{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:10:53Z","timestamp":1781712653170,"version":"3.54.5"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,12]]},"DOI":"10.7759\/cureus.62263","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T23:06:46Z","timestamp":1718233606000},"source":"Crossref","is-referenced-by-count":1,"title":["Blinatumomab Maintenance Therapy Following Bone Marrow Transplantation for Early Relapsed Pediatric B-cell Precursor Acute Lymphoblastic Leukemia and Analysis of Lymphocyte Subset Changes"],"prefix":"10.7759","author":[{"given":"Takanari","family":"Abematsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kasabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1400972","article-title":"Acute lymphoblastic leukemia in children","volume":"373","author":"Hunger SP","year":"2015","unstructured":"Hunger SP, Mullighan CG. Acute lymphoblastic leukemia in children. N Engl J Med. 2015, 373:1541-52. 10.1056\/NEJMra1400972","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8018","article-title":"Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the children's oncology group","volume":"30","author":"Hunger SP","year":"2012","unstructured":"Hunger SP, Lu X, Devidas M, et al.. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the children's oncology group. J Clin Oncol. 2012, 30:1663-9. 10.1200\/JCO.2011.37.8018","journal-title":"J Clin Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-265884","article-title":"How I treat relapsed childhood acute lymphoblastic leukemia","volume":"120","author":"Locatelli F","year":"2012","unstructured":"Locatelli F, Schrappe M, Bernardo ME, Rutella S. How I treat relapsed childhood acute lymphoblastic leukemia. Blood. 2012, 120:2807-16. 10.1182\/blood-2012-02-265884","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.1031","article-title":"Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: Results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-M\u00fcnster Group 87","volume":"23","author":"Einsiedel HG","year":"2005","unstructured":"Einsiedel HG, von Stackelberg A, Hartmann R, et al.. Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: Results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-M\u00fcnster Group 87. J Clin Oncol. 2005, 23:7942-50. 10.1200\/JCO.2005.01.1031","journal-title":"J Clin Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-704973","article-title":"Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia","volume":"128","author":"Irving JA","year":"2016","unstructured":"Irving JA, Enshaei A, Parker CA, et al.. Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia. Blood. 2016, 128:911-22. 10.1182\/blood-2016-03-704973","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0669","article-title":"Effect of postreinduction therapy consolidation with blinatumomab vs chemotherapy on disease-free survival in children, adolescents, and young adults with first relapse of B-cell acute lymphoblastic leukemia: A randomized clinical trial","volume":"325","author":"Brown PA","year":"2021","unstructured":"Brown PA, Ji L, Xu X, et al.. Effect of postreinduction therapy consolidation with blinatumomab vs chemotherapy on disease-free survival in children, adolescents, and young adults with first relapse of B-cell acute lymphoblastic leukemia: A randomized clinical trial. JAMA. 2021, 325:833-42. 10.1001\/jama.2021.0669","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0987","article-title":"Effect of blinatumomab vs chemotherapy on event-free survival among children with high-risk first-relapse B-cell acute lymphoblastic leukemia: A randomized clinical trial","volume":"325","author":"Locatelli F","year":"2021","unstructured":"Locatelli F, Zugmaier G, Rizzari C, et al.. Effect of blinatumomab vs chemotherapy on event-free survival among children with high-risk first-relapse B-cell acute lymphoblastic leukemia: A randomized clinical trial. JAMA. 2021, 325:843-54. 10.1001\/jama.2021.0987","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02200","article-title":"Children's Oncology Group AALL1331 Phase III trial of blinatumomab in children, adolescents, and young adults with low-risk B-cell ALL in first relapse","volume":"41","author":"Hogan LE","year":"2023","unstructured":"Hogan LE, Brown PA, Ji L, et al.. Children's Oncology Group AALL1331 Phase III trial of blinatumomab in children, adolescents, and young adults with low-risk B-cell ALL in first relapse. J Clin Oncol. 2023, 41:4118-29. 10.1200\/JCO.22.02200","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62002-8","article-title":"Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): An open-label randomised trial","volume":"376","author":"Parker C","year":"2010","unstructured":"Parker C, Waters R, Leighton C, et al.. Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): An open-label randomised trial. Lancet. 2010, 376:2009-17. 10.1016\/S0140-6736(10)62002-8","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.893545","article-title":"Naive T cells in graft versus host disease and graft versus leukemia: Innocent or guilty?","volume":"13","author":"Dekker L","year":"2022","unstructured":"Dekker L, Sanders E, Lindemans CA, de Koning C, Nierkens S. Naive T cells in graft versus host disease and graft versus leukemia: Innocent or guilty?. Front Immunol. 2022, 13:893545. 10.3389\/fimmu.2022.893545","journal-title":"Front Immunol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-400515","article-title":"Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19\/CD3-bispecific BiTE antibody blinatumomab","volume":"119","author":"Klinger M","year":"2012","unstructured":"Klinger M, Brandl C, Zugmaier G, et al.. Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19\/CD3-bispecific BiTE antibody blinatumomab. Blood. 2012, 119:6226-33. 10.1182\/blood-2012-01-400515","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-070051","article-title":"Safety and efficacy of post-haematopoietic cell transplantation maintenance therapy with blinatumomab for relapsed\/refractory CD19-positive B-cell acute lymphoblastic leukaemia: Protocol for a phase I-II, multicentre, non-blinded, non-controlled trial (JPLSG SCT-ALL-BLIN21)","volume":"13","author":"Sakaguchi H","year":"2023","unstructured":"Sakaguchi H, Umeda K, Kato I, et al.. Safety and efficacy of post-haematopoietic cell transplantation maintenance therapy with blinatumomab for relapsed\/refractory CD19-positive B-cell acute lymphoblastic leukaemia: Protocol for a phase I-II, multicentre, non-blinded, non-controlled trial (JPLSG SCT-ALL-BLIN21). BMJ Open. 2023, 13:e070051. 10.1136\/bmjopen-2022-070051","journal-title":"BMJ Open"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-017-0074-5","article-title":"Changes in clinical laboratory parameters and pharmacodynamic markers in response to blinatumomab treatment of patients with relapsed\/refractory ALL","volume":"6","author":"N\u00e4gele V","year":"2017","unstructured":"N\u00e4gele V, Kratzer A, Zugmaier G, et al.. Changes in clinical laboratory parameters and pharmacodynamic markers in response to blinatumomab treatment of patients with relapsed\/refractory ALL. Exp Hematol Oncol. 2017, 6:14. 10.1186\/s40164-017-0074-5","journal-title":"Exp Hematol Oncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013290","article-title":"Blinatumomab maintenance after allogeneic hematopoietic cell transplantation for B-lineage acute lymphoblastic leukemia","volume":"139","author":"Gaballa MR","year":"2022","unstructured":"Gaballa MR, Banerjee P, Milton DR, et al.. Blinatumomab maintenance after allogeneic hematopoietic cell transplantation for B-lineage acute lymphoblastic leukemia. Blood. 2022, 139:1908-19. 10.1182\/blood.2021013290","journal-title":"Blood"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/247240-blinatumomab-maintenance-therapy-following-bone-marrow-transplantation-for-early-relapsed-pediatric-b-cell-precursor-acute-lymphoblastic-leukemia-and-analysis-of-lymphocyte-subset-changes","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T23:06:50Z","timestamp":1718233610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/247240-blinatumomab-maintenance-therapy-following-bone-marrow-transplantation-for-early-relapsed-pediatric-b-cell-precursor-acute-lymphoblastic-leukemia-and-analysis-of-lymphocyte-subset-changes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":14,"URL":"https:\/\/doi.org\/10.7759\/cureus.62263","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,12]]}}}