{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:03:40Z","timestamp":1787727820022,"version":"build-2784847793"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,19]]},"DOI":"10.7759\/cureus.64887","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T08:12:16Z","timestamp":1721376736000},"source":"Crossref","is-referenced-by-count":1,"title":["The Association Between Dental Caries and Salivary Buffering Capacity in Syrian Patients Diagnosed with Sickle Cell Disease"],"prefix":"10.7759","author":[{"given":"Lynn","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer  A","family":"Aljoujou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Nadra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar Mahmoud","family":"Mashlah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima AlZahraa","family":"Al Beesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Alyafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haina","family":"Moulay Driss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC202101190","article-title":"Sickle cell disease","volume":"174","author":"Pecker LH","year":"2021","unstructured":"Pecker LH, Lanzkron S. Sickle cell disease. Ann Intern Med. 2021, 174:ITC1-16. 10.7326\/AITC202101190","journal-title":"Ann Intern Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.31782\/IJCRR.2020.121915","article-title":"Knowledge regarding sickle cell anaemia among newly married couples: A qualitative study","volume":"12","author":"Rakshale N","year":"2020","unstructured":"Rakshale N, Sebastian T, Hatwar K, et al.. Knowledge regarding sickle cell anaemia among newly married couples: A qualitative study. Int J Curr Res Rev. 2020, 12:128-33. 10.31782\/IJCRR.2020.121915","journal-title":"Int J Curr Res Rev"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(10)61029-x","article-title":"Sickle-cell disease","volume":"376","author":"Rees DC","year":"2010","unstructured":"Rees DC, Williams TN, Gladwin MT. Sickle-cell disease. Lancet. 2010, 376:2018-31. 10.1016\/s0140-6736(10)61029-x","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2014.08.003","article-title":"The association between dental and periodontal diseases and sickle cell disease. A pilot case-control study","volume":"27","author":"Al-Alawi H","year":"2015","unstructured":"Al-Alawi H, Al-Jawad A, Al-Shayeb M, Al-Ali A, Al-Khalifa K. The association between dental and periodontal diseases and sickle cell disease. A pilot case-control study. Saudi Dent J. 2015, 27:40-3. 10.1016\/j.sdentj.2014.08.003","journal-title":"Saudi Dent J"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2017.12.005","article-title":"Oral health management considerations for patients with sickle cell disease","volume":"64","author":"Kawar N","year":"2018","unstructured":"Kawar N, Alrayyes S, Yang B, Aljewari H. Oral health management considerations for patients with sickle cell disease. Dis Mon. 2018, 64:296-301. 10.1016\/j.disamonth.2017.12.005","journal-title":"Dis Mon"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2008.157","article-title":"Sickle cell anemia, the first molecular disease: Overview of molecular etiology, pathophysiology, and therapeutic approaches","volume":"8","author":"Steinberg MH","year":"2008","unstructured":"Steinberg MH. Sickle cell anemia, the first molecular disease: Overview of molecular etiology, pathophysiology, and therapeutic approaches. Sci World J. 2008, 8:1295-324. 10.1100\/tsw.2008.157","journal-title":"Sci World J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/gh9.0000000000000084","article-title":"Oral manifestations and management of sickle cell disease: A literature review","volume":"5","author":"Soualem H","year":"2022","unstructured":"Soualem H, Mainassara S, Beenjelloun L, Chbicheb S. Oral manifestations and management of sickle cell disease: A literature review. Int J Sur: Global Health. 2022, 5:e84. 10.1097\/gh9.0000000000000084","journal-title":"Int J Sur: Global Health"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5556708","article-title":"Orofacial manifestation and dental management of sickle cell disease: A scoping review","volume":"2021","author":"Kakkar M","year":"2021","unstructured":"Kakkar M, Holderle K, Sheth M, Arany S, Schiff L, Planerova A. Orofacial manifestation and dental management of sickle cell disease: A scoping review. Anemia. 2021, 2021:1-8. 10.1155\/2021\/5556708","journal-title":"Anemia"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-015-0052-4","article-title":"Caries prevalence and impact on oral health-related quality of life in children with sickle cell disease: Cross-sectional study","volume":"15","author":"Fernandes ML","year":"2015","unstructured":"Fernandes ML, Kawachi I, Corr\u00eaa-Faria P, Pattusi MP, Paiva SM, Pordeus IA. Caries prevalence and impact on oral health-related quality of life in children with sickle cell disease: Cross-sectional study. BMC Oral Health. 2015, 15:68. 10.1186\/s12903-015-0052-4","journal-title":"BMC Oral Health"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13415","article-title":"Biological factors associating pulp necrosis and sickle cell anemia","volume":"26","author":"Costa CP","year":"2020","unstructured":"Costa CP, Thomaz \u00c9BA, Ribeiro CC, Souza SF. Biological factors associating pulp necrosis and sickle cell anemia. Oral Dis. 2020, 26:1558-65. 10.1111\/odi.13415","journal-title":"Oral Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2019.4","article-title":"Oral manifestations of sickle cell disease","volume":"226","author":"Chekroun M","year":"2019","unstructured":"Chekroun M, Ch\u00e9rifi H, Fournier B, Gaultier F, Sitbon IY, Ferr\u00e9 FC, Gogly B. Oral manifestations of sickle cell disease. Br Dent J. 2019, 226:27-31. 10.1038\/sj.bdj.2019.4","journal-title":"Br Dent J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/31672000","article-title":"Quantitative MRI analysis of salivary glands in sickle cell disease","volume":"41","author":"Liao J","year":"2012","unstructured":"Liao J, Saito N, Ozonoff A, Jara H, Steinberg M, Sakai O. Quantitative MRI analysis of salivary glands in sickle cell disease. Dentomaxillofac Radiol. 2012, 41:630-6. 10.1259\/dmfr\/31672000","journal-title":"Dentomaxillofac Radiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1590\/1981-863720180003000063408","article-title":"Analysis of oral health conditions and risk factors for dental caries in patients with sickle cell disease","volume":"66","author":"Medeiros M","year":"2018","unstructured":"Medeiros M, Mendes L, Lopes S, et al.. Analysis of oral health conditions and risk factors for dental caries in patients with sickle cell disease.  Rev Ga\u00fach Odontol. 2018, 66:232-8. 10.1590\/1981-863720180003000063408","journal-title":"Rev Ga\u00fach Odontol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0629-9","article-title":"Association between sickle cell disease and the oral health condition of children and adolescents","volume":"18","author":"Brand\u00e3o CF","year":"2018","unstructured":"Brand\u00e3o CF, Oliveira VM, Santos AR, et al.. Association between sickle cell disease and the oral health condition of children and adolescents. BMC Oral Health. 2018, 18:169. 10.1186\/s12903-018-0629-9","journal-title":"BMC Oral Health"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.82322","article-title":"Science behind human saliva","volume":"2","author":"Tiwari M","year":"2011","unstructured":"Tiwari M. Science behind human saliva. J Nat Sci Biol Med. 2011, 2:53-8. 10.4103\/0976-9668.82322","journal-title":"J Nat Sci Biol Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-022-00209-w","article-title":"Promising applications of human-derived saliva biomarker testing in clinical diagnostics","volume":"15","author":"Song M","year":"2023","unstructured":"Song M, Bai H, Zhang P, Zhou X, Ying B. Promising applications of human-derived saliva biomarker testing in clinical diagnostics. Int J Oral Sci. 2023, 15:2. 10.1038\/s41368-022-00209-w","journal-title":"Int J Oral Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2000.tb00235.x","article-title":"Assessing caries risk in children","volume":"45","author":"Messer LB","year":"2000","unstructured":"Messer LB. Assessing caries risk in children. Aust Dent J. 2000, 45:10-6. 10.1111\/j.1834-7819.2000.tb00235.x","journal-title":"Aust Dent J"},{"key":"ref18","article-title":"Salivary flow rate and pH in patients with oral pathologies","volume":"21","author":"Foglio-Bonda PL","year":"2017","unstructured":"Foglio-Bonda PL, Brilli K, Pattarino F, Foglio-Bonda A. Salivary flow rate and pH in patients with oral pathologies. Eur Rev Med Pharmacol Sci. 2017, 21:369-74.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19010201","article-title":"Comparative study of salivary pH, buffer capacity, and flow in patients with and without gastroesophageal reflux disease","volume":"19","author":"Bechir F","year":"2021","unstructured":"Bechir F, Pacurar M, Tohati A, Bataga SM. Comparative study of salivary pH, buffer capacity, and flow in patients with and without gastroesophageal reflux disease. Int J Environ Res Public Health. 2021, 19:201. 10.3390\/ijerph19010201","journal-title":"Int J Environ Res Public Health"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/JBBBE.48.105","article-title":"The effect of cheese and milk on buffering capacity of saliva in children 10-12 years","volume":"48","author":"Sungkar S","year":"2020","unstructured":"Sungkar S, Chismirina S, Nasution AI, Imaduddin HK. The effect of cheese and milk on buffering capacity of saliva in children 10-12 years. J Biomimetic Biomater Biomed Eng. 2020, 48:105-10. 10.4028\/www.scientific.net\/JBBBE.48.105","journal-title":"J Biomimetic Biomater Biomed Eng"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.10","article-title":"Sickle cell disease","volume":"4","author":"Kato GJ","year":"2018","unstructured":"Kato GJ, Piel FB, Reid CD, et al.. Sickle cell disease. Nat Rev Dis Primers. 2018, 4:18010. 10.1038\/nrdp.2018.10","journal-title":"Nat Rev Dis Primers"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V126.23.2182.2182","article-title":"Accuracy of a rapid and simple point-of-care test for sickle cell disease","volume":"126","author":"McGann PT","year":"2015","unstructured":"McGann PT, Schaefer BA, Paniagua MC, Howard TA, Ware RE. Accuracy of a rapid and simple point-of-care test for sickle cell disease. Blood. 2015, 126:2182.","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.10233","article-title":"Sickle cell disease: A review","volume":"328","author":"Kavanagh PL","year":"2022","unstructured":"Kavanagh PL, Fasipe TA, Wun T. Sickle cell disease: A review. JAMA. 2022, 328:57-68. 10.1001\/jama.2022.10233","journal-title":"JAMA"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2014.978455","article-title":"Prenatal molecular diagnosis of \u03b2-thalassemia and sickle cell anemia in the Syrian population","volume":"38","author":"Murad H","year":"2014","unstructured":"Murad H, Moassas F, Jarjour R, Mukhalalaty Y, Al-Achkar W. Prenatal molecular diagnosis of \u03b2-thalassemia and sickle cell anemia in the Syrian population. Hemoglobin. 2014, 38:390-3. 10.3109\/03630269.2014.978455","journal-title":"Hemoglobin"},{"key":"ref25","article-title":"Simplified oral hygiene index in schoolchildren of 6 years of age, Ecuador, 2016","volume":"2","author":"Mora Bravo K","year":"2020","unstructured":"Mora Bravo K, Sacoto Figueroa F, Calle Prado D. Simplified oral hygiene index in schoolchildren of 6 years of age, Ecuador, 2016. Odontolog\u00eda Vital. 2020, 2:73-8.","journal-title":"Odontolog\u00eda Vital"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.5005\/jp-journals-10024-3189","article-title":"Aggravated dental and periodontal status in patients with sickle cell disease and its association with serum ferritin","volume":"22","author":"Davidopoulou S","year":"2021","unstructured":"Davidopoulou S, Pikilidou M, Yavropoulou MP, Kalogirou TE, Zebekakis P, Kalfas S. Aggravated dental and periodontal status in patients with sickle cell disease and its association with serum ferritin. J Contemp Dent Pract. 2021, 22:991-7.","journal-title":"J Contemp Dent Pract"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.2070","article-title":"Exploring the symptoms and sleep disorders associated with migraines in women of Syria: A cross-sectional observational study","volume":"7","author":"Martini N","year":"2024","unstructured":"Martini N, Hawa T, Hamdar H, et al.. Exploring the symptoms and sleep disorders associated with migraines in women of Syria: A cross-sectional observational study. Health Sci Rep. 2024, 7:e2070. 10.1002\/hsr2.2070","journal-title":"Health Sci Rep"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2017.12.003","article-title":"Sickle cell disease; An overview of the disease and its systemic effects","volume":"64","author":"Alrayyes S","year":"2018","unstructured":"Alrayyes S, Baghdan D, Haddad RY, Compton AA, Mohama S, Goreishi R, Kawar N. Sickle cell disease; An overview of the disease and its systemic effects. Dis Mon. 2018, 64:283-9. 10.1016\/j.disamonth.2017.12.003","journal-title":"Dis Mon"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-022-00167-3","article-title":"Expert consensus on dental caries management","volume":"14","author":"Cheng L","year":"2022","unstructured":"Cheng L, Zhang L, Yue L, et al.. Expert consensus on dental caries management. Int J Oral Sci. 2022, 14:17. 10.1038\/s41368-022-00167-3","journal-title":"Int J Oral Sci"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2012.00235.x","article-title":"Sickle cell disease does not predispose to caries or periodontal disease","volume":"32","author":"Passos CP","year":"2012","unstructured":"Passos CP, Santos PR, Aguiar MC, et al.. Sickle cell disease does not predispose to caries or periodontal disease. Spec Care Dentist. 2012, 32:55-60. 10.1111\/j.1754-4505.2012.00235.x","journal-title":"Spec Care Dentist"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2020.1748927","article-title":"Association between sickle cell disease and dental caries: A systematic review and meta-analysis","volume":"25","author":"Yue H","year":"2020","unstructured":"Yue H, Xu X, Liu Q, Li X, Jiang W, Hu B. Association between sickle cell disease and dental caries: A systematic review and meta-analysis. Hematology. 2020, 25:309-19. 10.1080\/16078454.2020.1748927","journal-title":"Hematology"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2006.tb01430.x","article-title":"The association between sickle cell disease and dental caries in African Americans","volume":"26","author":"Laurence B","year":"2006","unstructured":"Laurence B, George D, Woods D, et al.. The association between sickle cell disease and dental caries in African Americans. Spec Care Dentist. 2006, 26:95-100. 10.1111\/j.1754-4505.2006.tb01430.x","journal-title":"Spec Care Dentist"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.05.014","article-title":"Oral microbial colonization in children with sickle cell anaemia under long-term prophylaxis with penicillin","volume":"59","author":"de Matos BM","year":"2014","unstructured":"de Matos BM, Ribeiro ZE, Balducci I, et al.. Oral microbial colonization in children with sickle cell anaemia under long-term prophylaxis with penicillin. Arch Oral Biol. 2014, 59:1042-7. 10.1016\/j.archoralbio.2014.05.014","journal-title":"Arch Oral Biol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16003","article-title":"Rapid decline in estimated glomerular filtration rate is common in adults with sickle cell disease and associated with increased mortality","volume":"186","author":"Derebail VK","year":"2019","unstructured":"Derebail VK, Zhou Q, Ciccone EJ, Cai J, Ataga KI. Rapid decline in estimated glomerular filtration rate is common in adults with sickle cell disease and associated with increased mortality. Br J Haematol. 2019, 186:900-7. 10.1111\/bjh.16003","journal-title":"Br J Haematol"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014020205","article-title":"Current status of bicarbonate in CKD","volume":"26","author":"Dobre M","year":"2015","unstructured":"Dobre M, Rahman M, Hostetter TH. Current status of bicarbonate in CKD. J Am Soc Nephrol. 2015, 26:515-23. 10.1681\/ASN.2014020205","journal-title":"J Am Soc Nephrol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12029","article-title":"Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance","volume":"42","author":"Salvia AC","year":"2013","unstructured":"Salvia AC, Figueiredo MS, Braga JA, Pereira DF, Brighenti FL, Koga-Ito CY. Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance. J Oral Pathol Med. 2013, 42:570-5. 10.1111\/jop.12029","journal-title":"J Oral Pathol Med"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.5933\/JKAPD.2023.50.2.131","article-title":"Strategies for the prevention of dental caries as a non-communicable disease","volume":"50","author":"Kim JG","year":"2023","unstructured":"Kim JG. Strategies for the prevention of dental caries as a non-communicable disease. J Korean Acad Pediatr Dent. 2023, 50:131-41. 10.5933\/JKAPD.2023.50.2.131","journal-title":"J Korean Acad Pediatr Dent"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.4103\/0970-4388.115697","article-title":"A comparative study of salivary buffering capacity, flow rate, resting pH, and salivary Immunoglobulin A in children with rampant caries and caries-resistant children","volume":"31","author":"Kuriakose S","year":"2013","unstructured":"Kuriakose S, Sundaresan C, Mathai V, Khosla E, Gaffoor FM. A comparative study of salivary buffering capacity, flow rate, resting pH, and salivary Immunoglobulin A in children with rampant caries and caries-resistant children. J Indian Soc Pedod Prev Dent. 2013, 31:69-73. 10.4103\/0970-4388.115697","journal-title":"J Indian Soc Pedod Prev Dent"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/266144-the-association-between-dental-caries-and-salivary-buffering-capacity-in-syrian-patients-diagnosed-with-sickle-cell-disease","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T08:12:22Z","timestamp":1721376742000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/266144-the-association-between-dental-caries-and-salivary-buffering-capacity-in-syrian-patients-diagnosed-with-sickle-cell-disease"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":38,"URL":"https:\/\/doi.org\/10.7759\/cureus.64887","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,19]]}}}