{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:48:13Z","timestamp":1788479293548,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,18]]},"DOI":"10.7759\/cureus.64875","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T05:28:25Z","timestamp":1721366905000},"source":"Crossref","is-referenced-by-count":3,"title":["Development of a Synergistic Nanomaterial Scaffold Combining Silver Nanoparticles, Collagen, and Doxycycline for Enhanced Scar-Free Skin Regeneration"],"prefix":"10.7759","author":[{"given":"Chokkalingam","family":"Deepa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvaraj","family":"Bharathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poongazhalselvan","family":"Devagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baskaran","family":"Sivasankari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umapathi","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuppusamy","family":"Kavitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arumugam","family":"Rajalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubramanian","family":"Ramesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajapathi","family":"Balaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fmre.2022.08.016","article-title":"Skin neuropathy and immunomodulation in diseases","volume":"4","author":"Zhang M","year":"2024","unstructured":"Zhang M, Liu T, Yang J. Skin neuropathy and immunomodulation in diseases. Fundam Res. 2024, 4:218-25. 10.1016\/j.fmre.2022.08.016","journal-title":"Fundam Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6449550","article-title":"Topical application of Premna integrifolia linn on skin wound injury in rats accelerates the wound healing process: evidence from in vitro and in vivo experimental models","volume":"2022","author":"Alsareii SA","year":"2022","unstructured":"Alsareii SA, Alzerwi NA, AlAsmari MY, Alamri AM, Mahnashi MH, Shaikh IA. Topical application of Premna integrifolia linn on skin wound injury in rats accelerates the wound healing process: evidence from in vitro and in vivo experimental models. Evid Based Complement Alternat Med. 2022, 2022:6449550. 10.1155\/2022\/6449550","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/plants10010025","article-title":"A novel herbal hydrogel formulation of Moringa oleifera for wound healing","volume":"10","author":"Ali A","year":"2020","unstructured":"Ali A, Garg P, Goyal R, et al.. A novel herbal hydrogel formulation of Moringa oleifera for wound healing. Plants (Basel). 2020, 10:25. 10.3390\/plants10010025","journal-title":"Plants (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4877344","article-title":"Fabrication and characterization of chitosan-polyethylene glycol (Ch-Peg) based hydrogels and evaluation of their potency in rat skin wound model","volume":"2021","author":"Hasan MM","year":"2021","unstructured":"Hasan MM, Uddin MF, Zabin N, et al.. Fabrication and characterization of chitosan-polyethylene glycol (Ch-Peg) based hydrogels and evaluation of their potency in rat skin wound model. Int J Biomater. 2021, 2021:4877344. 10.1155\/2021\/4877344","journal-title":"Int J Biomater"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15112360","article-title":"Wound healing properties of selected natural products","volume":"15","author":"Ibrahim N'","year":"2018","unstructured":"Ibrahim N', Wong SK, Mohamed IN, Mohamed N, Chin KY, Ima-Nirwana S, Shuid AN. Wound healing properties of selected natural products. Int J Environ Res Public Health. 2018, 15:2360. 10.3390\/ijerph15112360","journal-title":"Int J Environ Res Public Health"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2018\/37415.12322","article-title":"Evaluation of analgesic activity of extracts of Delphinium denudatum in animal models: a dose-dependent pre-clinical trial","volume":"12","author":"Zaheer I","year":"2018","unstructured":"Zaheer I, Rahman SZ, Khan RA, Parveen M, Ahmad M. Evaluation of analgesic activity of extracts of Delphinium denudatum in animal models: a dose-dependent pre-clinical trial. J Clin Diagn. 2018, 12:1-4. 10.7860\/JCDR\/2018\/37415.12322","journal-title":"J Clin Diagn"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.01.396","article-title":"Evaluation of the antibacterial activity of silver nanoparticles, doxycycline, collagen and their amalgamation - an in vitro study","volume":"43","author":"Deepa C","year":"2021","unstructured":"Deepa C, Suresh G, Devagi P, Kowsalya A, Kavitha K, Ramesh B. Evaluation of the antibacterial activity of silver nanoparticles, doxycycline, collagen and their amalgamation - an in vitro study. Mater Today Proc. 2021, 43:3050-3. 10.1016\/j.matpr.2021.01.396","journal-title":"Mater Today Proc"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2014.02.030","article-title":"Green synthesis of silver nanoparticles using Delphinium denudatum root extract exhibits antibacterial and mosquito larvicidal activities","volume":"127","author":"Suresh G","year":"2014","unstructured":"Suresh G, Gunasekar PH, Kokila D, et al.. Green synthesis of silver nanoparticles using Delphinium denudatum root extract exhibits antibacterial and mosquito larvicidal activities. Spectrochim Acta A Mol Biomol Spectrosc. 2014, 127:61-6. 10.1016\/j.saa.2014.02.030","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4681041","article-title":"Doxycycline hyclate modulates antioxidant defenses, matrix metalloproteinases, and COX-2 activity accelerating skin wound healing by secondary intention in rats","volume":"2021","author":"Alto\u00e9 LS","year":"2021","unstructured":"Alto\u00e9 LS, Alves RS, Miranda LL, et al.. Doxycycline hyclate modulates antioxidant defenses, matrix metalloproteinases, and COX-2 activity accelerating skin wound healing by secondary intention in rats. Oxid Med Cell Longev. 2021, 2021:4681041. 10.1155\/2021\/4681041","journal-title":"Oxid Med Cell Longev"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.19-0603","article-title":"Morphological evaluation of polysaccharide content and collagen composition during cutaneous wound healing in the Sunda porcupine (Hystrix javanica)","volume":"82","author":"Prawira AY","year":"2020","unstructured":"Prawira AY, Hosaka YZ, Novelina S, Farida WR, Darusman HS, Agungpriyono S. Morphological evaluation of polysaccharide content and collagen composition during cutaneous wound healing in the Sunda porcupine (Hystrix javanica). J Vet Med Sci. 2020, 82:506-15. 10.1292\/jvms.19-0603","journal-title":"J Vet Med Sci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11787","article-title":"Doxycycline prevents matrix remodeling and contraction by trichiasis-derived conjunctival fibroblasts","volume":"54","author":"Li H","year":"2013","unstructured":"Li H, Ezra DG, Burton MJ, Bailly M. Doxycycline prevents matrix remodeling and contraction by trichiasis-derived conjunctival fibroblasts. Invest Ophthalmol Vis Sci. 2013, 54:4675-82. 10.1167\/iovs.13-11787","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2014.03.009","article-title":"Bioactive compound loaded stable silver nanoparticle synthesis from microwave irradiated aqueous extracellular leaf extracts of Naringi crenulata and its wound healing activity in experimental rat model","volume":"135","author":"Bhuvaneswari T","year":"2014","unstructured":"Bhuvaneswari T, Thiyagarajan M, Geetha N, Venkatachalam P. Bioactive compound loaded stable silver nanoparticle synthesis from microwave irradiated aqueous extracellular leaf extracts of Naringi crenulata and its wound healing activity in experimental rat model. Acta Trop. 2014, 135:55-61. 10.1016\/j.actatropica.2014.03.009","journal-title":"Acta Trop"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13206","article-title":"Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats","volume":"16","author":"Khalaf AA","year":"2019","unstructured":"Khalaf AA, Hassanen EI, Zaki AR, Tohamy AF, Ibrahim MA. Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats. Int Wound J. 2019, 16:1416-25. 10.1111\/iwj.13206","journal-title":"Int Wound J"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-021-03030-0","article-title":"Development of nanobiomaterial for wound healing based on silver nanoparticles loaded on chitosan hydrogel","volume":"11","author":"Bharathi S","year":"2021","unstructured":"Bharathi S, Ramesh B, Kumaran S, et al.. Development of nanobiomaterial for wound healing based on silver nanoparticles loaded on chitosan hydrogel. 3 Biotech. 2021, 11:490. 10.1007\/s13205-021-03030-0","journal-title":"3 Biotech"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12644","article-title":"L-arginine promotes gut hormone release and reduces food intake in rodents","volume":"18","author":"Alamshah A","year":"2016","unstructured":"Alamshah A, McGavigan AK, Spreckley E, et al.. L-arginine promotes gut hormone release and reduces food intake in rodents. Diabetes Obes Metab. 2016, 18:508-18. 10.1111\/dom.12644","journal-title":"Diabetes Obes Metab"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-120","article-title":"Histopathological and clinical evaluation of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rats: an experimental study","volume":"8","author":"Barati F","year":"2013","unstructured":"Barati F, Javanbakht J, Adib-Hashemi F, et al.. Histopathological and clinical evaluation of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rats: an experimental study. Diagn Pathol. 2013, 8:120. 10.1186\/1746-1596-8-120","journal-title":"Diagn Pathol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300923","article-title":"IGF-I gene transfer in thermally injured rats","volume":"6","author":"Jeschke MG","year":"1999","unstructured":"Jeschke MG, Barrow RE, Hawkins HK, et al.. IGF-I gene transfer in thermally injured rats. Gene Ther. 1999, 6:1015-20. 10.1038\/sj.gt.3300923","journal-title":"Gene Ther"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137544","article-title":"The effect of mesenchymal stem cells and chitosan gel on full thickness skin wound healing in albino rats: histological, immunohistochemical and fluorescent study","volume":"10","author":"El Sadik AO","year":"2015","unstructured":"El Sadik AO, El Ghamrawy TA, Abd El-Galil TI. The effect of mesenchymal stem cells and chitosan gel on full thickness skin wound healing in albino rats: histological, immunohistochemical and fluorescent study. PLoS One. 2015, 10:e0137544. 10.1371\/journal.pone.0137544","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.scp.2020.100315","article-title":"Collagen extraction and recent biological activities of collagen peptides derived from sea-food waste: A review","volume":"18","author":"Ahmed M","year":"2020","unstructured":"Ahmed M, Verma AK, Patel R. Collagen extraction and recent biological activities of collagen peptides derived from sea-food waste: A review. Sustain Chem Pharm. 2020, 18:100315. 10.1016\/j.scp.2020.100315","journal-title":"Sustain Chem Pharm"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ma13020358","article-title":"Comparison of the structural characteristics of native collagen fibrils derived from bovine tendons using two different methods: modified acid-solubilized and pepsin-aided extraction","volume":"13","author":"Ju H","year":"2020","unstructured":"Ju H, Liu X, Zhang G, Liu D, Yang Y. Comparison of the structural characteristics of native collagen fibrils derived from bovine tendons using two different methods: modified acid-solubilized and pepsin-aided extraction. Materials (Basel). 2020, 13:358. 10.3390\/ma13020358","journal-title":"Materials (Basel)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1088\/2053-1591\/acd379","article-title":"Comparison of collagens extracted from swim bladder and bovine Achilles tendon","volume":"10","author":"Li Y","year":"2023","unstructured":"Li Y, Tian Y, Xiong X, Chen H, Zhou Y, Zhou Y, Peng X. Comparison of collagens extracted from swim bladder and bovine Achilles tendon. Mater Res Express. 2023, 10:055403. 10.1088\/2053-1591\/acd379","journal-title":"Mater Res Express"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/ma12162540","article-title":"Antimicrobial silver nanoparticles for wound healing application: progress and future trends","volume":"12","author":"Paladini F","year":"2019","unstructured":"Paladini F, Pollini M. Antimicrobial silver nanoparticles for wound healing application: progress and future trends. Materials (Basel). 2019, 12:2540. 10.3390\/ma12162540","journal-title":"Materials (Basel)"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.07.065","article-title":"Antifungal activity of silver nanoparticles against Candida spp","volume":"30","author":"Pan\u00e1cek A","year":"2009","unstructured":"Pan\u00e1cek A, Kol\u00e1r M, Vecerov\u00e1 R, et al.. Antifungal activity of silver nanoparticles against Candida spp. Biomaterials. 2009, 30:6333-40. 10.1016\/j.biomaterials.2009.07.065","journal-title":"Biomaterials"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01262-x","article-title":"Enhanced wound healing properties of guar gum\/curcumin-stabilized silver nanoparticle hydrogels","volume":"11","author":"Bhubhanil S","year":"2021","unstructured":"Bhubhanil S, Talodthaisong C, Khongkow M, et al.. Enhanced wound healing properties of guar gum\/curcumin-stabilized silver nanoparticle hydrogels. Sci Rep. 2021, 11:21836. 10.1038\/s41598-021-01262-x","journal-title":"Sci Rep"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.04.119","article-title":"Antibacterial and wound healing-promoting effect of sponge-like chitosan-loaded silver nanoparticles biosynthesized by iturin","volume":"181","author":"Zhou L","year":"2021","unstructured":"Zhou L, Zhao X, Li M, et al.. Antibacterial and wound healing-promoting effect of sponge-like chitosan-loaded silver nanoparticles biosynthesized by iturin. Int J Biol Macromol. 2021, 181:1183-95. 10.1016\/j.ijbiomac.2021.04.119","journal-title":"Int J Biol Macromol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/269996-development-of-a-synergistic-nanomaterial-scaffold-combining-silver-nanoparticles-collagen-and-doxycycline-for-enhanced-scar-free-skin-regeneration","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T05:28:28Z","timestamp":1721366908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/269996-development-of-a-synergistic-nanomaterial-scaffold-combining-silver-nanoparticles-collagen-and-doxycycline-for-enhanced-scar-free-skin-regeneration"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,18]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.64875","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,18]]}}}