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Nutr Neurosci. 2021, 24:35-44. 10.1080\/1028415X.2019.1587247","journal-title":"Nutr Neurosci"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd5030038","article-title":"Potential impact of COMT-rs4680 G > A gene polymorphism in coronary artery disease","volume":"5","author":"Mir R","year":"2018","unstructured":"Mir R, Bhat M, Javid J, Jha C, Saxena A, Banu S. Potential impact of COMT-rs4680 G > A gene polymorphism in coronary artery disease. J Cardiovasc Dev Dis. 2018, 5:10.3390\/jcdd5030038","journal-title":"J Cardiovasc Dev Dis"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-017-0081-9","article-title":"Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson's disease","volume":"6","author":"Xiao Q","year":"2017","unstructured":"Xiao Q, Qian Y, Liu J, Xu S, Yang X. Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson's disease. Transl Neurodegener. 2017, 6:11. 10.1186\/s40035-017-0081-9","journal-title":"Transl Neurodegener"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040768","article-title":"Genetic biomarkers of metabolic detoxification for personalized lifestyle medicine","volume":"14","author":"Aronica L","year":"2022","unstructured":"Aronica L, Ordovas JM, Volkov A, et al.. Genetic biomarkers of metabolic detoxification for personalized lifestyle medicine. Nutrients. 2022, 14:10.3390\/nu14040768","journal-title":"Nutrients"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.34172\/jhp.2021.05","article-title":"Relaxant effect of quercetin on rabbit isolated bladder smooth muscles contractions","volume":"10","author":"Sadraei H","year":"2021","unstructured":"Sadraei H, Tabesh S. Relaxant effect of quercetin on rabbit isolated bladder smooth muscles contractions. J Herbmed Pharmacol. 2021, 10:61-7. 10.34172\/jhp.2021.05","journal-title":"J Herbmed Pharmacol"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.04.043","article-title":"Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats","volume":"70","author":"Yao HT","year":"2014","unstructured":"Yao HT, Hsu YR, Lii CK, Lin AH, Chang KH, Yang HT. Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats. Food Chem Toxicol. 2014, 70:120-7. 10.1016\/j.fct.2014.04.043","journal-title":"Food Chem Toxicol"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.10.003","article-title":"Green tea diet decreases PCB 126-induced oxidative stress in mice by up-regulating antioxidant enzymes","volume":"25","author":"Newsome BJ","year":"2014","unstructured":"Newsome BJ, Petriello MC, Han SG, et al.. 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World J Gastroenterol. 2003, 9:2742-4. 10.3748\/wjg.v9.i12.2742","journal-title":"World J Gastroenterol"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706255","article-title":"Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols","volume":"145","author":"Anger DL","year":"2005","unstructured":"Anger DL, Petre MA, Crankshaw DJ. Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols. Br J Pharmacol. 2005, 145:926-33. 10.1038\/sj.bjp.0706255","journal-title":"Br J Pharmacol"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2016.1258075","article-title":"The Val158Met polymorphism in COMT gene and cancer risk: role of endogenous and exogenous catechols","volume":"49","author":"Sak K","year":"2017","unstructured":"Sak K. The Val158Met polymorphism in COMT gene and cancer risk: role of endogenous and exogenous catechols. Drug Metab Rev. 2017, 49:56-83. 10.1080\/03602532.2016.1258075","journal-title":"Drug Metab Rev"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.01.024","article-title":"Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies","volume":"69","author":"Chen D","year":"2005","unstructured":"Chen D, Wang CY, Lambert JD, Ai N, Welsh WJ, Yang CS. Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. Biochem Pharmacol. 2005, 69:1523-31. 10.1016\/j.bcp.2005.01.024","journal-title":"Biochem Pharmacol"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2022.2128501","article-title":"Hepatotoxicity with high-dose green tea extract: effect of catechol-o-methyltransferase and uridine 5'-diphospho-glucuronosyltransferase 1a4 genotypes","volume":"20","author":"Acosta L","year":"2023","unstructured":"Acosta L, Byham-Gray L, Kurzer M, Samavat H. Hepatotoxicity with high-dose green tea extract: effect of catechol-o-methyltransferase and uridine 5'-diphospho-glucuronosyltransferase 1a4 genotypes. J Diet Suppl. 2023, 20:850-69. 10.1080\/19390211.2022.2128501","journal-title":"J Diet Suppl"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2006.9.451","article-title":"Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase","volume":"9","author":"Shixian Q","year":"2006","unstructured":"Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y. Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase. J Med Food. 2006, 9:451-8. 10.1089\/jmf.2006.9.451","journal-title":"J Med Food"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.23902\/trkjnat.302152","article-title":"Determination of monoamine oxidase inhibition and antioxidant effects of various herbal teas [Article in Turkish]","volume":"18","author":"Yuce Dursun B","year":"2017","unstructured":"Yuce Dursun B. 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