{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:25:04Z","timestamp":1721694304631},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,22]]},"DOI":"10.7759\/cureus.65073","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T08:21:00Z","timestamp":1721636460000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of Ondansetron on Maternal Hypotension During Spinal Anesthesia With Ropivacaine for Cesarean Sections: A Randomized, Double-Blind Trial"],"prefix":"10.7759","author":[{"given":"Stavroula","family":"Karachanidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anteia","family":"Paraskeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polyxeni","family":"Theodosopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Micha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u202aChryssoula","family":"Staikou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(83)80014-x","article-title":"The Bezold-Jarisch reflex revisited: clinical implications of inhibitory reflexes originating in the heart","volume":"1","author":"Mark AL","year":"1983","unstructured":"Mark AL. The Bezold-Jarisch reflex revisited: clinical implications of inhibitory reflexes originating in the heart. J Am Coll Cardiol. 1983, 1:90-102. 10.1016\/s0735-1097(83)80014-x","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1111\/j.1749-6632.2001.tb03666.x","article-title":"The Bezold-Jarisch reflex. A historical perspective of cardiopulmonary reflexes","volume":"940","author":"Aviado DM","year":"2001","unstructured":"Aviado DM, Guevara Aviado D. The Bezold-Jarisch reflex. A historical perspective of cardiopulmonary reflexes. Ann N Y Acad Sci. 2001, 940:48-58.","journal-title":"Ann N Y Acad Sci"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.94155","article-title":"Comparing the effect of bupivacaine and ropivacaine in cesarean delivery with spinal anesthesia","volume":"10","author":"Olapour A","year":"2020","unstructured":"Olapour A, Akhondzadeh R, Rashidi M, Gousheh M, Homayoon R. Comparing the effect of bupivacaine and ropivacaine in cesarean delivery with spinal anesthesia. Anesth Pain Med. 2020, 10:e94155. 10.5812\/aapm.94155","journal-title":"Anesth Pain Med"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2019.07.014","article-title":"The efficacy of ropivacaine and bupivacaine in the caesarean section and the effect on the vital signs and the hemodynamics of the lying-in women","volume":"26","author":"Wang H","year":"2019","unstructured":"Wang H, Gao Q, Xu R, Dong W, Zhang Y, Fan J. The efficacy of ropivacaine and bupivacaine in the caesarean section and the effect on the vital signs and the hemodynamics of the lying-in women. Saudi J Biol Sci. 2019, 26:1991-4. 10.1016\/j.sjbs.2019.07.014","journal-title":"Saudi J Biol Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5812\/aapm-134732","article-title":"A comparative study on the effect of intrathecal bupivacaine vs. ropivacaine on maternal and neonatal outcomes after cesarean section: a systematic review and meta-analysis","volume":"13","author":"Jaafarpour M","year":"2023","unstructured":"Jaafarpour M, Vasigh A, Najafi F, Sayadi H, Shafiei E. A comparative study on the effect of intrathecal bupivacaine vs. ropivacaine on maternal and neonatal outcomes after cesarean section: a systematic review and meta-analysis. Anesth Pain Med. 2023, 13:e134732. 10.5812\/aapm-134732","journal-title":"Anesth Pain Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90059-0","article-title":"Molecular biology of 5-HT receptors","volume":"33","author":"Boess FG","year":"1994","unstructured":"Boess FG, Martin IL. Molecular biology of 5-HT receptors. Neuropharmacology. 1994, 33:275-317. 10.1016\/0028-3908(94)90059-0","journal-title":"Neuropharmacology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(83)90659-3","article-title":"Failure of 5-methoxytryptamine to evoke the Bezold-Jarisch effect supports homology of excitatory 5-HT receptors on vagal afferents and postganglionic sympathetic neurones","volume":"25","author":"Fozard JR","year":"1983","unstructured":"Fozard JR. Failure of 5-methoxytryptamine to evoke the Bezold-Jarisch effect supports homology of excitatory 5-HT receptors on vagal afferents and postganglionic sympathetic neurones. Eur J Pharmacol. 1983, 25:331-2. 10.1016\/0014-2999(83)90659-3","journal-title":"Eur J Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.69.351","article-title":"Characteristics of inhibitory effects of serotonin (5-HT)3-receptor antagonists, YM060 and YM114 (KAE-393), on the von Bezold-Jarisch reflex induced by 2-methyl-5-HT, veratridine and electrical stimulation of vagus nerves in anesthetized rats","volume":"69","author":"Yamano M","year":"1995","unstructured":"Yamano M, Ito H, Kamato T, Miyata K. Characteristics of inhibitory effects of serotonin (5-HT)3-receptor antagonists, YM060 and YM114 (KAE-393), on the von Bezold-Jarisch reflex induced by 2-methyl-5-HT, veratridine and electrical stimulation of vagus nerves in anesthetized rats. Jpn J Pharmacol. 1995, 69:351-6. 10.1254\/jjp.69.351","journal-title":"Jpn J Pharmacol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000152616.57107.F6","article-title":"Systemic ondansetron antagonizes the sensory block produced by intrathecal lidocaine","volume":"100","author":"Fassoulaki A","year":"2005","unstructured":"Fassoulaki A, Melemeni A, Zotou M, Sarantopoulos C. Systemic ondansetron antagonizes the sensory block produced by intrathecal lidocaine. Anesth Analg. 2005, 100:1817-21. 10.1213\/01.ANE.0000152616.57107.F6","journal-title":"Anesth Analg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318165e012","article-title":"The effects of intravenous granisetron on the sensory and motor blockade produced by intrathecal bupivacaine","volume":"106","author":"Mowafi HA","year":"2008","unstructured":"Mowafi HA, Arab SA, Ismail SA, Al-Ghamdi A. The effects of intravenous granisetron on the sensory and motor blockade produced by intrathecal bupivacaine. Anesth Analg. 2008, 106:1322-5, table of contents. 10.1213\/ane.0b013e318165e012","journal-title":"Anesth Analg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002182","article-title":"A review of the impact of obstetric anesthesia on maternal and neonatal outcomes","volume":"129","author":"Lim G","year":"2018","unstructured":"Lim G, Facco FL, Nathan N, Waters JH, Wong CA, Eltzschig HK. A review of the impact of obstetric anesthesia on maternal and neonatal outcomes. Anesthesiology. 2018, 129:192-215. 10.1097\/ALN.0000000000002182","journal-title":"Anesthesiology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF03019100","article-title":"Witnessed asystole during spinal anesthesia treated with atropine and ondansetron: a case report","volume":"51","author":"Martinek RM","year":"2004","unstructured":"Martinek RM. Witnessed asystole during spinal anesthesia treated with atropine and ondansetron: a case report. Can J Anaesth. 2004, 51:226-30. 10.1007\/BF03019100","journal-title":"Can J Anaesth"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_22_19","article-title":"Effect of intravenous ondansetron on spinal anesthesia-induced hypotension and bradycardia: a randomized controlled double-blinded study","volume":"13","author":"Tatikonda CM","year":"2019","unstructured":"Tatikonda CM, Rajappa GC, Rath P, Abbas M, Madhapura VS, Gopal NV. Effect of intravenous ondansetron on spinal anesthesia-induced hypotension and bradycardia: a randomized controlled double-blinded study. Anesth Essays Res. 2019, 13:340-6. 10.4103\/aer.AER_22_19","journal-title":"Anesth Essays Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181b7c4f6","article-title":"Ropivacaine spinal anesthesia is not antagonized by ondansetron pretreatment","volume":"109","author":"Paraskeva A","year":"2009","unstructured":"Paraskeva A, Chatziara V, Siafaka I, Zotou M, Fassoulaki A. Ropivacaine spinal anesthesia is not antagonized by ondansetron pretreatment. Anesth Analg. 2009, 109:1684-7. 10.1213\/ANE.0b013e3181b7c4f6","journal-title":"Anesth Analg"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1037\/\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen J","year":"1992","unstructured":"Cohen J. A power primer. Psychol Bull. 1992, 112:155-9. 10.1037\/\/0033-2909.112.1.155","journal-title":"Psychol Bull"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2014.01.005","article-title":"The effect of intravenous ondansetron on maternal haemodynamics during elective caesarean delivery under spinal anaesthesia: a double-blind, randomised, placebo-controlled trial","volume":"23","author":"Ortiz-G\u00f3mez JR","year":"2014","unstructured":"Ortiz-G\u00f3mez JR, Palacio-Abizanda FJ, Morillas-Ramirez F, Fornet-Ruiz I, Lorenzo-Jim\u00e9nez A, Bermejo-Albares ML. The effect of intravenous ondansetron on maternal haemodynamics during elective caesarean delivery under spinal anaesthesia: a double-blind, randomised, placebo-controlled trial. Int J Obstet Anesth. 2014, 23:138-43. 10.1016\/j.ijoa.2014.01.005","journal-title":"Int J Obstet Anesth"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-018-0568-7","article-title":"Minimal effective weight-based dosing of ondansetron to reduce hypotension in cesarean section under spinal anesthesia: a randomized controlled superiority trial","volume":"18","author":"Oofuvong M","year":"2018","unstructured":"Oofuvong M, Kunapaisal T, Karnjanawanichkul O, Dilokrattanaphijit N, Leeratiwong J. Minimal effective weight-based dosing of ondansetron to reduce hypotension in cesarean section under spinal anesthesia: a randomized controlled superiority trial. BMC Anesthesiol. 2018, 18:105. 10.1186\/s12871-018-0568-7","journal-title":"BMC Anesthesiol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-017-2436-x","article-title":"Does prophylactic ondansetron reduce norepinephrine consumption in patients undergoing cesarean section with spinal anesthesia?","volume":"32","author":"Karacaer F","year":"2018","unstructured":"Karacaer F, Biricik E, \u00dcnal \u0130, B\u00fcy\u00fckkurt S, \u00dcnl\u00fcgen\u00e7 H. Does prophylactic ondansetron reduce norepinephrine consumption in patients undergoing cesarean section with spinal anesthesia?. J Anesth. 2018, 32:90-7. 10.1007\/s00540-017-2436-x","journal-title":"J Anesth"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517716502","article-title":"Efficacy of ondansetron for spinal anesthesia during cesarean section: a meta-analysis of randomized trials","volume":"46","author":"Zhou C","year":"2018","unstructured":"Zhou C, Zhu Y, Bao Z, Wang X, Liu Q. Efficacy of ondansetron for spinal anesthesia during cesarean section: a meta-analysis of randomized trials. J Int Med Res. 2018, 46:654-62. 10.1177\/0300060517716502","journal-title":"J Int Med Res"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2015.08.012","article-title":"Effects of prophylactic ondansetron on spinal anesthesia-induced hypotension: a meta-analysis","volume":"24","author":"Gao L","year":"2015","unstructured":"Gao L, Zheng G, Han J, Wang Y, Zheng J. Effects of prophylactic ondansetron on spinal anesthesia-induced hypotension: a meta-analysis. Int J Obstet Anesth. 2015, 24:335-43. 10.1016\/j.ijoa.2015.08.012","journal-title":"Int J Obstet Anesth"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001511","article-title":"Prevention of spinal anesthesia-induced hypotension during cesarean delivery by 5-hydroxytryptamine-3 receptor antagonists: a systematic review and meta-analysis and meta-regression","volume":"123","author":"Heesen M","year":"2016","unstructured":"Heesen M, Klimek M, Hoeks SE, Rossaint R. Prevention of spinal anesthesia-induced hypotension during cesarean delivery by 5-hydroxytryptamine-3 receptor antagonists: a systematic review and meta-analysis and meta-regression. Anesth Analg. 2016, 123:977-88. 10.1213\/ANE.0000000000001511","journal-title":"Anesth Analg"},{"key":"ref22","article-title":"Effects of ondansetron on attenuating spinal anesthesia-induced hypotension and bradycardia in obstetric and nonobstetric subjects: a systematic review and meta-analysis","volume":"85","author":"Tubog TD","year":"2017","unstructured":"Tubog TD, Kane TD, Pugh MA. Effects of ondansetron on attenuating spinal anesthesia-induced hypotension and bradycardia in obstetric and nonobstetric subjects: a systematic review and meta-analysis. AANA J. 2017, 85:113-22.","journal-title":"AANA J"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110469","article-title":"Granisetron or ondansentron to prevent hypotension after spinal anesthesia for elective cesarean delivery: a randomized placebo-controlled trial","volume":"75","author":"Aksoy M","year":"2021","unstructured":"Aksoy M, Dostbil A, Aksoy AN, Ince I, Bedir Z, Ozmen O. Granisetron or ondansentron to prevent hypotension after spinal anesthesia for elective cesarean delivery: a randomized placebo-controlled trial. J Clin Anesth. 2021, 75:110469. 10.1016\/j.jclinane.2021.110469","journal-title":"J Clin Anesth"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2020.12.028","article-title":"Effect of ondansetron on spinal anesthesia-induced hypotension in non-obstetric surgeries: a randomised, double-blind and placebo-controlled trial","volume":"71","author":"Mendon\u00e7a FT","year":"2021","unstructured":"Mendon\u00e7a FT, Crepaldi Junior LC, Gersanti RC, de Ara\u00fajo KC. Effect of ondansetron on spinal anesthesia-induced hypotension in non-obstetric surgeries: a randomised, double-blind and placebo-controlled trial. Braz J Anesthesiol. 2021, 71:233-40. 10.1016\/j.bjane.2020.12.028","journal-title":"Braz J Anesthesiol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004534","article-title":"A prospective, randomized, double-blinded study of the effect of intravenous ondansetron on the effective dose in 50% of subjects of prophylactic phenylephrine infusions for preventing spinal anesthesia-induced hypotension during cesarean delivery","volume":"131","author":"Xiao F","year":"2020","unstructured":"Xiao F, Wei C, Chang X, et al.. A prospective, randomized, double-blinded study of the effect of intravenous ondansetron on the effective dose in 50% of subjects of prophylactic phenylephrine infusions for preventing spinal anesthesia-induced hypotension during cesarean delivery. Anesth Analg. 2020, 131:564-9. 10.1213\/ANE.0000000000004534","journal-title":"Anesth Analg"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.130031","article-title":"A comparative evaluation of hyperbaric ropivacaine versus hyperbaric bupivacaine for elective surgery under spinal anesthesia","volume":"30","author":"Kulkarni KR","year":"2014","unstructured":"Kulkarni KR, Deshpande S, Namazi I, Singh SK, Kondilya K. A comparative evaluation of hyperbaric ropivacaine versus hyperbaric bupivacaine for elective surgery under spinal anesthesia. J Anaesthesiol Clin Pharmacol. 2014, 30:238-42. 10.4103\/0970-9185.130031","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"ref27","article-title":"Comparison of body height and vertebral column length in Chinese parturients [Article in Chinese]","volume":"30","author":"Lin IS","year":"1992","unstructured":"Lin IS, Lee CL, Wu JL, Wang CF, Liu CG, Lee YT. Comparison of body height and vertebral column length in Chinese parturients [Article in Chinese]. Ma Zui Xue Za Zhi. 1992, 30:21-5.","journal-title":"Ma Zui Xue Za Zhi"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2010.02239.x","article-title":"Definitions of hypotension after spinal anaesthesia for caesarean section: literature search and application to parturients","volume":"54","author":"Kl\u00f6hr S","year":"2010","unstructured":"Kl\u00f6hr S, Roth R, Hofmann T, Rossaint R, Heesen M. Definitions of hypotension after spinal anaesthesia for caesarean section: literature search and application to parturients. Acta Anaesthesiol Scand. 2010, 54:909-21. 10.1111\/j.1399-6576.2010.02239.x","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2001.02058-5.x","article-title":"Prevention and management of hypotension during spinal anaesthesia for elective caesarean section: a survey of practice","volume":"56","author":"Burns SM","year":"2001","unstructured":"Burns SM, Cowan CM, Wilkes RG. Prevention and management of hypotension during spinal anaesthesia for elective caesarean section: a survey of practice. Anaesthesia. 2001, 56:794-8. 10.1046\/j.1365-2044.2001.02058-5.x","journal-title":"Anaesthesia"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.20471\/acc.2019.58.s1.13","article-title":"Spinal anaesthesia-induced hypotension in obstetrics: prevention and therapy","volume":"58","author":"\u0160klebar I","year":"2019","unstructured":"\u0160klebar I, Bujas T, Habek D. Spinal anaesthesia-induced hypotension in obstetrics: prevention and therapy. Acta Clin Croat. 2019, 58:90-5. 10.20471\/acc.2019.58.s1.13","journal-title":"Acta Clin Croat"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/271935-effect-of-ondansetron-on-maternal-hypotension-during-spinal-anesthesia-with-ropivacaine-for-cesarean-sections-a-randomized-double-blind-trial","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T08:21:26Z","timestamp":1721636486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/271935-effect-of-ondansetron-on-maternal-hypotension-during-spinal-anesthesia-with-ropivacaine-for-cesarean-sections-a-randomized-double-blind-trial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.65073","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,22]]}}}