{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:47:56Z","timestamp":1792619276455,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,12]]},"DOI":"10.7759\/cureus.66743","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T06:52:53Z","timestamp":1723531973000},"source":"Crossref","is-referenced-by-count":1,"title":["Pan-Cancer Analysis Confirms the Prognostic and Immunological Implications of the 1,25-Dihydroxy Vitamin D3 Receptor in Cervical Squamous Cell Carcinoma"],"prefix":"10.7759","author":[{"given":"Israa Faris M","family":"Faris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noon","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomador S","family":"Zeanelabdeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Alfaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58121838","article-title":"Papillary squamotransitional cell carcinoma of the uterine cervix with atypical presentation: a case report with a literature review","volume":"58","author":"Yordanov A","year":"2022","unstructured":"Yordanov A, Karaivanov M, Kostov S, et al.. Papillary squamotransitional cell carcinoma of the uterine cervix with atypical presentation: a case report with a literature review. Medicina (Kaunas). 2022, 58:10.3390\/medicina58121838","journal-title":"Medicina (Kaunas)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4172\/2157-7099.1000449","article-title":"Primary vaginal invasive squamous cell carcinoma: a rare case report","volume":"8","author":"Santosh T","year":"2017","unstructured":"Santosh T, Sahu P, Patro MK, Mishra B. Primary vaginal invasive squamous cell carcinoma: a rare case report. J Cytol Histol. 2017, 8:2. 10.4172\/2157-7099.1000449","journal-title":"J Cytol Histol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000521078","article-title":"Diagnostic value of VDR in bone metastasis and prognosis of patients with breast cancer and expression correlation between vitamin D receptor and hairless protein","volume":"45","author":"Ding P","year":"2022","unstructured":"Ding P, Du X, Wan L, et al.. Diagnostic value of VDR in bone metastasis and prognosis of patients with breast cancer and expression correlation between vitamin D receptor and hairless protein. Oncol Res Treat. 2022, 45:166-77. 10.1159\/000521078","journal-title":"Oncol Res Treat"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.10.017","article-title":"Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer","volume":"148","author":"Bikle DD","year":"2015","unstructured":"Bikle DD, Oda Y, Tu CL, Jiang Y. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol. 2015, 148:47-51. 10.1016\/j.jsbmb.2014.10.017","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054675","article-title":"Exploiting vitamin D receptor and its ligands to target squamous cell carcinomas of the head and neck","volume":"24","author":"Koll L","year":"2023","unstructured":"Koll L, G\u00fcl D, Elnouaem MI, et al.. Exploiting vitamin D receptor and its ligands to target squamous cell carcinomas of the head and neck. Int J Mol Sci. 2023, 24:10.3390\/ijms24054675","journal-title":"Int J Mol Sci"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2007.tb00332.x","article-title":"Vitamin D receptor gene (VDR) associations with cancer","volume":"65","author":"Slattery ML","year":"2007","unstructured":"Slattery ML. Vitamin D receptor gene (VDR) associations with cancer. Nutr Rev. 2007, 65:S102-4. 10.1111\/j.1753-4887.2007.tb00332.x","journal-title":"Nutr Rev"},{"key":"ref7","article-title":"TIMER: Tumor IMmune Estimation Resource","author":"Li B","year":"2016","unstructured":"Li B, Li T. TIMER: Tumor IMmune Estimation Resource. Zenodo. 2016,","journal-title":"Zenodo"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1028-7","article-title":"Comprehensive analyses of tumor immunity: implications for cancer immunotherapy","volume":"17","author":"Li B","year":"2016","unstructured":"Li B, Severson E, Pignon JC, et al.. Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. Genome Biol. 2016, 17:174. 10.1186\/s13059-016-1028-7","journal-title":"Genome Biol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.060","article-title":"Comprehensive characterization of cancer driver genes and mutations","volume":"173","author":"Bailey MH","year":"2018","unstructured":"Bailey MH, Tokheim C, Porta-Pardo E, et al.. Comprehensive characterization of cancer driver genes and mutations. Cell. 2018, 173:371-385.e18. 10.1016\/j.cell.2018.02.060","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08883-9","article-title":"Exploring the biomarkers and potential therapeutic drugs for sepsis via integrated bioinformatic analysis","volume":"24","author":"Liang P","year":"2024","unstructured":"Liang P, Wu Y, Qu S, Younis M, Wang W, Wu Z, Huang X. Exploring the biomarkers and potential therapeutic drugs for sepsis via integrated bioinformatic analysis. BMC Infect Dis. 2024, 24:32. 10.1186\/s12879-023-08883-9","journal-title":"BMC Infect Dis"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060805","article-title":"Bioinformatics analysis for circulating cell-free DNA in cancer","volume":"11","author":"Huang CC","year":"2019","unstructured":"Huang CC, Du M, Wang L. Bioinformatics analysis for circulating cell-free DNA in cancer. Cancers (Basel). 2019, 11:10.3390\/cancers11060805","journal-title":"Cancers (Basel)"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186%2Fgb-2013-14-10-r110","article-title":"Modeling precision treatment of breast cancer","volume":"14","author":"Daemen A","year":"2013","unstructured":"Daemen A, Griffith OL, Heiser LM, et.al. Modeling precision treatment of breast cancer. Gene Biol. 2013, 14:10.1186%2Fgb-2013-14-10-r110","journal-title":"Gene Biol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2864120","article-title":"Analysis of the Cancer Genome Atlas data reveals novel putative ncRNAs targets in hepatocellular carcinoma","volume":"2018","author":"Falcon T","year":"2018","unstructured":"Falcon T, Freitas M, Mello AC, Coutinho L, Alvares-da-Silva MR, Matte U. Analysis of the Cancer Genome Atlas data reveals novel putative ncRNAs targets in hepatocellular carcinoma. Biomed Res Int. 2018, 2018:2864120. 10.1155\/2018\/2864120","journal-title":"Biomed Res Int"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4161\/derm.24156\u00a0","article-title":"The relevance of the vitamin D endocrine system (VDES) for tumorigenesis, prevention, and treatment of non-melanoma skin cancer (NMSC)","volume":"5","author":"Reichrath J","year":"2013","unstructured":"Reichrath J, Reichrath S. The relevance of the vitamin D endocrine system (VDES) for tumorigenesis, prevention, and treatment of non-melanoma skin cancer (NMSC). Pres Conc Fut Pers. 2013, 5:38-50. 10.4161\/derm.24156\u00a0","journal-title":"Pres Conc Fut Pers"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lungcan.2012.04.010","article-title":"Characterization of vitamin D receptor (VDR) in lung adenocarcinoma","volume":"77","author":"Kim S","year":"2012","unstructured":"Kim S, Chen G, King AN, et al.. Characterization of vitamin D receptor (VDR) in lung adenocarcinoma. Elsevier BV. 2012, 77:265-71. 10.1016%2Fj.lungcan.2012.04.010","journal-title":"Elsevier BV"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.02.006","article-title":"CYP24 inhibition preserves 1\u03b1,25-dihydroxyvitamin D(3) anti-proliferative signaling in lung cancer cells","volume":"355","author":"Zhang Q","year":"2012","unstructured":"Zhang Q, Kanterewicz B, Buch S, et al.. CYP24 inhibition preserves 1\u03b1,25-dihydroxyvitamin D(3) anti-proliferative signaling in lung cancer cells. Mol Cell Endocrinol. 2012, 355:153-61. 10.1016\/j.mce.2012.02.006","journal-title":"Mol Cell Endocrinol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.04.103","article-title":"Targeting vitamin D receptor (VDR)\/immune checkpoint inhibitor receptor ligand PD-L1 axis for immunotherapy of ovarian cancer","volume":"149","author":"Singh RK","year":"2018","unstructured":"Singh RK, Turner R, Kim K, et al.. Targeting vitamin D receptor (VDR)\/immune checkpoint inhibitor receptor ligand PD-L1 axis for immunotherapy of ovarian cancer. Gynec Oncol. 2018, 149:48. 10.1016\/j.ygyno.2018.04.103","journal-title":"Gynec Oncol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S174244","article-title":"Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer","volume":"10","author":"Kholghi Oskooei V","year":"2018","unstructured":"Kholghi Oskooei V, Geranpayeh L, Omrani MD, Ghafouri-Fard S. Assessment of functional variants and expression of long noncoding RNAs in vitamin D receptor signaling in breast cancer. Cancer Manag Res. 2018, 10:3451-62. 10.2147\/CMAR.S174244","journal-title":"Cancer Manag Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2174\/156800906776842939","article-title":"Vitamin D receptor is a novel drug target for ovarian cancer treatment","volume":"6","author":"Zhang X","year":"2006","unstructured":"Zhang X, Nicosia SV, Bai W. Vitamin D receptor is a novel drug target for ovarian cancer treatment. Curr Cancer Drug Targets. 2006, 6:229-44. 10.2174\/156800906776842939","journal-title":"Curr Cancer Drug Targets"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-020-01894-6","article-title":"Cytoplasmic VDR expression as an independent risk factor for ovarian cancer","volume":"154","author":"Czogalla B","year":"2020","unstructured":"Czogalla B, Deuster E, Liao Y, et al.. Cytoplasmic VDR expression as an independent risk factor for ovarian cancer. Histochem Cell Biol. 2020, 154:421-9. 10.1007\/s00418-020-01894-6","journal-title":"Histochem Cell Biol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/nu16091392","article-title":"Vitamins in gynecologic malignancies","volume":"16","author":"Wierzbowska N","year":"2024","unstructured":"Wierzbowska N, Olszowski T, Chlubek D, Koz\u0142owski M, Cymbaluk-P\u0142oska A. Vitamins in gynecologic malignancies. Nutrients. 2024, 16:1392. 10.3390\/nu16091392","journal-title":"Nutrients"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/278092-pan-cancer-analysis-confirms-the-prognostic-and-immunological-implications-of-the-125-dihydroxy-vitamin-d3-receptor-in-cervical-squamous-cell-carcinoma","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T06:52:56Z","timestamp":1723531976000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/278092-pan-cancer-analysis-confirms-the-prognostic-and-immunological-implications-of-the-125-dihydroxy-vitamin-d3-receptor-in-cervical-squamous-cell-carcinoma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":21,"URL":"https:\/\/doi.org\/10.7759\/cureus.66743","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,12]]}}}