{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:08:57Z","timestamp":1779174537955,"version":"3.51.4"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,15]]},"DOI":"10.7759\/cureus.62451","type":"journal-article","created":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T02:37:09Z","timestamp":1718505429000},"source":"Crossref","is-referenced-by-count":1,"title":["Massive Pulmonary Embolism Associated With Factor V Leiden Mutation in a Young Female on Oral Contraceptive Pills: A Case Report"],"prefix":"10.7759","author":[{"given":"Sushil","family":"Rayamajhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Sayonara Lopez Capa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia","family":"Carolina Flores Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vyshnavidevi","family":"Sunkara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania Beatriz","family":"Marin Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameer M","family":"Farrukh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000319051","article-title":"Contraception-related deep venous thrombosis and pulmonary embolism in a 17-Year-old girl heterozygous for factor V leiden, prothrombin G20210A mutation, MTHFR C677T and homozygous for PAI-1 mutation: report of a family with multiple genetic risk factors and review of the literature","volume":"37","author":"Lenicek Krleza J","year":"2010","unstructured":"Lenicek Krleza J, Jakovljevic G, Bronic A, Coen Herak D, Bonevski A, Stepan-Giljevic J, Roic G. Contraception-related deep venous thrombosis and pulmonary embolism in a 17-Year-old girl heterozygous for factor V leiden, prothrombin G20210A mutation, MTHFR C677T and homozygous for PAI-1 mutation: report of a family with multiple genetic risk factors and review of the literature. Pathophysiol Haemost Thromb. 2010, 37:24-9. 10.1159\/000319051","journal-title":"Pathophysiol Haemost Thromb"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609334629","article-title":"Massive pulmonary embolism associated with factor V Leiden, prothrombin, and methylenetetrahydrofolate reductase gene mutations in a young patient on oral contraceptive pills: a case report","volume":"16","author":"Charafeddine KM","year":"2010","unstructured":"Charafeddine KM, Mahfouz RA, Ibrahim GY, Taher AT, Hoballah JJ, Taha AM. Massive pulmonary embolism associated with factor V Leiden, prothrombin, and methylenetetrahydrofolate reductase gene mutations in a young patient on oral contraceptive pills: a case report. Clin Appl Thromb Hemost. 2010, 16:594-8. 10.1177\/1076029609334629","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32658-1","article-title":"Venous thromboembolism","volume":"398","author":"Khan F","year":"2021","unstructured":"Khan F, Tritschler T, Kahn SR, Rodger MA. Venous thromboembolism. Lancet. 2021, 398:64-77. 10.1016\/S0140-6736(20)32658-1","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13340","article-title":"Initial anticoagulation in patients with pulmonary embolism: thrombolysis, unfractionated heparin, LMWH, fondaparinux, or DOACs?","volume":"83","author":"Leentjens J","year":"2017","unstructured":"Leentjens J, Peters M, Esselink AC, Smulders Y, Kramers C. Initial anticoagulation in patients with pulmonary embolism: thrombolysis, unfractionated heparin, LMWH, fondaparinux, or DOACs?. Br J Clin Pharmacol. 2017, 83:2356-66. 10.1111\/bcp.13340","journal-title":"Br J Clin Pharmacol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)","volume":"41","author":"Konstantinides SV","year":"2020","unstructured":"Konstantinides SV, Meyer G, Becattini C, et al.. 2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020, 41:543-603. 10.1093\/eurheartj\/ehz405","journal-title":"Eur Heart J"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1592333","article-title":"Environmental and genetic risk factors associated with venous thromboembolism","volume":"42","author":"Crous-Bou M","year":"2016","unstructured":"Crous-Bou M, Harrington LB, Kabrhel C. Environmental and genetic risk factors associated with venous thromboembolism. Semin Thromb Hemost. 2016, 42:808-20. 10.1055\/s-0036-1592333","journal-title":"Semin Thromb Hemost"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0268-960x(99)90019-x","article-title":"Factor V Leiden: should all women be screened prior to commencing the contraceptive pill?","volume":"13","author":"Walker ID","year":"1999","unstructured":"Walker ID. Factor V Leiden: should all women be screened prior to commencing the contraceptive pill?. Blood Rev. 1999, 13:8-13. 10.1016\/s0268-960x(99)90019-x","journal-title":"Blood Rev"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016318","article-title":"Acute pulmonary thromboembolism caused by factor V Leiden mutation in South Korea: a case report","volume":"98","author":"Choe HJ","year":"2019","unstructured":"Choe HJ, Suh KJ, Lee JY, et al.. Acute pulmonary thromboembolism caused by factor V Leiden mutation in South Korea: a case report. Medicine (Baltimore). 2019, 98:e16318. 10.1097\/MD.0000000000016318","journal-title":"Medicine (Baltimore)"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181faa0f2","article-title":"Factor V Leiden thrombophilia","volume":"13","author":"Kujovich JL","year":"2011","unstructured":"Kujovich JL. Factor V Leiden thrombophilia. Genet Med. 2011, 13:1-16. 10.1097\/GIM.0b013e3181faa0f2","journal-title":"Genet Med"},{"key":"ref10","article-title":"Factor V Leiden mutation","author":"Albagoush SA","year":"2024","unstructured":"Albagoush SA, Koya S, Chakraborty RK, et al.. Factor V Leiden mutation. StatPearls Publishing, Treasure Island, FL; 2024."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000473362.92597.d8","article-title":"A patient with factor V Leiden and a related pulmonary embolism","volume":"29","author":"Downs J","year":"2016","unstructured":"Downs J, Childers WA Jr. A patient with factor V Leiden and a related pulmonary embolism. JAAPA. 2016, 29:34-5. 10.1097\/01.JAA.0000473362.92597.d8","journal-title":"JAAPA"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(80)91550-0","article-title":"Oral contraceptives and thromboembolic disease: effects of lowering oestrogen content","volume":"1","author":"B\u00f6ttiger LE","year":"1980","unstructured":"B\u00f6ttiger LE, Boman G, Eklund G, Westerholm B. Oral contraceptives and thromboembolic disease: effects of lowering oestrogen content. Lancet. 1980, 1:1097-101. 10.1016\/s0140-6736(80)91550-0","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112148","article-title":"Thrombosis with low-estrogen oral contraceptives","volume":"102","author":"Stolley PD","year":"1975","unstructured":"Stolley PD, Tonascia JA, Tockman MS, Sartwell PE, Rutledge AH, Jacobs MP. Thrombosis with low-estrogen oral contraceptives. Am J Epidemiol. 1975, 102:197-208. 10.1093\/oxfordjournals.aje.a112148","journal-title":"Am J Epidemiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-6-891","article-title":"Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan","volume":"98","author":"Hull RD","year":"1983","unstructured":"Hull RD, Hirsh J, Carter CJ, et al.. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Ann Intern Med. 1983, 98:891-9. 10.7326\/0003-4819-98-6-891","journal-title":"Ann Intern Med"},{"key":"ref15","article-title":"Pulmonary embolism an update","volume":"46","author":"Doherty S","year":"2017","unstructured":"Doherty S. Pulmonary embolism an update. Aust Fam Physician. 2017, 46:816-20.","journal-title":"Aust Fam Physician"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/215344-massive-pulmonary-embolism-associated-with-factor-v-leiden-mutation-in-a-young-female-on-oral-contraceptive-pills-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T02:37:14Z","timestamp":1718505434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/215344-massive-pulmonary-embolism-associated-with-factor-v-leiden-mutation-in-a-young-female-on-oral-contraceptive-pills-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.62451","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,15]]}}}