{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:39:11Z","timestamp":1759991951272},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,21]]},"DOI":"10.7759\/cureus.65033","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T13:33:32Z","timestamp":1721568812000},"source":"Crossref","is-referenced-by-count":1,"title":["Is Low-Dose Lung Radiotherapy for Severe COVID-19 Pneumonia a Therapeutic Alternative?"],"prefix":"10.7759","author":[{"given":"Fatima","family":"Safini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bouchra","family":"Amaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenza","family":"Oqbani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanae","family":"Abbaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slimane","family":"Semghouli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"World Health Organization (WHO). Coronavirus dashboard. (2024). Accessed. August 18, 2023: https:\/\/covid19.who.int."},{"key":"ref2","article-title":"Features, Evaluation, and Treatment of Coronavirus (COVID-19)","author":"Cascella M","year":"2024","unstructured":"Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features, Evaluation, and Treatment of Coronavirus (COVID-19). StatPearls Publishing, Treasure Island, FL; 2024."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine","volume":"383","author":"Polack FP","year":"2020","unstructured":"Polack FP, Thomas SJ, Kitchin N, et al.. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020, 383:2603-15. 10.1056\/NEJMoa2034577","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine","volume":"384","author":"Baden LR","year":"2021","unstructured":"Baden LR, El Sahly HM, Essink B, et al.. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021, 384:403-16. 10.1056\/NEJMoa2035389","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19499","article-title":"Association between mRNA vaccination and COVID-19 hospitalization and disease severity","volume":"326","author":"Tenforde MW","year":"2021","unstructured":"Tenforde MW, Self WH, Adams K, et al.. Association between mRNA vaccination and COVID-19 hospitalization and disease severity. JAMA. 2021, 326:2043-54. 10.1001\/jama.2021.19499","journal-title":"JAMA"},{"key":"ref6","article-title":"How radiotherapy was historically used to treat pneumonia: could it be useful today?","volume":"86","author":"Calabrese EJ","year":"2013","unstructured":"Calabrese EJ, Dhawan G. How radiotherapy was historically used to treat pneumonia: could it be useful today?. Yale J Biol Med. 2013, 86:555-70.","journal-title":"Yale J Biol Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta P","year":"2020","unstructured":"Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020, 395:1033-4. 10.1016\/S0140-6736(20)30628-0","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/09553000701317358","article-title":"Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy","volume":"83","author":"R\u00f6del F","year":"2007","unstructured":"R\u00f6del F, Keilholz L, Herrmann M, Sauer R, Hildebrandt G. Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy. Int J Radiat Biol. 2007, 83:357-66. 10.1080\/09553000701317358","journal-title":"Int J Radiat Biol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.03.022","article-title":"Low doses of radiation increase the immunosuppressive profile of lung macrophages during viral infection and pneumonia","volume":"110","author":"Meziani L","year":"2021","unstructured":"Meziani L, Robert C, Classe M, et al.. Low doses of radiation increase the immunosuppressive profile of lung macrophages during viral infection and pneumonia. Int J Radiat Oncol Biol Phys. 2021, 110:1283-94. 10.1016\/j.ijrobp.2021.03.022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1182927","article-title":"Low-dose radiation therapy suppresses viral pneumonia by enhancing broad-spectrum anti-inflammatory responses via transforming growth factor-\u03b2 production","volume":"14","author":"Song HY","year":"2023","unstructured":"Song HY, Chen F, Park HR, et al.. Low-dose radiation therapy suppresses viral pneumonia by enhancing broad-spectrum anti-inflammatory responses via transforming growth factor-\u03b2 production. Front Immunol. 2023, 14:1182927. 10.3389\/fimmu.2023.1182927","journal-title":"Front Immunol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33130","article-title":"Low-dose whole-lung radiation for COVID-19 pneumonia: planned day 7 interim analysis of a registered clinical trial","volume":"126","author":"Hess CB","year":"2020","unstructured":"Hess CB, Buchwald ZS, Stokes W, et al.. Low-dose whole-lung radiation for COVID-19 pneumonia: planned day 7 interim analysis of a registered clinical trial. Cancer. 2020, 126:5109-13. 10.1002\/cncr.33130","journal-title":"Cancer"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.12.011","article-title":"Immunomodulatory low-dose whole-lung radiation for patients with coronavirus disease 2019-related pneumonia","volume":"109","author":"Hess CB","year":"2021","unstructured":"Hess CB, Nasti TH, Dhere VR, et al.. Immunomodulatory low-dose whole-lung radiation for patients with coronavirus disease 2019-related pneumonia. Int J Radiat Oncol Biol Phys. 2021, 109:867-79. 10.1016\/j.ijrobp.2020.12.011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.10.003","article-title":"Whole-lung low-dose radiation therapy (LD-RT) for non-intubated oxygen-dependent patients with COVID-19-related pneumonia receiving dexamethasone and\/or remdesevir","volume":"165","author":"Hess CB","year":"2021","unstructured":"Hess CB, Eng TY, Nasti TH, et al.. Whole-lung low-dose radiation therapy (LD-RT) for non-intubated oxygen-dependent patients with COVID-19-related pneumonia receiving dexamethasone and\/or remdesevir. Radiother Oncol. 2021, 165:20-31. 10.1016\/j.radonc.2021.10.003","journal-title":"Radiother Oncol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.07.026","article-title":"Low-dose whole-lung irradiation for COVID-19 pneumonia: short course results","volume":"108","author":"Ameri A","year":"2020","unstructured":"Ameri A, Rahnama N, Bozorgmehr R, et al.. Low-dose whole-lung irradiation for COVID-19 pneumonia: short course results. Int J Radiat Oncol Biol Phys. 2020, 108:1134-9. 10.1016\/j.ijrobp.2020.07.026","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jmrs.542","article-title":"Low-dose whole-lung irradiation in severe COVID-19 pneumonia: a controlled clinical trial","volume":"68","author":"Mousavi Darzikolaee N","year":"2021","unstructured":"Mousavi Darzikolaee N, Kolahdouzan K, Abtahi H, et al.. Low-dose whole-lung irradiation in severe COVID-19 pneumonia: a controlled clinical trial. J Med Radiat Sci. 2021, 68:396-406. 10.1002\/jmrs.542","journal-title":"J Med Radiat Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.11.049","article-title":"Low-Dose Radiation Therapy in the Management of Coronavirus Disease 2019 (COVID-19) Pneumonia (LOWRAD-Cov19): preliminary report","volume":"109","author":"Sanmamed N","year":"2021","unstructured":"Sanmamed N, Alcantara P, Cerezo E, et al.. Low-Dose Radiation Therapy in the Management of Coronavirus Disease 2019 (COVID-19) Pneumonia (LOWRAD-Cov19): preliminary report. Int J Radiat Oncol Biol Phys. 2021, 109:880-5. 10.1016\/j.ijrobp.2020.11.049","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2022.03.015","article-title":"Low-dose Radiation Therapy in the Management of COVID-19 Pneumonia (LOWRAD-Cov19). Final results of a prospective phase I-II trial","volume":"171","author":"Sanmamed N","year":"2022","unstructured":"Sanmamed N, Alcantara P, G\u00f3mez S, et al.. Low-dose Radiation Therapy in the Management of COVID-19 Pneumonia (LOWRAD-Cov19). Final results of a prospective phase I-II trial. Radiother Oncol. 2022, 171:25-9. 10.1016\/j.radonc.2022.03.015","journal-title":"Radiother Oncol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.02.054","article-title":"Low-dose radiation therapy for severe COVID-19 pneumonia: a randomized double-blind study","volume":"110","author":"Papachristofilou A","year":"2021","unstructured":"Papachristofilou A, Finazzi T, Blum A, et al.. Low-dose radiation therapy for severe COVID-19 pneumonia: a randomized double-blind study. Int J Radiat Oncol Biol Phys. 2021, 110:1274-82. 10.1016\/j.ijrobp.2021.02.054","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-023-02067-9","article-title":"Treatment of COVID-19 pneumonia with low-dose radiotherapy plus standard of care versus standard of care alone in frail patients : the SEOR-GICOR IPACOVID comparative cohort trial","volume":"199","author":"Arenas M","year":"2023","unstructured":"Arenas M, Piqu\u00e9 B, Torres-Royo L, et al.. Treatment of COVID-19 pneumonia with low-dose radiotherapy plus standard of care versus standard of care alone in frail patients : the SEOR-GICOR IPACOVID comparative cohort trial. Strahlenther Onkol. 2023, 199:847-56. 10.1007\/s00066-023-02067-9","journal-title":"Strahlenther Onkol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.08.001","article-title":"Whole lung irradiation as a novel treatment for COVID-19: interim results of an ongoing phase 2 trial in India","volume":"163","author":"Ganesan G","year":"2021","unstructured":"Ganesan G, Ponniah S, Sundaram V, et al.. Whole lung irradiation as a novel treatment for COVID-19: interim results of an ongoing phase 2 trial in India. Radiother Oncol. 2021, 163:83-90. 10.1016\/j.radonc.2021.08.001","journal-title":"Radiother Oncol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.12.024","article-title":"Whole lung irradiation as a novel treatment for COVID-19: final results of the prospective randomized trial (WINCOVID trial)","volume":"167","author":"Ganesan G","year":"2022","unstructured":"Ganesan G, Ponniah S, Sundaram V, et al.. Whole lung irradiation as a novel treatment for COVID-19: final results of the prospective randomized trial (WINCOVID trial). Radiother Oncol. 2022, 167:133-42. 10.1016\/j.radonc.2021.12.024","journal-title":"Radiother Oncol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.822902","article-title":"Interim analysis of impact of adding low dose pulmonary radiotherapy to moderate COVID-19 pneumonia patients: IMpaCt-RT study","volume":"12","author":"Singh P","year":"2022","unstructured":"Singh P, Mandal A, Singh D, et al.. Interim analysis of impact of adding low dose pulmonary radiotherapy to moderate COVID-19 pneumonia patients: IMpaCt-RT study. Front Oncol. 2022, 12:822902. 10.3389\/fonc.2022.822902","journal-title":"Front Oncol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20230022","article-title":"Efficacy of low-dose lung radiotherapy in the management of COVID-19 patients: a randomised, open-label study","volume":"96","author":"Dinakar K","year":"2023","unstructured":"Dinakar K, Jakka MK, Vemannagari PK, et al.. Efficacy of low-dose lung radiotherapy in the management of COVID-19 patients: a randomised, open-label study. Br J Radiol. 2023, 96:20230022. 10.1259\/bjr.20230022","journal-title":"Br J Radiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.11.013","article-title":"The clinical efficacy of low-dose whole-lung irradiation in moderate-to-severe COVID-19 pneumonia: RTMX-20 trial","volume":"166","author":"Ortiz CS","year":"2022","unstructured":"Ortiz CS, Hern\u00e1ndez D, Trujillo C, et al.. The clinical efficacy of low-dose whole-lung irradiation in moderate-to-severe COVID-19 pneumonia: RTMX-20 trial. Radiother Oncol. 2022, 166:133-6. 10.1016\/j.radonc.2021.11.013","journal-title":"Radiother Oncol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270594","article-title":"A pilot phase Ib\/II study of whole-lung low dose radiation therapy (LDRT) for the treatment of severe COVID-19 pneumonia: first experience from Africa","volume":"17","author":"Saleh M","year":"2022","unstructured":"Saleh M, Sharma K, Shah J, et al.. A pilot phase Ib\/II study of whole-lung low dose radiation therapy (LDRT) for the treatment of severe COVID-19 pneumonia: first experience from Africa. PLoS One. 2022, 17:e0270594. 10.1371\/journal.pone.0270594","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11030858","article-title":"Low-dose radiotherapy for patients with pneumonia due to COVID-19: a single-institution prospective study","volume":"11","author":"Rutkowski TW","year":"2023","unstructured":"Rutkowski TW, Jaroszewicz J, Piotrowski D, et al.. Low-dose radiotherapy for patients with pneumonia due to COVID-19: a single-institution prospective study. Biomedicines. 2023, 11:858.","journal-title":"Biomedicines"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-020-00915-x","article-title":"Low dose radiation therapy for COVID-19 pneumonia: brief review of the evidence","volume":"43","author":"Metcalfe PE","year":"2020","unstructured":"Metcalfe PE. Low dose radiation therapy for COVID-19 pneumonia: brief review of the evidence. Phys Eng Sci Med. 2020, 43:761-3. 10.1007\/s13246-020-00915-x","journal-title":"Phys Eng Sci Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2020.04.006","article-title":"Low dose lung radiotherapy for COVID-19 pneumonia. The rationale for a cost-effective anti-inflammatory treatment","volume":"23","author":"Lara PC","year":"2020","unstructured":"Lara PC, Burgos J, Macias D. Low dose lung radiotherapy for COVID-19 pneumonia. The rationale for a cost-effective anti-inflammatory treatment. Clin Transl Radiat Oncol. 2020, 23:27-9. 10.1016\/j.ctro.2020.04.006","journal-title":"Clin Transl Radiat Oncol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.04.060","article-title":"Lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable","volume":"147","author":"Kirsch DG","year":"2020","unstructured":"Kirsch DG, Diehn M, Cucinotta FA, Weichselbaum R. Lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable. Radiother Oncol. 2020, 147:217-20. 10.1016\/j.radonc.2020.04.060","journal-title":"Radiother Oncol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-020-01635-7","article-title":"Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?","volume":"196","author":"R\u00f6del F","year":"2020","unstructured":"R\u00f6del F, Arenas M, Ott OJ, et al.. Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?. Strahlenther Onkol. 2020, 196:679-82. 10.1007\/s00066-020-01635-7","journal-title":"Strahlenther Onkol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/264682-is-low-dose-lung-radiotherapy-for-severe-covid-19-pneumonia-a-therapeutic-alternative","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T13:33:40Z","timestamp":1721568820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/264682-is-low-dose-lung-radiotherapy-for-severe-covid-19-pneumonia-a-therapeutic-alternative"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,21]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.65033","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,21]]}}}