{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:16:07Z","timestamp":1777652167629,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,26]]},"DOI":"10.7759\/cureus.63208","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T15:06:06Z","timestamp":1719414366000},"source":"Crossref","is-referenced-by-count":2,"title":["The Effect of a Casein and Gluten-Free Diet on the Epigenetic Characteristics of FoxP3 in Patients With Hashimoto's Thyroiditis"],"prefix":"10.7759","author":[{"given":"Elif  S","family":"Aslan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulsen","family":"Meral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ece","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"Caglayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aytug","family":"Altundag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyda","family":"Demirkol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gizem","family":"Gormus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Solak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furkan","family":"Ayaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.32322\/jhsm.1243597","article-title":"Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimato's thyroiditis: a clinical and molecular docking study","volume":"6","author":"Aslan ES","year":"2023","unstructured":"Aslan ES, Sava\u015f GUR. Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimato's thyroiditis: a clinical and molecular docking study. J Health Sci Med. 2023, 6:705-12. 10.32322\/jhsm.1243597","journal-title":"J Health Sci Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00396","article-title":"The emerging role of epigenetics in autoimmune thyroid diseases","volume":"8","author":"Wang B","year":"2017","unstructured":"Wang B, Shao X, Song R, Xu D, Zhang JA. The emerging role of epigenetics in autoimmune thyroid diseases. Front Immunol. 2017, 8:396. 10.3389\/fimmu.2017.00396","journal-title":"Front Immunol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0470-8","article-title":"Foxp3, regulatory T cell, and autoimmune diseases","volume":"40","author":"Tao JH","year":"2017","unstructured":"Tao JH, Cheng M, Tang JP, Liu Q, Pan F, Li XP. Foxp3, regulatory T cell, and autoimmune diseases. Inflammation. 2017, 40:328-39. 10.1007\/s10753-016-0470-8","journal-title":"Inflammation"},{"key":"ref4","article-title":"Nutrigenetik-Epigenetik","author":"Meral G","year":"2023","unstructured":"Meral G, Aslan ES. Nutrigenetik-Epigenetik. T\u00fcrkiye Bilimler Akademisi, 2023."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0632-2","article-title":"The emerging role of epigenetics in human autoimmune disorders","volume":"11","author":"Mazzone R","year":"2019","unstructured":"Mazzone R, Zwergel C, Artico M, Taurone S, Ralli M, Greco A, Mai A. The emerging role of epigenetics in human autoimmune disorders. Clin Epigenetics. 2019, 11:34. 10.1186\/s13148-019-0632-2","journal-title":"Clin Epigenetics"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab526","article-title":"Analysis of expression of different histone deacetylases in autoimmune thyroid disease","volume":"106","author":"Sacrist\u00e1n-G\u00f3mez P","year":"2021","unstructured":"Sacrist\u00e1n-G\u00f3mez P, Serrano-Somavilla A, Gonz\u00e1lez-Amaro R, Mart\u00ednez-Hern\u00e1ndez R, Marazuela M. Analysis of expression of different histone deacetylases in autoimmune thyroid disease. J Clin Endocrinol Metab. 2021, 106:3213-27. 10.1210\/clinem\/dgab526","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2016.31.4.493","article-title":"Clinical update in aspects of the management of autoimmune thyroid diseases","volume":"31","author":"Topliss DJ","year":"2016","unstructured":"Topliss DJ. Clinical update in aspects of the management of autoimmune thyroid diseases. Endocrinol Metab (Seoul). 2016, 31:493-9. 10.3803\/EnM.2016.31.4.493","journal-title":"Endocrinol Metab (Seoul)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/ni1455","article-title":"Foxp3 in control of the regulatory T cell lineage","volume":"8","author":"Zheng Y","year":"2007","unstructured":"Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol. 2007, 8:457-62. 10.1038\/ni1455","journal-title":"Nat Immunol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nux054","article-title":"Adverse effects of gluten ingestion and advantages of gluten withdrawal in nonceliac autoimmune disease","volume":"75","author":"Lerner A","year":"2017","unstructured":"Lerner A, Shoenfeld Y, Matthias T. Adverse effects of gluten ingestion and advantages of gluten withdrawal in nonceliac autoimmune disease. Nutr Rev. 2017, 75:1046-58. 10.1093\/nutrit\/nux054","journal-title":"Nutr Rev"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.07.004","article-title":"The role of FOXP3 in autoimmunity","volume":"43","author":"Pesenacker AM","year":"2016","unstructured":"Pesenacker AM, Cook L, Levings MK. The role of FOXP3 in autoimmunity. Curr Opin Immunol. 2016, 43:16-23. 10.1016\/j.coi.2016.07.004","journal-title":"Curr Opin Immunol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03136","article-title":"Molecular mechanisms controlling FOXP3 expression in health and autoimmunity: from epigenetic to post-translational regulation","volume":"10","author":"Colamatteo A","year":"2019","unstructured":"Colamatteo A, Carbone F, Bruzzaniti S, et al.. Molecular mechanisms controlling FOXP3 expression in health and autoimmunity: from epigenetic to post-translational regulation. Front Immunol. 2019, 10:3136. 10.3389\/fimmu.2019.03136","journal-title":"Front Immunol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0252-z","article-title":"Epigenetic features of FoxP3 in children with cow's milk allergy","volume":"8","author":"Paparo L","year":"2016","unstructured":"Paparo L, Nocerino R, Cosenza L, et al.. Epigenetic features of FoxP3 in children with cow's milk allergy. Clin Epigenetics. 2016, 8:86. 10.1186\/s13148-016-0252-z","journal-title":"Clin Epigenetics"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-019-00684-7","article-title":"Regulatory T cells: the many faces of foxp3","volume":"39","author":"Georgiev P","year":"2019","unstructured":"Georgiev P, Charbonnier LM, Chatila TA. Regulatory T cells: the many faces of foxp3. J Clin Immunol. 2019, 39:623-40. 10.1007\/s10875-019-00684-7","journal-title":"J Clin Immunol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/nri3650","article-title":"FOXP3 and scurfy: how it all began","volume":"14","author":"Ramsdell F","year":"2014","unstructured":"Ramsdell F, Ziegler SF. FOXP3 and scurfy: how it all began. Nat Rev Immunol. 2014, 14:343-9. 10.1038\/nri3650","journal-title":"Nat Rev Immunol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2424","article-title":"The Foxp3 interactome: a network perspective of T(reg) cells","volume":"13","author":"Hori S","year":"2012","unstructured":"Hori S. The Foxp3 interactome: a network perspective of T(reg) cells. Nat Immunol. 2012, 13:943-5. 10.1038\/ni.2424","journal-title":"Nat Immunol"},{"key":"ref16","article-title":"The future of ovarian cancer treatment: the promise of epigenetic markers","volume":"93","author":"Alghazawi F","year":"2023","unstructured":"Alghazawi F, Azami N, Dehghani A. The future of ovarian cancer treatment: the promise of epigenetic markers. Curr Res Health Sci. 2023, 93:","journal-title":"Curr Res Health Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00598-9","article-title":"FOXP3 as a master regulator of T(reg) cells","volume":"21","author":"Hori S","year":"2021","unstructured":"Hori S. FOXP3 as a master regulator of T(reg) cells. Nat Rev Immunol. 2021, 21:618-9. 10.1038\/s41577-021-00598-9","journal-title":"Nat Rev Immunol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2021.104412","article-title":"Targeting immunosuppressor cells with nanoparticles in autoimmunity: how far have we come to?","volume":"368","author":"Ahmad S","year":"2021","unstructured":"Ahmad S, Al-Hatamleh MA, Mohamud R. Targeting immunosuppressor cells with nanoparticles in autoimmunity: how far have we come to?. Cell Immunol. 2021, 368:104412. 10.1016\/j.cellimm.2021.104412","journal-title":"Cell Immunol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-16073-9_21","article-title":"Nutrition, immunity, and autoimmune diseases","author":"Arabi S","year":"2019","unstructured":"Arabi S, Molazadeh M; Rezaei N. Nutrition, immunity, and autoimmune diseases. Nutr Immun. 2019, 415-36. 10.1007\/978-3-030-16073-9_21","journal-title":"Nutr Immun"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuab073","article-title":"A systematic review and meta-analysis of the benefits of a gluten-free diet and\/or casein-free diet for children with autism spectrum disorder","volume":"80","author":"Quan L","year":"2022","unstructured":"Quan L, Xu X, Cui Y, Han H, Hendren RL, Zhao L, You X. A systematic review and meta-analysis of the benefits of a gluten-free diet and\/or casein-free diet for children with autism spectrum disorder. Nutr Rev. 2022, 80:1237-46. 10.1093\/nutrit\/nuab073","journal-title":"Nutr Rev"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020470","article-title":"The effect of a combined gluten- and casein-free diet on children and adolescents with autism spectrum disorders: a systematic review and meta-analysis","volume":"13","author":"Keller A","year":"2021","unstructured":"Keller A, Rimestad ML, Friis Rohde J, et al.. The effect of a combined gluten- and casein-free diet on children and adolescents with autism spectrum disorders: a systematic review and meta-analysis. Nutrients. 2021, 13:470. 10.3390\/nu13020470","journal-title":"Nutrients"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.09.009","article-title":"The association of other autoimmune diseases in patients with autoimmune thyroiditis: Review of the literature and report of a large series of patients","volume":"15","author":"Fallahi P","year":"2016","unstructured":"Fallahi P, Ferrari SM, Ruffilli I, et al.. The association of other autoimmune diseases in patients with autoimmune thyroiditis: Review of the literature and report of a large series of patients. Autoimmun Rev. 2016, 15:1125-8. 10.1016\/j.autrev.2016.09.009","journal-title":"Autoimmun Rev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac664","article-title":"DNA methylation in autoimmune thyroid disease","volume":"108","author":"Lafontaine N","year":"2023","unstructured":"Lafontaine N, Wilson SG, Walsh JP. DNA methylation in autoimmune thyroid disease. J Clin Endocrinol Metab. 2023, 108:604-13. 10.1210\/clinem\/dgac664","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa975","article-title":"Epigenome-wide association study of thyroid function traits identifies novel associations of FT3 with Klf9 and DOT1L","volume":"106","author":"Lafontaine N","year":"2021","unstructured":"Lafontaine N, Campbell PJ, Castillo-Fernandez JE, et al.. Epigenome-wide association study of thyroid function traits identifies novel associations of FT3 with Klf9 and DOT1L. J Clin Endocrinol Metab. 2021, 106:e2191-202. 10.1210\/clinem\/dgaa975","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060918","article-title":"Molecular mechanisms in autoimmune thyroid disease","volume":"12","author":"Vargas-Uricoechea H","year":"2023","unstructured":"Vargas-Uricoechea H. Molecular mechanisms in autoimmune thyroid disease. Cells. 2023, 12:918. 10.3390\/cells12060918","journal-title":"Cells"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00149","article-title":"Epigenetics and autoimmune thyroid diseases","volume":"8","author":"Copped\u00e8 F","year":"2017","unstructured":"Copped\u00e8 F. Epigenetics and autoimmune thyroid diseases. Front Endocrinol (Lausanne). 2017, 8:149. 10.3389\/fendo.2017.00149","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104713","article-title":"Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics","volume":"9","author":"Tomer Y","year":"2014","unstructured":"Tomer Y. Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics. Annu Rev Pathol. 2014, 9:147-56. 10.1146\/annurev-pathol-012513-104713","journal-title":"Annu Rev Pathol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/all.13299","article-title":"Altered miR-193a-5p expression in children with cow's milk allergy","volume":"73","author":"D'Argenio V","year":"2018","unstructured":"D'Argenio V, Del Monaco V, Paparo L, et al.. Altered miR-193a-5p expression in children with cow's milk allergy. Allergy. 2018, 73:379-86. 10.1111\/all.13299","journal-title":"Allergy"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1259903","article-title":"Genome-wide DNA methylation pattern in whole blood of patients with Hashimoto thyroiditis","volume":"14","author":"Zhou Z","year":"2023","unstructured":"Zhou Z, Liu J, Chen Y, et al.. Genome-wide DNA methylation pattern in whole blood of patients with Hashimoto thyroiditis. Front Endocrinol (Lausanne). 2023, 14:1259903. 10.3389\/fendo.2023.1259903","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38738-w","article-title":"Randomized controlled trial on the influence of dietary intervention on epigenetic mechanisms in children with cow's milk allergy: the EPICMA study","volume":"9","author":"Paparo L","year":"2019","unstructured":"Paparo L, Nocerino R, Bruno C, et al.. Randomized controlled trial on the influence of dietary intervention on epigenetic mechanisms in children with cow's milk allergy: the EPICMA study. Sci Rep. 2019, 9:2828. 10.1038\/s41598-019-38738-w","journal-title":"Sci Rep"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3833","article-title":"Evaluation of the effect of gluten-free diet and Mediterranean diet on autoimmune system in patients with Hashimoto's thyroiditis","volume":"12","author":"\u00dclker MT","year":"2024","unstructured":"\u00dclker MT, \u00c7olak GA, Ba\u015f M, Erdem MG. Evaluation of the effect of gluten-free diet and Mediterranean diet on autoimmune system in patients with Hashimoto's thyroiditis. Food Sci Nutr. 2024, 12:1180-8. 10.1002\/fsn3.3833","journal-title":"Food Sci Nutr"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12007","article-title":"Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB\/c mice","volume":"138","author":"Antvorskov JC","year":"2013","unstructured":"Antvorskov JC, Fundova P, Buschard K, Funda DP. Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB\/c mice. Immunology. 2013, 138:23-33. 10.1111\/imm.12007","journal-title":"Immunology"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601751","article-title":"Role of substance P neuropeptide in inflammation, wound healing, and tissue homeostasis","volume":"199","author":"Suvas S","year":"2017","unstructured":"Suvas S. Role of substance P neuropeptide in inflammation, wound healing, and tissue homeostasis. J Immunol. 2017, 199:1543-52. 10.4049\/jimmunol.1601751","journal-title":"J Immunol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/262618-the-effect-of-a-casein-and-gluten-free-diet-on-the-epigenetic-characteristics-of-foxp3-in-patients-with-hashimotos-thyroiditis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T15:06:11Z","timestamp":1719414371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/262618-the-effect-of-a-casein-and-gluten-free-diet-on-the-epigenetic-characteristics-of-foxp3-in-patients-with-hashimotos-thyroiditis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":33,"URL":"https:\/\/doi.org\/10.7759\/cureus.63208","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,26]]}}}