{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:39:59Z","timestamp":1774629599409,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,31]]},"DOI":"10.7759\/cureus.65829","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:06:35Z","timestamp":1722423995000},"source":"Crossref","is-referenced-by-count":2,"title":["Mathematical Approach to Synergistic Management of Bladder Pain Syndrome\/Interstitial Cystitis and Vulvodynia: A Case Series Utilizing Principal Component Analysis, Cluster Analysis, and Combination Laser Therapy"],"prefix":"10.7759","author":[{"given":"Nobuo","family":"Okui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiko A","family":"Okui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.086","article-title":"Diagnosis and treatment of interstitial cystitis\/bladder pain syndrome: AUA guideline amendment","volume":"193","author":"Hanno PM","year":"2015","unstructured":"Hanno PM, Erickson D, Moldwin R, Faraday MM. Diagnosis and treatment of interstitial cystitis\/bladder pain syndrome: AUA guideline amendment. J Urol. 2015, 193:1545-53. 10.1016\/j.juro.2015.01.086","journal-title":"J Urol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.101848","article-title":"Bladder pain syndrome and interstitial cystitis beyond horizon: reports from the Global Interstitial Cystitis\/Bladder Pain Society (GIBS) Meeting 2019 Mumbai - India","volume":"10","author":"Rahnama'i MS","year":"2020","unstructured":"Rahnama'i MS, Javan A, Vyas N, et al.. Bladder pain syndrome and interstitial cystitis beyond horizon: reports from the Global Interstitial Cystitis\/Bladder Pain Society (GIBS) Meeting 2019 Mumbai - India. Anesth Pain Med. 2020, 10:e101848. 10.5812\/aapm.101848","journal-title":"Anesth Pain Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-022-05327-x","article-title":"Comparison of two different methods for cervicovaginal reconstruction: a long-term follow-up","volume":"34","author":"Liu X","year":"2023","unstructured":"Liu X, Ding J, Li Y, Hua K, Zhang X. Comparison of two different methods for cervicovaginal reconstruction: a long-term follow-up. Int Urogynecol J. 2023, 34:247-54. 10.1007\/s00192-022-05327-x","journal-title":"Int Urogynecol J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.01.079","article-title":"Insight into urogynecologic features of women with interstitial cystitis\/painful bladder syndrome","volume":"54","author":"Gardella B","year":"2008","unstructured":"Gardella B, Porru D, Ferdeghini F, Martinotti Gabellotti E, Nappi RE, Rovereto B, Spinillo A. Insight into urogynecologic features of women with interstitial cystitis\/painful bladder syndrome. Eur Urol. 2008, 54:1145-51. 10.1016\/j.eururo.2008.01.079","journal-title":"Eur Urol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000515647","article-title":"Cure of interstitial cystitis and non-ulcerating Hunner\u2019s ulcer by cardinal\/uterosacral ligament repair","volume":"105","author":"Scheffler K","year":"2021","unstructured":"Scheffler K, Hakenberg OW, Petros P. Cure of interstitial cystitis and non-ulcerating Hunner\u2019s ulcer by cardinal\/uterosacral ligament repair. Urol Int. 2021, 105:920-3. 10.1159\/000515647","journal-title":"Urol Int"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24847","article-title":"On-table urodynamic with ureteric occlusion: a resource for measuring bladder capacity and compliance in the management of patients with gross vesico-ureteric reflux","volume":"41","author":"Garriboli M","year":"2022","unstructured":"Garriboli M, Solomon E. On-table urodynamic with ureteric occlusion: a resource for measuring bladder capacity and compliance in the management of patients with gross vesico-ureteric reflux. Neurourol Urodyn. 2022, 41:448-55. 10.1002\/nau.24847","journal-title":"Neurourol Urodyn"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11061017","article-title":"The effect of delayed surgical debridement in the management of open tibial fractures: a systematic review and meta-analysis","volume":"11","author":"Nicolaides M","year":"2021","unstructured":"Nicolaides M, Vris A, Heidari N, Bates P, Pafitanis G. The effect of delayed surgical debridement in the management of open tibial fractures: a systematic review and meta-analysis. Diagnostics (Basel). 2021, 11:10.3390\/diagnostics11061017","journal-title":"Diagnostics (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-022-05220-7","article-title":"Examining vaginal and vulvar health and sexual dysfunction in patients with interstitial cystitis (UNICORN-1 study)","volume":"33","author":"Okui N","year":"2022","unstructured":"Okui N, Okui M, Gambacciani M. Examining vaginal and vulvar health and sexual dysfunction in patients with interstitial cystitis (UNICORN-1 study). Int Urogynecol J. 2022, 33:2493-9. 10.1007\/s00192-022-05220-7","journal-title":"Int Urogynecol J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02251.x","article-title":"Interstitial cystitis is associated with vulvodynia and sexual dysfunction--a case-control study","volume":"8","author":"Gardella B","year":"2011","unstructured":"Gardella B, Porru D, Nappi RE, Dacc\u00f2 MD, Chiesa A, Spinillo A. Interstitial cystitis is associated with vulvodynia and sexual dysfunction--a case-control study. J Sex Med. 2011, 8:1726-34. 10.1111\/j.1743-6109.2011.02251.x","journal-title":"J Sex Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.757878","article-title":"Unsupervised machine learning approaches reveal distinct phenotypes of perceived bladder pain: a pilot study","volume":"2","author":"Mwesigwa PJ","year":"2021","unstructured":"Mwesigwa PJ, Jackson NJ, Caron AT, et al.. Unsupervised machine learning approaches reveal distinct phenotypes of perceived bladder pain: a pilot study. Front Pain Res (Lausanne). 2021, 2:10.3389\/fpain.2021.757878","journal-title":"Front Pain Res (Lausanne)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.62585","article-title":"Unsupervised machine learning reveals a vulvodynia-predominant subtype in bladder pain syndrome\/interstitial cystitis","volume":"16","author":"Okui N","year":"2024","unstructured":"Okui N. Unsupervised machine learning reveals a vulvodynia-predominant subtype in bladder pain syndrome\/interstitial cystitis. Cureus. 2024, 16:62585. 10.7759\/cureus.62585","journal-title":"Cureus"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2019.1703940","article-title":"Effects of non-ablative vaginal erbium:YAG laser treatment for interstitial cystitis\/bladder pain syndrome: a case series (UNICORN-2 study)","volume":"23","author":"Okui N","year":"2020","unstructured":"Okui N, Okui M, Vizintin Z. Effects of non-ablative vaginal erbium:YAG laser treatment for interstitial cystitis\/bladder pain syndrome: a case series (UNICORN-2 study). Climacteric. 2020, 23:S14-7. 10.1080\/13697137.2019.1703940","journal-title":"Climacteric"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.31228","article-title":"Is erbium\/neodymium laser combination therapy an effective treatment option for interstitial cystitis\/bladder pain syndrome with vulvodynia?","volume":"14","author":"Okui N","year":"2022","unstructured":"Okui N, Okui M, Gambacciani M. Is erbium\/neodymium laser combination therapy an effective treatment option for interstitial cystitis\/bladder pain syndrome with vulvodynia?. Cureus. 2022, 14:e31228. 10.7759\/cureus.31228","journal-title":"Cureus"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.41786","article-title":"Laser treatment for patients with vulvodynia and interstitial cystitis\/bladder pain syndrome: a case series (the UNICORN-3 study)","volume":"15","author":"Okui N","year":"2023","unstructured":"Okui N, Okui MA, Kouno Y, Nakano K. Laser treatment for patients with vulvodynia and interstitial cystitis\/bladder pain syndrome: a case series (the UNICORN-3 study). Cureus. 2023, 15:e41786. 10.7759\/cureus.41786","journal-title":"Cureus"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1063119","article-title":"Effect of local estrogen therapy (LET) on urinary and sexual symptoms in premenopausal women with interstitial cystitis\/bladder pain syndrome (IC\/BPS)","volume":"31","author":"Gardella B","year":"2015","unstructured":"Gardella B, Iacobone AD, Porru D, et al.. Effect of local estrogen therapy (LET) on urinary and sexual symptoms in premenopausal women with interstitial cystitis\/bladder pain syndrome (IC\/BPS). Gynecol Endocrinol. 2015, 31:828-32. 10.3109\/09513590.2015.1063119","journal-title":"Gynecol Endocrinol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14234","article-title":"Clinical guidelines for interstitial cystitis\/bladder pain syndrome","volume":"27","author":"Homma Y","year":"2020","unstructured":"Homma Y, Akiyama Y, Tomoe H, et al.. Clinical guidelines for interstitial cystitis\/bladder pain syndrome. Int J Urol. 2020, 27:578-89. 10.1111\/iju.14234","journal-title":"Int J Urol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.005","article-title":"Interstitial cystitis\/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome","volume":"184","author":"Nickel JC","year":"2010","unstructured":"Nickel JC, Tripp DA, Pontari M, et al.. Interstitial cystitis\/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome. J Urol. 2010, 184:1358-63. 10.1016\/j.juro.2010.06.005","journal-title":"J Urol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38604","article-title":"Efficacy of two laser treatment strategies for breast cancer survivors with genitourinary syndrome of menopause","volume":"15","author":"Okui N","year":"2023","unstructured":"Okui N, Okui M, Kouno Y, Nakano K, Gambacciani M. Efficacy of two laser treatment strategies for breast cancer survivors with genitourinary syndrome of menopause. Cureus. 2023, 15:e38604. 10.7759\/cureus.38604","journal-title":"Cureus"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.45495","article-title":"Vaginal laser treatment for the genitourinary syndrome of menopause in breast cancer survivors: a narrative review","volume":"15","author":"Okui N","year":"2023","unstructured":"Okui N. Vaginal laser treatment for the genitourinary syndrome of menopause in breast cancer survivors: a narrative review. Cureus. 2023, 15:e45495. 10.7759\/cureus.45495","journal-title":"Cureus"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-019-0718-2","article-title":"Measurement and application of patient similarity in personalized predictive modeling based on electronic medical records","volume":"18","author":"Wang N","year":"2019","unstructured":"Wang N, Huang Y, Liu H, Fei X, Wei L, Zhao X, Chen H. Measurement and application of patient similarity in personalized predictive modeling based on electronic medical records. Biomed Eng Online. 2019, 18:98. 10.1186\/s12938-019-0718-2","journal-title":"Biomed Eng Online"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/271671-mathematical-approach-to-synergistic-management-of-bladder-pain-syndromeinterstitial-cystitis-and-vulvodynia-a-case-series-utilizing-principal-component-analysis-cluster-analysis-and-combination-laser-therapy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:06:38Z","timestamp":1722423998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/271671-mathematical-approach-to-synergistic-management-of-bladder-pain-syndromeinterstitial-cystitis-and-vulvodynia-a-case-series-utilizing-principal-component-analysis-cluster-analysis-and-combination-laser-therapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.65829","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,31]]}}}