{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:00:21Z","timestamp":1787032821971,"version":"build-2736575974"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,5]]},"DOI":"10.7759\/cureus.66236","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:22:22Z","timestamp":1722903742000},"source":"Crossref","is-referenced-by-count":4,"title":["Estimation of Levels of Salivary Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen (ICTP) in Periodontally Healthy and Diseased Patients at Various Time Intervals Before and After Periodontal Therapy"],"prefix":"10.7759","author":[{"given":"Priyal","family":"Agrawal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashish","family":"Pandit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin K","family":"Malagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis V","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubramanyam","family":"Vasant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Tembhurne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2012.00663.x","article-title":"Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology","volume":"27","author":"Hajishengallis G","year":"2012","unstructured":"Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012, 27:409-19. 10.1111\/j.2041-1014.2012.00663.x","journal-title":"Mol Oral Microbiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"26","author":"Pihlstrom BL","year":"2005","unstructured":"Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005, 26:1809-20. 10.1016\/S0140-6736(05)67728-8","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12366","article-title":"Primary prevention of periodontitis: managing gingivitis","volume":"42 Suppl 16","author":"Chapple IL","year":"2015","unstructured":"Chapple IL, Van der Weijden F, Doerfer C, et al.. Primary prevention of periodontitis: managing gingivitis. J Clin Periodontol. 2015, 42 Suppl 16:S71-6. 10.1111\/jcpe.12366","journal-title":"J Clin Periodontol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006","article-title":"Staging and grading of periodontitis: framework and proposal of a new classification and case definition","volume":"89 Suppl 1","author":"Tonetti MS","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018, 89 Suppl 1:S159-72. 10.1002\/JPER.18-0006","journal-title":"J Periodontol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00450.x","article-title":"Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts","volume":"62","author":"Bartold PM","year":"2013","unstructured":"Bartold PM, Van Dyke TE. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontol 2000. 2013, 62:203-17. 10.1111\/j.1600-0757.2012.00450.x","journal-title":"Periodontol 2000"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1016\/0169-6009(91)90143-N","article-title":"Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease","volume":"8","author":"Uebelhart D","year":"1990","unstructured":"Uebelhart D, Gineyts E, Chapuy MC, Delmas PD. Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease. Bone Miner. 1990, 8:187-91.","journal-title":"Bone Miner"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-5347(05)65930-7","article-title":"Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen as a useful marker for monitoring metastatic bone activity in men with prostate cancer","volume":"166","author":"Noguchi M","year":"2001","unstructured":"Noguchi M, Noda S. Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen as a useful marker for monitoring metastatic bone activity in men with prostate cancer. J Urol. 2001, 166:1106-10.","journal-title":"J Urol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1995.tb01793.x","article-title":"Crevicular fluid osteocalcin and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. A pilot study in beagle dogs","volume":"22","author":"Giannobile WV","year":"1995","unstructured":"Giannobile WV, Lynch SE, Denmark RG, Paquette DW, Fiorellini JP, Williams RC. Crevicular fluid osteocalcin and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. A pilot study in beagle dogs. J Clin Periodontol. 1995, 22:903-10. 10.1111\/j.1600-051x.1995.tb01793.x","journal-title":"J Clin Periodontol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07698.x","article-title":"C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction","volume":"878","author":"Giannobile WV","year":"1999","unstructured":"Giannobile WV. C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction. Ann N Y Acad Sci. 1999, 878:404-12. 10.1111\/j.1749-6632.1999.tb07698.x","journal-title":"Ann N Y Acad Sci"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1016\/S8756-3282(96)00351-1","article-title":"Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry","volume":"20","author":"Littlewood-Evans A","year":"1997","unstructured":"Littlewood-Evans A, Kokubo R, Ishibashi O, Inaoka T, Wlodarski B, Gallagher JA, Bilbe G. Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry. Bone. 1997, 20:81-6.","journal-title":"Bone"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2008.01879.x","article-title":"Possible impact of inflammatory status on C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels around oral implants with peri-implantitis: a controlled clinical trial","volume":"35","author":"T\u00fcmer C","year":"2008","unstructured":"T\u00fcmer C, Aksoy Y, G\u00fcnc\u00fc GN, Nohutcu RM, Kilinc K, T\u00f6z\u00fcm TF. Possible impact of inflammatory status on C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels around oral implants with peri-implantitis: a controlled clinical trial. J Oral Rehabil. 2008, 35:934-9. 10.1111\/j.1365-2842.2008.01879.x","journal-title":"J Oral Rehabil"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345204","article-title":"Biochemical markers of bone metabolism in the assessment of osteoporosis: useful or not?","volume":"26","author":"Seibel MJ","year":"2003","unstructured":"Seibel MJ. Biochemical markers of bone metabolism in the assessment of osteoporosis: useful or not?. J Endocrinol Invest. 2003, 26:464-71. 10.1007\/BF03345204","journal-title":"J Endocrinol Invest"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.8.835","article-title":"Effect of locally delivered minocycline microspheres on markers of bone resorption","volume":"73","author":"Oringer RJ","year":"2002","unstructured":"Oringer RJ, Al-Shammari KF, Aldredge WA, et al.. Effect of locally delivered minocycline microspheres on markers of bone resorption. J Periodontol. 2002, 73:835-42. 10.1902\/jop.2002.73.8.835","journal-title":"J Periodontol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.09.009","article-title":"Effects of smoking on salivary C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels","volume":"54","author":"G\u00fcrlek O","year":"2009","unstructured":"G\u00fcrlek O, Lappin DF, Buduneli N. Effects of smoking on salivary C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels. Arch Oral Biol. 2009, 54:1099-104. 10.1016\/j.archoralbio.2009.09.009","journal-title":"Arch Oral Biol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1998.tb02383.x","article-title":"Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis","volume":"25","author":"Palys MD","year":"1998","unstructured":"Palys MD, Haffajee AD, Socransky SS, Giannobile WV. Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis. J Clin Periodontol. 1998, 25:865-71. 10.1111\/j.1600-051x.1998.tb02383.x","journal-title":"J Clin Periodontol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/12689.6498","article-title":"Evaluation of salivary levels of pyridinoline cross linked carboxyterminal telopeptide of type I collagen (ICTP) in periodontal health and disease","volume":"9","author":"Mishra D","year":"2015","unstructured":"Mishra D, Gopalakrishnan S, Arun KV, Kumar TS, Devanathan S, Misra SR. Evaluation of salivary levels of pyridinoline cross linked carboxyterminal telopeptide of type I collagen (ICTP) in periodontal health and disease. J Clin Diagn Res. 2015, 9:ZC50-5. 10.7860\/JCDR\/2015\/12689.6498","journal-title":"J Clin Diagn Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-010-9225-0","article-title":"Plasma levels of C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin in chronic periodontitis","volume":"34","author":"Oz\u00e7aka O","year":"2011","unstructured":"Oz\u00e7aka O, Nalbantsoy A, B\u0131\u00e7ak\u00e7\u0131 N, K\u00f6se T, Buduneli N. Plasma levels of C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin in chronic periodontitis. Inflammation. 2011, 34:203-8. 10.1007\/s10753-010-9225-0","journal-title":"Inflammation"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.028","article-title":"Oral fluid-based biomarkers of alveolar bone loss in periodontitis","volume":"1098","author":"Kinney JS","year":"2007","unstructured":"Kinney JS, Ramseier CA, Giannobile WV. Oral fluid-based biomarkers of alveolar bone loss in periodontitis. Ann N Y Acad Sci. 2007, 1098:230-51. 10.1196\/annals.1384.028","journal-title":"Ann N Y Acad Sci"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01563.x","article-title":"Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis","volume":"37","author":"Gursoy UK","year":"2010","unstructured":"Gursoy UK, K\u00f6n\u00f6nen E, Pradhan-Palikhe P, Tervahartiala T, Pussinen PJ, Suominen-Taipale L, Sorsa T. Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis. J Clin Periodontol. 2010, 37:487-93. 10.1111\/j.1600-051X.2010.01563.x","journal-title":"J Clin Periodontol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-6009(08)80147-x","article-title":"Assessment of bone remodeling using biochemical indicators of type I collagen synthesis and degradation: relation to calcium kinetics","volume":"24","author":"Charles P","year":"1994","unstructured":"Charles P, Mosekilde L, Risteli L, Risteli J, Eriksen EF. Assessment of bone remodeling using biochemical indicators of type I collagen synthesis and degradation: relation to calcium kinetics. Bone Miner. 1994, 24:81-94. 10.1016\/s0169-6009(08)80147-x","journal-title":"Bone Miner"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/276812-estimation-of-levels-of-salivary-pyridinoline-cross-linked-carboxyterminal-telopeptide-of-type-i-collagen-ictp-in-periodontally-healthy-and-diseased-patients-at-various-time-intervals-before-and-after-periodontal-therapy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:22:26Z","timestamp":1722903746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/276812-estimation-of-levels-of-salivary-pyridinoline-cross-linked-carboxyterminal-telopeptide-of-type-i-collagen-ictp-in-periodontally-healthy-and-diseased-patients-at-various-time-intervals-before-and-after-periodontal-therapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,5]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.66236","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,5]]}}}