{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:44:58Z","timestamp":1781649898824,"version":"3.54.5"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,11]]},"DOI":"10.7759\/cureus.62143","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T12:01:29Z","timestamp":1718107289000},"source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Impact of Proteinuria at Manifestation in Adult Nephrotic Syndrome Patients: Insights from a Prospective Cohort Study"],"prefix":"10.7759","author":[{"given":"Srinivas","family":"Nagaram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Charles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanumanthappa","family":"Nandeesha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreejith","family":"Parameswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palanivel","family":"Chinnakali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Nachiappa Ganesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-020-01864-1","article-title":"Incidence of remission and relapse of proteinuria, end-stage kidney disease, mortality, and major outcomes in primary nephrotic syndrome: the Japan Nephrotic Syndrome Cohort Study (JNSCS)","volume":"24","author":"Yamamoto R","year":"2020","unstructured":"Yamamoto R, Imai E, Maruyama S, et al.. Incidence of remission and relapse of proteinuria, end-stage kidney disease, mortality, and major outcomes in primary nephrotic syndrome: the Japan Nephrotic Syndrome Cohort Study (JNSCS). Clin Exp Nephrol. 2020, 24:526-40. 10.1007\/s10157-020-01864-1","journal-title":"Clin Exp Nephrol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2009.009007","article-title":"How should proteinuria be detected and measured?","volume":"46","author":"Lamb EJ","year":"2009","unstructured":"Lamb EJ, MacKenzie F, Stevens PE. How should proteinuria be detected and measured?. Ann Clin Biochem. 2009, 46:205-17. 10.1258\/acb.2009.009007","journal-title":"Ann Clin Biochem"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/546039","article-title":"Understanding the mechanisms of proteinuria: therapeutic implications","volume":"2012","author":"Toblli JE","year":"2012","unstructured":"Toblli JE, Bevione P, Di Gennaro F, Madalena L, Cao G, Angerosa M. Understanding the mechanisms of proteinuria: therapeutic implications. Int J Nephrol. 2012, 2012:546039. 10.1155\/2012\/546039","journal-title":"Int J Nephrol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00840.x","article-title":"Pathophysiology of proteinuria","volume":"63","author":"D'Amico G","year":"2003","unstructured":"D'Amico G, Bazzi C. Pathophysiology of proteinuria. Kidney Int. 2003, 63:809-25. 10.1046\/j.1523-1755.2003.00840.x","journal-title":"Kidney Int"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000168199","article-title":"Proteinuria and progression in human glomerular diseases","volume":"10 Suppl 1","author":"Cameron JS","year":"1990","unstructured":"Cameron JS. Proteinuria and progression in human glomerular diseases. Am J Nephrol. 1990, 10 Suppl 1:81-7. 10.1159\/000168199","journal-title":"Am J Nephrol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2023.2178378","article-title":"Progress in understanding primary glomerular disease: insights from urinary proteomics and in-depth analyses of potential biomarkers based on bioinformatics","volume":"60","author":"Ge L","year":"2023","unstructured":"Ge L, Liu J, Lin B, Qin X. Progress in understanding primary glomerular disease: insights from urinary proteomics and in-depth analyses of potential biomarkers based on bioinformatics. Crit Rev Clin Lab Sci. 2023, 60:346-65. 10.1080\/10408363.2023.2178378","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195968","article-title":"Impact of early proteinuria reduction in glomerular disease and decline of kidney function: a retrospective cohort","volume":"11","author":"Marques F","year":"2022","unstructured":"Marques F, Reis J, Godinho I, et al.. Impact of early proteinuria reduction in glomerular disease and decline of kidney function: a retrospective cohort. J Clin Med. 2022, 11:5968. 10.3390\/jcm11195968","journal-title":"J Clin Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006040377","article-title":"How does proteinuria cause progressive renal damage?","volume":"17","author":"Abbate M","year":"2006","unstructured":"Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage?. J Am Soc Nephrol. 2006, 17:2974-84. 10.1681\/ASN.2006040377","journal-title":"J Am Soc Nephrol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9215","article-title":"Correlation of TNF-\u03b1 and IL-10 gene polymorphisms with primary nephrotic syndrome","volume":"20","author":"Xiao M","year":"2020","unstructured":"Xiao M, Bai S, Chen J, et al.. Correlation of TNF-\u03b1 and IL-10 gene polymorphisms with primary nephrotic syndrome. Exp Ther Med. 2020, 20:87. 10.3892\/etm.2020.9215","journal-title":"Exp Ther Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.021","article-title":"KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases","volume":"100","year":"2021","unstructured":"KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Int. 2021, 100.S1-S276. 10.1016\/j.kint.2021.05.021","journal-title":"Kidney Int"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190493","article-title":"Prognosis of chronic kidney disease with normal-range proteinuria: The CKD-ROUTE study","volume":"13","author":"Iimori S","year":"2018","unstructured":"Iimori S, Naito S, Noda Y, et al.. Prognosis of chronic kidney disease with normal-range proteinuria: The CKD-ROUTE study. PLoS One. 2018, 13:e0190493. 10.1371\/journal.pone.0190493","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-022-02799-3","article-title":"The difference between patients with nephrotic syndrome and nephrotic-range proteinuria in IgA nephropathy: a propensity score matched cohort study","volume":"23","author":"Li H","year":"2022","unstructured":"Li H, Wang F, Jia J, Yan T, Liu Y, Lin S. The difference between patients with nephrotic syndrome and nephrotic-range proteinuria in IgA nephropathy: a propensity score matched cohort study. BMC Nephrol. 2022, 23:163. 10.1186\/s12882-022-02799-3","journal-title":"BMC Nephrol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00874.x","article-title":"Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. \"Gruppo Italiano di Studi Epidemiologici in Nefrologia\" (GISEN)","volume":"53","author":"Ruggenenti P","year":"1998","unstructured":"Ruggenenti P, Perna A, Mosconi L, Pisoni R, Remuzzi G. Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. \"Gruppo Italiano di Studi Epidemiologici in Nefrologia\" (GISEN). Kidney Int. 1998, 53:1209-16. 10.1046\/j.1523-1755.1998.00874.x","journal-title":"Kidney Int"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00580111","article-title":"Albuminuria and estimated glomerular filtration rate as predictors of diabetic end-stage renal disease and death","volume":"6","author":"Berhane AM","year":"2011","unstructured":"Berhane AM, Weil EJ, Knowler WC, Nelson RG, Hanson RL. Albuminuria and estimated glomerular filtration rate as predictors of diabetic end-stage renal disease and death. Clin J Am Soc Nephrol. 2011, 6:2444-51. 10.2215\/CJN.00580111","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.111","article-title":"Risk of developing end-stage renal disease in a cohort of mass screening","volume":"49","author":"Iseki K","year":"1996","unstructured":"Iseki K, Iseki C, Ikemiya Y, Fukiyama K. Risk of developing end-stage renal disease in a cohort of mass screening. Kidney Int. 1996, 49:800-5. 10.1038\/ki.1996.111","journal-title":"Kidney Int"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13067-7","article-title":"Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study","volume":"12","author":"Yamamoto R","year":"2022","unstructured":"Yamamoto R, Imai E, Maruyama S, et al.. Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study. Sci Rep. 2022, 12:9782. 10.1038\/s41598-022-13067-7","journal-title":"Sci Rep"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.737700","article-title":"Clinical outcomes of patients with primary membranous nephropathy and subnephrotic proteinuria","volume":"8","author":"He P","year":"2021","unstructured":"He P, Zha Y, Liu J, Wang H, He L. Clinical outcomes of patients with primary membranous nephropathy and subnephrotic proteinuria. Front Med (Lausanne). 2021, 8:737700. 10.3389\/fmed.2021.737700","journal-title":"Front Med (Lausanne)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2023.12.016","article-title":"Time-varying proteinuria and progression of IgA nephropathy: a cohort study","author":"Tang C","year":"2024","unstructured":"Tang C, Chen P, Si FL, et al.. Time-varying proteinuria and progression of IgA nephropathy: a cohort study. Am J Kidney Dis. 2024, 10.1053\/j.ajkd.2023.12.016","journal-title":"Am J Kidney Dis"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12104","article-title":"Pathophysiology of proteinuria and its value as an outcome measure in chronic kidney disease","volume":"76","author":"Cravedi P","year":"2013","unstructured":"Cravedi P, Remuzzi G. Pathophysiology of proteinuria and its value as an outcome measure in chronic kidney disease. Br J Clin Pharmacol. 2013, 76:516-23. 10.1111\/bcp.12104","journal-title":"Br J Clin Pharmacol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-016-0551-3","article-title":"Comparison of urinary total proteins by four different methods","volume":"31","author":"Yalamati P","year":"2016","unstructured":"Yalamati P, Karra ML, Bhongir AV. Comparison of urinary total proteins by four different methods. Indian J Clin Biochem. 2016, 31:463-7. 10.1007\/s12291-016-0551-3","journal-title":"Indian J Clin Biochem"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/46.3.392","article-title":"Total protein determination in urine: elimination of a differential response between the coomassie blue and pyrogallol red protein dye-binding assays","volume":"46","author":"Marshall T","year":"2000","unstructured":"Marshall T, Williams KM. Total protein determination in urine: elimination of a differential response between the coomassie blue and pyrogallol red protein dye-binding assays. Clin Chem. 2000, 46:392-8.","journal-title":"Clin Chem"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/262469-prognostic-impact-of-proteinuria-at-manifestation-in-adult-nephrotic-syndrome-patients-insights-from-a-prospective-cohort-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T12:01:50Z","timestamp":1718107310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/262469-prognostic-impact-of-proteinuria-at-manifestation-in-adult-nephrotic-syndrome-patients-insights-from-a-prospective-cohort-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.62143","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,11]]}}}