{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:32:54Z","timestamp":1791415974018,"version":"4.3.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,12]]},"DOI":"10.7759\/cureus.66675","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:30:27Z","timestamp":1723462227000},"source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Chlorhexidine and Aloe Vera Mouthwash in Patients With Periodontal Disease: A Randomized Controlled Trial"],"prefix":"10.7759","author":[{"given":"Nasreen Hamarash","family":"Hamonari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.53033","article-title":"Comparative efficacy of aloe vera mouthwash and chlorhexidine on periodontal health: a randomized controlled trial","volume":"8","author":"Vangipuram S","year":"2016","unstructured":"Vangipuram S, Jha A, Bhashyam M. Comparative efficacy of aloe vera mouthwash and chlorhexidine on periodontal health: a randomized controlled trial. J Clin Exp Dent. 2016, 8:e442-7. 10.4317\/jced.53033","journal-title":"J Clin Exp Dent"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.37506\/ijfmt.v15i3.15873","article-title":"The effect of aloevera mouthwash in reducing periodontal disease among secondary school students in Duhok, Kurdistan Region, Iraq: a quasi-experimental study","volume":"15","author":"Hamonari NH","year":"2021","unstructured":"Hamonari NH, Al-Dabbagh S, Mudhir AM. The effect of aloevera mouthwash in reducing periodontal disease among secondary school students in Duhok, Kurdistan Region, Iraq: a quasi-experimental study. Indian J Forensic Med Toxicol. 2021, 15:3707-14. 10.37506\/ijfmt.v15i3.15873","journal-title":"Indian J Forensic Med Toxicol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtumed.2021.10.006","article-title":"Aloe vera mouthwashes can be a natural alternative to chemically formulated ones - a randomized-controlled trial","volume":"17","author":"Pattnaik N","year":"2022","unstructured":"Pattnaik N, Mohanty R, Satpathy A, Nayak R, Shamim R, Praharaj AK. Aloe vera mouthwashes can be a natural alternative to chemically formulated ones - a randomized-controlled trial. J Taibah Univ Med Sci. 2022, 17:424-32. 10.1016\/j.jtumed.2021.10.006","journal-title":"J Taibah Univ Med Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12615","article-title":"Comparison of antiplaque and anti-gingivitis effects of aloe vera mouthwash with chlorhexidine in fixed orthodontic patients-a randomized controlled trial","volume":"21","author":"Kamath DG","year":"2023","unstructured":"Kamath DG, Nadimpalli H, Nayak SU, Rajendran V, Natarajan S. Comparison of antiplaque and anti-gingivitis effects of aloe vera mouthwash with chlorhexidine in fixed orthodontic patients-a randomized controlled trial. Int J Dent Hyg. 2023, 21:211-8. 10.1111\/idh.12615","journal-title":"Int J Dent Hyg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-77572008000400012","article-title":"Effect of a dentifrice containing aloe vera on plaque and gingivitis control. A double-blind clinical study in humans","volume":"16","author":"de Oliveira SM","year":"2008","unstructured":"de Oliveira SM, Torres TC, Pereira SL, Mota OM, Carlos MX. Effect of a dentifrice containing aloe vera on plaque and gingivitis control. A double-blind clinical study in humans. J Appl Oral Sci. 2008, 16:293-6. 10.1590\/s1678-77572008000400012","journal-title":"J Appl Oral Sci"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00429.x","article-title":"Low-cost periodontal therapy","volume":"60","author":"Slots J","year":"2012","unstructured":"Slots J. Low-cost periodontal therapy. Periodontol 2000. 2012, 60:110-37. 10.1111\/j.1600-0757.2011.00429.x","journal-title":"Periodontol 2000"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01883.x","article-title":"Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review","volume":"39","author":"Van Strydonck DA","year":"2012","unstructured":"Van Strydonck DA, Slot DE, Van der Velden U, Van der Weijden F. Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. J Clin Periodontol. 2012, 39:1042-55. 10.1111\/j.1600-051X.2012.01883.x","journal-title":"J Clin Periodontol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.106905","article-title":"A randomized, double-blind clinical study to assess the antiplaque and antigingivitis efficacy of aloe vera mouth rinse","volume":"16","author":"Chandrahas B","year":"2012","unstructured":"Chandrahas B, Jayakumar A, Naveen A, Butchibabu K, Reddy PK, Muralikrishna T. A randomized, double-blind clinical study to assess the antiplaque and antigingivitis efficacy of aloe vera mouth rinse. J Indian Soc Periodontol. 2012, 16:543-8. 10.4103\/0972-124X.106905","journal-title":"J Indian Soc Periodontol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24381","article-title":"Salivary acetaldehyde increase due to alcohol-containing mouthwash use: a risk factor for oral cancer","volume":"125","author":"Lachenmeier DW","year":"2009","unstructured":"Lachenmeier DW, Gumbel-Mako S, Sohnius EM, Keck-Wilhelm A, Kratz E, Mildau G. Salivary acetaldehyde increase due to alcohol-containing mouthwash use: a risk factor for oral cancer. Int J Cancer. 2009, 125:730-5. 10.1002\/ijc.24381","journal-title":"Int J Cancer"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4314\/ejhs.v24i2.6","article-title":"Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial","volume":"24","author":"Gupta RK","year":"2014","unstructured":"Gupta RK, Gupta D, Bhaskar DJ, Yadav A, Obaid K, Mishra S. Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial. Ethiop J Health Sci. 2014, 24:139-44. 10.4314\/ejhs.v24i2.6","journal-title":"Ethiop J Health Sci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12393","article-title":"Efficacy of aloe vera mouthwash versus chlorhexidine on plaque and gingivitis: a systematic review","volume":"18","author":"Al-Maweri SA","year":"2020","unstructured":"Al-Maweri SA, Nassani MZ, Alaizari N, et al.. Efficacy of aloe vera mouthwash versus chlorhexidine on plaque and gingivitis: a systematic review. Int J Dent Hyg. 2020, 18:44-51. 10.1111\/idh.12393","journal-title":"Int J Dent Hyg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2174\/138945011798109464","article-title":"Identification of novel anti-inflammatory agents from ayurvedic medicine for prevention of chronic diseases: \"reverse pharmacology\" and \"bedside to bench\" approach","volume":"12","author":"Aggarwal BB","year":"2011","unstructured":"Aggarwal BB, Prasad S, Reuter S, et al.. Identification of novel anti-inflammatory agents from ayurvedic medicine for prevention of chronic diseases: \"reverse pharmacology\" and \"bedside to bench\" approach. Curr Drug Targets. 2011, 12:1595-653. 10.2174\/138945011798109464","journal-title":"Curr Drug Targets"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion","volume":"22","author":"Silness J","year":"1964","unstructured":"Silness J , L\u00f6e H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand. 1964, 22:121-35. 10.3109\/00016356408993968","journal-title":"Acta Odontol Scand"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy. I. Prevalence and severity","volume":"21","author":"L\u00f6e H","year":"1963","unstructured":"L\u00f6e H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand. 1963, 21:533-51. 10.3109\/00016356309011240","journal-title":"Acta Odontol Scand"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.92542","article-title":"Ayurveda and herbs in dental health","volume":"32","author":"Saini R","year":"2011","unstructured":"Saini R, Sharma S, Saini S. Ayurveda and herbs in dental health. Ayu. 2011, 32:285-6. 10.4103\/0974-8520.92542","journal-title":"Ayu"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2011.0006","article-title":"Herbs in dentistry","volume":"61","author":"Taheri JB","year":"2011","unstructured":"Taheri JB, Azimi S, Rafieian N, Zanjani HA. Herbs in dentistry. Int Dent J. 2011, 61:287-96. 10.1111\/j.1875-595X.2011.0006","journal-title":"Int Dent J"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601913010214","article-title":"Gingival inflammatory indices and dental stain index after using aloe vera-green tea mouthwash, matrica mouthwash, or 0.2% chlorhexidine mouthwash compared with placebo in patients with gingival inflammation","volume":"13","author":"Yaghini J","year":"2019","unstructured":"Yaghini J, Naghsh N, Sadeghi SM, Soltani S. Gingival inflammatory indices and dental stain index after using aloe vera-green tea mouthwash, matrica mouthwash, or 0.2% chlorhexidine mouthwash compared with placebo in patients with gingival inflammation. Open Dent J. 2019, 13:14-20. 10.2174\/1874210601913010214","journal-title":"Open Dent J"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdj.2020.01.001","article-title":"Effect of aloe vera mouthwash on dental plaque and gingivitis indices in children: a randomized controlled clinical trial","volume":"30","author":"Alnouri DMH","year":"2020","unstructured":"Alnouri DMH, Kouchaji C, Nattouf AH, AlSayed Hasan MMA. Effect of aloe vera mouthwash on dental plaque and gingivitis indices in children: a randomized controlled clinical trial. Pedi Dent J. 2020, 30:1-8. 10.1016\/j.pdj.2020.01.001","journal-title":"Pedi Dent J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2019.100473","article-title":"Effects of a chlorhexidine mouthwash on clinical parameters of gingivitis, dental plaque and oral polymorphonuclear leukocytes (PMN)","volume":"19","author":"Sreenivasan PK","year":"2020","unstructured":"Sreenivasan PK, Prasad KV. Effects of a chlorhexidine mouthwash on clinical parameters of gingivitis, dental plaque and oral polymorphonuclear leukocytes (PMN). Contemp Clin Trials Commun. 2020, 19:100473. 10.1016\/j.conctc.2019.100473","journal-title":"Contemp Clin Trials Commun"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05081-4","article-title":"Effects of water flossing on gingival inflammation and supragingival plaque microbiota: a 12-week randomized controlled trial","volume":"27","author":"Xu X","year":"2023","unstructured":"Xu X, Zhou Y, Liu C, et al.. Effects of water flossing on gingival inflammation and supragingival plaque microbiota: a 12-week randomized controlled trial. Clin Oral Investig. 2023, 27:4567-77. 10.1007\/s00784-023-05081-4","journal-title":"Clin Oral Investig"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2015.08.008","article-title":"Effect of aloe vera, chlorine dioxide, and chlorhexidine mouth rinses on plaque and gingivitis: a randomized controlled trial","volume":"6","author":"Yeturu SK","year":"2016","unstructured":"Yeturu SK, Acharya S, Urala AS, Pentapati KC. Effect of aloe vera, chlorine dioxide, and chlorhexidine mouth rinses on plaque and gingivitis: a randomized controlled trial. J Oral Biol Craniofac Res. 2016, 6:54-8. 10.1016\/j.jobcr.2015.08.008","journal-title":"J Oral Biol Craniofac Res"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5812\/jjnpp-122155","article-title":"Evaluation of aloe vera as a natural pharmaceutic in mouthwashes: a narrative review","author":"Poorkazemi D","year":"2022174","unstructured":"Poorkazemi D, Malekzadeh Shafaroudi A, Nasiri P, Aarabi M, Mehrani Sabet J. Evaluation of aloe vera as a natural pharmaceutic in mouthwashes: a narrative review. Jundishapur J Nat Pharm Prod. 2022174, 122155. 10.5812\/jjnpp-122155","journal-title":"Jundishapur J Nat Pharm Prod"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0754.115773","article-title":"Comparative evaluation of effectiveness between aloe vera and two commercially available mouth rinses on plaque and gingival status: a randomized control trial","volume":"3","author":"Parkar S","year":"2011","unstructured":"Parkar S, Janu U. Comparative evaluation of effectiveness between aloe vera and two commercially available mouth rinses on plaque and gingival status: a randomized control trial. J Int Clin Dent Res Organ. 2011, 3:25. 10.4103\/2231-0754.115773","journal-title":"J Int Clin Dent Res Organ"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/282005-effectiveness-of-chlorhexidine-and-aloe-vera-mouthwash-in-patients-with-periodontal-disease-a-randomized-controlled-trial","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:30:32Z","timestamp":1723462232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/282005-effectiveness-of-chlorhexidine-and-aloe-vera-mouthwash-in-patients-with-periodontal-disease-a-randomized-controlled-trial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.66675","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,12]]}}}