{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:17:38Z","timestamp":1761808658908},"reference-count":32,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,12]]},"DOI":"10.7759\/cureus.62235","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T12:57:40Z","timestamp":1718197060000},"source":"Crossref","is-referenced-by-count":1,"title":["Thick Skin on the Dorsal Spine in Osteoproliferative Disease: Ossification of the Posterior Longitudinal Ligament and Diffuse Idiopathic Skeletal Hyperostosis"],"prefix":"10.7759","author":[{"given":"Tadatsugu","family":"Morimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaomi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Permsak","family":"Paholpak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Umeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohito","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Toda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-023-06711-z","article-title":"Risk of developing age-related macular degeneration in patients with osteoporosis: a population-based, longitudinal follow-up study","volume":"34","author":"Hsu SC","year":"2023","unstructured":"Hsu SC, Feng SH, Pan SL. Risk of developing age-related macular degeneration in patients with osteoporosis: a population-based, longitudinal follow-up study. Osteoporos Int. 2023, 34:793-801. 10.1007\/s00198-023-06711-z","journal-title":"Osteoporos Int"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000472","article-title":"Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next","volume":"3","author":"Mader R","year":"2017","unstructured":"Mader R, Verlaan JJ, Eshed I, et al.. Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next. RMD Open. 2017, 3:e000472. 10.1136\/rmdopen-2017-000472","journal-title":"RMD Open"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2020.07.027","article-title":"Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of ossification of the spinal ligament, 2019","volume":"26","author":"Kawaguchi Y","year":"2021","unstructured":"Kawaguchi Y, Imagama S, Iwasaki M, et al.. Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of ossification of the spinal ligament, 2019. J Orthop Sci. 2021, 26:1-45. 10.1016\/j.jos.2020.07.027","journal-title":"J Orthop Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28605","article-title":"Nothing but skin and bone","volume":"116","author":"Ross FP","year":"2006","unstructured":"Ross FP, Christiano AM. Nothing but skin and bone. J Clin Invest. 2006, 116:1140-9. 10.1172\/JCI28605","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.04.034","article-title":"A digital light processing 3D-printed artificial skin model and full-thickness wound models using silk fibroin bioink","volume":"164","author":"Choi KY","year":"2023","unstructured":"Choi KY, Ajiteru O, Hong H, et al.. A digital light processing 3D-printed artificial skin model and full-thickness wound models using silk fibroin bioink. Acta Biomater. 2023, 164:159-74. 10.1016\/j.actbio.2023.04.034","journal-title":"Acta Biomater"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1053","article-title":"Keratinocyte growth inhibition through the modification of Wnt signaling by androgen in balding dermal papilla cells","volume":"94","author":"Kitagawa T","year":"2009","unstructured":"Kitagawa T, Matsuda K, Inui S, et al.. Keratinocyte growth inhibition through the modification of Wnt signaling by androgen in balding dermal papilla cells. J Clin Endocrinol Metab. 2009, 94:1288-94. 10.1210\/jc.2008-1053","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1360483","article-title":"A view on the skin-bone axis: unraveling similarities and potential of crosstalk","volume":"11","author":"Morimoto T","year":"2024","unstructured":"Morimoto T, Hirata H, Sugita K, et al.. A view on the skin-bone axis: unraveling similarities and potential of crosstalk. Front Med (Lausanne). 2024, 11:1360483. 10.3389\/fmed.2024.1360483","journal-title":"Front Med (Lausanne)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1919.02610470001001","article-title":"The skin: a mirror to the system","volume":"73","author":"Engman MF","year":"1919","unstructured":"Engman MF. The skin: a mirror to the system. JAMA. 1919, 73:1565-8. 10.1001\/jama.1919.02610470001001","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.3.160088","article-title":"Correlation between skin and bone parameters in women with postmenopausal osteoporosis: a systematic review","volume":"3","author":"Aur\u00e9gan JC","year":"2018","unstructured":"Aur\u00e9gan JC, Bosser C, Bensidhoum M, B\u00e9gu\u00e9 T, Hoc T. Correlation between skin and bone parameters in women with postmenopausal osteoporosis: a systematic review. EFORT Open Rev. 2018, 3:449-60. 10.1302\/2058-5241.3.160088","journal-title":"EFORT Open Rev"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.06.003","article-title":"Skin manifestations associated with systemic diseases - part II","volume":"96","author":"Leal JM","year":"2021","unstructured":"Leal JM, de Souza GH, Marsillac PF, Gripp AC. Skin manifestations associated with systemic diseases - part II. An Bras Dermatol. 2021, 96:672-87. 10.1016\/j.abd.2021.06.003","journal-title":"An Bras Dermatol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0447-8","article-title":"Diagnostic criteria for primary osteoporosis: year 2012 revision","volume":"31","author":"Soen S","year":"2013","unstructured":"Soen S, Fukunaga M, Sugimoto T, et al.. Diagnostic criteria for primary osteoporosis: year 2012 revision. J Bone Miner Metab. 2013, 31:247-57. 10.1007\/s00774-013-0447-8","journal-title":"J Bone Miner Metab"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1148\/119.3.559","article-title":"Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH)","volume":"119","author":"Resnick D","year":"1976","unstructured":"Resnick D, Niwayama G. Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology. 1976, 119:559-68. 10.1148\/119.3.559","journal-title":"Radiology"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-018-2009-7","article-title":"Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification: a multicenter study (JOSL CT study)","volume":"19","author":"Hirai T","year":"2018","unstructured":"Hirai T, Yoshii T, Nagoshi N, et al.. Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification: a multicenter study (JOSL CT study). BMC Musculoskelet Disord. 2018, 19:107. 10.1186\/s12891-018-2009-7","journal-title":"BMC Musculoskelet Disord"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2016.04.009","article-title":"Characteristics of ossification of the spinal ligament; incidence of ossification of the ligamentum flavum in patients with cervical ossification of the posterior longitudinal ligament - analysis of the whole spine using multidetector CT","volume":"21","author":"Kawaguchi Y","year":"2016","unstructured":"Kawaguchi Y, Nakano M, Yasuda T, et al.. Characteristics of ossification of the spinal ligament; incidence of ossification of the ligamentum flavum in patients with cervical ossification of the posterior longitudinal ligament - analysis of the whole spine using multidetector CT. J Orthop Sci. 2016, 21:439-45. 10.1016\/j.jos.2016.04.009","journal-title":"J Orthop Sci"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1042\/bj2940271","article-title":"Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I","volume":"294 ( Pt 1)","author":"Takeshita S","year":"1993","unstructured":"Takeshita S, Kikuno R, Tezuka K, Amann E. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 1993, 294 ( Pt 1):271-8. 10.1042\/bj2940271","journal-title":"Biochem J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.OA.21.00111","article-title":"Serum periostin level reflects progression of ossification of the posterior longitudinal ligament","volume":"7","author":"Kawaguchi Y","year":"2022","unstructured":"Kawaguchi Y, Kitajima I, Yasuda T, et al.. Serum periostin level reflects progression of ossification of the posterior longitudinal ligament. JB JS Open Access. 2022, 7:e21.00111. 10.2106\/JBJS.OA.21.00111","journal-title":"JB JS Open Access"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-5122(99)00077-8","article-title":"Effects of postmenopausal hypoestrogenism on skin collagen","volume":"33","author":"Affinito P","year":"1999","unstructured":"Affinito P, Palomba S, Sorrentino C, Di Carlo C, Bifulco G, Arienzo MP, Nappi C. Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas. 1999, 33:239-47. 10.1016\/s0378-5122(99)00077-8","journal-title":"Maturitas"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.51.159","article-title":"Effects of aging and postmenopausal hypoestrogenism on skin elasticity and bone mineral density in Japanese women","volume":"51","author":"Sumino H","year":"2004","unstructured":"Sumino H, Ichikawa S, Abe M, et al.. Effects of aging and postmenopausal hypoestrogenism on skin elasticity and bone mineral density in Japanese women. Endocr J. 2004, 51:159-64. 10.1507\/endocrj.51.159","journal-title":"Endocr J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0141076820910315","article-title":"Osteoporosis, like skin ageing, is caused by collagen loss which is reversible","volume":"113","author":"Shuster S","year":"2020","unstructured":"Shuster S. Osteoporosis, like skin ageing, is caused by collagen loss which is reversible. J R Soc Med. 2020, 113:158-60. 10.1177\/0141076820910315","journal-title":"J R Soc Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1972.tb00397.x","article-title":"Skin collagen and thickness in acromegaly and hypopituitarism","volume":"1","author":"Black MM","year":"1972","unstructured":"Black MM, Shuster S, Bottoms E. Skin collagen and thickness in acromegaly and hypopituitarism. Clin Endocrinol (Oxf). 1972, 1:259-63. 10.1111\/j.1365-2265.1972.tb00397.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1991.tb01225.x","article-title":"New aspects of the mechanism of corticosteroid-induced dermal atrophy","volume":"16","author":"Oikarinen A","year":"1991","unstructured":"Oikarinen A, Autio P. New aspects of the mechanism of corticosteroid-induced dermal atrophy. Clin Exp Dermatol. 1991, 16:416-9. 10.1111\/j.1365-2230.1991.tb01225.x","journal-title":"Clin Exp Dermatol"},{"key":"ref22","article-title":"Histochemical and immunohistochemical study on the skin of patients with ossification of the posterior longitudinal ligament in the cervical spine","volume":"9","author":"Imamura T","year":"1995","unstructured":"Imamura T, Sakou T, Matsunaga S, Taketomi E, Ishido Y, Yoshida H. Histochemical and immunohistochemical study on the skin of patients with ossification of the posterior longitudinal ligament in the cervical spine. In Vivo. 1995, 9:167-71.","journal-title":"In Vivo"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200405000-00021","article-title":"New developments in our understanding of DISH (diffuse idiopathic skeletal hyperostosis)","volume":"16","author":"Sarzi-Puttini P","year":"2004","unstructured":"Sarzi-Puttini P, Atzeni F. New developments in our understanding of DISH (diffuse idiopathic skeletal hyperostosis). Curr Opin Rheumatol. 2004, 16:287-92. 10.1097\/00002281-200405000-00021","journal-title":"Curr Opin Rheumatol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174881","article-title":"Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): inflammation in OPLL","volume":"12","author":"Kawaguchi Y","year":"2017","unstructured":"Kawaguchi Y, Nakano M, Yasuda T, et al.. Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): inflammation in OPLL. PLoS One. 2017, 12:e0174881. 10.1371\/journal.pone.0174881","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015485","article-title":"The role of vitamin D and its molecular bases in insulin resistance, diabetes, metabolic syndrome, and cardiovascular disease: state of the art","volume":"24","author":"Argano C","year":"2023","unstructured":"Argano C, Mirarchi L, Amodeo S, Orlando V, Torres A, Corrao S. The role of vitamin D and its molecular bases in insulin resistance, diabetes, metabolic syndrome, and cardiovascular disease: state of the art. Int J Mol Sci. 2023, 24:15485. 10.3390\/ijms242015485","journal-title":"Int J Mol Sci"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01607","article-title":"Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes","volume":"10","author":"Zatterale F","year":"2019","unstructured":"Zatterale F, Longo M, Naderi J, Raciti GA, Desiderio A, Miele C, Beguinot F. Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes. Front Physiol. 2019, 10:1607. 10.3389\/fphys.2019.01607","journal-title":"Front Physiol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02427-9","article-title":"The gut microbiota in osteoarthritis: where do we stand and what can we do?","volume":"23","author":"Hao X","year":"2021","unstructured":"Hao X, Shang X, Liu J, Chi R, Zhang J, Xu T. The gut microbiota in osteoarthritis: where do we stand and what can we do?. Arthritis Res Ther. 2021, 23:42. 10.1186\/s13075-021-02427-9","journal-title":"Arthritis Res Ther"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1290858","article-title":"Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases","volume":"14","author":"Morimoto T","year":"2023","unstructured":"Morimoto T, Kobayashi T, Kakiuchi T, et al.. Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases. Front Microbiol. 2023, 14:1290858. 10.3389\/fmicb.2023.1290858","journal-title":"Front Microbiol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.04.037","article-title":"Embelin reduces cutaneous TNF-\u03b1 level and ameliorates skin edema in acute and chronic model of skin inflammation in mice","volume":"662","author":"Kalyan Kumar G","year":"2011","unstructured":"Kalyan Kumar G, Dhamotharan R, Kulkarni NM, Mahat MY, Gunasekaran J, Ashfaque M. Embelin reduces cutaneous TNF-\u03b1 level and ameliorates skin edema in acute and chronic model of skin inflammation in mice. Eur J Pharmacol. 2011, 662:63-9. 10.1016\/j.ejphar.2011.04.037","journal-title":"Eur J Pharmacol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.afos.2016.12.001","article-title":"Bone turnover rate and bone formation\/resorption balance during the early stage after switching from a bone resorption inhibitor to denosumab are predictive factors of bone mineral density change","volume":"3","author":"Nakatoh S","year":"2017","unstructured":"Nakatoh S. Bone turnover rate and bone formation\/resorption balance during the early stage after switching from a bone resorption inhibitor to denosumab are predictive factors of bone mineral density change. Osteoporos Sarcopenia. 2017, 3:45-52. 10.1016\/j.afos.2016.12.001","journal-title":"Osteoporos Sarcopenia"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.4103\/tjps.TJPS_2_17","article-title":"Measurement of epidermis, dermis, and total skin thicknesses from six different body regions with a new ethical histometric technique","volume":"26","author":"Oltulu P","year":"2018","unstructured":"Oltulu P, Ince B, Kokbudak N, Findik S, Kilinc F. Measurement of epidermis, dermis, and total skin thicknesses from six different body regions with a new ethical histometric technique. Turk J Plast Surg. 2018, 26:56-61. 10.4103\/tjps.TJPS_2_17","journal-title":"Turk J Plast Surg"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(94)00859-6","article-title":"Limited value of ultrasound measured skin thickness in predicting bone mineral density in peri- and postmenopausal women","volume":"21","author":"Varila E","year":"1995","unstructured":"Varila E, Siev\u00e4nen H, Vuori I, Oksanen H, Punnonen R. Limited value of ultrasound measured skin thickness in predicting bone mineral density in peri- and postmenopausal women. Maturitas. 1995, 21:45-9. 10.1016\/0378-5122(94)00859-6","journal-title":"Maturitas"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/248874-thick-skin-on-the-dorsal-spine-in-osteoproliferative-disease-ossification-of-the-posterior-longitudinal-ligament-and-diffuse-idiopathic-skeletal-hyperostosis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T12:57:44Z","timestamp":1718197064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/248874-thick-skin-on-the-dorsal-spine-in-osteoproliferative-disease-ossification-of-the-posterior-longitudinal-ligament-and-diffuse-idiopathic-skeletal-hyperostosis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":32,"URL":"https:\/\/doi.org\/10.7759\/cureus.62235","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,12]]}}}