{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:33:03Z","timestamp":1780597983158,"version":"3.54.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,11]]},"DOI":"10.7759\/cureus.62125","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T08:15:26Z","timestamp":1718093726000},"source":"Crossref","is-referenced-by-count":1,"title":["Metronidazole-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome With Parvovirus B19 Reactivation: A Pediatric Case"],"prefix":"10.7759","author":[{"given":"Bahaeddine","family":"Dridi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Agrebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhouha","family":"Sahnoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaker","family":"Ben Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.04.007","article-title":"The variable clinical picture of drug-induced hypersensitivity syndrome\/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug","volume":"29","author":"Kano Y","year":"2009","unstructured":"Kano Y, Shiohara T. The variable clinical picture of drug-induced hypersensitivity syndrome\/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug. Immunol Allergy Clin North Am. 2009, 29:481-501. 10.1016\/j.iac.2009.04.007","journal-title":"Immunol Allergy Clin North Am"},{"key":"ref2","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome","volume":"6","author":"Choudhary S","year":"2013","unstructured":"Choudhary S, McLeod M, Torchia D, Romanelli P. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. J Clin Aesthet Dermatol. 2013, 6:31-7.","journal-title":"J Clin Aesthet Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.03.081","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS) in the pediatric population: a systematic review of the literature","volume":"83","author":"Kim GY","year":"2020","unstructured":"Kim GY, Anderson KR, Davis DM, Hand JL, Tollefson MM. Drug reaction with eosinophilia and systemic symptoms (DRESS) in the pediatric population: a systematic review of the literature. J Am Acad Dermatol. 2020, 83:1323-30. 10.1016\/j.jaad.2020.03.081","journal-title":"J Am Acad Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.02.013","article-title":"Severe cutaneous adverse drug reactions in pediatric patients: a multicenter study","volume":"5","author":"Dibek Misirlioglu E","year":"2017","unstructured":"Dibek Misirlioglu E, Guvenir H, Bahceci S, et al.. Severe cutaneous adverse drug reactions in pediatric patients: a multicenter study. J Allergy Clin Immunol Pract. 2017, 5:757-63. 10.1016\/j.jaip.2017.02.013","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo CA","year":"1981","unstructured":"Naranjo CA, Busto U, Sellers EM, et al.. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981, 30:239-45. 10.1038\/clpt.1981.154","journal-title":"Clin Pharmacol Ther"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14090","article-title":"Patch testing in drug reaction with eosinophilia and systemic symptoms (DRESS): a literature review","volume":"86","author":"de Groot AC","year":"2022","unstructured":"de Groot AC. Patch testing in drug reaction with eosinophilia and systemic symptoms (DRESS): a literature review. Contact Dermatitis. 2022, 86:443-79. 10.1111\/cod.14090","journal-title":"Contact Dermatitis"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01659.x","article-title":"Epicutaneous patch testing in drug hypersensitivity syndrome (DRESS)","volume":"62","author":"Santiago F","year":"2010","unstructured":"Santiago F, Gon\u00e7alo M, Vieira R, Coelho S, Figueiredo A. Epicutaneous patch testing in drug hypersensitivity syndrome (DRESS). Contact Dermatitis. 2010, 62:47-53. 10.1111\/j.1600-0536.2009.01659.x","journal-title":"Contact Dermatitis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1157\/13086750","article-title":"Hypersensitivity reactions to metronidazole","volume":"34","author":"Garc\u00eda-Rubio I","year":"2006","unstructured":"Garc\u00eda-Rubio I, Mart\u00ednez-C\u00f3cera C, Santos Magad\u00e1n S, Rodr\u00edguez-Jim\u00e9nez B, V\u00e1zquez-Cort\u00e9s S. Hypersensitivity reactions to metronidazole. Allergol Immunopathol (Madr). 2006, 34:70-2. 10.1157\/13086750","journal-title":"Allergol Immunopathol (Madr)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08878-x","article-title":"Immediate and delayed hypersensitivity reactions to antibiotics: aminoglycosides, clindamycin, linezolid, and metronidazole","volume":"62","author":"Dilley M","year":"2022","unstructured":"Dilley M, Geng B. Immediate and delayed hypersensitivity reactions to antibiotics: aminoglycosides, clindamycin, linezolid, and metronidazole. Clin Rev Allergy Immunol. 2022, 62:463-75. 10.1007\/s12016-021-08878-x","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q478","article-title":"Immediate hypersensitivity reaction induced by metronidazole","volume":"46","author":"Seto K","year":"2012","unstructured":"Seto K, Knowles SR, Weber EA. Immediate hypersensitivity reaction induced by metronidazole. Ann Pharmacother. 2012, 46:763-4. 10.1345\/aph.1Q478","journal-title":"Ann Pharmacother"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/j.pbj.0000000000000154","article-title":"DRESS syndrome: an unlikely diagnosis with an unlikely cause","volume":"7","author":"Soares SG","year":"2022","unstructured":"Soares SG, Mendes MH, Pinto-Lopes P. DRESS syndrome: an unlikely diagnosis with an unlikely cause. Porto Biomed J. 2022, 7:e154. 10.1097\/j.pbj.0000000000000154","journal-title":"Porto Biomed J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.11.027","article-title":"Virus reactivation in drug reaction with eosinophilia and systemic symptoms (Dress) results from a strong drug-specific immune response","volume":"5","author":"Roujeau JC","year":"2017","unstructured":"Roujeau JC, Dupin N. Virus reactivation in drug reaction with eosinophilia and systemic symptoms (Dress) results from a strong drug-specific immune response. J Allergy Clin Immunol Pract. 2017, 5:811-2. 10.1016\/j.jaip.2016.11.027","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.017","article-title":"Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution","volume":"68","author":"Ushigome Y","year":"2013","unstructured":"Ushigome Y, Kano Y, Ishida T, Hirahara K, Shiohara T. Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution. J Am Acad Dermatol. 2013, 68:721-8. 10.1016\/j.jaad.2012.10.017","journal-title":"J Am Acad Dermatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10050999","article-title":"Drug reaction with eosinophilia and systemic symptoms (DReSS)\/drug-induced hypersensitivity syndrome (DiHS)-readdressing the DReSS","volume":"10","author":"Stirton H","year":"2022","unstructured":"Stirton H, Shear NH, Dodiuk-Gad RP. Drug reaction with eosinophilia and systemic symptoms (DReSS)\/drug-induced hypersensitivity syndrome (DiHS)-readdressing the DReSS. Biomedicines. 2022, 10:999. 10.3390\/biomedicines10050999","journal-title":"Biomedicines"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.145.1.67","article-title":"Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure","volume":"145","author":"Eshki M","year":"2009","unstructured":"Eshki M, Allanore L, Musette P, et al.. Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. Arch Dermatol. 2009, 145:67-72. 10.1001\/archderm.145.1.67","journal-title":"Arch Dermatol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08167.x","article-title":"Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome","volume":"157","author":"Tohyama M","year":"2007","unstructured":"Tohyama M, Hashimoto K, Yasukawa M, et al.. Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Br J Dermatol. 2007, 157:934-40. 10.1111\/j.1365-2133.2007.08167.x","journal-title":"Br J Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13007","article-title":"Drug hypersensitivity syndrome with prolonged course complicated by parvovirus infection","volume":"33","author":"Coughlin CC","year":"2016","unstructured":"Coughlin CC, Jen MV, Boos MD. Drug hypersensitivity syndrome with prolonged course complicated by parvovirus infection. Pediatr Dermatol. 2016, 33:e364-5. 10.1111\/pde.13007","journal-title":"Pediatr Dermatol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2018.03.024","article-title":"Reticular rash in drug reaction with eosinophilia and systemic symptoms syndrome: a clue to parvovirus B19 reactivation?","volume":"4","author":"Cura MJ","year":"2018","unstructured":"Cura MJ, Torre AC, Cueto Sarmiento KY, et al.. Reticular rash in drug reaction with eosinophilia and systemic symptoms syndrome: a clue to parvovirus B19 reactivation?. JAAD Case Rep. 2018, 4:728-32. 10.1016\/j.jdcr.2018.03.024","journal-title":"JAAD Case Rep"},{"key":"ref19","article-title":"Parvovirus B19 infection mimicking drug-induced hypersensitivity syndrome [Article in French]","volume":"127","author":"Regnier S","year":"2000","unstructured":"Regnier S, Descamps V, Boui M, et al.. Parvovirus B19 infection mimicking drug-induced hypersensitivity syndrome [Article in French]. Ann Dermatol Venereol. 2000, 127:505-6.","journal-title":"Ann Dermatol Venereol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/262623-metronidazole-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-with-parvovirus-b19-reactivation-a-pediatric-case","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T08:16:03Z","timestamp":1718093763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/262623-metronidazole-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-with-parvovirus-b19-reactivation-a-pediatric-case"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.62125","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,11]]}}}