{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:01:18Z","timestamp":1790611278332,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,19]]},"DOI":"10.7759\/cureus.62729","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:40:56Z","timestamp":1718844056000},"source":"Crossref","is-referenced-by-count":1,"title":["Metformin-Associated Lactic Acidosis in an Older Adult: A Case Report and Review"],"prefix":"10.7759","author":[{"given":"Sakshi","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Sekhon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelin Shamili","family":"Leo Pradeep Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Gummadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premalkumar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghuma","family":"Nakka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharajan","family":"Gunendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athmananda","family":"Nanjundappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Jose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Naga","family":"Garapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saketh","family":"Palasamudram Shekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaraja","family":"Kanitkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.19","article-title":"Metformin and other antidiabetic agents in renal failure patients","volume":"87","author":"Lalau JD","year":"2015","unstructured":"Lalau JD, Arnouts P, Sharif A, De Broe ME. Metformin and other antidiabetic agents in renal failure patients. Kidney Int. 2015, 87:308-22. 10.1038\/ki.2014.19","journal-title":"Kidney Int"},{"key":"ref2","article-title":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group","volume":"352","year":"1998","unstructured":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998, 352.854-65.","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508313330902","article-title":"Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group","volume":"333","author":"DeFronzo RA","year":"1995","unstructured":"DeFronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med. 1995, 333:541-9. 10.1056\/NEJM199508313330902","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-239154","article-title":"Metformin-associated lactic acidosis","volume":"14","author":"Fadden EJ","year":"2021","unstructured":"Fadden EJ, Longley C, Mahambrey T. Metformin-associated lactic acidosis. BMJ Case Rep. 2021, 14:e239154. 10.1136\/bcr-2020-239154","journal-title":"BMJ Case Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200601000-00016","article-title":"Metformin-associated lactic acidosis precipitated by acute renal failure","volume":"331","author":"Shenoy C","year":"2006","unstructured":"Shenoy C. Metformin-associated lactic acidosis precipitated by acute renal failure. Am J Med Sci. 2006, 331:55-7. 10.1097\/00000441-200601000-00016","journal-title":"Am J Med Sci"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.24220","article-title":"Metformin-associated lactic acidosis: a case report and review","volume":"14","author":"Ashraf S","year":"2022","unstructured":"Ashraf S, Upreti P, Karki S, Khan M, Nasr R. Metformin-associated lactic acidosis: a case report and review. Cureus. 2022, 14:e24220. 10.7759\/cureus.24220","journal-title":"Cureus"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2008.027","article-title":"Metformin therapy and clinical uses","volume":"5","author":"Scarpello JH","year":"2008","unstructured":"Scarpello JH, Howlett HC. Metformin therapy and clinical uses. Diab Vasc Dis Res. 2008, 5:157-67. 10.3132\/dvdr.2008.027","journal-title":"Diab Vasc Dis Res"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0176-9","article-title":"Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin","volume":"49","author":"Evans JM","year":"2006","unstructured":"Evans JM, Ogston SA, Emslie-Smith A, Morris AD. Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia. 2006, 49:930-6. 10.1007\/s00125-006-0176-9","journal-title":"Diabetologia"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015121308","article-title":"Renal aging: causes and consequences","volume":"28","author":"O'Sullivan ED","year":"2017","unstructured":"O'Sullivan ED, Hughes J, Ferenbach DA. Renal aging: causes and consequences. J Am Soc Nephrol. 2017, 28:407-20. 10.1681\/ASN.2015121308","journal-title":"J Am Soc Nephrol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12994","article-title":"Metformin-associated lactic acidosis: moving towards a new paradigm?","volume":"19","author":"Bicsak TA","year":"2017","unstructured":"Bicsak TA, Walsh B, Fineman M. Metformin-associated lactic acidosis: moving towards a new paradigm?. Diabetes Obes Metab. 2017, 19:1499-501. 10.1111\/dom.12994","journal-title":"Diabetes Obes Metab"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s40800-018-0076-1","article-title":"Metformin-associated lactic acidosis: a case report","volume":"5","author":"Umeda T","year":"2018","unstructured":"Umeda T, Minami T, Bartolomei K, Summerhill E. Metformin-associated lactic acidosis: a case report. Drug Saf Case Rep. 2018, 5:8. 10.1007\/s40800-018-0076-1","journal-title":"Drug Saf Case Rep"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-019-2311-5","article-title":"A patient with metformin-associated lactic acidosis successfully treated with continuous renal replacement therapy: a case report","volume":"13","author":"Kinoshita H","year":"2019","unstructured":"Kinoshita H, Yanai M, Ariyoshi K, Ando M, Tamura R. A patient with metformin-associated lactic acidosis successfully treated with continuous renal replacement therapy: a case report. J Med Case Rep. 2019, 13:371. 10.1186\/s13256-019-2311-5","journal-title":"J Med Case Rep"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-159","article-title":"Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report","volume":"8","author":"Ncomanzi D","year":"2014","unstructured":"Ncomanzi D, Sicat RM, Sundararajan K. Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report. J Med Case Rep. 2014, 8:159. 10.1186\/1752-1947-8-159","journal-title":"J Med Case Rep"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-008855","article-title":"Feeling blue with metformin-associated lactic acidosis","volume":"2013","author":"Plumb B","year":"2013","unstructured":"Plumb B, Parker A, Wong P. Feeling blue with metformin-associated lactic acidosis. BMJ Case Rep. 2013, 2013:bcr2013008855. 10.1136\/bcr-2013-008855","journal-title":"BMJ Case Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2015.10.012","article-title":"Metformin-associated lactic acidosis presenting as acute ST-elevation myocardial infarction","volume":"50","author":"White S","year":"2016","unstructured":"White S, Driver BE, Cole JB. Metformin-associated lactic acidosis presenting as acute ST-elevation myocardial infarction. J Emerg Med. 2016, 50:32-6. 10.1016\/j.jemermed.2015.10.012","journal-title":"J Emerg Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020990","article-title":"Extracorporeal membrane oxygenation with continuous renal replacement therapy to treat metformin-associated lactic acidosis: a case report","volume":"99","author":"Chen T","year":"2020","unstructured":"Chen T, Zhu C, Liu B. Extracorporeal membrane oxygenation with continuous renal replacement therapy to treat metformin-associated lactic acidosis: a case report. Medicine (Baltimore). 2020, 99:e20990. 10.1097\/MD.0000000000020990","journal-title":"Medicine (Baltimore)"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.937865","article-title":"Unusual case of metformin-associated lactic acidosis in patient with type 2 diabetes mellitus","volume":"23","author":"Hai PD","year":"2022","unstructured":"Hai PD, Thu NT, Phuong LL, Manh NV, Hoa LT. Unusual case of metformin-associated lactic acidosis in patient with type 2 diabetes mellitus. Am J Case Rep. 2022, 23:e937865. 10.12659\/AJCR.937865","journal-title":"Am J Case Rep"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001367","article-title":"Outcomes of patients discharged to skilled nursing facilities after acute care hospitalizations","volume":"263","author":"Hakkarainen TW","year":"2016","unstructured":"Hakkarainen TW, Arbabi S, Willis MM, Davidson GH, Flum DR. Outcomes of patients discharged to skilled nursing facilities after acute care hospitalizations. Ann Surg. 2016, 263:280-5. 10.1097\/SLA.0000000000001367","journal-title":"Ann Surg"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2015.08.004","article-title":"Structural and functional changes with the aging kidney","volume":"23","author":"Denic A","year":"2016","unstructured":"Denic A, Glassock RJ, Rule AD. Structural and functional changes with the aging kidney. Adv Chronic Kidney Dis. 2016, 23:19-28. 10.1053\/j.ackd.2015.08.004","journal-title":"Adv Chronic Kidney Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/243906-metformin-associated-lactic-acidosis-in-an-older-adult-a-case-report-and-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:41:00Z","timestamp":1718844060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/243906-metformin-associated-lactic-acidosis-in-an-older-adult-a-case-report-and-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,19]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.62729","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,19]]}}}