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Cardiovasc Res. 2020, 116:1972-80. 10.1093\/cvr\/cvz290","journal-title":"Cardiovasc Res"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0673-8","article-title":"Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis","volume":"18","author":"Zhang X","year":"2017","unstructured":"Zhang X, Donnan PT, Bell S, Guthrie B. Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis. 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