{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:49:44Z","timestamp":1781768984180,"version":"3.54.5"},"reference-count":118,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"DOI":"10.7759\/cureus.65393","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:20:55Z","timestamp":1721971255000},"source":"Crossref","is-referenced-by-count":7,"title":["Insulin-Like Growth Factor 1 Has the Potential to Be Used as a Diagnostic Tool and Treatment Target for Autism Spectrum Disorders"],"prefix":"10.7759","author":[{"given":"Jiamin","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.05.007","article-title":"Autism spectrum disorder: classification, diagnosis and therapy","volume":"190","author":"Sharma SR","year":"2018","unstructured":"Sharma SR, Gonda X, Tarazi FI. Autism spectrum disorder: classification, diagnosis and therapy. Pharmacol Ther. 2018, 190:91-104. 10.1016\/j.pharmthera.2018.05.007","journal-title":"Pharmacol Ther"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013173.pub2","article-title":"Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD)","volume":"9","author":"Elliott SJ","year":"2021","unstructured":"Elliott SJ, Marshall D, Morley K, Uphoff E, Kumar M, Meader N. Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD). Cochrane Database Syst Rev. 2021, 9:CD013173. 10.1002\/14651858.CD013173.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.23661","article-title":"Autism spectrum disorder: a review","volume":"329","author":"Hirota T","year":"2023","unstructured":"Hirota T, King BH. Autism spectrum disorder: a review. JAMA. 2023, 329:157-68. 10.1001\/jama.2022.23661","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6904a1","article-title":"Prevalence of autism spectrum disorder among children aged 8 years - Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2016","volume":"69","author":"Maenner MJ","year":"2020","unstructured":"Maenner MJ, Shaw KA, Baio J, et al.. Prevalence of autism spectrum disorder among children aged 8 years - Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2016. MMWR Surveill Summ. 2020, 69:1-12. 10.15585\/mmwr.ss6904a1","journal-title":"MMWR Surveill Summ"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7202a1","article-title":"Prevalence and characteristics of autism spectrum disorder among children aged 8 years - Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2020","volume":"72","author":"Maenner MJ","year":"2023","unstructured":"Maenner MJ, Warren Z, Williams AR, et al.. Prevalence and characteristics of autism spectrum disorder among children aged 8 years - Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2020. MMWR Surveill Summ. 2023, 72:1-14. 10.15585\/mmwr.ss7202a1","journal-title":"MMWR Surveill Summ"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2022.37.e1","article-title":"Prevalence and premature mortality statistics of autism spectrum disorder among children in Korea: a nationwide population-based birth cohort study","volume":"37","author":"Yoo SM","year":"2022","unstructured":"Yoo SM, Kim KN, Kang S, Kim HJ, Yun J, Lee JY. Prevalence and premature mortality statistics of autism spectrum disorder among children in Korea: a nationwide population-based birth cohort study. J Korean Med Sci. 2022, 37:e1. 10.3346\/jkms.2022.37.e1","journal-title":"J Korean Med Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/1362361316673977","article-title":"Diagnoses of autism spectrum disorders in Germany: time trends in administrative prevalence and diagnostic stability","volume":"22","author":"Bachmann CJ","year":"2018","unstructured":"Bachmann CJ, Gerste B, Hoffmann F. Diagnoses of autism spectrum disorders in Germany: time trends in administrative prevalence and diagnostic stability. Autism. 2018, 22:283-90. 10.1177\/1362361316673977","journal-title":"Autism"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2019.19.04.005","article-title":"Revisiting the prevalence of autism spectrum disorder among Omani children: a multicentre study","volume":"19","author":"Al-Mamri W","year":"2019","unstructured":"Al-Mamri W, Idris AB, Dakak S, et al.. Revisiting the prevalence of autism spectrum disorder among Omani children: a multicentre study. Sultan Qaboos Univ Med J. 2019, 19:e305-9. 10.18295\/squmj.2019.19.04.005","journal-title":"Sultan Qaboos Univ Med J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-019-04014-z","article-title":"The economic costs of autism spectrum disorder: a literature review","volume":"49","author":"Rogge N","year":"2019","unstructured":"Rogge N, Janssen J. The economic costs of autism spectrum disorder: a literature review. J Autism Dev Disord. 2019, 49:2873-900. 10.1007\/s10803-019-04014-z","journal-title":"J Autism Dev Disord"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102664","article-title":"The role of insulin-like growth factor-1 (IGF-1) in the control of neuroendocrine regulation of growth","volume":"10","author":"Al-Samerria S","year":"2021","unstructured":"Al-Samerria S, Radovick S. The role of insulin-like growth factor-1 (IGF-1) in the control of neuroendocrine regulation of growth. Cells. 2021, 10:2664. 10.3390\/cells10102664","journal-title":"Cells"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.08.006","article-title":"Involvement of insulin-like growth factor-I in the control of glucose homeostasis","volume":"6","author":"Clemmons DR","year":"2006","unstructured":"Clemmons DR. Involvement of insulin-like growth factor-I in the control of glucose homeostasis. Curr Opin Pharmacol. 2006, 6:620-5. 10.1016\/j.coph.2006.08.006","journal-title":"Curr Opin Pharmacol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1220031","article-title":"Insulin-like growth factor axis during embryonic development","volume":"122","author":"Allan GJ","year":"2001","unstructured":"Allan GJ, Flint DJ, Patel K. Insulin-like growth factor axis during embryonic development. Reproduction. 2001, 122:31-9. 10.1530\/rep.0.1220031","journal-title":"Reproduction"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000054","article-title":"Genetic and physiological effects of insulin-like growth factor-1 (IGF-1) on human urate homeostasis","volume":"34","author":"Mandal AK","year":"2023","unstructured":"Mandal AK, Leask MP, Sumpter NA, Choi HK, Merriman TR, Mount DB. Genetic and physiological effects of insulin-like growth factor-1 (IGF-1) on human urate homeostasis. J Am Soc Nephrol. 2023, 34:451-66. 10.1681\/ASN.0000000000000054","journal-title":"J Am Soc Nephrol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.55.030193.001023","article-title":"The insulin-like growth factors","volume":"55","author":"Cohick WS","year":"1993","unstructured":"Cohick WS, Clemmons DR. The insulin-like growth factors. Annu Rev Physiol. 1993, 55:131-53. 10.1146\/annurev.ph.55.030193.001023","journal-title":"Annu Rev Physiol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13350","article-title":"Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development","volume":"105","author":"Hellstr\u00f6m A","year":"2016","unstructured":"Hellstr\u00f6m A, Ley D, Hansen-Pupp I, et al.. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 2016, 105:576-86. 10.1111\/apa.13350","journal-title":"Acta Paediatr"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.03.056","article-title":"The role of insulin-like growth factor 1 (IGF-1) in brain development, maturation and neuroplasticity","volume":"325","author":"Dyer AH","year":"2016","unstructured":"Dyer AH, Vahdatpour C, Sanfeliu A, Tropea D. The role of insulin-like growth factor 1 (IGF-1) in brain development, maturation and neuroplasticity. Neuroscience. 2016, 325:89-99. 10.1016\/j.neuroscience.2016.03.056","journal-title":"Neuroscience"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1142644","article-title":"New insights on the cardiovascular effects of IGF-1","volume":"14","author":"Macvanin M","year":"2023","unstructured":"Macvanin M, Gluvic Z, Radovanovic J, Essack M, Gao X, Isenovic ER. New insights on the cardiovascular effects of IGF-1. Front Endocrinol (Lausanne). 2023, 14:1142644. 10.3389\/fendo.2023.1142644","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124125","article-title":"The role of insulin-like growth factor-1 in bone remodeling: A review","volume":"238","author":"Fang J","year":"2023","unstructured":"Fang J, Zhang X, Chen X, et al.. The role of insulin-like growth factor-1 in bone remodeling: A review. Int J Biol Macromol. 2023, 238:124125. 10.1016\/j.ijbiomac.2023.124125","journal-title":"Int J Biol Macromol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901107RR","article-title":"CRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression","volume":"34","author":"Roberston MJ","year":"2020","unstructured":"Roberston MJ, Raghunathan S, Potaman VN, Zhang F, Stewart MD, McConnell BK, Schwartz RJ. CRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression. FASEB J. 2020, 34:555-70. 10.1096\/fj.201901107RR","journal-title":"FASEB J"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000002146","article-title":"The role of insulin-like growth factor-1 and its receptor in the eye: a review and implications for IGF-1R inhibition","volume":"39","author":"Truong T","year":"2023","unstructured":"Truong T, Silkiss RZ. The role of insulin-like growth factor-1 and its receptor in the eye: a review and implications for IGF-1R inhibition. Ophthalmic Plast Reconstr Surg. 2023, 39:4-12. 10.1097\/IOP.0000000000002146","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1530\/REP-22-0040","article-title":"Effect of estradiol and IGF1 on glycogen synthesis in bovine uterine epithelial cells","volume":"164","author":"Gonzalez A","year":"2022","unstructured":"Gonzalez A, Berg MD, Southey B, Dean M. Effect of estradiol and IGF1 on glycogen synthesis in bovine uterine epithelial cells. Reproduction. 2022, 164:97-108. 10.1530\/REP-22-0040","journal-title":"Reproduction"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0252","article-title":"Role of the GH-IGF1 axis on the hypothalamus-pituitary-testicular axis function: lessons from Laron syndrome","volume":"10","author":"Cannarella R","year":"2021","unstructured":"Cannarella R, Crafa A, La Vignera S, Condorelli RA, Calogero AE. Role of the GH-IGF1 axis on the hypothalamus-pituitary-testicular axis function: lessons from Laron syndrome. Endocr Connect. 2021, 10:1006-17. 10.1530\/EC-21-0252","journal-title":"Endocr Connect"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2009.0703","article-title":"Treatment of dwarfism with recombinant human insulin-like growth factor-1","volume":"106","author":"Ranke MB","year":"2009","unstructured":"Ranke MB, W\u00f6lfle J, Schnabel D, Bettendorf M. Treatment of dwarfism with recombinant human insulin-like growth factor-1. Dtsch Arztebl Int. 2009, 106:703-9. 10.3238\/arztebl.2009.0703","journal-title":"Dtsch Arztebl Int"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-5276.18.05069-7","article-title":"Correlation of serum levels of LH, IGF-1 and leptin in girls with the development of idiopathic central precocious puberty","volume":"75","author":"He J","year":"2023","unstructured":"He J, Kang Y, Zheng L. Correlation of serum levels of LH, IGF-1 and leptin in girls with the development of idiopathic central precocious puberty. Minerva Pediatr (Torino). 2023, 75:381-6. 10.23736\/S2724-5276.18.05069-7","journal-title":"Minerva Pediatr (Torino)"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.12.004","article-title":"Association of insulin-like growth factor-1 with polycystic ovarian syndrome: a systematic review and meta-analysis","volume":"29","author":"Li H","year":"2023","unstructured":"Li H, Zhang Y, Liu C, Zhang Y, Yang H, Fu S, Lv H. Association of insulin-like growth factor-1 with polycystic ovarian syndrome: a systematic review and meta-analysis. Endocr Pract. 2023, 29:388-97. 10.1016\/j.eprac.2022.12.004","journal-title":"Endocr Pract"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15210","article-title":"The potential role of insulin-like growth factor 1 in acne vulgaris and its correlation with the clinical response before and after treatment with metformin","volume":"21","author":"Albalat W","year":"2022","unstructured":"Albalat W, Darwish H, Abd-Elaal WH, AbouHadeed MH, Essam R. The potential role of insulin-like growth factor 1 in acne vulgaris and its correlation with the clinical response before and after treatment with metformin. J Cosmet Dermatol. 2022, 21:6209-14. 10.1111\/jocd.15210","journal-title":"J Cosmet Dermatol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmac039","article-title":"Association of RS5742612 polymorphism in the promoter region of IGF1 gene with nonalcoholic fatty liver disease: a case-control study","volume":"53","author":"Nobakht H","year":"2022","unstructured":"Nobakht H, Mahmoudi T, Rezamand G, et al.. Association of RS5742612 polymorphism in the promoter region of IGF1 gene with nonalcoholic fatty liver disease: a case-control study. Lab Med. 2022, 53:504-8. 10.1093\/labmed\/lmac039","journal-title":"Lab Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2014.10.004","article-title":"Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance","volume":"2","author":"Denduluri SK","year":"2015","unstructured":"Denduluri SK, Idowu O, Wang Z, et al.. Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance. Genes Dis. 2015, 2:13-25. 10.1016\/j.gendis.2014.10.004","journal-title":"Genes Dis"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-22-0414","article-title":"GH and IGF1 in cancer therapy resistance","volume":"30","author":"Basu R","year":"2023","unstructured":"Basu R, Kopchick JJ. GH and IGF1 in cancer therapy resistance. Endocr Relat Cancer. 2023, 30:10.1530\/ERC-22-0414","journal-title":"Endocr Relat Cancer"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20778","article-title":"Toward a comprehensive neurobiology of IGF-I","volume":"70","author":"Torres-Aleman I","year":"2010","unstructured":"Torres-Aleman I. Toward a comprehensive neurobiology of IGF-I. Dev Neurobiol. 2010, 70:384-96. 10.1002\/dneu.20778","journal-title":"Dev Neurobiol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102056","article-title":"Insulin-like growth factors in the pathogenesis of neurological diseases in children","volume":"18","author":"Riikonen R","year":"2017","unstructured":"Riikonen R. Insulin-like growth factors in the pathogenesis of neurological diseases in children. Int J Mol Sci. 2017, 18:2056. 10.3390\/ijms18102056","journal-title":"Int J Mol Sci"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas DL","year":"2005","unstructured":"Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 2005, 57:67-81. 10.1002\/ana.20315","journal-title":"Ann Neurol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17503-6","article-title":"BDNF, proBDNF and IGF-1 serum levels in na\u00efve and medicated subjects with autism","volume":"12","author":"Robinson-Agramonte ML","year":"2022","unstructured":"Robinson-Agramonte ML, Michalski B, Vidal-Martinez B, Hern\u00e1ndez LR, Santiesteban MW, Fahnestock M. BDNF, proBDNF and IGF-1 serum levels in na\u00efve and medicated subjects with autism. Sci Rep. 2022, 12:13768. 10.1038\/s41598-022-17503-6","journal-title":"Sci Rep"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-990282","article-title":"Urinary epidermal and insulin-like growth factor excretion in autistic children","volume":"38","author":"Anlar B","year":"2007","unstructured":"Anlar B, Oktem F, Bakkaloglu B, et al.. Urinary epidermal and insulin-like growth factor excretion in autistic children. Neuropediatrics. 2007, 38:151-3. 10.1055\/s-2007-990282","journal-title":"Neuropediatrics"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61695-8","article-title":"Genetic landscape of autism spectrum disorder in Vietnamese children","volume":"10","author":"Tran KT","year":"2020","unstructured":"Tran KT, Le VS, Bui HT, et al.. Genetic landscape of autism spectrum disorder in Vietnamese children. Sci Rep. 2020, 10:5034. 10.1038\/s41598-020-61695-8","journal-title":"Sci Rep"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02374-w","article-title":"Comorbidities in autism spectrum disorder and their etiologies","volume":"13","author":"Khachadourian V","year":"2023","unstructured":"Khachadourian V, Mahjani B, Sandin S, Kolevzon A, Buxbaum JD, Reichenberg A, Janecka M. Comorbidities in autism spectrum disorder and their etiologies. Transl Psychiatry. 2023, 13:71. 10.1038\/s41398-023-02374-w","journal-title":"Transl Psychiatry"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.01.007","article-title":"Maternal inflammation and its ramifications on fetal neurodevelopment","volume":"43","author":"Kwon HK","year":"2022","unstructured":"Kwon HK, Choi GB, Huh JR. Maternal inflammation and its ramifications on fetal neurodevelopment. Trends Immunol. 2022, 43:230-44. 10.1016\/j.it.2022.01.007","journal-title":"Trends Immunol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.12.017","article-title":"Activation of the maternal immune system induces endocrine changes in the placenta via IL-6","volume":"25","author":"Hsiao EY","year":"2011","unstructured":"Hsiao EY, Patterson PH. Activation of the maternal immune system induces endocrine changes in the placenta via IL-6. Brain Behav Immun. 2011, 25:604-15. 10.1016\/j.bbi.2010.12.017","journal-title":"Brain Behav Immun"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-4-2062","article-title":"Effect of maternal fasting on fetal growth, serum insulin-like growth factors (IGFs), and tissue IGF messenger ribonucleic acids","volume":"126","author":"Davenport ML","year":"1990","unstructured":"Davenport ML, D'Ercole AJ, Underwood LE. Effect of maternal fasting on fetal growth, serum insulin-like growth factors (IGFs), and tissue IGF messenger ribonucleic acids. Endocrinology. 1990, 126:2062-7. 10.1210\/endo-126-4-2062","journal-title":"Endocrinology"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-016-9816-z","article-title":"Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3","volume":"31","author":"Kartal \u00d6","year":"2016","unstructured":"Kartal \u00d6, Ayd\u0131n\u00f6z S, Kartal AT, et al.. Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3. Metab Brain Dis. 2016, 31:827-35. 10.1007\/s11011-016-9816-z","journal-title":"Metab Brain Dis"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-015-8341-2","article-title":"NNZ-2566, a novel analog of (1-3) IGF-1, as a potential therapeutic agent for fragile X syndrome","volume":"17","author":"Deacon RM","year":"2015","unstructured":"Deacon RM, Glass L, Snape M, Hurley MJ, Altimiras FJ, Biekofsky RR, Cogram P. NNZ-2566, a novel analog of (1-3) IGF-1, as a potential therapeutic agent for fragile X syndrome. Neuromolecular Med. 2015, 17:71-82. 10.1007\/s12017-015-8341-2","journal-title":"Neuromolecular Med"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113199","article-title":"Lif-IGF axis contributes to the proliferation of neural progenitor cells in developing rat cerebrum","volume":"23","author":"Takata S","year":"2022","unstructured":"Takata S, Sakata-Haga H, Shimada H, et al.. Lif-IGF axis contributes to the proliferation of neural progenitor cells in developing rat cerebrum. Int J Mol Sci. 2022, 23:13199. 10.3390\/ijms232113199","journal-title":"Int J Mol Sci"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040666","article-title":"Research progress on neuroprotection of insulin-like growth factor-1 towards glutamate-induced neurotoxicity","volume":"11","author":"Ge L","year":"2022","unstructured":"Ge L, Liu S, Rubin L, Lazarovici P, Zheng W. Research progress on neuroprotection of insulin-like growth factor-1 towards glutamate-induced neurotoxicity. Cells. 2022, 11:666. 10.3390\/cells11040666","journal-title":"Cells"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00365","article-title":"Insulin-like growth factor-1 and neuroinflammation","volume":"9","author":"Labandeira-Garcia JL","year":"2017","unstructured":"Labandeira-Garcia JL, Costa-Besada MA, Labandeira CM, Villar-Cheda B, Rodr\u00edguez-Perez AI. Insulin-like growth factor-1 and neuroinflammation. Front Aging Neurosci. 2017, 9:365. 10.3389\/fnagi.2017.00365","journal-title":"Front Aging Neurosci"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1255","article-title":"Partial IGF-1 deficiency induces brain oxidative damage and edema, which are ameliorated by replacement therapy","volume":"42","author":"Puche JE","year":"2016","unstructured":"Puche JE, Mu\u00f1oz \u00da, Garc\u00eda-Magari\u00f1o M, S\u00e1daba MC, Castilla-Cort\u00e1zar I. Partial IGF-1 deficiency induces brain oxidative damage and edema, which are ameliorated by replacement therapy. Biofactors. 2016, 42:60-79. 10.1002\/biof.1255","journal-title":"Biofactors"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.4003","article-title":"Trofinetide receives FDA approval as first drug for Rett syndrome","volume":"329","author":"Harris E","year":"2023","unstructured":"Harris E. Trofinetide receives FDA approval as first drug for Rett syndrome. JAMA. 2023, 329:1142. 10.1001\/jama.2023.4003","journal-title":"JAMA"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3209","article-title":"The many faces of insulin-like peptide signalling in the brain","volume":"13","author":"Fernandez AM","year":"2012","unstructured":"Fernandez AM, Torres-Alem\u00e1n I. The many faces of insulin-like peptide signalling in the brain. Nat Rev Neurosci. 2012, 13:225-39. 10.1038\/nrn3209","journal-title":"Nat Rev Neurosci"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.10.002","article-title":"Growth hormone, insulin-like growth factor-1 and the aging brain","volume":"68","author":"Ashpole NM","year":"2015","unstructured":"Ashpole NM, Sanders JE, Hodges EL, Yan H, Sonntag WE. Growth hormone, insulin-like growth factor-1 and the aging brain. Exp Gerontol. 2015, 68:76-81. 10.1016\/j.exger.2014.10.002","journal-title":"Exp Gerontol"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020217","article-title":"Insulin-like growth factor-1 (IGF-1) and its monitoring in medical diagnostic and in sports","volume":"11","author":"Bailes J","year":"2021","unstructured":"Bailes J, Soloviev M. Insulin-like growth factor-1 (IGF-1) and its monitoring in medical diagnostic and in sports. Biomolecules. 2021, 11:217. 10.3390\/biom11020217","journal-title":"Biomolecules"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0024","article-title":"The insulin-like growth factor system and its pleiotropic functions in brain","volume":"26","author":"Russo VC","year":"2005","unstructured":"Russo VC, Gluckman PD, Feldman EL, Werther GA. The insulin-like growth factor system and its pleiotropic functions in brain. Endocr Rev. 2005, 26:916-43. 10.1210\/er.2004-0024","journal-title":"Endocr Rev"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3390\/v13081488","article-title":"The IGF-1 signaling pathway in viral infections","volume":"13","author":"J\u00f3zefiak A","year":"2021","unstructured":"J\u00f3zefiak A, Larska M, Pomorska-M\u00f3l M, Ruszkowski JJ. The IGF-1 signaling pathway in viral infections. Viruses. 2021, 13:1488. 10.3390\/v13081488","journal-title":"Viruses"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0311","article-title":"IGF1 receptor signaling pathways","volume":"61","author":"Hakuno F","year":"2018","unstructured":"Hakuno F, Takahashi SI. IGF1 receptor signaling pathways. J Mol Endocrinol. 2018, 61:T69-86. 10.1530\/JME-17-0311","journal-title":"J Mol Endocrinol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/s1734-1140(13)71523-8","article-title":"Possible contribution of IGF-1 to depressive disorder","volume":"65","author":"Szcz\u0119sny E","year":"2013","unstructured":"Szcz\u0119sny E, Slusarczyk J, G\u0142ombik K, et al.. Possible contribution of IGF-1 to depressive disorder. Pharmacol Rep. 2013, 65:1622-31. 10.1016\/s1734-1140(13)71523-8","journal-title":"Pharmacol Rep"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90216-3","article-title":"Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons","volume":"14","author":"Beck KD","year":"1995","unstructured":"Beck KD, Powell-Braxton L, Widmer HR, Valverde J, Hefti F. Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron. 1995, 14:717-30. 10.1016\/0896-6273(95)90216-3","journal-title":"Neuron"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-022-02134-4","article-title":"Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants","volume":"93","author":"Hellstr\u00f6m W","year":"2023","unstructured":"Hellstr\u00f6m W, Hortensius LM, L\u00f6fqvist C, et al.. Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants. Pediatr Res. 2023, 93:666-74. 10.1038\/s41390-022-02134-4","journal-title":"Pediatr Res"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2003.08.002","article-title":"Insulin-like growth factor-1 and post-ischemic brain injury","volume":"70","author":"Guan J","year":"2003","unstructured":"Guan J, Bennet L, Gluckman PD, Gunn AJ. Insulin-like growth factor-1 and post-ischemic brain injury. Prog Neurobiol. 2003, 70:443-62. 10.1016\/j.pneurobio.2003.08.002","journal-title":"Prog Neurobiol"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/736104","article-title":"Role and importance of IGF-1 in traumatic brain injuries","volume":"2015","author":"Mangiola A","year":"2015","unstructured":"Mangiola A, Vigo V, Anile C, De Bonis P, Marziali G, Lofrese G. Role and importance of IGF-1 in traumatic brain injuries. Biomed Res Int. 2015, 2015:10.1155\/2015\/736104","journal-title":"Biomed Res Int"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2291","article-title":"Insulin-like growth factor and insulin-like growth factor receptor expression in human idiopathic autism fusiform gyrus tissue","volume":"13","author":"Cioana M","year":"2020","unstructured":"Cioana M, Michalski B, Fahnestock M. Insulin-like growth factor and insulin-like growth factor receptor expression in human idiopathic autism fusiform gyrus tissue. Autism Res. 2020, 13:897-907. 10.1002\/aur.2291","journal-title":"Autism Res"},{"key":"ref59","article-title":"Low levels of insulin-like growth factor-I in cerebrospinal fluid in children with autism","volume":"43","author":"Vanhala R","year":"2001","unstructured":"Vanhala R, Turpeinen U, Riikonen R. Low levels of insulin-like growth factor-I in cerebrospinal fluid in children with autism. Dev Med Child Neurol. 2001, 43:614-6.","journal-title":"Dev Med Child Neurol"},{"key":"ref60","doi-asserted-by":"crossref","DOI":"10.1017\/S0012162206001605","article-title":"Cerebrospinal fluid insulin-like growth factors IGF-1 and IGF-2 in infantile autism","volume":"48","author":"Riikonen R","year":"2006","unstructured":"Riikonen R, Makkonen I, Vanhala R, Turpeinen U, Kuikka J, Kokki H. Cerebrospinal fluid insulin-like growth factors IGF-1 and IGF-2 in infantile autism. Dev Med Child Neurol. 2006, 48:751-5.","journal-title":"Dev Med Child Neurol"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-020-04820-w","article-title":"Comparison of serum VEGF, IGF-1, and HIF-1\u03b1 levels in children with autism spectrum disorder and healthy controls","volume":"51","author":"\u015eim\u015fek F","year":"2021","unstructured":"\u015eim\u015fek F, I\u015f\u0131k \u00dc, Aktepe E, K\u0131l\u0131\u00e7 F, \u015eirin FB, Bozkurt M. Comparison of serum VEGF, IGF-1, and HIF-1\u03b1 levels in children with autism spectrum disorder and healthy controls. J Autism Dev Disord. 2021, 51:3564-74. 10.1007\/s10803-020-04820-w","journal-title":"J Autism Dev Disord"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02868.x","article-title":"Elevated levels of growth-related hormones in autism and autism spectrum disorder","volume":"67","author":"Mills JL","year":"2007","unstructured":"Mills JL, Hediger ML, Molloy CA, et al.. Elevated levels of growth-related hormones in autism and autism spectrum disorder. Clin Endocrinol (Oxf). 2007, 67:230-7. 10.1111\/j.1365-2265.2007.02868.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref63","article-title":"Serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in children with autism spectrum disorder","volume":"24","author":"Li Z","year":"2022","unstructured":"Li Z, Xiao GY, He CY, Liu X, Fan X, Zhao Y, Wang NR. Serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in children with autism spectrum disorder. Zhongguo Dang Dai Er Ke Za Zhi. 2022, 24:186-91.","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2022.03.031","article-title":"Analysis of Insulin-like growth factor-1 serum levels and promoter (rs12579108) polymorphism in the children with autism spectrum disorders","volume":"99","author":"Abedini M","year":"2022","unstructured":"Abedini M, Mashayekhi F, Salehi Z. Analysis of Insulin-like growth factor-1 serum levels and promoter (rs12579108) polymorphism in the children with autism spectrum disorders. J Clin Neurosci. 2022, 99:289-93. 10.1016\/j.jocn.2022.03.031","journal-title":"J Clin Neurosci"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198802000-00002","article-title":"Immunoreactive somatomedin C\/insulin-like growth factor I in urine from normal subjects, pituitary dwarfs, and acromegalics","volume":"23","author":"Yokoya S","year":"1988","unstructured":"Yokoya S, Suwa S, Maesaka H, Tanaka T. Immunoreactive somatomedin C\/insulin-like growth factor I in urine from normal subjects, pituitary dwarfs, and acromegalics. Pediatr Res. 1988, 23:151-4. 10.1203\/00006450-198802000-00002","journal-title":"Pediatr Res"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.11.007","article-title":"The placental interleukin-6 signaling controls fetal brain development and behavior","volume":"62","author":"Wu WL","year":"2017","unstructured":"Wu WL, Hsiao EY, Yan Z, Mazmanian SK, Patterson PH. The placental interleukin-6 signaling controls fetal brain development and behavior. Brain Behav Immun. 2017, 62:11-23. 10.1016\/j.bbi.2016.11.007","journal-title":"Brain Behav Immun"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23420","article-title":"Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3","volume":"113","author":"Al-Shanti N","year":"2012","unstructured":"Al-Shanti N, Stewart CE. Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3. J Cell Biochem. 2012, 113:923-33. 10.1002\/jcb.23420","journal-title":"J Cell Biochem"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1571319","article-title":"Insulin-like growth factor-1 levels in term newborns with hypoxic-ischemic encephalopathy","volume":"33","author":"Umran RM","year":"2016","unstructured":"Umran RM, Al-Tahir M, Jagdish D, Chouthai N. Insulin-like growth factor-1 levels in term newborns with hypoxic-ischemic encephalopathy. Am J Perinatol. 2016, 33:640-5. 10.1055\/s-0036-1571319","journal-title":"Am J Perinatol"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201805_15078","article-title":"Study on the correlation of changes of IGF-1, GH, and NGB levels and NBNA score in neonates with hypoxic ischemic encephalopathy","volume":"22","author":"Liu G","year":"2018","unstructured":"Liu G, Wu HW, Li ZG. Study on the correlation of changes of IGF-1, GH, and NGB levels and NBNA score in neonates with hypoxic ischemic encephalopathy. Eur Rev Med Pharmacol Sci. 2018, 22:3173-81. 10.26355\/eurrev_201805_15078","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.01.001","article-title":"Mild prenatal hypoxia-ischemia leads to social deficits and central and peripheral inflammation in exposed offspring","volume":"69","author":"Driscoll DJ'","year":"2018","unstructured":"Driscoll DJ', Felice VD, Kenny LC, Boylan GB, O'Keeffe GW. Mild prenatal hypoxia-ischemia leads to social deficits and central and peripheral inflammation in exposed offspring. Brain Behav Immun. 2018, 69:418-27. 10.1016\/j.bbi.2018.01.001","journal-title":"Brain Behav Immun"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-020-00370-1","article-title":"Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology","volume":"11","author":"Cheroni C","year":"2020","unstructured":"Cheroni C, Caporale N, Testa G. Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology. Mol Autism. 2020, 11:69. 10.1186\/s13229-020-00370-1","journal-title":"Mol Autism"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-020-00359-w","article-title":"IGF-1 treatment causes unique transcriptional response in neurons from individuals with idiopathic autism","volume":"11","author":"Linker SB","year":"2020","unstructured":"Linker SB, Mendes AP, Marchetto MC. IGF-1 treatment causes unique transcriptional response in neurons from individuals with idiopathic autism. Mol Autism. 2020, 11:55. 10.1186\/s13229-020-00359-w","journal-title":"Mol Autism"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1038\/nature09146","article-title":"Functional impact of global rare copy number variation in autism spectrum disorders","volume":"466","author":"Pinto D","year":"2010","unstructured":"Pinto D, Pagnamenta AT, Klei L, et al.. Functional impact of global rare copy number variation in autism spectrum disorders. Nature. 2010, 466:368-72. 10.1038\/nature09146","journal-title":"Nature"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0365-8","article-title":"SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons","volume":"22","author":"Zaslavsky K","year":"2019","unstructured":"Zaslavsky K, Zhang WB, McCready FP, et al.. SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons. Nat Neurosci. 2019, 22:556-64. 10.1038\/s41593-019-0365-8","journal-title":"Nat Neurosci"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.285002","article-title":"Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons","volume":"15","author":"Chen ST","year":"2020","unstructured":"Chen ST, Lai WJ, Zhang WJ, Chen QP, Zhou LB, So KF, Shi LL. Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons. Neural Regen Res. 2020, 15:2335-43. 10.4103\/1673-5374.285002","journal-title":"Neural Regen Res"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3792","article-title":"Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases","volume":"49","author":"Stessman HA","year":"2017","unstructured":"Stessman HA, Xiong B, Coe BP, et al.. Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases. Nat Genet. 2017, 49:515-26. 10.1038\/ng.3792","journal-title":"Nat Genet"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.01.012","article-title":"DYRK1A mutations cause undergrowth of cortical pyramidal neurons via dysregulated growth factor signaling","volume":"90","author":"Levy JA","year":"2021","unstructured":"Levy JA, LaFlamme CW, Tsaprailis G, Crynen G, Page DT. DYRK1A mutations cause undergrowth of cortical pyramidal neurons via dysregulated growth factor signaling. Biol Psychiatry. 2021, 90:295-306. 10.1016\/j.biopsych.2021.01.012","journal-title":"Biol Psychiatry"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.3390\/genes12081218","article-title":"FMR1 and autism, an intriguing connection revisited","volume":"12","author":"Fyke W","year":"2021","unstructured":"Fyke W, Velinov M. FMR1 and autism, an intriguing connection revisited. Genes (Basel). 2021, 12:1218. 10.3390\/genes12081218","journal-title":"Genes (Basel)"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13316","article-title":"De novo genic mutations among a Chinese autism spectrum disorder cohort","volume":"7","author":"Wang T","year":"2016","unstructured":"Wang T, Guo H, Xiong B, et al.. De novo genic mutations among a Chinese autism spectrum disorder cohort. Nat Commun. 2016, 7:13316. 10.1038\/ncomms13316","journal-title":"Nat Commun"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-017-0157-5","article-title":"Identification of autism-related MECP2 mutations by whole-exome sequencing and functional validation","volume":"8","author":"Wen Z","year":"2017","unstructured":"Wen Z, Cheng TL, Li GZ, et al.. Identification of autism-related MECP2 mutations by whole-exome sequencing and functional validation. Mol Autism. 2017, 8:43. 10.1186\/s13229-017-0157-5","journal-title":"Mol Autism"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.09.001","article-title":"Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons","volume":"13","author":"Li Y","year":"2013","unstructured":"Li Y, Wang H, Muffat J, et al.. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell. 2013, 13:446-58. 10.1016\/j.stem.2013.09.001","journal-title":"Cell Stem Cell"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812394106","article-title":"Partial reversal of Rett syndrome-like symptoms in MeCP2 mutant mice","volume":"106","author":"Tropea D","year":"2009","unstructured":"Tropea D, Giacometti E, Wilson NR, et al.. Partial reversal of Rett syndrome-like symptoms in MeCP2 mutant mice. Proc Natl Acad Sci U S A. 2009, 106:2029-34. 10.1073\/pnas.0812394106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1172\/JCI159806","article-title":"GIGYF1 disruption associates with autism and impaired IGF-1R signaling","volume":"132","author":"Chen G","year":"2022","unstructured":"Chen G, Yu B, Tan S, et al.. GIGYF1 disruption associates with autism and impaired IGF-1R signaling. J Clin Invest. 2022, 132:10.1172\/JCI159806","journal-title":"J Clin Invest"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-019-01051-3","article-title":"Dynamic expression and new functions of early B cell factor 2 in cerebellar development","volume":"18","author":"Badaloni A","year":"2019","unstructured":"Badaloni A, Casoni F, Croci L, et al.. Dynamic expression and new functions of early B cell factor 2 in cerebellar development. Cerebellum. 2019, 18:999-1010. 10.1007\/s12311-019-01051-3","journal-title":"Cerebellum"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02437","article-title":"A key role for the HLH transcription factor EBF2COE2,O\/E-3 in Purkinje neuron migration and cerebellar cortical topography","volume":"133","author":"Croci L","year":"2006","unstructured":"Croci L, Chung SH, Masserdotti G, et al.. A key role for the HLH transcription factor EBF2COE2,O\/E-3 in Purkinje neuron migration and cerebellar cortical topography. Development. 2006, 133:2719-29. 10.1242\/dev.02437","journal-title":"Development"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.78","article-title":"Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth","volume":"18","author":"Croci L","year":"2011","unstructured":"Croci L, Barili V, Chia D, et al.. Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth. Cell Death Differ. 2011, 18:48-59. 10.1038\/cdd.2010.78","journal-title":"Cell Death Differ"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.11.066","article-title":"The new P2Y-like receptor G protein-coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats","volume":"202","author":"Zhao B","year":"2012","unstructured":"Zhao B, Zhao CZ, Zhang XY, et al.. The new P2Y-like receptor G protein-coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats. Neuroscience. 2012, 202:42-57. 10.1016\/j.neuroscience.2011.11.066","journal-title":"Neuroscience"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031513","article-title":"Insulin-like growth factor 1 promotes cell proliferation by downregulation of G-protein-coupled receptor 17 expression via PI3K\/Akt\/FoxO1 signaling in SK-N-SH cells","volume":"23","author":"Lin KN","year":"2022","unstructured":"Lin KN, Zhang K, Zhao W, Huang SY, Li H. Insulin-like growth factor 1 promotes cell proliferation by downregulation of G-protein-coupled receptor 17 expression via PI3K\/Akt\/FoxO1 signaling in SK-N-SH cells. Int J Mol Sci. 2022, 23:1513. 10.3390\/ijms23031513","journal-title":"Int J Mol Sci"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1179\/174313208X338133","article-title":"Delayed IGF-1 treatment reduced long-term hypoxia-ischemia-induced brain damage and improved behavior recovery of immature rats","volume":"31","author":"Zhong J","year":"2009","unstructured":"Zhong J, Zhao L, Du Y, Wei G, Yao WG, Lee WH. Delayed IGF-1 treatment reduced long-term hypoxia-ischemia-induced brain damage and improved behavior recovery of immature rats. Neurol Res. 2009, 31:483-9. 10.1179\/174313208X338133","journal-title":"Neurol Res"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.12.026","article-title":"Increased excitation-inhibition ratio stabilizes synapse and circuit excitability in four autism mouse models","volume":"101","author":"Antoine MW","year":"2019","unstructured":"Antoine MW, Langberg T, Schnepel P, Feldman DE. Increased excitation-inhibition ratio stabilizes synapse and circuit excitability in four autism mouse models. Neuron. 2019, 101:648-61.e4. 10.1016\/j.neuron.2018.12.026","journal-title":"Neuron"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx165","article-title":"Autism related neuroligin-4 knockout impairs intracortical processing but not sensory inputs in mouse barrel cortex","volume":"28","author":"Unichenko P","year":"2018","unstructured":"Unichenko P, Yang JW, Kirischuk S, et al.. Autism related neuroligin-4 knockout impairs intracortical processing but not sensory inputs in mouse barrel cortex. Cereb Cortex. 2018, 28:2873-86. 10.1093\/cercor\/bhx165","journal-title":"Cereb Cortex"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20059","article-title":"MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders","volume":"5","author":"Harrington AJ","year":"2016","unstructured":"Harrington AJ, Raissi A, Rajkovich K, et al.. MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife. 2016, 5:10.7554\/eLife.20059","journal-title":"Elife"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.95","article-title":"Altered proliferation and networks in neural cells derived from idiopathic autistic individuals","volume":"22","author":"Marchetto MC","year":"2017","unstructured":"Marchetto MC, Belinson H, Tian Y, et al.. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2017, 22:820-35. 10.1038\/mp.2016.95","journal-title":"Mol Psychiatry"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-9","article-title":"Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay","volume":"4","author":"Bozdagi O","year":"2013","unstructured":"Bozdagi O, Tavassoli T, Buxbaum JD. Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay. Mol Autism. 2013, 4:9. 10.1186\/2040-2392-4-9","journal-title":"Mol Autism"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.04.037","article-title":"The influence of neuroinflammation in autism spectrum disorder","volume":"79","author":"Matta SM","year":"2019","unstructured":"Matta SM, Hill-Yardin EL, Crack PJ. The influence of neuroinflammation in autism spectrum disorder. Brain Behav Immun. 2019, 79:75-90. 10.1016\/j.bbi.2019.04.037","journal-title":"Brain Behav Immun"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2206758120","article-title":"Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex","volume":"120","author":"Zhang P","year":"2023","unstructured":"Zhang P, Omanska A, Ander BP, Gandal MJ, Stamova B, Schumann CM. Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex. Proc Natl Acad Sci U S A. 2023, 120:e2206758120. 10.1073\/pnas.2206758120","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911077","article-title":"Hyperbaric oxygen therapy alleviates social behavior dysfunction and neuroinflammation in a mouse model for autism spectrum disorders","volume":"23","author":"Fischer I","year":"2022","unstructured":"Fischer I, Shohat S, Levy G, Bar E, Trangle SS, Efrati S, Barak B. Hyperbaric oxygen therapy alleviates social behavior dysfunction and neuroinflammation in a mouse model for autism spectrum disorders. Int J Mol Sci. 2022, 23:11077. 10.3390\/ijms231911077","journal-title":"Int J Mol Sci"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2022.102296","article-title":"4-hydroxyisoleucine mediated IGF-1\/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats","volume":"96","author":"Bhalla S","year":"2022","unstructured":"Bhalla S, Mehan S. 4-hydroxyisoleucine mediated IGF-1\/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats. Neuropeptides. 2022, 96:102296. 10.1016\/j.npep.2022.102296","journal-title":"Neuropeptides"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.2174\/1389203724666221208145549","article-title":"Hyperbaric oxygen therapy alleviates social behavior dysfunction and neuroinflammation in a mouse model for autism spectrum disorders","volume":"24","author":"Sha Y","year":"2023","unstructured":"Sha Y, Chen L, Xu C, Zhang B, Hong H, Wang C. Hyperbaric oxygen therapy alleviates social behavior dysfunction and neuroinflammation in a mouse model for autism spectrum disorders. Curr Protein Pept Sci. 2023, 24:143-55. 10.2174\/1389203724666221208145549","journal-title":"Curr Protein Pept Sci"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24163","article-title":"IGF-1 regulates astrocytic phagocytosis and inflammation through the p110\u03b1 isoform of PI3K in a sex-specific manner","volume":"70","author":"Pinto-Benito D","year":"2022","unstructured":"Pinto-Benito D, Paradela-Leal C, Ganchala D, de Castro-Molina P, Arevalo MA. IGF-1 regulates astrocytic phagocytosis and inflammation through the p110\u03b1 isoform of PI3K in a sex-specific manner. Glia. 2022, 70:1153-69. 10.1002\/glia.24163","journal-title":"Glia"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2022.136575","article-title":"Role of IGF-1 in neuroinflammation and cognition deficits induced by sleep deprivation","volume":"776","author":"Wan Y","year":"2022","unstructured":"Wan Y, Gao W, Zhou K, Liu X, Jiang W, Xue R, Wu W. Role of IGF-1 in neuroinflammation and cognition deficits induced by sleep deprivation. Neurosci Lett. 2022, 776:136575. 10.1016\/j.neulet.2022.136575","journal-title":"Neurosci Lett"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093293","article-title":"Oxidative stress and immune system dysfunction in autism spectrum disorders","volume":"21","author":"Pangrazzi L","year":"2020","unstructured":"Pangrazzi L, Balasco L, Bozzi Y. Oxidative stress and immune system dysfunction in autism spectrum disorders. Int J Mol Sci. 2020, 21:3293. 10.3390\/ijms21093293","journal-title":"Int J Mol Sci"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065487","article-title":"Neuroinflammation and oxidative stress in the pathogenesis of autism spectrum disorder","volume":"24","author":"Usui N","year":"2023","unstructured":"Usui N, Kobayashi H, Shimada S. Neuroinflammation and oxidative stress in the pathogenesis of autism spectrum disorder. Int J Mol Sci. 2023, 24:5487. 10.3390\/ijms24065487","journal-title":"Int J Mol Sci"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01742-2","article-title":"Oxidative stress in autism spectrum disorder","volume":"57","author":"Bj\u00f8rklund G","year":"2020","unstructured":"Bj\u00f8rklund G, Meguid NA, El-Bana MA, et al.. Oxidative stress in autism spectrum disorder. Mol Neurobiol. 2020, 57:2314-32. 10.1007\/s12035-019-01742-2","journal-title":"Mol Neurobiol"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-30402-7_7","article-title":"Role of oxidative stress and antioxidants in autism","author":"Manivasagam T","year":"2020","unstructured":"Manivasagam T, Arunadevi S, Essa MM, SaravanaBabu C, Borah A, Thenmozhi AJ, Qoronfleh MW. Role of oxidative stress and antioxidants in autism. Adv Neurobiol. Essa M, Qoronfleh M (ed): Springer, Cham, Switzerland; 2020. 10.1007\/978-3-030-30402-7_7"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601004R","article-title":"Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study","volume":"31","author":"Rose S","year":"2017","unstructured":"Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE. Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study. FASEB J. 2017, 31:904-9. 10.1096\/fj.201601004R","journal-title":"FASEB J"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.12.013","article-title":"Insulin-like growth factor 1 specifically up-regulates expression of modifier subunit of glutamate-cysteine ligase and enhances glutathione synthesis in SH-SY5Y cells","volume":"771","author":"Takahashi S","year":"2016","unstructured":"Takahashi S, Hisatsune A, Kurauchi Y, Seki T, Katsuki H. Insulin-like growth factor 1 specifically up-regulates expression of modifier subunit of glutamate-cysteine ligase and enhances glutathione synthesis in SH-SY5Y cells. Eur J Pharmacol. 2016, 771:99-106. 10.1016\/j.ejphar.2015.12.013","journal-title":"Eur J Pharmacol"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.751304","article-title":"Insulin-like growth factor-1 differentially modulates glutamate-induced toxicity and stress in cells of the neurogliovascular unit","volume":"13","author":"Hayes CA","year":"2021","unstructured":"Hayes CA, Ashmore BG, Vijayasankar A, Marshall JP, Ashpole NM. Insulin-like growth factor-1 differentially modulates glutamate-induced toxicity and stress in cells of the neurogliovascular unit. Front Aging Neurosci. 2021, 13:751304. 10.3389\/fnagi.2021.751304","journal-title":"Front Aging Neurosci"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s6178","article-title":"Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency","volume":"5","author":"Fintini D","year":"2009","unstructured":"Fintini D, Brufani C, Cappa M. Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency. Ther Clin Risk Manag. 2009, 5:553-9. 10.2147\/tcrm.s6178","journal-title":"Ther Clin Risk Manag"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.01.001","article-title":"The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders","volume":"63","author":"Costales J","year":"2016","unstructured":"Costales J, Kolevzon A. The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders. Neurosci Biobehav Rev. 2016, 63:207-22. 10.1016\/j.neubiorev.2016.01.001","journal-title":"Neurosci Biobehav Rev"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00450","article-title":"Insulin-like growth factor 1 and related compounds in the treatment of childhood-onset neurodevelopmental disorders","volume":"10","author":"Vahdatpour C","year":"2016","unstructured":"Vahdatpour C, Dyer AH, Tropea D. Insulin-like growth factor 1 and related compounds in the treatment of childhood-onset neurodevelopmental disorders. Front Neurosci. 2016, 10:450. 10.3389\/fnins.2016.00450","journal-title":"Front Neurosci"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02398-1","article-title":"Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study","volume":"29","author":"Neul JL","year":"2023","unstructured":"Neul JL, Percy AK, Benke TA, et al.. Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study. Nat Med. 2023, 29:1468-75. 10.1038\/s41591-023-02398-1","journal-title":"Nat Med"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311141111","article-title":"Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome","volume":"111","author":"Khwaja OS","year":"2014","unstructured":"Khwaja OS, Ho E, Barnes KV, et al.. Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome. Proc Natl Acad Sci U S A. 2014, 111:4596-601. 10.1073\/pnas.1311141111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007316","article-title":"Double-blind, randomized, placebo-controlled study of trofinetide in pediatric Rett syndrome","volume":"92","author":"Glaze DG","year":"2019","unstructured":"Glaze DG, Neul JL, Kaufmann WE, et al.. Double-blind, randomized, placebo-controlled study of trofinetide in pediatric Rett syndrome. Neurology. 2019, 92:e1912-25. 10.1212\/WNL.0000000000007316","journal-title":"Neurology"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2021.06.002","article-title":"The neurological manifestations of Phelan-McDermid syndrome","volume":"122","author":"Frank Y","year":"2021","unstructured":"Frank Y. The neurological manifestations of Phelan-McDermid syndrome. Pediatr Neurol. 2021, 122:59-64. 10.1016\/j.pediatrneurol.2021.06.002","journal-title":"Pediatr Neurol"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-5-54","article-title":"A pilot controlled trial of insulin-like growth factor-1 in children with Phelan-McDermid syndrome","volume":"5","author":"Kolevzon A","year":"2014","unstructured":"Kolevzon A, Bush L, Wang AT, et al.. A pilot controlled trial of insulin-like growth factor-1 in children with Phelan-McDermid syndrome. Mol Autism. 2014, 5:54. 10.1186\/2040-2392-5-54","journal-title":"Mol Autism"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1386764","article-title":"Autism and fragile X syndrome","volume":"34","author":"Yu TW","year":"2014","unstructured":"Yu TW, Berry-Kravis E. Autism and fragile X syndrome. Semin Neurol. 2014, 34:258-65. 10.1055\/s-0034-1386764","journal-title":"Semin Neurol"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2020.04.019","article-title":"A double-blind, randomized, placebo-controlled clinical study of trofinetide in the treatment of fragile X syndrome","volume":"110","author":"Berry-Kravis E","year":"2020","unstructured":"Berry-Kravis E, Horrigan JP, Tartaglia N, et al.. A double-blind, randomized, placebo-controlled clinical study of trofinetide in the treatment of fragile X syndrome. Pediatr Neurol. 2020, 110:30-41. 10.1016\/j.pediatrneurol.2020.04.019","journal-title":"Pediatr Neurol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/267686-insulin-like-growth-factor-1-has-the-potential-to-be-used-as-a-diagnostic-tool-and-treatment-target-for-autism-spectrum-disorders","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:21:03Z","timestamp":1721971263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/267686-insulin-like-growth-factor-1-has-the-potential-to-be-used-as-a-diagnostic-tool-and-treatment-target-for-autism-spectrum-disorders"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":118,"URL":"https:\/\/doi.org\/10.7759\/cureus.65393","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,25]]}}}