{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:02:33Z","timestamp":1787500953104,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,21]]},"DOI":"10.7759\/cureus.67382","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T18:32:38Z","timestamp":1724265158000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Intravenous Ondansetron and Dexamethasone for Preventing Propofol-Induced Pain During Laparoscopic Cholecystectomy: A Double-Blind, Randomized Study"],"prefix":"10.7759","author":[{"given":"Aravind","family":"Aditya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasimul","family":"Hoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Oraon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladhu","family":"Lakra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1998.00405.x","article-title":"Pain on injection of propofol","volume":"53","author":"Tan CH","year":"1998","unstructured":"Tan CH, Onsiong MK. Pain on injection of propofol. Anaesthesia. 1998, 53:468-76. 10.1046\/j.1365-2044.1998.00405.x","journal-title":"Anaesthesia"},{"key":"ref2","article-title":"Role of tramadol in reducing pain on propofol injection","volume":"42","author":"Wong WH","year":"2001","unstructured":"Wong WH, Cheong KF. Role of tramadol in reducing pain on propofol injection. Singapore Med J. 2001, 42:193-5.","journal-title":"Singapore Med J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.1992.tb00182.x","article-title":"Propofol in paediatric anaesthesia","volume":"2","author":"Morton NS","year":"1992","unstructured":"Morton NS, Johnston G, White M, Marsh BJ. Propofol in paediatric anaesthesia. Pediatric Anesthesia. 1992, 2:89-97. 10.1111\/j.1460-9592.1992.tb00182.x","journal-title":"Pediatric Anesthesia"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.194845","article-title":"Pain on propofol injection: causes and remedies","volume":"48","author":"Desousa KA","year":"2016","unstructured":"Desousa KA. Pain on propofol injection: causes and remedies. Indian J Pharmacol. 2016, 48:617-23. 10.4103\/0253-7613.194845","journal-title":"Indian J Pharmacol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1590\/s0034-70942007000100004","article-title":"Effect of pretreatment with lidocaine, intravenous paracetamol and lidocaine-fentanyl on propofol injection pain. Comparative study [Article in English, Portuguese]","volume":"57","author":"El-Radaideh KM","year":"2007","unstructured":"El-Radaideh KM. Effect of pretreatment with lidocaine, intravenous paracetamol and lidocaine-fentanyl on propofol injection pain. Comparative study [Article in English, Portuguese]. Rev Bras Anestesiol. 2007, 57:32-8. 10.1590\/s0034-70942007000100004","journal-title":"Rev Bras Anestesiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13741-022-00243-6","article-title":"What is the impact of dexamethasone on postoperative pain in adults undergoing general anaesthesia for elective abdominal surgery: a systematic review and meta-analysis","volume":"11","author":"Mitchell C","year":"2022","unstructured":"Mitchell C, Cheuk SJ, O'Donnell CM, Bampoe S, Walker D. What is the impact of dexamethasone on postoperative pain in adults undergoing general anaesthesia for elective abdominal surgery: a systematic review and meta-analysis. Perioper Med (Lond). 2022, 11:13. 10.1186\/s13741-022-00243-6","journal-title":"Perioper Med (Lond)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199711000-00029","article-title":"Ondansetron exhibits the properties of a local anesthetic","volume":"1","author":"Ye JH","year":"1997","unstructured":"Ye JH, Mui WC, Ren J, Hunt TE, Wu WH, Zbuzek VK. Ondansetron exhibits the properties of a local anesthetic. Anesth Analg. 1997, 1:1116-21. 10.1097\/00000539-199711000-00029","journal-title":"Anesth Analg"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000227054","article-title":"Mechanism of the anti-emetic activity of 5-HT3 receptor antagonists","volume":"49","author":"Tyers MB","year":"1992","unstructured":"Tyers MB, Freeman AJ. Mechanism of the anti-emetic activity of 5-HT3 receptor antagonists. Oncology. 1992, 49:263-8. 10.1159\/000227054","journal-title":"Oncology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.174810","article-title":"A comparative study of attenuation of propofol-induced pain by lignocaine, ondansetron, and ramosetron","volume":"60","author":"Sumalatha GB","year":"2016","unstructured":"Sumalatha GB, Dodawad RR, Pandarpurkar S, Jajee PR. A comparative study of attenuation of propofol-induced pain by lignocaine, ondansetron, and ramosetron. Indian J Anaesth. 2016, 60:25-9. 10.4103\/0019-5049.174810","journal-title":"Indian J Anaesth"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/734531","article-title":"The effect of intravenous dexamethasone and lidocaine on propofol-induced vascular pain: a randomized double-blinded placebo-controlled trial","volume":"2013","author":"Ahmad S","year":"2013","unstructured":"Ahmad S, De Oliveira GS Jr, Fitzgerald PC, McCarthy RJ. The effect of intravenous dexamethasone and lidocaine on propofol-induced vascular pain: a randomized double-blinded placebo-controlled trial. Pain Res Treat. 2013, 2013:734531. 10.1155\/2013\/734531","journal-title":"Pain Res Treat"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.aat.2011.06.002","article-title":"Dexamethasone prevents postoperative nausea and vomiting: benefit versus risk","volume":"49","author":"Ho CM","year":"2011","unstructured":"Ho CM, Wu HL, Ho ST, Wang JJ. Dexamethasone prevents postoperative nausea and vomiting: benefit versus risk. Acta Anaesthesiol Taiwan. 2011, 49:100-4. 10.1016\/j.aat.2011.06.002","journal-title":"Acta Anaesthesiol Taiwan"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542158","article-title":"Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients","volume":"153","author":"Kharitonov SA","year":"1996","unstructured":"Kharitonov SA, Yates DH, Barnes PJ. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med. 1996, 153:454-7. 10.1164\/ajrccm.153.1.8542158","journal-title":"Am J Respir Crit Care Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.3.207","article-title":"Nitric oxide production in cells derived from the human joint","volume":"35","author":"Grabowski PS","year":"1996","unstructured":"Grabowski PS, Macpherson H, Ralston SH. Nitric oxide production in cells derived from the human joint. Br J Rheumatol. 1996, 35:207-12. 10.1093\/rheumatology\/35.3.207","journal-title":"Br J Rheumatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-022-01650-4","article-title":"A comparison of ondansetron and lidocaine in reducing injection pain of propofol: a randomized controlled study","volume":"22","author":"Wasinwong W","year":"2022","unstructured":"Wasinwong W, Termthong S, Plansangkate P, Tanasansuttiporn J, Kosem R, Chaofan S. A comparison of ondansetron and lidocaine in reducing injection pain of propofol: a randomized controlled study. BMC Anesthesiol. 2022, 22:109. 10.1186\/s12871-022-01650-4","journal-title":"BMC Anesthesiol"},{"key":"ref15","article-title":"Prevention of propofol injection pain with small-dose ketamine","volume":"20","author":"Zahedi H","year":"2009","unstructured":"Zahedi H, Nikooseresht M, Seifrabie M. Prevention of propofol injection pain with small-dose ketamine. Middle East J Anaesthesiol. 2009, 20:401-4.","journal-title":"Middle East J Anaesthesiol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_186_17","article-title":"Comparison the effect of granisetron and dexamethasone on intravenous propofol pain","volume":"7","author":"Adinehmehr L","year":"2018","unstructured":"Adinehmehr L, Salimi S, Sane S, Sina V, Najafizadeh R. Comparison the effect of granisetron and dexamethasone on intravenous propofol pain. Adv Biomed Res. 2018, 7:74. 10.4103\/abr.abr_186_17","journal-title":"Adv Biomed Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20201319","article-title":"Effect of dexamethasone with granisetron or ondansetron for prevention of post-operative nausea vomiting in patients undergoing laparoscopic gynaecological surgery","volume":"8","author":"Sharma SK","year":"2020","unstructured":"Sharma SK, Singh S, Paul D, Ameta N, Taank P, Singh T. Effect of dexamethasone with granisetron or ondansetron for prevention of post-operative nausea vomiting in patients undergoing laparoscopic gynaecological surgery. Int J Res Med Sci. 2020, 8:1331-5. 10.18203\/2320-6012.ijrms20201319","journal-title":"Int J Res Med Sci"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_115_18","article-title":"The effect of intravenous dexamethasone on intraoperative and early postoperative pain in lumbar spine surgery: a randomized double-blind placebo-controlled study","volume":"12","author":"Sharma M","year":"2018","unstructured":"Sharma M, Gupta S, Purohit S, Goyal AK. The effect of intravenous dexamethasone on intraoperative and early postoperative pain in lumbar spine surgery: a randomized double-blind placebo-controlled study. Anesth Essays Res. 2018, 12:803-8. 10.4103\/aer.AER_115_18","journal-title":"Anesth Essays Res"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2020.08.001","article-title":"Effect of palonosetron, ondansetron and dexamethasone in the prevention of postoperative nausea and vomiting in video cholecystectomy with total venous anesthesia with propofol-remifentanil - randomized clinical trial [Article in Portuguese]","volume":"70","author":"Fonseca NM","year":"2020","unstructured":"Fonseca NM, Pedrosa LR, Melo N, Oliveira R\u00c1. Effect of palonosetron, ondansetron and dexamethasone in the prevention of postoperative nausea and vomiting in video cholecystectomy with total venous anesthesia with propofol-remifentanil - randomized clinical trial [Article in Portuguese]. Braz J Anesthesiol. 2020, 70:464-70. 10.1016\/j.bjan.2020.08.001","journal-title":"Braz J Anesthesiol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2017.04.001","article-title":"Comparison of granisetron and lidocaine on reducing injection pain of etomidate: a controlled randomized study","volume":"67","author":"Saliminia A","year":"2017","unstructured":"Saliminia A, Azimaraghi O, Javadi A, Abdoulahpoor M, Movafegh A. Comparison of granisetron and lidocaine on reducing injection pain of etomidate: a controlled randomized study. Rev Bras Anestesiol. 2017, 67:615-8. 10.1016\/j.bjane.2017.04.001","journal-title":"Rev Bras Anestesiol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2011.02.002","article-title":"Preventing postoperative nausea and vomiting after laparoscopic cholecystectomy: a prospective, randomized, double-blind study","volume":"72","author":"Arslan M","year":"2011","unstructured":"Arslan M, Ci\u00e7ek R, Kalender H\u00dc, Yilmaz H. Preventing postoperative nausea and vomiting after laparoscopic cholecystectomy: a prospective, randomized, double-blind study. Curr Ther Res Clin Exp. 2011, 72:1-12. 10.1016\/j.curtheres.2011.02.002","journal-title":"Curr Ther Res Clin Exp"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/83.5.772","article-title":"Dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy","volume":"83","author":"Wang JJ","year":"1999","unstructured":"Wang JJ, Ho ST, Liu YH, Lee SC, Liu YC, Liao YC, Ho CM. Dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy. Br J Anaesth. 1999, 83:772-5. 10.1093\/bja\/83.5.772","journal-title":"Br J Anaesth"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/285739-comparison-of-intravenous-ondansetron-and-dexamethasone-for-preventing-propofol-induced-pain-during-laparoscopic-cholecystectomy-a-double-blind-randomized-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T18:32:42Z","timestamp":1724265162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/285739-comparison-of-intravenous-ondansetron-and-dexamethasone-for-preventing-propofol-induced-pain-during-laparoscopic-cholecystectomy-a-double-blind-randomized-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":22,"URL":"https:\/\/doi.org\/10.7759\/cureus.67382","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,21]]}}}