{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:45:09Z","timestamp":1790084709679,"version":"4.0.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,23]]},"DOI":"10.7759\/cureus.62984","type":"journal-article","created":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T22:48:00Z","timestamp":1719182880000},"source":"Crossref","is-referenced-by-count":5,"title":["Lipoprotein(a)'s Role in Atherosclerosis and Aortic Stenosis: A Contemporary Literature Review"],"prefix":"10.7759","author":[{"given":"Mukosolu F","family":"Obi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shardil","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safi Ur Rehman","family":"Daim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngozi T","family":"Kanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1905239","article-title":"Lipoprotein(a) reduction in persons with cardiovascular disease","volume":"382","author":"Tsimikas S","year":"2020","unstructured":"Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, et al.. Lipoprotein(a) reduction in persons with cardiovascular disease. N Engl J Med. 2020, 382:244-55. 10.1056\/NEJMoa1905239","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.04.001","article-title":"Oxidized phospholipid modification of lipoprotein(a): epidemiology, biochemistry and pathophysiology","volume":"349","author":"Koschinsky ML","year":"2022","unstructured":"Koschinsky ML, Boffa MB. Oxidized phospholipid modification of lipoprotein(a): epidemiology, biochemistry and pathophysiology. Atherosclerosis. 2022, 349:92-100. 10.1016\/j.atherosclerosis.2022.04.001","journal-title":"Atherosclerosis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.02.006","article-title":"Lipoprotein lipase: biosynthesis, regulatory factors, and its role in atherosclerosis and other diseases","volume":"480","author":"He PP","year":"2018","unstructured":"He PP, Jiang T, OuYang XP, et al.. Lipoprotein lipase: biosynthesis, regulatory factors, and its role in atherosclerosis and other diseases. Clin Chim Acta. 2018, 480:126-37. 10.1016\/j.cca.2018.02.006","journal-title":"Clin Chim Acta"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26050","article-title":"Lipoprotein(a): a missing culprit in the management of athero-thrombosis?","volume":"233","author":"Ferretti G","year":"2018","unstructured":"Ferretti G, Bacchetti T, Johnston TP, Banach M, Pirro M, Sahebkar A. Lipoprotein(a): a missing culprit in the management of athero-thrombosis?. J Cell Physiol. 2018, 233:2966-81. 10.1002\/jcp.26050","journal-title":"J Cell Physiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-824048-9.00015-8","article-title":"Lipoprotein(a)","author":"Boffa MB","year":"2021","unstructured":"Boffa MB, Koschinsky ML. Lipoprotein(a). Elsevier eBooks, 2021. 10.1016\/b978-0-12-824048-9.00015-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5245308","article-title":"Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis","volume":"2020","author":"Khatana C","year":"2020","unstructured":"Khatana C, Saini NK, Chakrabarti S, Saini V, Sharma A, Saini RV, Saini AK. Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis. Oxid Med Cell Longev. 2020, 2020:5245308. 10.1155\/2020\/5245308","journal-title":"Oxid Med Cell Longev"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11070459","article-title":"Lipoprotein proteomics and aortic valve transcriptomics identify biological pathways linking lipoprotein(A) levels to aortic stenosis","volume":"11","author":"Bourgeois R","year":"2021","unstructured":"Bourgeois R, Bourgault J, Despres AA, et al.. Lipoprotein proteomics and aortic valve transcriptomics identify biological pathways linking lipoprotein(A) levels to aortic stenosis. Metabolites. 2021, 11:10.3390\/metabo11070459","journal-title":"Metabolites"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R060582","article-title":"Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease?","volume":"57","author":"Boffa MB","year":"2016","unstructured":"Boffa MB, Koschinsky ML. Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease?. J Lipid Res. 2016, 57:745-57. 10.1194\/jlr.R060582","journal-title":"J Lipid Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313864","article-title":"Potential causality and emerging medical therapies for lipoprotein(A) and its associated oxidized phospholipids in calcific aortic valve stenosis","volume":"124","author":"Tsimikas S","year":"2019","unstructured":"Tsimikas S. Potential causality and emerging medical therapies for lipoprotein(A) and its associated oxidized phospholipids in calcific aortic valve stenosis. Circ Res. 2019, 124:405-15. 10.1161\/CIRCRESAHA.118.313864","journal-title":"Circ Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.0929","article-title":"The functional role of lipoproteins in atherosclerosis: novel directions for diagnosis and targeting therapy","volume":"13","author":"Lu Y","year":"2022","unstructured":"Lu Y, Cui X, Zhang L, et al.. The functional role of lipoproteins in atherosclerosis: novel directions for diagnosis and targeting therapy. Aging Dis. 2022, 13:491-520. 10.14336\/AD.2021.0929","journal-title":"Aging Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000001077","article-title":"Lipoprotein(a): a genetic marker for cardiovascular disease and target for emerging therapies","volume":"22","author":"Cesaro A","year":"2021","unstructured":"Cesaro A, Schiavo A, Moscarella E, et al.. Lipoprotein(a): a genetic marker for cardiovascular disease and target for emerging therapies. J Cardiovasc Med (Hagerstown). 2021, 22:151-61. 10.2459\/JCM.0000000000001077","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1890","article-title":"Oxidized phospholipids and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) in atherosclerotic cardiovascular disease: an update","volume":"48","author":"Pantazi D","year":"2022","unstructured":"Pantazi D, Tellis C, Tselepis AD. Oxidized phospholipids and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) in atherosclerotic cardiovascular disease: an update. Biofactors. 2022, 48:1257-70. 10.1002\/biof.1890","journal-title":"Biofactors"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-024-04931-3","article-title":"Neutrophil extracellular traps: a catalyst for atherosclerosis","author":"Wang Y","year":"2024","unstructured":"Wang Y, Wang C, Li J. Neutrophil extracellular traps: a catalyst for atherosclerosis. Mol Cell Biochem. 2024, 10.1007\/s11010-024-04931-3","journal-title":"Mol Cell Biochem"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2020.06.001","article-title":"Lipoprotein(a): Expanding our knowledge of aortic valve narrowing","volume":"31","author":"Youssef A","year":"2021","unstructured":"Youssef A, Clark JR, Koschinsky ML, Boffa MB. Lipoprotein(a): Expanding our knowledge of aortic valve narrowing. Trends Cardiovasc Med. 2021, 31:305-11. 10.1016\/j.tcm.2020.06.001","journal-title":"Trends Cardiovasc Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018139","article-title":"A not-so-little role for lipoprotein(a) in the development of calcific aortic valve disease","volume":"132","author":"Rogers MA","year":"2015","unstructured":"Rogers MA, Aikawa E. A not-so-little role for lipoprotein(a) in the development of calcific aortic valve disease. Circulation. 2015, 132:621-3. 10.1161\/CIRCULATIONAHA.115.018139","journal-title":"Circulation"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/biom12010026","article-title":"Lipoprotein(a)-the crossroads of atherosclerosis, atherothrombosis and inflammation","volume":"12","author":"Ugov\u0161ek S","year":"2021","unstructured":"Ugov\u0161ek S, \u0160ebe\u0161tjen M. Lipoprotein(a)-the crossroads of atherosclerosis, atherothrombosis and inflammation. Biomolecules. 2021, 12:10.3390\/biom12010026","journal-title":"Biomolecules"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20186721","article-title":"Lipoprotein(a) as a risk factor for cardiovascular diseases: pathophysiology and treatment perspectives","volume":"20","author":"Vinci P","year":"2023","unstructured":"Vinci P, Di Girolamo FG, Panizon E, et al.. Lipoprotein(a) as a risk factor for cardiovascular diseases: pathophysiology and treatment perspectives. Int J Environ Res Public Health. 2023, 20:10.3390\/ijerph20186721","journal-title":"Int J Environ Res Public Health"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4103\/vit.vit_14_23","article-title":"Lipoprotein (a) in atherosclerosis: a bibliometric and visualization analysis","volume":"6","author":"Wang H","year":"2023","unstructured":"Wang H, Pan D, Liao L, et al.. Lipoprotein (a) in atherosclerosis: a bibliometric and visualization analysis. Vasc Investig Ther. 2023, 6:100-9. 10.4103\/vit.vit_14_23","journal-title":"Vasc Investig Ther"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28030969","article-title":"Lipoprotein(a) in atherosclerotic diseases: from pathophysiology to diagnosis and treatment","volume":"28","author":"Lampsas S","year":"2023","unstructured":"Lampsas S, Xenou M, Oikonomou E, et al.. Lipoprotein(a) in atherosclerotic diseases: from pathophysiology to diagnosis and treatment. Molecules. 2023, 28:10.3390\/molecules28030969","journal-title":"Molecules"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.923797","article-title":"Lipoprotein(A) in cardiovascular diseases: insight from a bibliometric study","volume":"10","author":"\u0160uran D","year":"2022","unstructured":"\u0160uran D, Bla\u017eun Vo\u0161ner H, Zavr\u0161nik J, et al.. Lipoprotein(A) in cardiovascular diseases: insight from a bibliometric study. Front Public Health. 2022, 10:923797. 10.3389\/fpubh.2022.923797","journal-title":"Front Public Health"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/265776-lipoproteinas-role-in-atherosclerosis-and-aortic-stenosis-a-contemporary-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T22:48:04Z","timestamp":1719182884000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/265776-lipoproteinas-role-in-atherosclerosis-and-aortic-stenosis-a-contemporary-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,23]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.62984","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,23]]}}}