{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:08:38Z","timestamp":1774598918896,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,21]]},"DOI":"10.7759\/cureus.65036","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T14:54:04Z","timestamp":1721573644000},"source":"Crossref","is-referenced-by-count":2,"title":["Histopathological Spectrum of Gliomas and Its Immunohistochemical Correlation in a Tertiary Care Setup"],"prefix":"10.7759","author":[{"given":"Srishti","family":"Malla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupali","family":"Bavikar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charusheela","family":"Gore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Chugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushama","family":"Gurwale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_377_20","article-title":"Clinicopathological correlation of glioma patients with respect to immunohistochemistry markers: a prospective study of 115 patients in a tertiary care hospital in North India","volume":"16","author":"Dahuja G","year":"2021","unstructured":"Dahuja G, Gupta A, Jindal A, Jain G, Sharma S, Kumar A. Clinicopathological correlation of glioma patients with respect to immunohistochemistry markers: a prospective study of 115 patients in a tertiary care hospital in North India. Asian J Neurosurg. 2021, 16:732-7. 10.4103\/ajns.AJNS_377_20","journal-title":"Asian J Neurosurg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.18203\/2349-2902.isj20203792","article-title":"A single-centre observational study of 124 surgically managed glioma patients: molecular subtyping and its correlation with clinico-radiological profile","volume":"7","author":"Singh A","year":"2020","unstructured":"Singh A, Singh S, Agrawal S, et al.. A single-centre observational study of 124 surgically managed glioma patients: molecular subtyping and its correlation with clinico-radiological profile. Int Surg J. 2020, 7:3047-55. 10.18203\/2349-2902.isj20203792","journal-title":"Int Surg J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9070799","article-title":"IDH mutations in glioma: double-edged sword in clinical applications?","volume":"9","author":"Kayabolen A","year":"2021","unstructured":"Kayabolen A, Yilmaz E, Bagci-Onder T. IDH mutations in glioma: double-edged sword in clinical applications?. Biomedicines. 2021, 9:799. 10.3390\/biomedicines9070799","journal-title":"Biomedicines"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-017-0311-6","article-title":"Molecular subgroups of glioblastoma- an assessment by immunohistochemical markers","volume":"25","author":"Nagy \u00c1","year":"2019","unstructured":"Nagy \u00c1, Garzuly F, Pad\u00e1nyi G, et al.. Molecular subgroups of glioblastoma- an assessment by immunohistochemical markers. Pathol Oncol Res. 2019, 25:21-31. 10.1007\/s12253-017-0311-6","journal-title":"Pathol Oncol Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-023-04250-5","article-title":"Updates on the WHO diagnosis of IDH-mutant glioma","volume":"162","author":"Reuss DE","year":"2023","unstructured":"Reuss DE. Updates on the WHO diagnosis of IDH-mutant glioma. J Neurooncol. 2023, 162:461-9. 10.1007\/s11060-023-04250-5","journal-title":"J Neurooncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S397550","article-title":"Immunohistochemical expression of IDH1, ATRX, Ki67, GFAP, and prognosis in Indonesian glioma patients","volume":"16","author":"Priambada D","year":"2023","unstructured":"Priambada D, Thohar Arifin M, Saputro A, et al.. Immunohistochemical expression of IDH1, ATRX, Ki67, GFAP, and prognosis in Indonesian glioma patients. Int J Gen Med. 2023, 16:393-403. 10.2147\/IJGM.S397550","journal-title":"Int J Gen Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2022.118183","article-title":"WHO CNS5 2021 classification of gliomas: a\u00a0practical review and road signs for diagnosing pathologists and proper patho-clinical and neuro-oncological cooperation","volume":"60","author":"Sejda A","year":"2022","unstructured":"Sejda A, Grajkowska W, Trubicka J, Szutowicz E, Wojdacz T, Kloc W, I\u017cycka-\u015awieszewska E. WHO CNS5 2021 classification of gliomas: a\u00a0practical review and road signs for diagnosing pathologists and proper patho-clinical and neuro-oncological cooperation. Folia Neuropathol. 2022, 60:137-52. 10.5114\/fn.2022.118183","journal-title":"Folia Neuropathol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1131642","article-title":"Clinical updates on gliomas and implications of the 5th edition of the WHO classification of central nervous system tumors","volume":"13","author":"Guo X","year":"2023","unstructured":"Guo X, Shi Y, Liu D, et al.. Clinical updates on gliomas and implications of the 5th edition of the WHO classification of central nervous system tumors. Front Oncol. 2023, 13:1131642. 10.3389\/fonc.2023.1131642","journal-title":"Front Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-022-00428-3","article-title":"The 2021 WHO classification of tumors, 5th edition, central nervous system tumors: the 10 basic principles","volume":"39","author":"Komori T","year":"2022","unstructured":"Komori T. The 2021 WHO classification of tumors, 5th edition, central nervous system tumors: the 10 basic principles. Brain Tumor Pathol. 2022, 39:47-50. 10.1007\/s10014-022-00428-3","journal-title":"Brain Tumor Pathol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.13062","article-title":"Classification of adult-type diffuse gliomas: impact of the World Health Organization 2021 update","volume":"32","author":"Whitfield BT","year":"2022","unstructured":"Whitfield BT, Huse JT. Classification of adult-type diffuse gliomas: impact of the World Health Organization 2021 update. Brain Pathol. 2022, 32:e13062. 10.1111\/bpa.13062","journal-title":"Brain Pathol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1743265","article-title":"Study of surrogate immunohistochemical markers IDH1, ATRX, BRAF V600E, and p53 mutation in astrocytic and oligodendroglial tumors","volume":"12","author":"Sharma S","year":"2023","unstructured":"Sharma S, Mathur K, Mittal A, Mukta M, Jindal A, Kumar M. Study of surrogate immunohistochemical markers IDH1, ATRX, BRAF V600E, and p53 mutation in astrocytic and oligodendroglial tumors. Indian J Neurosurg. 2023, 12:137-46. 10.1055\/s-0042-1743265","journal-title":"Indian J Neurosurg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808710","article-title":"IDH1 and IDH2 mutations in gliomas","volume":"360","author":"Yan H","year":"2009","unstructured":"Yan H, Parsons DW, Jin G, et al.. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009, 360:765-73. 10.1056\/NEJMoa0808710","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.9317","article-title":"Association between IDH1\/2 mutations and brain glioma grade","volume":"16","author":"Deng L","year":"2018","unstructured":"Deng L, Xiong P, Luo Y, Bu X, Qian S, Zhong W, Lv S. Association between IDH1\/2 mutations and brain glioma grade. Oncol Lett. 2018, 16:5405-9. 10.3892\/ol.2018.9317","journal-title":"Oncol Lett"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.18410\/jebmh\/2016\/496","article-title":"Histopathological spectrum and grading of CNS tumours in tertiary centre: case study of 83 cases","volume":"3","author":"Sumathi V","year":"2016","unstructured":"Sumathi V, Balakrishnan K, Krishna MS, Maheshwari KU. Histopathological spectrum and grading of CNS tumours in tertiary centre: case study of 83 cases. J Evid Based Med Healthcare. 2016, 3:2240-3.","journal-title":"J Evid Based Med Healthcare"},{"key":"ref15","article-title":"Histopathological spectrum of brain tumors: a 4-year retrospective study from a single tertiary care facility","volume":"8","author":"Hamdani SM","year":"2019","unstructured":"Hamdani SM, Dar NQ, Reshi R. Histopathological spectrum of brain tumors: a 4-year retrospective study from a single tertiary care facility. Int J Med Sci Public Health. 2019, 8:673-6.","journal-title":"Int J Med Sci Public Health"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3329\/bjms.v13i3.19148","article-title":"Analysis of brain tumors in Kashmir Valley - a 10 year study","volume":"13","author":"Dhar A","year":"2014","unstructured":"Dhar A, Bhat AR, Nizami FA, et al.. Analysis of brain tumors in Kashmir Valley - a 10 year study. Bangladesh J Med Sci. 2014, 13:268-77. 10.3329\/bjms.v13i3.19148","journal-title":"Bangladesh J Med Sci"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.5455\/ijmsph.2014.080720141","article-title":"Retrospective histological analysis of CNS tumors - a 5 year study","volume":"3","author":"Ghanghoria S","year":"2014","unstructured":"Ghanghoria S, Mehar R, Kulkarni CV, Mittal M, Yadav A, Patidar H. Retrospective histological analysis of CNS tumors - a 5 year study. Int J Med Sci Public Health. 2014, 3:1205-7.","journal-title":"Int J Med Sci Public Health"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPZOIY3WY4KIKE","article-title":"IDH1 mutations in diffusely infiltrating astrocytomas: grade specificity, association with protein expression, and clinical relevance","volume":"138","author":"Thota B","year":"2012","unstructured":"Thota B, Shukla SK, Srividya MR, et al.. IDH1 mutations in diffusely infiltrating astrocytomas: grade specificity, association with protein expression, and clinical relevance. Am J Clin Pathol. 2012, 138:177-84. 10.1309\/AJCPZOIY3WY4KIKE","journal-title":"Am J Clin Pathol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.588","article-title":"Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas","volume":"3","author":"Jiao Y","year":"2012","unstructured":"Jiao Y, Killela PJ, Reitman ZJ, et al.. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget. 2012, 3:709-22. 10.18632\/oncotarget.588","journal-title":"Oncotarget"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1156-z","article-title":"ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis","volume":"126","author":"Wiestler B","year":"2013","unstructured":"Wiestler B, Capper D, Holland-Letz T, et al.. ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis. Acta Neuropathol. 2013, 126:443-51. 10.1007\/s00401-013-1156-z","journal-title":"Acta Neuropathol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0331-6","article-title":"ATRX immunostaining predicts IDH and H3F3A status in gliomas","volume":"4","author":"Ebrahimi A","year":"2016","unstructured":"Ebrahimi A, Skardelly M, Bonzheim I, et al.. ATRX immunostaining predicts IDH and H3F3A status in gliomas. Acta Neuropathol Commun. 2016, 4:60. 10.1186\/s40478-016-0331-6","journal-title":"Acta Neuropathol Commun"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4497","article-title":"IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas","volume":"6","author":"Leeper HE","year":"2015","unstructured":"Leeper HE, Caron AA, Decker PA, Jenkins RB, Lachance DH, Giannini C. IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas. Oncotarget. 2015, 6:30295-305. 10.18632\/oncotarget.4497","journal-title":"Oncotarget"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/his.12927","article-title":"Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas","volume":"69","author":"Ikemura M","year":"2016","unstructured":"Ikemura M, Shibahara J, Mukasa A, et al.. Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas. Histopathology. 2016, 69:260-7. 10.1111\/his.12927","journal-title":"Histopathology"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1838","article-title":"ATRX mRNA expression combined with IDH1\/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples samples","volume":"5","author":"Cai J","year":"2014","unstructured":"Cai J, Yang P, Zhang C, et al.. ATRX mRNA expression combined with IDH1\/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples samples. Oncotarget. 2014, 5:2551-61. 10.18632\/oncotarget.1838","journal-title":"Oncotarget"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59111918","article-title":"General clinico-pathological characteristics in glioblastomas in correlation with p53 and Ki67","volume":"59","author":"Sipos TC","year":"2023","unstructured":"Sipos TC, K\u00f6vecsi A, Ovidiu-Ioan \u0218, Zsuzs\u00e1nna P. General clinico-pathological characteristics in glioblastomas in correlation with p53 and Ki67. Medicina (Kaunas). 2023, 59:1918. 10.3390\/medicina59111918","journal-title":"Medicina (Kaunas)"},{"key":"ref26","article-title":"Monoexponential, biexponential and stretched exponential models of diffusion weighted magnetic resonance imaging in glioma in relation to histopathologic grade and Ki-67 labeling index using high B values","volume":"13","author":"Chaudhary N","year":"2021","unstructured":"Chaudhary N, Zhang G, Li S, Zhu W. Monoexponential, biexponential and stretched exponential models of diffusion weighted magnetic resonance imaging in glioma in relation to histopathologic grade and Ki-67 labeling index using high B values. Am J Transl Res. 2021, 13:12480-94.","journal-title":"Am J Transl Res"},{"key":"ref27","article-title":"Gliomas: correlation of histologic grade, Ki67 and p53 expression with patient survival","volume":"11","author":"Arshad H","year":"2010","unstructured":"Arshad H, Ahmad Z, Hasan SH. Gliomas: correlation of histologic grade, Ki67 and p53 expression with patient survival. Asian Pac J Cancer Prev. 2010, 11:1637-40.","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95958-9","article-title":"Prognostic role of Ki-67 in glioblastomas excluding contribution from non-neoplastic cells","volume":"11","author":"Dahlrot RH","year":"2021","unstructured":"Dahlrot RH, Bangs\u00f8 JA, Petersen JK, et al.. Prognostic role of Ki-67 in glioblastomas excluding contribution from non-neoplastic cells. Sci Rep. 2021, 11:17918. 10.1038\/s41598-021-95958-9","journal-title":"Sci Rep"},{"key":"ref29","article-title":"Immunohistochemical study of P53 and Ki-67 in astrocytoma","volume":"1","author":"Muslim LM","year":"2021","unstructured":"Muslim LM, Hasan MM, Dosh ZN, Altoraihi KM. Immunohistochemical study of P53 and Ki-67 in astrocytoma. Ann Rom Soc Cell Biol. 2021, 1:6507-25.","journal-title":"Ann Rom Soc Cell Biol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/273852-histopathological-spectrum-of-gliomas-and-its-immunohistochemical-correlation-in-a-tertiary-care-setup","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T14:54:10Z","timestamp":1721573650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/273852-histopathological-spectrum-of-gliomas-and-its-immunohistochemical-correlation-in-a-tertiary-care-setup"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,21]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.65036","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,21]]}}}