{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:01:02Z","timestamp":1773396062805,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,26]]},"DOI":"10.7759\/cureus.63214","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T16:13:02Z","timestamp":1719418382000},"source":"Crossref","is-referenced-by-count":1,"title":["Non-surgical Treatment of Severe Drug-Influenced Gingival Enlargement: A Report of Two Cases"],"prefix":"10.7759","author":[{"given":"Ibrahim","family":"Fidan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Delamotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Laure","family":"Colombier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevimy","family":"Agossa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199615030-00007","article-title":"Gingival enlargement induced by drugs","volume":"15","author":"Brunet L","year":"1996","unstructured":"Brunet L, Miranda J, Farr\u00e9 M, Berini L, Mendieta C. Gingival enlargement induced by drugs. Drug Saf. 1996, 15:219-31. 10.2165\/00002018-199615030-00007","journal-title":"Drug Saf"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01878.x","article-title":"Drug-induced gingival overgrowth: a study in the French Pharmacovigilance Database","volume":"39","author":"Bondon-Guitton E","year":"2012","unstructured":"Bondon-Guitton E, Bagheri H, Montastruc JL. Drug-induced gingival overgrowth: a study in the French Pharmacovigilance Database. J Clin Periodontol. 2012, 39:513-8. 10.1111\/j.1600-051X.2012.01878.x","journal-title":"J Clin Periodontol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.10.1424","article-title":"Informational Paper: drug-associated gingival enlargement","volume":"75","year":"2004","unstructured":"Informational Paper. drug-associated gingival enlargement. J Periodontol. 2004, 75:1424-31. 10.1902\/jop.2004.75.10.1424","journal-title":"J Periodontol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515571265","article-title":"Molecular and clinical aspects of drug-induced gingival overgrowth","volume":"94","author":"Trackman PC","year":"2015","unstructured":"Trackman PC, Kantarci A. Molecular and clinical aspects of drug-induced gingival overgrowth. J Dent Res. 2015, 94:540-6. 10.1177\/0022034515571265","journal-title":"J Dent Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25009","article-title":"Refining the mechanism of drug-influenced gingival enlargement and its management","volume":"14","author":"Sabarudin MA","year":"2022","unstructured":"Sabarudin MA, Taib H, Wan Mohamad WM. Refining the mechanism of drug-influenced gingival enlargement and its management. Cureus. 2022, 14:e25009. 10.7759\/cureus.25009","journal-title":"Cureus"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027004217.x","article-title":"Risk factors for drug-induced gingival overgrowth","volume":"27","author":"Seymour RA","year":"2000","unstructured":"Seymour RA, Ellis JS, Thomason JM. Risk factors for drug-induced gingival overgrowth. J Clin Periodontol. 2000, 27:217-23. 10.1034\/j.1600-051x.2000.027004217.x","journal-title":"J Clin Periodontol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0095","article-title":"Dental plaque-induced gingival conditions","volume":"89 Suppl 1","author":"Murakami S","year":"2018","unstructured":"Murakami S, Mealey BL, Mariotti A, Chapple IL. Dental plaque-induced gingival conditions. J Periodontol. 2018, 89 Suppl 1:S17-27. 10.1002\/JPER.17-0095","journal-title":"J Periodontol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.10.020","article-title":"Management of medication-induced gingival hyperplasia: a systematic review","volume":"131","author":"Mawardi H","year":"2021","unstructured":"Mawardi H, Alsubhi A, Salem N, Alhadlaq E, Dakhil S, Zahran M, Elbadawi L. Management of medication-induced gingival hyperplasia: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2021, 131:62-72. 10.1016\/j.oooo.2020.10.020","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4067\/S2452-55882021000200184","article-title":"Non-surgical periodontal treatment for drug-influenced gingival enlargement: a four-year follow-up case report","volume":"14","author":"Srynczyk-da Silva F","year":"2021","unstructured":"Srynczyk-da Silva F, Hisse-Gomes G, Rilling-Nova Cruz LE, Aitken-Saavedra JP, Martos J. Non-surgical periodontal treatment for drug-influenced gingival enlargement: a four-year follow-up case report. Int J Interdiscip Dent. 2021, 14:184-86. 10.4067\/S2452-55882021000200184","journal-title":"Int J Interdiscip Dent"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89 Suppl 1","author":"Papapanou PN","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, et al.. Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018, 89 Suppl 1:S173-82. 10.1002\/JPER.17-0721","journal-title":"J Periodontol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.omsc.2020.100143","article-title":"Severe drug-induced gingival enlargement and periodontitis: a case series with clinical presentation and management","volume":"6","author":"Deeb JG","year":"2020","unstructured":"Deeb JG, Lyons DJ, Laskin DM, Deeb GR. Severe drug-induced gingival enlargement and periodontitis: a case series with clinical presentation and management. Oral Maxillofac Surg Cases. 2020, 6:100143. 10.1016\/j.omsc.2020.100143","journal-title":"Oral Maxillofac Surg Cases"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290","article-title":"Treatment of stage I-III periodontitis-the EFP S3 level clinical practice guideline","volume":"47 Suppl 22","author":"Sanz M","year":"2020","unstructured":"Sanz M, Herrera D, Kebschull M, et al.. Treatment of stage I-III periodontitis-the EFP S3 level clinical practice guideline. J Clin Periodontol. 2020, 47 Suppl 22:4-60. 10.1111\/jcpe.13290","journal-title":"J Clin Periodontol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808701110","article-title":"Mechanism of azithromycin treatment on gingival overgrowth","volume":"87","author":"Kim JY","year":"2008","unstructured":"Kim JY, Park SH, Cho KS, et al.. Mechanism of azithromycin treatment on gingival overgrowth. J Dent Res. 2008, 87:1075-9. 10.1177\/154405910808701110","journal-title":"J Dent Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.04.004","article-title":"Effect of metronidazole and modulation of cytokine production on human periodontal ligament cells","volume":"10","author":"Rizzo A","year":"2010","unstructured":"Rizzo A, Paolillo R, Guida L, Annunziata M, Bevilacqua N, Tufano MA. Effect of metronidazole and modulation of cytokine production on human periodontal ligament cells. Int Immunopharmacol. 2010, 10:744-50. 10.1016\/j.intimp.2010.04.004","journal-title":"Int Immunopharmacol"},{"key":"ref15","article-title":"Drug-induced gingival enlargement: a review of diagnosis and current treatment strategies","volume":"43","author":"Barsoum F","year":"2022","unstructured":"Barsoum F, Prete BR, Ouanounou A. Drug-induced gingival enlargement: a review of diagnosis and current treatment strategies. Compend Contin Educ Dent. 2022, 43:276-85.","journal-title":"Compend Contin Educ Dent"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13264","article-title":"Adjunctive effect of systemic antimicrobials in periodontitis therapy: a systematic review and meta-analysis","volume":"47 Suppl 22","author":"Teughels W","year":"2020","unstructured":"Teughels W, Feres M, Oud V, Mart\u00edn C, Matesanz P, Herrera D. Adjunctive effect of systemic antimicrobials in periodontitis therapy: a systematic review and meta-analysis. J Clin Periodontol. 2020, 47 Suppl 22:257-81. 10.1111\/jcpe.13264","journal-title":"J Clin Periodontol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.9.848","article-title":"The influence of supragingival plaque control on clinical and microbial outcomes following the use of antibiotics for the treatment of periodontitis","volume":"65","author":"Kornman KS","year":"1994","unstructured":"Kornman KS, Newman MG, Moore DJ, Singer RE. The influence of supragingival plaque control on clinical and microbial outcomes following the use of antibiotics for the treatment of periodontitis. J Periodontol. 1994, 65:848-54. 10.1902\/jop.1994.65.9.848","journal-title":"J Periodontol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2019.06.017","article-title":"Impact of antibiotic prophylaxis on the incidence, nature, magnitude, and duration of bacteremia associated with dental procedures: a systematic review","volume":"150","author":"Lafaurie GI","year":"2019","unstructured":"Lafaurie GI, Noriega LA, Torres CC, et al.. Impact of antibiotic prophylaxis on the incidence, nature, magnitude, and duration of bacteremia associated with dental procedures: a systematic review. J Am Dent Assoc. 2019, 150:948-959.e4. 10.1016\/j.adaj.2019.06.017","journal-title":"J Am Dent Assoc"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12426","article-title":"Management of periodontal disease in patients using calcium channel blockers - gingival overgrowth, prescribed medications, treatment responses and added treatment costs","volume":"42","author":"Fardal \u00d8","year":"2015","unstructured":"Fardal \u00d8, Lygre H. Management of periodontal disease in patients using calcium channel blockers - gingival overgrowth, prescribed medications, treatment responses and added treatment costs. J Clin Periodontol. 2015, 42:640-6. 10.1111\/jcpe.12426","journal-title":"J Clin Periodontol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/249014-non-surgical-treatment-of-severe-drug-influenced-gingival-enlargement-a-report-of-two-cases","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T16:13:05Z","timestamp":1719418385000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/249014-non-surgical-treatment-of-severe-drug-influenced-gingival-enlargement-a-report-of-two-cases"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.63214","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,26]]}}}