{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:03:15Z","timestamp":1787500995305,"version":"build-2736575974"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,5]]},"DOI":"10.7759\/cureus.63930","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:42:10Z","timestamp":1720226530000},"source":"Crossref","is-referenced-by-count":1,"title":["Studies on In Vitro Antimicrobial, Anticancer, and Anti-oxidative Inflammatory Response of Methanolic Tuber Extracts Derived From Terminalia chebula"],"prefix":"10.7759","author":[{"given":"Devadharshini","family":"Suresh kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arockia","family":"Alex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahma","family":"Neha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"R","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugumar","family":"Vimal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"","author":"Bhat RA","year":"2021","unstructured":"Bhat RA, Hakeem KR, Dervash MA. Phytomedicine: A Treasure of Pharmacologically Active Products from Plants.  Bhat RA, Dervash MA, Hakeem RK (ed): Elsevier Science, Amsterdam, Netherland; 2021. https:\/\/www.google.co.in\/books\/edition\/Phytomedicine\/I-P7DwAAQBAJ?hl=en&gbpv=0."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(13)60059-3","article-title":"The development of Terminalia chebula Retz. (Combretaceae) in clinical research","volume":"3","author":"Bag A","year":"2013","unstructured":"Bag A, Bhattacharyya SK, Chattopadhyay RR. The development of Terminalia chebula Retz. (Combretaceae) in clinical research. Asian Pac J Trop Biomed. 2013, 3:244-52. 10.1016\/S2221-1691(13)60059-3","journal-title":"Asian Pac J Trop Biomed"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-28780-0_9","article-title":"Medicinal plants in the Indian traditional medicine and current practices","author":"Basu R","year":"2023","unstructured":"Basu R, Dasgupta S, Babu SN, Noor A. Medicinal plants in the Indian traditional medicine and current practices. Bioprospecting of Tropical Medicinal Plants. Arunachalam K, Yang X, Puthanpura Sasidharan S (ed): Springer Nature,  Cham, Switzerland; 2023. 253-86. 10.1007\/978-3-031-28780-0_9"},{"key":"ref4","article-title":"Forests, trees and human health and well-being: introduction","author":"Nilsson K","year":"2010","unstructured":"Nilsson K, Sangster M, Konijnendijk CC. Forests, trees and human health and well-being: introduction. Forests, Trees and Human Health. Springer Link, Dordrecht, Netherlands; 2010. 1-19."},{"key":"ref5","article-title":"Treasures Hunt in old mines: Terminalia chebula-based traditional herbal medicinal products","volume":"5","author":"Riaz M","year":"2015","unstructured":"Riaz M, Asghar A, Rashid R, Syed S. Treasures Hunt in old mines: Terminalia chebula-based traditional herbal medicinal products. J Nat Prod. 2015, 5:252-67.","journal-title":"J Nat Prod"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12088-018-0754-9","article-title":"Terminalia chebula Retz. fruit extracts inhibit bacterial triggers of some autoimmune diseases and potentiate the activity of tetracycline","volume":"58","author":"Mandeville A","year":"2018","unstructured":"Mandeville A, Cock IE. Terminalia chebula Retz. fruit extracts inhibit bacterial triggers of some autoimmune diseases and potentiate the activity of tetracycline. Indian J Microbiol. 2018, 58:496-506. 10.1007\/s12088-018-0754-9","journal-title":"Indian J Microbiol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-006-0139-4","article-title":"Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes","volume":"81","author":"Lee HS","year":"2007","unstructured":"Lee HS, Jung SH, Yun BS, Lee KW. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxicol. 2007, 81:211-8. 10.1007\/s00204-006-0139-4","journal-title":"Arch Toxicol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117428","article-title":"Terminalia chebula Retz. aqueous extract inhibits the Helicobacter pylori-induced inflammatory response by regulating the inflammasome signaling and ER-stress pathway","volume":"320","author":"Ou L","year":"2024","unstructured":"Ou L, Liu HR, Shi XY, et al.. Terminalia chebula Retz. aqueous extract inhibits the Helicobacter pylori-induced inflammatory response by regulating the inflammasome signaling and ER-stress pathway. J Ethnopharmacol. 2024, 320:117428. 10.1016\/j.jep.2023.117428","journal-title":"J Ethnopharmacol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.467","article-title":"Antibacterial and antioxidant effect of ethanol extracts of Terminalia chebula on Streptococcus mutans","volume":"7","author":"Nam YJ","year":"2021","unstructured":"Nam YJ, Hwang YS. Antibacterial and antioxidant effect of ethanol extracts of Terminalia chebula on Streptococcus mutans. Clin Exp Dent Res. 2021, 7:987-94. 10.1002\/cre2.467","journal-title":"Clin Exp Dent Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5555\/20143278738","article-title":"Evaluation of antitussive activity of fruits of Terminalia chebula Retz. on cough reflex induced by different cough induced models in mice","volume":"5","author":"Sweta S","year":"2014","unstructured":"Sweta S, Choudhary GP. Evaluation of antitussive activity of fruits of Terminalia chebula Retz. on cough reflex induced by different cough induced models in mice. Int J Univers Pharm Life Sci. 2014, 5:3497. 10.5555\/20143278738","journal-title":"Int J Univers Pharm Life Sci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1399","article-title":"Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens","volume":"17","author":"Vonshak A","year":"2003","unstructured":"Vonshak A, Barazani O, Sathiyamoorthy P, Shalev R, Vardy D, Golan-Goldhirsh A. Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens. Phytother Res. 2003, 17:1123-5. 10.1002\/ptr.1399","journal-title":"Phytother Res"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2010.488631","article-title":"Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae)","volume":"24","author":"Manosroi A","year":"2010","unstructured":"Manosroi A, Jantrawut P, Akazawa H, Akihisa T, Manosroi J. Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae). Nat Prod Res. 2010, 24:1915-26. 10.1080\/14786419.2010.488631","journal-title":"Nat Prod Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.02.037","article-title":"Antioxidant activity of Smilax excelsa L. leaf extracts","volume":"110","author":"Ozsoy N","year":"2008","unstructured":"Ozsoy N, Can A, Yanardag R, Akev A. Antioxidant activity of Smilax excelsa L. leaf extracts. Food Chem. 2008, 110:571-83. 10.1016\/j.foodchem.2008.02.037","journal-title":"Food Chem"},{"key":"ref14","article-title":"Antioxidant, antibacterial and anti-inflammatory activity of Acalypha indica and Terminalia chebula: an in-vitro analysis","volume":"6","author":"E. Soruba","year":"2015","unstructured":"E. Soruba, Sundaram V, Manian RP,  Kulanthaivelu K, Balasundaram S. Antioxidant, antibacterial and anti-inflammatory activity of Acalypha indica and Terminalia chebula: an in-vitro analysis. CABI digital library. 2015, 6:180-8.","journal-title":"CABI digital library"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bionut.2013.03.009","article-title":"Cytotoxicity induction by ethanolic extract of Acalypha indica loaded casein-chitosan microparticles in human prostate cancer cell line in vitro","volume":"4","author":"Amarnath K","year":"2014","unstructured":"Amarnath K, Dhanabal J, Agarwal I, Seshadry S. Cytotoxicity induction by ethanolic extract of Acalypha indica loaded casein-chitosan microparticles in human prostate cancer cell line in vitro. Biomed Prev Nutr. 2014, 4:445-50. 10.1016\/j.bionut.2013.03.009","journal-title":"Biomed Prev Nutr"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01428-9","article-title":"Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study","volume":"32","author":"El-Shamarka ME","year":"2024","unstructured":"El-Shamarka ME, Aboulthana WM, Omar NI, Mahfouz MM. Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study. Inflammopharmacology. 2024, 32:1439-60. 10.1007\/s10787-024-01428-9","journal-title":"Inflammopharmacology"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/phrev.phrev_21_17","article-title":"Developing new antimicrobial therapies: are synergistic combinations of plant extracts\/compounds with conventional antibiotics the solution?","volume":"11","author":"Cheesman MJ","year":"2017","unstructured":"Cheesman MJ, Ilanko A, Blonk B, Cock IE. Developing new antimicrobial therapies: are synergistic combinations of plant extracts\/compounds with conventional antibiotics the solution?. Pharmacogn Rev. 2017, 11:57-72. 10.4103\/phrev.phrev_21_17","journal-title":"Pharmacogn Rev"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2174\/0115680096294098240123104657","article-title":"PPT1 promotes growth and inhibits ferroptosis of oral squamous cell carcinoma cells","volume":"24","author":"Luo Q","year":"2024","unstructured":"Luo Q, Hu S, Tang Y, Yang D, Chen Q. PPT1 promotes growth and inhibits ferroptosis of oral squamous cell carcinoma cells. Curr Cancer Drug Targets. 2024, 24:1040-60. 10.2174\/0115680096294098240123104657","journal-title":"Curr Cancer Drug Targets"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2013.02.011","article-title":"Determination of apoptotic and necrotic cell death in vitro and in vivo","volume":"61","author":"Vanden Berghe T","year":"2013","unstructured":"Vanden Berghe T, Grootjans S, Goossens V, Dondelinger Y, Krysko DV, Takahashi N, Vandenabeele P. Determination of apoptotic and necrotic cell death in vitro and in vivo. Methods. 2013, 61:117-29. 10.1016\/j.ymeth.2013.02.011","journal-title":"Methods"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2012.05.002","article-title":"Review on in vivo and in vitro methods evaluation of antioxidant activity","volume":"21","author":"Alam MN","year":"2013","unstructured":"Alam MN, Bristi NJ, Rafiquzzaman M. Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharm J.  2013, 21:143-52. 10.1016\/j.jsps.2012.05.002","journal-title":"Saudi Pharm J"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/236456-studies-on-in-vitro-antimicrobial-anticancer-and-anti-oxidative-inflammatory-response-of-methanolic-tuber-extracts-derived-from-terminalia-chebula","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:42:13Z","timestamp":1720226533000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/236456-studies-on-in-vitro-antimicrobial-anticancer-and-anti-oxidative-inflammatory-response-of-methanolic-tuber-extracts-derived-from-terminalia-chebula"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.63930","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,5]]}}}