{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:51:34Z","timestamp":1790794294123,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,26]]},"DOI":"10.7759\/cureus.63200","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T13:43:31Z","timestamp":1719409411000},"source":"Crossref","is-referenced-by-count":1,"title":["Monomeric C-Reactive Protein Potential Utilization in the Histological Assessment of Inflammatory Bowel Disease (IBD) Patients"],"prefix":"10.7759","author":[{"given":"Simona","family":"Muresan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Slevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emoke","family":"Szasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrada","family":"Loghin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2017.400","article-title":"Changing treatment paradigms for the management of inflammatory bowel disease","volume":"33","author":"Im JP","year":"2018","unstructured":"Im JP, Ye BD, Kim YS, Kim JS. Changing treatment paradigms for the management of inflammatory bowel disease. Korean J Intern Med. 2018, 33:28-35. 10.3904\/kjim.2017.400","journal-title":"Korean J Intern Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy113","article-title":"ECCO-ESGAR guideline for diagnostic assessment in IBD Part 1: initial diagnosis, monitoring of known IBD, detection of complications","volume":"13","author":"Maaser C","year":"2019","unstructured":"Maaser C, Sturm A, Vavricka SR, et al.. ECCO-ESGAR guideline for diagnostic assessment in IBD Part 1: initial diagnosis, monitoring of known IBD, detection of complications. J Crohns Colitis. 2019, 13:144-64. 10.1093\/ecco-jcc\/jjy113","journal-title":"J Crohns Colitis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.59009","article-title":"C-reactive protein: an inflammatory biomarker and a predictor of neurodegenerative disease in patients with inflammatory bowel disease?","volume":"16","author":"Muresan S","year":"2024","unstructured":"Muresan S, Slevin M. C-reactive protein: an inflammatory biomarker and a predictor of neurodegenerative disease in patients with inflammatory bowel disease?. Cureus. 2024, 16:e59009. 10.7759\/cureus.59009","journal-title":"Cureus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1204727","article-title":"Association between inflammatory bowel disease and risk of stroke: a systematic review and meta-analysis of cohort studies","volume":"14","author":"Fan JS","year":"2023","unstructured":"Fan JS, Wang M, Chen N, Sun BC, Zhang QB, Li Y, Huang MJ. Association between inflammatory bowel disease and risk of stroke: a systematic review and meta-analysis of cohort studies. Front Neurol. 2023, 14:10.3389\/fneur.2023.1204727","journal-title":"Front Neurol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5009\/gnl220523","article-title":"Inflammatory bowel disease and neurodegenerative diseases","volume":"17","author":"Kim JS","year":"2023","unstructured":"Kim JS, Chen MH, Wang HE, Lu CL, Wang YP, Zhang B. Inflammatory bowel disease and neurodegenerative diseases. Gut Liver. 2023, 17:495-504. 10.5009\/gnl220523","journal-title":"Gut Liver"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000437","article-title":"Histological remission in ulcerative colitis: under the microscope is the cure","volume":"115","author":"Chateau T","year":"2020","unstructured":"Chateau T, Feakins R, Marchal-Bressenot A, Magro F, Danese S, Peyrin-Biroulet L. Histological remission in ulcerative colitis: under the microscope is the cure. Am J Gastroenterol. 2020, 115:179-89. 10.14309\/ajg.0000000000000437","journal-title":"Am J Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000527846","article-title":"Positioning and usefulness of biomarkers in inflammatory bowel disease","volume":"104","author":"Sakurai T","year":"2023","unstructured":"Sakurai T, Saruta M. Positioning and usefulness of biomarkers in inflammatory bowel disease. Digestion. 2023, 104:30-41. 10.1159\/000527846","journal-title":"Digestion"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa110","article-title":"ECCO position paper: harmonization of the approach to ulcerative colitis histopathology","volume":"14","author":"Magro F","year":"2020","unstructured":"Magro F, Doherty G, Peyrin-Biroulet L, et al.. ECCO position paper: harmonization of the approach to ulcerative colitis histopathology. J Crohns Colitis. 2020, 14:1503-11. 10.1093\/ecco-jcc\/jjaa110","journal-title":"J Crohns Colitis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac006","article-title":"ECCO position on harmonisation of crohn's disease mucosal histopathology","volume":"16","author":"Magro F","year":"2022","unstructured":"Magro F, Sabino J, Rosini F, et al.. ECCO position on harmonisation of crohn's disease mucosal histopathology. J Crohns Colitis. 2022, 16:876-83. 10.1093\/ecco-jcc\/jjac006","journal-title":"J Crohns Colitis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11040939","article-title":"Histological scores in patients with inflammatory bowel diseases: the state of the art","volume":"11","author":"Vespa E","year":"2022","unstructured":"Vespa E, D'Amico F, Sollai M, et al.. Histological scores in patients with inflammatory bowel diseases: the state of the art. J Clin Med. 2022, 11:939. 10.3390\/jcm11040939","journal-title":"J Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000511641","article-title":"Biomarkers of inflammation in inflammatory bowel disease: how long before abandoning single-marker aproaches?","volume":"39","author":"Dragoni G","year":"2021","unstructured":"Dragoni G, Innocenti T, Galli A. Biomarkers of inflammation in inflammatory bowel disease: how long before abandoning single-marker aproaches?. Dig Dis. 2021, 39:190-203. 10.1159\/000511641","journal-title":"Dig Dis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.13164","article-title":"Monomeric C-reactive protein: a novel biomarker predicting neurodegenerative disease and vascular dysfunction","volume":"33","author":"Pastorello Y","year":"2023","unstructured":"Pastorello Y, Carare RO, Banescu C, Potempa L, Di Napoli M, Slevin M. Monomeric C-reactive protein: a novel biomarker predicting neurodegenerative disease and vascular dysfunction. Brain Pathol. 2023, 33:e13164. 10.1111\/bpa.13164","journal-title":"Brain Pathol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad087","article-title":"A comparative evaluation of the measurement properties of three histological indices of mucosal healing in ulcerative colitis: Geboes score, Robarts histopathology index and Nancy index","volume":"17","author":"Peyrin-Biroulet L","year":"2023","unstructured":"Peyrin-Biroulet L, Arenson E, Rubin DT, et al.. A comparative evaluation of the measurement properties of three histological indices of mucosal healing in ulcerative colitis: Geboes score, Robarts histopathology index and Nancy index. J Crohns Colitis. 2023, 17:1733-43. 10.1093\/ecco-jcc\/jjad087","journal-title":"J Crohns Colitis"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg407","article-title":"Tubular staining of modified C-reactive protein in diabetic chronic kidney disease","volume":"18","author":"Schwedler SB","year":"2003","unstructured":"Schwedler SB, Guderian F, D\u00e4mmrich J, Potempa LA, Wanner C. Tubular staining of modified C-reactive protein in diabetic chronic kidney disease. Nephrol Dial Transplant. 2003, 18:2300-7. 10.1093\/ndt\/gfg407","journal-title":"Nephrol Dial Transplant"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00256.x","article-title":"Modified C-reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesis in vitro","volume":"20","author":"Slevin M","year":"2010","unstructured":"Slevin M, Matou-Nasri S, Turu M, et al.. Modified C-reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesis in vitro. Brain Pathol. 2010, 20:151-65. 10.1111\/j.1750-3639.2008.00256.x","journal-title":"Brain Pathol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01995.x","article-title":"Leukaemia inhibitory factor is over-expressed by ischaemic brain tissue concomitant with reduced plasma expression following acute stroke","volume":"15","author":"Slevin M","year":"2008","unstructured":"Slevin M, Krupinski J, Mitsios N, et al.. Leukaemia inhibitory factor is over-expressed by ischaemic brain tissue concomitant with reduced plasma expression following acute stroke. Eur J Neurol. 2008, 15:29-37. 10.1111\/j.1468-1331.2007.01995.x","journal-title":"Eur J Neurol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012351","article-title":"Histologic scoring indices for evaluation of disease activity in Crohn\u2019s disease","volume":"2016","author":"Novak G","year":"2016","unstructured":"Novak G, Parker CE, Lacey C, et al.. Histologic scoring indices for evaluation of disease activity in Crohn\u2019s disease. Cochrane Database Syst Rev. 2016, 2016:10.1002\/14651858.CD012351","journal-title":"Cochrane Database Syst Rev"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.048","article-title":"Self-maintaining gut macrophages are essential for intestinal homeostasis","volume":"175","author":"De Schepper S","year":"2018","unstructured":"De Schepper S, Verheijden S, Aguilera-Lizarraga J, et al.. Self-maintaining gut macrophages are essential for intestinal homeostasis. Cell. 2018, 175:400-15. 10.1016\/j.cell.2018.07.048","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01386-9","article-title":"Macrophage polarization in inflammatory bowel disease","volume":"21","author":"Zhang K","year":"2023","unstructured":"Zhang K, Guo J, Yan W, Xu L. Macrophage polarization in inflammatory bowel disease. Cell Commun Signal. 2023, 21:367. 10.1186\/s12964-023-01386-9","journal-title":"Cell Commun Signal"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1170443","article-title":"Fueling the flames of colon cancer - does CRP play a direct pro-inflammatory role?","volume":"14","author":"K\u00f8stner AH","year":"2023","unstructured":"K\u00f8stner AH, Fuglestad AJ, Georgsen JB, et al.. Fueling the flames of colon cancer - does CRP play a direct pro-inflammatory role?. Front Immunol. 2023, 14:10.3389\/fimmu.2023.1170443","journal-title":"Front Immunol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01351","article-title":"Dissociation of C-reactive protein localizes and amplifies inflammation: evidence for a direct biological role of C-reactive protein and its conformational changes","volume":"9","author":"McFadyen JD","year":"2018","unstructured":"McFadyen JD, Kiefer J, Braig D, Loseff-Silver J, Potempa LA, Eisenhardt SU, Peter K. Dissociation of C-reactive protein localizes and amplifies inflammation: evidence for a direct biological role of C-reactive protein and its conformational changes. Front Immunol. 2018, 9:1351. 10.3389\/fimmu.2018.01351","journal-title":"Front Immunol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00430","article-title":"C-reactive protein in atherothrombosis and angiogenesis","volume":"9","author":"Badimon L","year":"2018","unstructured":"Badimon L, Pe\u00f1a E, Arderiu G, Padr\u00f3 T, Slevin M, Vilahur G, Chiva-Blanch G. C-reactive protein in atherothrombosis and angiogenesis. Front Immunol. 2018, 9:430. 10.3389\/fimmu.2018.00430","journal-title":"Front Immunol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.14670\/HH-24.1473","article-title":"A role for monomeric C-reactive protein in regulation of angiogenesis, endothelial cell inflammation and thrombus formation in cardiovascular\/cerebrovascular disease?","volume":"24","author":"Slevin M","year":"2009","unstructured":"Slevin M, Krupinski J. A role for monomeric C-reactive protein in regulation of angiogenesis, endothelial cell inflammation and thrombus formation in cardiovascular\/cerebrovascular disease?. Histol Histopathol. 2009, 24:1473-8. 10.14670\/HH-24.1473","journal-title":"Histol Histopathol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202212_30543","article-title":"Association of monomeric c-reactive protein (m-CRP) with hypothalamic neurons after CRP hippo-campal administration in a model of dementia","volume":"26","author":"Al-Baradie RS","year":"2022","unstructured":"Al-Baradie RS, Abdel-Hadi A, Ahmad F, et al.. Association of monomeric c-reactive protein (m-CRP) with hypothalamic neurons after CRP hippo-campal administration in a model of dementia. Eur Rev Med Pharmacol Sci. 2022, 26:8713-8. 10.26355\/eurrev_202212_30543","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.866379","article-title":"Monomeric c-reactive protein: current perspectives for utilization and inclusion as a prognostic indicator and therapeutic target","volume":"13","author":"Slevin M","year":"2022","unstructured":"Slevin M, Heidari N, Azamfirei L. Monomeric c-reactive protein: current perspectives for utilization and inclusion as a prognostic indicator and therapeutic target. Front Immunol. 2022, 13:866379. 10.3389\/fimmu.2022.866379","journal-title":"Front Immunol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/266722-monomeric-c-reactive-protein-potential-utilization-in-the-histological-assessment-of-inflammatory-bowel-disease-ibd-patients","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T13:43:35Z","timestamp":1719409415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/266722-monomeric-c-reactive-protein-potential-utilization-in-the-histological-assessment-of-inflammatory-bowel-disease-ibd-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.63200","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,26]]}}}