{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:20:17Z","timestamp":1769505617559,"version":"3.49.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,18]]},"DOI":"10.7759\/cureus.67127","type":"journal-article","created":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T17:08:45Z","timestamp":1724000925000},"source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of Severe Preeclampsia and HELLP (Hemolysis, Increased Liver Enzymes, Low Platelets) Syndrome With Complex Clinical Presentation"],"prefix":"10.7759","author":[{"given":"Vidya","family":"Gaikwad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhas","family":"Gaikwad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha","family":"Aramandla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rushikesh","family":"Phutane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.01.006","article-title":"Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy","volume":"25","author":"Hutcheon JA","year":"2011","unstructured":"Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol. 2011, 25:391-403. 10.1016\/j.bpobgyn.2011.01.006","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2016-009","article-title":"Pre-eclampsia: its pathogenesis and pathophysiolgy","volume":"27","author":"Gathiram P","year":"2016","unstructured":"Gathiram P, Moodley J. Pre-eclampsia: its pathogenesis and pathophysiolgy. Cardiovasc J Afr. 2016, 27:71-8. 10.5830\/CVJA-2016-009","journal-title":"Cardiovasc J Afr"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.6.559","article-title":"HELLP syndrome: hemolysis, elevated liver enzymes, and low platelets","volume":"280","author":"Stone JH","year":"1998","unstructured":"Stone JH. HELLP syndrome: hemolysis, elevated liver enzymes, and low platelets. JAMA. 1998, 280:559-62. 10.1001\/jama.280.6.559","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.10.024","article-title":"Revisiting HELLP syndrome","volume":"451","author":"Dusse LM","year":"2015","unstructured":"Dusse LM, Alpoim PN, Silva JT, Rios DR, Brand\u00e3o AH, Cabral AC. Revisiting HELLP syndrome. Clin Chim Acta. 2015, 451:117-20. 10.1016\/j.cca.2015.10.024","journal-title":"Clin Chim Acta"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-8","article-title":"The HELLP syndrome: clinical issues and management. A review","volume":"9","author":"Haram K","year":"2009","unstructured":"Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: clinical issues and management. A review. BMC Pregnancy Childbirth. 2009, 9:8. 10.1186\/1471-2393-9-8","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1088004","article-title":"Potential targets for the treatment of preeclampsia","volume":"19","author":"Oyston CJ","year":"2015","unstructured":"Oyston CJ, Stanley JL, Baker PN. Potential targets for the treatment of preeclampsia. Expert Opin Ther Targets. 2015, 19:1517-30. 10.1517\/14728222.2015.1088004","journal-title":"Expert Opin Ther Targets"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2010.035","article-title":"Management of severe preeclampsia","volume":"65","author":"Brichant G","year":"2010","unstructured":"Brichant G, Dewandre PY, Foidart JM, Brichant JF. Management of severe preeclampsia. Acta Clin Belg. 2010, 65:163-9. 10.1179\/acb.2010.035","journal-title":"Acta Clin Belg"},{"key":"ref8","article-title":"Eclampsia: feto-maternal outcomes in a tertiary care centre in Eastern Nepal","volume":"54","author":"Ghimire S","year":"2016","unstructured":"Ghimire S. Eclampsia: feto-maternal outcomes in a tertiary care centre in Eastern Nepal. JNMA J Nepal Med Assoc. 2016, 54:24-28.","journal-title":"JNMA J Nepal Med Assoc"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150567","article-title":"Long-term renal and cardiovascular risk after preeclampsia: towards screening and prevention","volume":"130","author":"Paauw ND","year":"2016","unstructured":"Paauw ND, Luijken K, Franx A, Verhaar MC, Lely AT. Long-term renal and cardiovascular risk after preeclampsia: towards screening and prevention. Clin Sci (Lond). 2016, 130:239-46. 10.1042\/CS20150567","journal-title":"Clin Sci (Lond)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2015.07.001","article-title":"An essay of reflection: why does preeclampsia exist in humans, and why are there such huge geographical differences in epidemiology?","volume":"114","author":"Robillard PY","year":"2016","unstructured":"Robillard PY, Dekker G, Iacobelli S, Chaouat G. An essay of reflection: why does preeclampsia exist in humans, and why are there such huge geographical differences in epidemiology?. J Reprod Immunol. 2016, 114:44-7. 10.1016\/j.jri.2015.07.001","journal-title":"J Reprod Immunol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1114081","article-title":"Pre-eclampsia and preterm birth in Reunion Island: a 13 years cohort-based study. Comparison with international data","volume":"29","author":"Iacobelli S","year":"2016","unstructured":"Iacobelli S, Bonsante F, Robillard PY. Pre-eclampsia and preterm birth in Reunion Island: a 13 years cohort-based study. Comparison with international data. J Matern Fetal Neonatal Med. 2016, 29:3035-40. 10.3109\/14767058.2015.1114081","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13210","article-title":"Liver dysfunction in women with pregnancy-induced antithrombin deficiency","volume":"43","author":"Morikawa M","year":"2017","unstructured":"Morikawa M, Kawabata K, Kato-Hirayama E, et al.. Liver dysfunction in women with pregnancy-induced antithrombin deficiency. J Obstet Gynaecol Res. 2017, 43:257-64. 10.1111\/jog.13210","journal-title":"J Obstet Gynaecol Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.12.034","article-title":"HELLP syndrome: an atypical presentation","volume":"198","author":"Stella CL","year":"2008","unstructured":"Stella CL, Malik KM, Sibai BM. HELLP syndrome: an atypical presentation. Am J Obstet Gynecol. 2008, 198:6-8. 10.1016\/j.ajog.2007.12.034","journal-title":"Am J Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90043-i","article-title":"Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)","volume":"169","author":"Sibai BM","year":"1993","unstructured":"Sibai BM, Ramadan MK, Usta I, et al.. Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol. 1993, 169:1000-6. 10.1016\/0002-9378(93)90043-i","journal-title":"Am J Obstet Gynecol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)91429-z","article-title":"The natural history of HELLP syndrome: patterns of disease progression and regression","volume":"164","author":"Martin JN","year":"1991","unstructured":"Martin JN, Blake PG, Perry KG, McCaul JF, Hess LW, Martin RW. The natural history of HELLP syndrome: patterns of disease progression and regression. Am J Obstet Gynecol. 1991, 164:1500-9. 10.1016\/0002-9378(91)91429-z","journal-title":"Am J Obstet Gynecol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90266-8","article-title":"Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsiaeclampsia","volume":"155","author":"Sibai BM","year":"1986","unstructured":"Sibai BM, Taslimi MM, el-Nazer A, Amon E, Mabie BC, Ryan GM. Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsiaeclampsia. Am J Obstet Gynecol. 1986, 155:501-9. 10.1016\/0002-9378(86)90266-8","journal-title":"Am J Obstet Gynecol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90376-i","article-title":"The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing?","volume":"162","author":"Sibai BM","year":"1990","unstructured":"Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing?. Am J Obstet Gynecol. 1990, 162:311-6. 10.1016\/0002-9378(90)90376-i","journal-title":"Am J Obstet Gynecol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.41283","article-title":"Pregnancy-related acute renal failure: a single-center experience","volume":"18","author":"Goplani KR","year":"2008","unstructured":"Goplani KR, Shah PR, Gera DN, et al.. Pregnancy-related acute renal failure: a single-center experience. Indian J Nephrol. 2008, 18:17-21. 10.4103\/0971-4065.41283","journal-title":"Indian J Nephrol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0551-4","article-title":"Acute kidney injury during pregnancy and puerperium: a retrospective study in a single center","volume":"18","author":"Huang C","year":"2017","unstructured":"Huang C, Chen S. Acute kidney injury during pregnancy and puerperium: a retrospective study in a single center. BMC Nephrol. 2017, 18:146. 10.1186\/s12882-017-0551-4","journal-title":"BMC Nephrol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4103\/1596-3519.57247","article-title":"Reversible blindness in fulminating preeclampsia","volume":"8","author":"Swende TZ","year":"2009","unstructured":"Swende TZ, Abwa T. Reversible blindness in fulminating preeclampsia. Ann Afr Med. 2009, 8:189-91. 10.4103\/1596-3519.57247","journal-title":"Ann Afr Med"},{"key":"ref21","article-title":"Pregnancy outcome in eclamptics at the University of Abuja Teaching Hospital, Gwagwalada, Abuja: a 3 year review","volume":"13","author":"Agida ET","year":"2010","unstructured":"Agida ET, Adeka BI, Jibril KA. Pregnancy outcome in eclamptics at the University of Abuja Teaching Hospital, Gwagwalada, Abuja: a 3 year review.  Niger J Clin Pract. 2010, 13:394-8.","journal-title":"Niger J Clin Pract"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008148.pub2","article-title":"Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy","author":"Woudstra DM","year":"2010","unstructured":"Woudstra DM, Chandra S, Hofmeyr GJ, Dowswell T. Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy. Cochrane Database Syst Rev. 2010, CD008148. 10.1002\/14651858.CD008148.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.02.001","article-title":"Milestones in the quest for best management of patients with HELLP syndrome (microangiopathic hemolytic anemia, hepatic dysfunction, thrombocytopenia)","volume":"121","author":"Martin JN Jr","year":"2013","unstructured":"Martin JN Jr. Milestones in the quest for best management of patients with HELLP syndrome (microangiopathic hemolytic anemia, hepatic dysfunction, thrombocytopenia). Int J Gynaecol Obstet. 2013, 121:202-7. 10.1016\/j.ijgo.2013.02.001","journal-title":"Int J Gynaecol Obstet"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000151116.84113.56","article-title":"Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressure","volume":"105","author":"Martin JN Jr","year":"2005","unstructured":"Martin JN Jr, Thigpen BD, Moore RC, Rose CH, Cushman J, May W. Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressure. Obstet Gynecol. 2005, 105:246-54. 10.1097\/01.AOG.0000151116.84113.56","journal-title":"Obstet Gynecol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/280580-a-rare-case-of-severe-preeclampsia-and-hellp-hemolysis-increased-liver-enzymes-low-platelets-syndrome-with-complex-clinical-presentation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T17:08:50Z","timestamp":1724000930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/280580-a-rare-case-of-severe-preeclampsia-and-hellp-hemolysis-increased-liver-enzymes-low-platelets-syndrome-with-complex-clinical-presentation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,18]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.67127","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,18]]}}}