{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:39:11Z","timestamp":1781311151430,"version":"3.54.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,28]]},"DOI":"10.7759\/cureus.61238","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T14:36:42Z","timestamp":1716907002000},"source":"Crossref","is-referenced-by-count":3,"title":["Exploring the Relationship Between Helicobacter pylori Infection and Biliary Diseases: A Comprehensive Analysis Using the United States National Inpatient Sample (2016-2020)"],"prefix":"10.7759","author":[{"given":"Syed  O","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"AlAmr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Taftafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim M","family":"AlMazmomy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourah","family":"Alkahmous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah M","family":"Alharran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulhadi  M","family":"Almarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fajer","family":"Alyaqout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulbadih R","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz M","family":"Alazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef M","family":"Alharran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Abotela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abu-Zaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00431-8","article-title":"Helicobacter pylori infection","volume":"9","author":"Malfertheiner P","year":"2023","unstructured":"Malfertheiner P, Camargo MC, El-Omar E, et al.. Helicobacter pylori infection. Nat Rev Dis Primers. 2023, 9:19. 10.1038\/s41572-023-00431-8","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00070-5","article-title":"Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis","volume":"8","author":"Li Y","year":"2023","unstructured":"Li Y, Choi H, Leung K, Jiang F, Graham DY, Leung WK. Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2023, 8:553-64. 10.1016\/S2468-1253(23)00070-5","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref3","article-title":"Peptic ulcer disease and H. pylori infection: common questions and answers","volume":"107","author":"McConaghy JR","year":"2023","unstructured":"McConaghy JR, Decker A, Nair S. Peptic ulcer disease and H. pylori infection: common questions and answers. Am Fam Physician. 2023, 107:165-72.","journal-title":"Am Fam Physician"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176463","article-title":"Associations between cytokine gene polymorphisms and susceptibility to Helicobacter pylori infection and Helicobacter pylori related gastric cancer, peptic ulcer disease: a meta-analysis","volume":"12","author":"Ma J","year":"2017","unstructured":"Ma J, Wu D, Hu X, Li J, Cao M, Dong W. Associations between cytokine gene polymorphisms and susceptibility to Helicobacter pylori infection and Helicobacter pylori related gastric cancer, peptic ulcer disease: a meta-analysis. PLoS One. 2017, 12:e0176463. 10.1371\/journal.pone.0176463","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12910","article-title":"Correlation between the intensity of Helicobacter pylori colonization and severity of gastritis: results of a prospective study","volume":"27","author":"Souissi S","year":"2022","unstructured":"Souissi S, Makni C, Belhadj Ammar L, Bousnina O, Kallel L. Correlation between the intensity of Helicobacter pylori colonization and severity of gastritis: results of a prospective study. Helicobacter. 2022, 27:e12910. 10.1111\/hel.12910","journal-title":"Helicobacter"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v14.i1.55","article-title":"Effects of Helicobacter pylori infection in gastrointestinal tract malignant diseases: from the oral cavity to rectum","volume":"14","author":"Kuo YC","year":"2022","unstructured":"Kuo YC, Yu LY, Wang HY, et al.. Effects of Helicobacter pylori infection in gastrointestinal tract malignant diseases: from the oral cavity to rectum. World J Gastrointest Oncol. 2022, 14:55-74. 10.4251\/wjgo.v14.i1.55","journal-title":"World J Gastrointest Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyab055","article-title":"Effects of Helicobacter pylori eradication on gastric cancer incidence in the Japanese population: a systematic evidence review","volume":"51","author":"Lin Y","year":"2021","unstructured":"Lin Y, Kawai S, Sasakabe T, et al.. Effects of Helicobacter pylori eradication on gastric cancer incidence in the Japanese population: a systematic evidence review. Jpn J Clin Oncol. 2021, 51:1158-70. 10.1093\/jjco\/hyab055","journal-title":"Jpn J Clin Oncol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s41043-021-00280-9","article-title":"Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis","volume":"41","author":"Keikha M","year":"2022","unstructured":"Keikha M, Sahebkar A, Yamaoka Y, Karbalaei M. Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis. J Health Popul Nutr. 2022, 41:2. 10.1186\/s41043-021-00280-9","journal-title":"J Health Popul Nutr"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8886085","article-title":"The relationship between Helicobacter pylori infection of the gallbladder and chronic cholecystitis and cholelithiasis: a systematic review and meta-analysis","volume":"2021","author":"Wang L","year":"2021","unstructured":"Wang L, Chen J, Jiang W, et al.. The relationship between Helicobacter pylori infection of the gallbladder and chronic cholecystitis and cholelithiasis: a systematic review and meta-analysis. Can J Gastroenterol Hepatol. 2021, 2021:8886085. 10.1155\/2021\/8886085","journal-title":"Can J Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.22-056","article-title":"The link between Helicobacter pylori infection and gallbladder and biliary tract diseases: a review","volume":"27","author":"Lim KP","year":"2023","unstructured":"Lim KP, Lee AJ, Jiang X, Teng TZ, Shelat VG. The link between Helicobacter pylori infection and gallbladder and biliary tract diseases: a review. Ann Hepatobiliary Pancreat Surg. 2023, 27:241-50. 10.14701\/ahbps.22-056","journal-title":"Ann Hepatobiliary Pancreat Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01424.x","article-title":"Helicobacter DNA in bile: correlation with hepato-biliary diseases","volume":"17","author":"Fallone CA","year":"2003","unstructured":"Fallone CA, Tran S, Semret M, Discepola F, Behr M, Barkun AN. Helicobacter DNA in bile: correlation with hepato-biliary diseases. Aliment Pharmacol Ther. 2003, 17:453-8. 10.1046\/j.1365-2036.2003.01424.x","journal-title":"Aliment Pharmacol Ther"},{"key":"ref12","unstructured":"NIS overview. (2023). Accessed. April 11, 2024: https:\/\/hcup-us.ahrq.gov\/nisoverview.jsp."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2022.06.001","article-title":"Racial differences in Helicobacter pylori prevalence in the US: a systematic review","volume":"1","author":"Brown H","year":"2022","unstructured":"Brown H, Cantrell S, Tang H, Epplein M, Garman KS. Racial differences in Helicobacter pylori prevalence in the US: a systematic review. Gastro Hep Adv. 2022, 1:857-68. 10.1016\/j.gastha.2022.06.001","journal-title":"Gastro Hep Adv"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089\/heq.2022.0063","article-title":"Systematic review: impact of social determinants of health on the management and prognosis of gallstone disease","volume":"6","author":"Dupont B","year":"2022","unstructured":"Dupont B, Dejardin O, Bouvier V, Piquet MA, Alves A. Systematic review: impact of social determinants of health on the management and prognosis of gallstone disease. Health Equity. 2022, 6:819-35. 10.1089\/heq.2022.0063","journal-title":"Health Equity"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.06.064","article-title":"Ethnicity and insurance status affect health disparities in patients with gallstone disease","volume":"175","author":"Freeman J","year":"2012","unstructured":"Freeman J, Boomer L, Fursevich D, Feliz A. Ethnicity and insurance status affect health disparities in patients with gallstone disease. J Surg Res. 2012, 175:1-5. 10.1016\/j.jss.2011.06.064","journal-title":"J Surg Res"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i29.8912","article-title":"Helicobacter pylori infection is associated with gallstones: epidemiological survey in China","volume":"21","author":"Zhang FM","year":"2015","unstructured":"Zhang FM, Yu CH, Chen HT, Shen Z, Hu FL, Yuan XP, Xu GQ. Helicobacter pylori infection is associated with gallstones: epidemiological survey in China. World J Gastroenterol. 2015, 21:8912-9. 10.3748\/wjg.v21.i29.8912","journal-title":"World J Gastroenterol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1089\/pancan.2021.0010","article-title":"A case control study of the seroprevalence of Helicobacter pylori proteins and their association with pancreatic cancer risk","volume":"7","author":"Permuth JB","year":"2021","unstructured":"Permuth JB, Rahman S, Chen DT, Waterboer T, Giuliano AR. A case control study of the seroprevalence of Helicobacter pylori proteins and their association with pancreatic cancer risk. J Pancreat Cancer. 2021, 7:57-64. 10.1089\/pancan.2021.0010","journal-title":"J Pancreat Cancer"},{"key":"ref18","article-title":"The correlation of Helicobacter pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in Saudi Arabia","volume":"19","author":"Guraya SY","year":"2015","unstructured":"Guraya SY, Ahmad AA, El-Ageery SM, Hemeg HA, Ozbak HA, Yousef K, Abdel-Aziz NA. The correlation of Helicobacter pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in Saudi Arabia. Eur Rev Med Pharmacol Sci. 2015, 19:3873-80.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12457","article-title":"Helicobacter pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: a systematic review and meta-analysis","volume":"23","author":"Cen L","year":"2018","unstructured":"Cen L, Pan J, Zhou B, Yu C, Li Y, Chen W, Shen Z. Helicobacter pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: a systematic review and meta-analysis. Helicobacter. 2018, 23:10.1111\/hel.12457","journal-title":"Helicobacter"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0000000000000235","article-title":"Risk factors for cholelithiasis","volume":"39","author":"Pak M","year":"2016","unstructured":"Pak M, Lindseth G. Risk factors for cholelithiasis. Gastroenterol Nurs. 2016, 39:297-309. 10.1097\/SGA.0000000000000235","journal-title":"Gastroenterol Nurs"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz103","article-title":"Smoking, alcohol, and biliary tract cancer risk: a pooling project of 26 prospective studies","volume":"111","author":"McGee EE","year":"2019","unstructured":"McGee EE, Jackson SS, Petrick JL, et al.. Smoking, alcohol, and biliary tract cancer risk: a pooling project of 26 prospective studies. J Natl Cancer Inst. 2019, 111:1263-78. 10.1093\/jnci\/djz103","journal-title":"J Natl Cancer Inst"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i18.2136","article-title":"From the stomach to other organs: Helicobacter pylori and the liver","volume":"7","author":"Waluga M","year":"2015","unstructured":"Waluga M, Kukla M, \u017borniak M, Bacik A, Kotulski R. From the stomach to other organs: Helicobacter pylori and the liver. World J Hepatol. 2015, 7:2136-46. 10.4254\/wjh.v7.i18.2136","journal-title":"World J Hepatol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/BF02968117","article-title":"Helicobacter pylori infection increases following cholecystectomy","volume":"164","author":"Caldwell MT","year":"1995","unstructured":"Caldwell MT, McDermott M, Jazrawi S, et al.. Helicobacter pylori infection increases following cholecystectomy. Ir J Med Sci. 1995, 164:52-5. 10.1007\/BF02968117","journal-title":"Ir J Med Sci"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296496","article-title":"Patients with uncomplicated cholelithiasis acidify bile normally","volume":"37","author":"Magnuson TH","year":"1992","unstructured":"Magnuson TH, Lillemoe KD, Zarkin BA, Pitt HA. Patients with uncomplicated cholelithiasis acidify bile normally. Dig Dis Sci. 1992, 37:1517-22. 10.1007\/BF01296496","journal-title":"Dig Dis Sci"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1086\/596660","article-title":"Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling","volume":"199","author":"Nagy TA","year":"2009","unstructured":"Nagy TA, Frey MR, Yan F, Israel DA, Polk DB, Peek RM Jr. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis. 2009, 199:641-51. 10.1086\/596660","journal-title":"J Infect Dis"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02140-2","article-title":"NF-kB-dependent activation of STAT3 by H. pylori is suppressed by TFF1","volume":"21","author":"Soutto M","year":"2021","unstructured":"Soutto M, Bhat N, Khalafi S, et al.. NF-kB-dependent activation of STAT3 by H. pylori is suppressed by TFF1. Cancer Cell Int. 2021, 21:444. 10.1186\/s12935-021-02140-2","journal-title":"Cancer Cell Int"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504927102","article-title":"Activation of beta-catenin by carcinogenic Helicobacter pylori","volume":"102","author":"Franco AT","year":"2005","unstructured":"Franco AT, Israel DA, Washington MK, et al.. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A. 2005, 102:10646-51. 10.1073\/pnas.0504927102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/01.mog.0000181711.04529.d5","article-title":"Helicobacter pylori virulence factors: facts and fantasies","volume":"21","author":"Lu H","year":"2005","unstructured":"Lu H, Yamaoka Y, Graham DY. Helicobacter pylori virulence factors: facts and fantasies. Curr Opin Gastroenterol. 2005, 21:653-9. 10.1097\/01.mog.0000181711.04529.d5","journal-title":"Curr Opin Gastroenterol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i6.1438","article-title":"A review of Helicobacter pylori diagnosis, treatment, and methods to detect eradication","volume":"20","author":"Garza-Gonz\u00e1lez E","year":"2014","unstructured":"Garza-Gonz\u00e1lez E, Perez-Perez GI, Maldonado-Garza HJ, Bosques-Padilla FJ. A review of Helicobacter pylori diagnosis, treatment, and methods to detect eradication. World J Gastroenterol. 2014, 20:1438-49. 10.3748\/wjg.v20.i6.1438","journal-title":"World J Gastroenterol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/258230-exploring-the-relationship-between-helicobacter-pylori-infection-and-biliary-diseases-a-comprehensive-analysis-using-the-united-states-national-inpatient-sample-2016-2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T14:36:47Z","timestamp":1716907007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/258230-exploring-the-relationship-between-helicobacter-pylori-infection-and-biliary-diseases-a-comprehensive-analysis-using-the-united-states-national-inpatient-sample-2016-2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.61238","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,28]]}}}