{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:34:42Z","timestamp":1787902482837,"version":"build-2784847793"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,28]]},"DOI":"10.7759\/cureus.61256","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T19:23:37Z","timestamp":1716924217000},"source":"Crossref","is-referenced-by-count":4,"title":["The Importance of Nutrigenetics and Microbiota in Personalized Medicine: From Phenotype to Genotype"],"prefix":"10.7759","author":[{"given":"Gulsen","family":"Meral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif S","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verda","family":"Tunaligil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neval","family":"Burkay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esma G\u00f6kcen","family":"Alper Acar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Yunus","family":"Alp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Evaluation of personalized type and genome research in the context of health outcomes","volume":"22","author":"Tekp\u0131nar L","year":"2019","unstructured":"Tekp\u0131nar L, Erdem R. Evaluation of personalized type and genome research in the context of health outcomes. Hacettepe J Health. 2019, 22:843-862.","journal-title":"Hacettepe J Health"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.52880\/sagakaderg.1132907","article-title":"\u201c4P medicine\u201d in health: Is traditional medicine becoming history?","volume":"9","author":"Caml\u0131ca T","year":"2022","unstructured":"Caml\u0131ca T, Aslan FE. \u201c4P medicine\u201d in health: Is traditional medicine becoming history?. J Health Acad. 2022, 9:382-387. 10.52880\/sagakaderg.1132907","journal-title":"J Health Acad"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182011222","article-title":"Extending the reach of public health genomics: what should be the agenda for public health in an era of genome-based and \u201cpersonalized\u201d medicine?","volume":"12","author":"Burke W","year":"2010","unstructured":"Burke W, Burton H, Hall AE, et al.. Extending the reach of public health genomics: what should be the agenda for public health in an era of genome-based and \u201cpersonalized\u201d medicine?. Genet Med. 2010, 12:785-791. 10.1097\/GIM.0b013e3182011222","journal-title":"Genet Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-011-0041-5","article-title":"Some considerations about a report on 'Public health in an era of genomic-based and personalized medicine' from the Public Health Foundation, Cambridge","volume":"2","author":"Cassiman JJ","year":"2011","unstructured":"Cassiman JJ. Some considerations about a report on 'Public health in an era of genomic-based and personalized medicine' from the Public Health Foundation, Cambridge. J Community Genet. 2011, 2:107-109. 10.1007\/s12687-011-0041-5","journal-title":"J Community Genet"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2217\/pme.12.16","article-title":"Public health perspective: from personalized medicine to personal health","volume":"9","author":"Cesuroglu T","year":"2012","unstructured":"Cesuroglu T, van Ommen B, Malats N, Sudbrak R, Lehrach H, Brand A. Public health perspective: from personalized medicine to personal health. Per Med. 2012, 9:115-119. 10.2217\/pme.12.16","journal-title":"Per Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/cku030","article-title":"Why is personalized medicine relevant to public health?","volume":"24","author":"Boccia S","year":"2014","unstructured":"Boccia S. Why is personalized medicine relevant to public health?. Eur J Public Health. 2014, 24:349-350. 10.1093\/eurpub\/cku030","journal-title":"Eur J Public Health"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0000082","article-title":"Human epigenome project--up and running","volume":"1","author":"Bradbury J","year":"2003","unstructured":"Bradbury J. Human epigenome project--up and running. PLoS Biol. 2003, 1:E82. 10.1371\/journal.pbio.0000082","journal-title":"PLoS Biol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1101\/gr.4413105","article-title":"The International HapMap project web site","volume":"15","author":"Thorisson GA","year":"2005","unstructured":"Thorisson GA, Smith AV, Krishnan L, Stein LD. The International HapMap project web site. Genome Res. 2005, 15:1592-1593. 10.1101\/gr.4413105","journal-title":"Genome Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/bmb.20952","article-title":"A decade of human genome project conclusion: scientific diffusion about our genome knowledge","volume":"44","author":"Moraes F","year":"2016","unstructured":"Moraes F, G\u00f3es A. A decade of human genome project conclusion: scientific diffusion about our genome knowledge. Biochem Mol Biol Educ. 2016, 44:215-223. 10.1002\/bmb.20952","journal-title":"Biochem Mol Biol Educ"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.15167\/2421-4248\/jpmh2022.63.2S3.2754","article-title":"Polymorphisms, diet and nutrigenomics","volume":"63","author":"Kiani AK","year":"2022","unstructured":"Kiani AK, Bonetti G, Donato K, et al.. Polymorphisms, diet and nutrigenomics. J Prev Med Hyg. 2022, 63:E125-E141. 10.15167\/2421-4248\/jpmh2022.63.2S3.2754","journal-title":"J Prev Med Hyg"},{"key":"ref11","article-title":"Nutrigenomics: nutritional effect from genotype to phenotype","volume":"1","author":"Koc G","year":"2018","unstructured":"Koc G. Nutrigenomics: nutritional effect from genotype to phenotype. J Med Fac Clin. 2018, 1:79-92.","journal-title":"J Med Fac Clin"},{"key":"ref12","unstructured":"Meral G, Aslan ES. Nutrigenetik-Epigenetik. (2023). Accessed: February 24, 2024: https:\/\/openaccess.biruni.edu.tr\/xmlui\/handle\/20.500.12445\/3336."},{"key":"ref13","article-title":"Nutrigenomics and nutrigenetics","volume":"39","author":"Farhud D","year":"2010","unstructured":"Farhud D, Zarif Yeganeh M, Zarif Yeganeh M. Nutrigenomics and nutrigenetics. Iran J Public Health. 2010, 39:1-14.","journal-title":"Iran J Public Health"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.2022407","article-title":"Epigenetic regulation by gut microbiota","volume":"14","author":"Woo V","year":"2022","unstructured":"Woo V, Alenghat T. Epigenetic regulation by gut microbiota. Gut Microbes. 2022, 14:2022407. 10.1080\/19490976.2021.2022407","journal-title":"Gut Microbes"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2217\/epi.11.71","article-title":"Epigenetic diet: impact on the epigenome and cancer","volume":"3","author":"Hardy TM","year":"2011","unstructured":"Hardy TM, Tollefsbol TO. Epigenetic diet: impact on the epigenome and cancer. Epigenomics. 2011, 3:503-518. 10.2217\/epi.11.71","journal-title":"Epigenomics"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/202759","article-title":"Nutrigenomics: definitions and advances of this new science","volume":"2014","author":"Sales NM","year":"2014","unstructured":"Sales NM, Pelegrini PB, Goersch MC. Nutrigenomics: definitions and advances of this new science. J Nutr Metab. 2014, 2014:202759. 10.1155\/2014\/202759","journal-title":"J Nutr Metab"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker GS","year":"2017","unstructured":"Ducker GS, Rabinowitz JD. One-carbon metabolism in health and disease. Cell Metab. 2017, 25:27-42. 10.1016\/j.cmet.2016.08.009","journal-title":"Cell Metab"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.9.2475S","article-title":"Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies","volume":"134","author":"Giovannucci E","year":"2004","unstructured":"Giovannucci E. Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies. J Nutr. 2004, 134:2475S-2481S. 10.1093\/jn\/134.9.2475S","journal-title":"J Nutr"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010193","article-title":"The implication of a polymorphism in the methylenetetrahydrofolate reductase gene in homocysteine metabolism and related civilisation diseases","volume":"25","author":"Zarembska E","year":"2023","unstructured":"Zarembska E, \u015alusarczyk K, Wrzosek M. The implication of a polymorphism in the methylenetetrahydrofolate reductase gene in homocysteine metabolism and related civilisation diseases. Int J Mol Sci. 2023, 25:193. 10.3390\/ijms25010193","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124562","article-title":"Methylenetetrahydrofolate (MTHFR), the one-carbon cycle, and cardiovascular risks","volume":"13","author":"Raghubeer S","year":"2021","unstructured":"Raghubeer S, Matsha TE. Methylenetetrahydrofolate (MTHFR), the one-carbon cycle, and cardiovascular risks. Nutrients. 2021, 13:4562. 10.3390\/nu13124562","journal-title":"Nutrients"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/genes14030709","article-title":"Folate-methionine cycle disruptions in ASD patients and possible interventions: a systematic review","volume":"14","author":"Roufael M","year":"2023","unstructured":"Roufael M, Bitar T, Sacre Y, Andres C, Hleihel W. Folate-methionine cycle disruptions in ASD patients and possible interventions: a systematic review. Genes (Basel). 2023, 14:10.3390\/genes14030709","journal-title":"Genes (Basel)"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e32832cebd2","article-title":"Aberrations in folate metabolic pathway and altered susceptibility to autism","volume":"19","author":"Mohammad NS","year":"2009","unstructured":"Mohammad NS, Jain JM, Chintakindi KP, Singh RP, Naik U, Akella RR. Aberrations in folate metabolic pathway and altered susceptibility to autism. Psychiatr Genet. 2009, 19:171-176. 10.1097\/YPG.0b013e32832cebd2","journal-title":"Psychiatr Genet"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02330-3","article-title":"Association between MTHFR C677T\/A1298C and susceptibility to autism spectrum disorders: a meta-analysis","volume":"20","author":"Li Y","year":"2020","unstructured":"Li Y, Qiu S, Shi J, Guo Y, Li Z, Cheng Y, Liu Y. Association between MTHFR C677T\/A1298C and susceptibility to autism spectrum disorders: a meta-analysis. BMC Pediatr. 2020, 20:449. 10.1186\/s12887-020-02330-3","journal-title":"BMC Pediatr"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.147723","article-title":"Comprehensive systematic review and meta-analysis of the association between common genetic variants and autism spectrum disorder","volume":"887","author":"Fang Y","year":"2023","unstructured":"Fang Y, Cui Y, Yin Z, et al.. Comprehensive systematic review and meta-analysis of the association between common genetic variants and autism spectrum disorder. Gene. 2023, 887:147723. 10.1016\/j.gene.2023.147723","journal-title":"Gene"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0000000000000152","article-title":"Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders","volume":"26","author":"Shaik Mohammad N","year":"2016","unstructured":"Shaik Mohammad N, Sai Shruti P, Bharathi V, et al.. Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders. Psychiatr Genet. 2016, 26:281-286. 10.1097\/YPG.0000000000000152","journal-title":"Psychiatr Genet"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00739-5","article-title":"The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations","volume":"157","author":"Gaughan DJ","year":"2001","unstructured":"Gaughan DJ, Kluijtmans LA, Barbaux S, et al.. The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis. 2001, 157:451-456. 10.1016\/S0021-9150(00)00739-5","journal-title":"Atherosclerosis"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.26559\/mersinsbd.890545","article-title":"Plasma amino acid profile in autism spectrum disorder (ASD)","volume":"20","author":"Bala KA","year":"2016","unstructured":"Bala KA, Do\u011fan M, Mutluer T, et al.. Plasma amino acid profile in autism spectrum disorder (ASD). Eur Rev Med Pharmacol Sci. 2016, 20:923-929. 10.26559\/mersinsbd.890545","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.01.147","article-title":"Single nucleotide polymorphisms related to vitamin B12 serum levels in autoimmune gastritis patients with or without pernicious anaemia","volume":"47","author":"Lahner E","year":"2015","unstructured":"Lahner E, Gentile G, Purchiaroni F, Mora B, Simmaco M, Annibale B. Single nucleotide polymorphisms related to vitamin B12 serum levels in autoimmune gastritis patients with or without pernicious anaemia. Dig Liver Dis. 2015, 47:285-290. 10.1016\/j.dld.2015.01.147","journal-title":"Dig Liver Dis"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx071","article-title":"GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians","volume":"26","author":"Nongmaithem SS","year":"2017","unstructured":"Nongmaithem SS, Joglekar CV, Krishnaveni GV, et al.. GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians. Hum Mol Genet. 2017, 26:2551-2564. 10.1093\/hmg\/ddx071","journal-title":"Hum Mol Genet"},{"key":"ref30","article-title":"Association study of polymorphisms at A66G (rs1801394) of MTRR gene and autism spectrum disorders in a Kurdish population","author":"Miasko MH","year":"2020","unstructured":"Miasko MH, Smail SW, Karim AY, et al.. Association study of polymorphisms at A66G (rs1801394) of MTRR gene and autism spectrum disorders in a Kurdish population. Gene Rep. 2020,","journal-title":"Gene Rep"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2015.015","article-title":"Randomized, placebo-controlled trial of methyl B12 for children with autism","volume":"26","author":"Hendren RL","year":"2016","unstructured":"Hendren RL, James SJ, Widjaja F, Lawton B, Rosenblatt A, Bent S. Randomized, placebo-controlled trial of methyl B12 for children with autism. J Child Adolesc Psychopharmacol. 2016, 26:774-783. 10.1089\/cap.2015.015","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30366","article-title":"Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism","volume":"141B","author":"James SJ","year":"2006","unstructured":"James SJ, Melnyk S, Jernigan S, et al.. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet. 2006, 141B:947-956. 10.1002\/ajmg.b.30366","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3580com","article-title":"Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)","volume":"19","author":"Song J","year":"2005","unstructured":"Song J, da Costa KA, Fischer LM, Kohlmeier M, Kwock L, Wang S, Zeisel SH. Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). FASEB J. 2005, 19:1266-1271. 10.1096\/fj.04-3580com","journal-title":"FASEB J"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/578429","article-title":"Dietary intake and plasma levels of choline and betaine in children with autism spectrum disorders","volume":"2013","author":"Hamlin JC","year":"2013","unstructured":"Hamlin JC, Pauly M, Melnyk S, Pavliv O, Starrett W, Crook TA, James SJ. Dietary intake and plasma levels of choline and betaine in children with autism spectrum disorders. Autism Res Treat. 2013, 2013:578429. 10.1155\/2013\/578429","journal-title":"Autism Res Treat"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2015.7.6.538","article-title":"Is folate status a risk factor for asthma or other allergic diseases?","volume":"7","author":"Wang T","year":"2015","unstructured":"Wang T, Zhang HP, Zhang X, Liang ZA, Ji YL, Wang G. Is folate status a risk factor for asthma or other allergic diseases?. Allergy Asthma Immunol Res. 2015, 7:538-546. 10.4168\/aair.2015.7.6.538","journal-title":"Allergy Asthma Immunol Res"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02378.x","article-title":"Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults","volume":"65","author":"Thuesen BH","year":"2010","unstructured":"Thuesen BH, Husemoen LL, Ovesen L, J\u00f8rgensen T, Fenger M, Gilderson G, Linneberg A. Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults. Allergy. 2010, 65:1446-1454. 10.1111\/j.1398-9995.2010.02378.x","journal-title":"Allergy"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.12932\/AP-300422-1375","article-title":"The association between MTHFR polymorphism, dietary methyl donors, and childhood asthma and atopy","author":"Choi YJ","year":"2023","unstructured":"Choi YJ, Lee SY, Kwon SO, et al.. The association between MTHFR polymorphism, dietary methyl donors, and childhood asthma and atopy. Asian Pac J Allergy Immunol. 2023, 10.12932\/AP-300422-1375","journal-title":"Asian Pac J Allergy Immunol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl094","article-title":"The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy?","volume":"35","author":"Husemoen LL","year":"2006","unstructured":"Husemoen LL, Toft U, Fenger M, J\u00f8rgensen T, Johansen N, Linneberg A. The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy?. Int J Epidemiol. 2006, 35:954-961. 10.1093\/ije\/dyl094","journal-title":"Int J Epidemiol"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/1660\/1\/012007","article-title":"Role of MTHFR C667T and MTRR A66G genes polymorphism with thyroid disorders","volume":"1660","author":"Al-Hassani OMH","year":"2020","unstructured":"Al-Hassani OMH. Role of MTHFR C667T and MTRR A66G genes polymorphism with thyroid disorders. J Phys Conf Series. 2020, 1660:12007. 10.1088\/1742-6596\/1660\/1\/012007","journal-title":"J Phys Conf Series"},{"key":"ref40","article-title":"Association between MTHFR gene polymorphisms (C677T, A1298C) and subclinical hypothyroidism susceptibility","volume":"6","author":"Kvaratskhelia E","year":"2020","unstructured":"Kvaratskhelia E, Kvaratskhelia T, Surmava S, Kvintradze M, Asatiani K, Abzianidze E. Association between MTHFR gene polymorphisms (C677T, A1298C) and subclinical hypothyroidism susceptibility. J Endocr Disord. 2020, 6:1034.","journal-title":"J Endocr Disord"},{"key":"ref41","doi-asserted-by":"crossref","DOI":"10.3390\/nu14235104","article-title":"Nongenomic activities of vitamin D","volume":"14","author":"\u017bmijewski MA","year":"2022","unstructured":"\u017bmijewski MA. Nongenomic activities of vitamin D. Nutrients. 2022, 14:5104.","journal-title":"Nutrients"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054689","article-title":"How does vitamin D affect immune cells crosstalk in autoimmune diseases?","volume":"24","author":"Gallo D","year":"2023","unstructured":"Gallo D, Baci D, Kustrimovic N, et al.. How does vitamin D affect immune cells crosstalk in autoimmune diseases?. Int J Mol Sci. 2023, 24:4689. 10.3390\/ijms24054689","journal-title":"Int J Mol Sci"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-019-01464-z","article-title":"The correlation between vitamin D receptor (VDR) gene polymorphisms and autism: a meta-analysis","volume":"70","author":"Yang H","year":"2020","unstructured":"Yang H, Wu X. The correlation between vitamin D receptor (VDR) gene polymorphisms and autism: a meta-analysis. J Mol Neurosci. 2020, 70:260-268. 10.1007\/s12031-019-01464-z","journal-title":"J Mol Neurosci"},{"key":"ref44","article-title":"Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto's thyroiditis: a meta-analysis","volume":"7","author":"Wang X","year":"2017","unstructured":"Wang X, Cheng W, Ma Y, Zhu J. Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto's thyroiditis: a meta-analysis. Sci Rep. 2017, 7:41540.","journal-title":"Sci Rep"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.14196\/mjiri.32.4","article-title":"The association of FokI and ApaI polymorphisms in vitamin D receptor gene with autoimmune thyroid diseases in the northwest of Iran","volume":"32","author":"Zarrin R","year":"2018","unstructured":"Zarrin R, Bagheri M, Mehdizadeh A, Ayremlou P, Faghfouri AH. The association of FokI and ApaI polymorphisms in vitamin D receptor gene with autoimmune thyroid diseases in the northwest of Iran. Med J Islam Repub Iran. 2018, 32:4. 10.14196\/mjiri.32.4","journal-title":"Med J Islam Repub Iran"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2019.1674325","article-title":"VDR gene polymorphisms and allergic diseases: evidence from a meta-analysis","volume":"49","author":"Zhang L","year":"2020","unstructured":"Zhang L, Zhang S, He C, Wang X. VDR gene polymorphisms and allergic diseases: evidence from a meta-analysis. Immunol Invest. 2020, 49:166-177. 10.1080\/08820139.2019.1674325","journal-title":"Immunol Invest"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2118-6","article-title":"Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus","volume":"40","author":"Mostowska A","year":"2013","unstructured":"Mostowska A, Lianeri M, Wudarski M, Olesi\u0144ska M, Jagodzi\u0144ski PP. Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus. Mol Biol Rep. 2013, 40:803-810. 10.1007\/s11033-012-2118-6","journal-title":"Mol Biol Rep"},{"key":"ref48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-64226-7","article-title":"Vitamin D receptor promotes healthy microbial metabolites and microbiome","volume":"10","author":"Chatterjee I","year":"2020","unstructured":"Chatterjee I, Lu R, Zhang Y, Zhang J, Dai Y, Xia Y, Sun J. Vitamin D receptor promotes healthy microbial metabolites and microbiome. Sci Rep. 2020, 10:7340.","journal-title":"Sci Rep"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2806116","article-title":"Exploring the role of vitamin D and the vitamin D receptor in the composition of the gut microbiota","volume":"28","author":"Aggeletopoulou I","year":"2023","unstructured":"Aggeletopoulou I, Tsounis EP, Mouzaki A, Triantos C. Exploring the role of vitamin D and the vitamin D receptor in the composition of the gut microbiota. Front Biosci (Landmark Ed). 2023, 28:116. 10.31083\/j.fbl2806116","journal-title":"Front Biosci (Landmark Ed)"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-022-08939-9","article-title":"Microbial dysbiosis tunes the immune response towards allergic disease outcomes","volume":"65","author":"Augustine T","year":"2023","unstructured":"Augustine T, Kumar M, Al Khodor S, van Panhuys N. Microbial dysbiosis tunes the immune response towards allergic disease outcomes. Clin Rev Allergy Immunol. 2023, 65:43-71. 10.1007\/s12016-022-08939-9","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030521","article-title":"Autism spectrum disorders and the gut microbiota","volume":"11","author":"Fattorusso A","year":"2019","unstructured":"Fattorusso A, Di Genova L, Dell'Isola GB, Mencaroni E, Esposito S. Autism spectrum disorders and the gut microbiota. Nutrients. 2019, 11:521. 10.3390\/nu11030521","journal-title":"Nutrients"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4262","article-title":"Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial","volume":"98","author":"Jones ML","year":"2013","unstructured":"Jones ML, Martoni CJ, Prakash S. Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J Clin Endocrinol Metab. 2013, 98:2944-2951. 10.1210\/jc.2012-4262","journal-title":"J Clin Endocrinol Metab"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1080\/09735070.2016.11905474","article-title":"Is vitamin D deficiency associated with dysbiosis in bowel flora?","volume":"10","author":"Meral G","year":"2016","unstructured":"Meral G, Uslu A, Guven A, Can G, Yozgatli AU, Akcay F, Yaprak P. Is vitamin D deficiency associated with dysbiosis in bowel flora?. Ethno Med. 2016, 10:71-75. 10.1080\/09735070.2016.11905474","journal-title":"Ethno Med"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666161202150008","article-title":"Vitamin D\/VDR, probiotics, and gastrointestinal diseases","volume":"24","author":"Shang M","year":"2017","unstructured":"Shang M, Sun J. Vitamin D\/VDR, probiotics, and gastrointestinal diseases. Curr Med Chem. 2017, 24:876-887. 10.2174\/0929867323666161202150008","journal-title":"Curr Med Chem"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/255064-the-importance-of-nutrigenetics-and-microbiota-in-personalized-medicine-from-phenotype-to-genotype","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T19:23:58Z","timestamp":1716924238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/255064-the-importance-of-nutrigenetics-and-microbiota-in-personalized-medicine-from-phenotype-to-genotype"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":54,"URL":"https:\/\/doi.org\/10.7759\/cureus.61256","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,28]]}}}