year":"2011","unstructured":"Banerjee M, Ghosh AK, Basak S, Das KD, Gangopadhyay DN. Comparative evaluation of effectivity and safety of topical amorolfine and clotrimazole in the treatment of tinea corporis. Indian J Dermatol. 2011, 56:657-62. 10.4103\/0019-5154.91823","journal-title":"Indian J Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1989.tb00912.x","article-title":"A clinical double-blind trial comparing amorolfine cream 0.5% (RO-14-4767) with bifonazole cream 1% in the treatment of dermatomycoses","volume":"14","author":"del Palacio-Hernanz A","year":"1989","unstructured":"del Palacio-Hernanz A, L\u00f3pez-G\u00f3mez S, Moreno-Palancar P, Gonz\u00e1lez-Lastra F. A clinical double-blind trial comparing amorolfine cream 0.5% (RO-14-4767) with bifonazole cream 1% in the treatment of dermatomycoses. Clin Exp Dermatol. 1989, 14:141-4. 10.1111\/j.1365-2230.1989.tb00912.x","journal-title":"Clin Exp Dermatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000247613","article-title":"Experience with amorolfine in the treatment of dermatomycoses","volume":"184 Suppl 1","author":"del Palacio A","year":"1992","unstructured":"del Palacio A, L\u00f3pez-G\u00f3mez S, Garc\u00eda-Bravo M, Cu\u00e9tara S, Iglesias-Diez L, Rodriguez-Noriega A. Experience with amorolfine in the treatment of dermatomycoses. Dermatology. 1992, 184 Suppl 1:25-9. 10.1159\/000247613","journal-title":"Dermatology"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb00279.x","article-title":"Dose-finding study of amorolfine cream (0.125%, 0.25% and 0.5%) in the treatment of dermatomycoses","volume":"17 Suppl 1","author":"del Palacio A","year":"1992","unstructured":"del Palacio A, Gip L, Bergstraesser M, Zaug M. Dose-finding study of amorolfine cream (0.125%, 0.25% and 0.5%) in the treatment of dermatomycoses. Clin Exp Dermatol. 1992, 17 Suppl 1:50-5. 10.1111\/j.1365-2230.1992.tb00279.x","journal-title":"Clin Exp Dermatol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb00280.x","article-title":"Double-blind comparison of amorolfine and bifonazole in the treatment of dermatomycoses","volume":"17 Suppl 1","author":"Nolting S","year":"1992","unstructured":"Nolting S, Semig G, Friedrich HK, Dietz M, Reckers-Czaschka R, Bergstraesser M, Zaug M. Double-blind comparison of amorolfine and bifonazole in the treatment of dermatomycoses. Clin Exp Dermatol. 1992, 17 Suppl 1:56-60. 10.1111\/j.1365-2230.1992.tb00280.x","journal-title":"Clin Exp Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2017\/1360","article-title":"To compare the efficacy of once a day versus twice daily application of amorolfine 0.25% cream- A single-blinded, randomized, control study","volume":"6","author":"Lade N","year":"2017","unstructured":"Lade N, Pathrabe N, Morey P. To compare the efficacy of once a day versus twice daily application of amorolfine 0.25% cream- A single-blinded, randomized, control study. J Evolution Med Dent Sci. 2017, 6:6258-60. 10.14260\/jemds\/2017\/1360","journal-title":"J Evolution Med Dent Sci"},{"key":"ref18","article-title":"Management of superficial mycotic infections: a review","volume":"2","author":"Anto A","year":"2016","unstructured":"Anto A, Bincy CM, Mincy C Das, Babitha M. Management of superficial mycotic infections: a review. Res Pharm Healt Sci. 2016, 2:152-6.","journal-title":"Res Pharm Healt Sci"},{"key":"ref19","article-title":"Comparison of safety and efficacy of laliconazole and other antifungal agents","volume":"5","author":"Chandana T","year":"2014","unstructured":"Chandana T, Saritha C, Shankaraiah P. Comparison of safety and efficacy of laliconazole and other antifungal agents. International Journal of Pharma Sciences and Research. 2014, 5:1-9.","journal-title":"International Journal of Pharma Sciences and Research"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S169333","article-title":"The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA","volume":"8","author":"Walsh JA","year":"2018","unstructured":"Walsh JA, Jones H, Mallbris L, Duffin KC, Krueger GG, Clegg DO, Szumski A. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. Psoriasis (Auckl). 2018, 8:65-74. 10.2147\/PTT.S169333","journal-title":"Psoriasis (Auckl)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708060-00007","article-title":"Comparative study of 2% sertaconazole solution and cream formulations in patients with tinea corporis, tinea pedis interdigitalis, or a corresponding candidosis","volume":"8","author":"Borelli C","year":"2007","unstructured":"Borelli C, Kl\u00f6vekorn G, Ernst TM, B\u00f6deker RH, Korting HC, Neumeister C. Comparative study of 2% sertaconazole solution and cream formulations in patients with tinea corporis, tinea pedis interdigitalis, or a corresponding candidosis. Am J Clin Dermatol. 2007, 8:371-8. 10.2165\/00128071-200708060-00007","journal-title":"Am J Clin Dermatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4103\/ijdd.ijdd_8_22","article-title":"A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection","volume":"8","author":"Jain D","year":"2022","unstructured":"Jain D, Kumar P, Chowdhuri S. A retrospective analysis of real-world data to evaluate the safety and effectiveness of topical amorolfine in tinea infection. Indian J Drugs Dermatol. 2022, 8:66. 10.4103\/ijdd.ijdd_8_22","journal-title":"Indian J Drugs Dermatol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1993.tb00686.x","article-title":"Combination of amorolfine with various antifungal drugs in dermatophytosis","volume":"36","author":"Polak A","year":"1993","unstructured":"Polak A. Combination of amorolfine with various antifungal drugs in dermatophytosis. Mycoses. 1993, 36:43-9. 10.1111\/j.1439-0507.1993.tb00686.x","journal-title":"Mycoses"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/248057-efficacy-and-safety-of-amorolfine-lotion-025-wv-compared-to-amorolfine-cream-025-ww-in-patients-with-superficial-fungal-infections-of-the-skin-a-multi-center-randomized-open-label-active-controlled-non-inferiority-phase-iii-clinical-trial","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:55:06Z","timestamp":1715568906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/248057-efficacy-and-safety-of-amorolfine-lotion-025-wv-compared-to-amorolfine-cream-025-ww-in-patients-with-superficial-fungal-infections-of-the-skin-a-multi-center-randomized-open-label-active-controlled-non-inferiority-phase-iii-clinical-trial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,12]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.60162","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,12]]}}}