{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:54:35Z","timestamp":1778172875051,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,22]]},"DOI":"10.7759\/cureus.67506","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T16:50:45Z","timestamp":1724345445000},"source":"Crossref","is-referenced-by-count":7,"title":["A Comprehensive Review of the Role of Stem Cells in Neuroregeneration: Potential Therapies for Neurological Disorders"],"prefix":"10.7759","author":[{"given":"Navanath","family":"Deokate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sourya","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajvardhan","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail M","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineet","family":"Karwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031851","article-title":"A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics","volume":"23","author":"Lamptey RN","year":"2022","unstructured":"Lamptey RN, Chaulagain B, Trivedi R, Gothwal A, Layek B, Singh J. A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics. Int J Mol Sci. 2022, 23:1851. 10.3390\/ijms23031851","journal-title":"Int J Mol Sci"},{"key":"ref2","unstructured":"Over 1 in 3 people affected by neurological conditions, the leading cause of illness and disability worldwide. (2023). Accessed. July 28, 2024: https:\/\/www.who.int\/news\/item\/14-03-2024-over-1-in-3-people-affected-by-neurological-conditions--the-leading-cause-of...."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060904","article-title":"Neuroprotective and therapeutic strategies against Parkinson\u2019s disease: recent perspectives","volume":"17","author":"Sarkar S","year":"2016","unstructured":"Sarkar S, Raymick J, Imam S. Neuroprotective and therapeutic strategies against Parkinson\u2019s disease: recent perspectives. Int J Mol Sci. 2016, 17:904. 10.3390\/ijms17060904","journal-title":"Int J Mol Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-020-00259-3","article-title":"Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury","volume":"7","author":"Nagappan PG","year":"2020","unstructured":"Nagappan PG, Chen H, Wang DY. Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury. Mil Med Res. 2020, 7:30. 10.1186\/s40779-020-00259-3","journal-title":"Mil Med Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1181816","article-title":"Neuronal regeneration after injury: a new perspective on gene therapy","volume":"17","author":"Zeng CW","year":"2023","unstructured":"Zeng CW, Zhang CL. Neuronal regeneration after injury: a new perspective on gene therapy. Front Neurosci. 2023, 17:1181816. 10.3389\/fnins.2023.1181816","journal-title":"Front Neurosci"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01134-4","article-title":"Stem cell-based therapy for human diseases","volume":"7","author":"Hoang DM","year":"2022","unstructured":"Hoang DM, Pham PT, Bach TQ, et al.. Stem cell-based therapy for human diseases. Signal Transduct Target Ther. 2022, 7:272. 10.1038\/s41392-022-01134-4","journal-title":"Signal Transduct Target Ther"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01873-0","article-title":"Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy","volume":"22","author":"Chehelgerdi M","year":"2023","unstructured":"Chehelgerdi M, Behdarvand Dehkordi F, Chehelgerdi M, et al.. Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy. Mol Cancer. 2023, 22:189. 10.1186\/s12943-023-01873-0","journal-title":"Mol Cancer"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1165-5","article-title":"Stem cells: past, present, and future","volume":"10","author":"Zakrzewski W","year":"2019","unstructured":"Zakrzewski W, Dobrzy\u0144ski M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther. 2019, 10:68. 10.1186\/s13287-019-1165-5","journal-title":"Stem Cell Res Ther"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2010-0543","article-title":"Human embryonic stem cells: derivation, culture, and differentiation: a review","volume":"28","author":"Vazin T","year":"2010","unstructured":"Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010, 28:589-603. 10.3233\/RNN-2010-0543","journal-title":"Restor Neurol Neurosci"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0031","article-title":"Ethical issues in stem cell research","volume":"30","author":"Lo B","year":"2009","unstructured":"Lo B, Parham L. Ethical issues in stem cell research. Endocr Rev. 2009, 30:204-13. 10.1210\/er.2008-0031","journal-title":"Endocr Rev"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9978837","article-title":"Stem cells: a historical review about biological, religious, and ethical issues","volume":"2021","author":"Charitos IA","year":"2021","unstructured":"Charitos IA, Ballini A, Cantore S, et al.. Stem cells: a historical review about biological, religious, and ethical issues. Stem Cells Int. 2021, 2021:9978837. 10.1155\/2021\/9978837","journal-title":"Stem Cells Int"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.25122\/jml-2022-0346","article-title":"Differentiation of neurosphere after transplantation into the damaged spinal cord","volume":"16","author":"Gramatiuk SM","year":"2023","unstructured":"Gramatiuk SM, Ivanova YV, Hudyma AA, Sargsyan K, Kryvoruchko IA, Puliaieva IS. Differentiation of neurosphere after transplantation into the damaged spinal cord. J Med Life. 2023, 16:689-98. 10.25122\/jml-2022-0346","journal-title":"J Med Life"},{"key":"ref13","article-title":"Therapeutic application of neural stem cells and adult neurogenesis for neurodegenerative disorders: regeneration and beyond","volume":"1","author":"Latchney SE","year":"2012","unstructured":"Latchney SE, Eisch AJ. Therapeutic application of neural stem cells and adult neurogenesis for neurodegenerative disorders: regeneration and beyond. Eur J Neurodegener Dis. 2012, 1:335-51.","journal-title":"Eur J Neurodegener Dis"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.676621","article-title":"Immune response in neurological pathology: emerging role of central and peripheral immune crosstalk","volume":"12","author":"Passaro AP","year":"2021","unstructured":"Passaro AP, Lebos AL, Yao Y, Stice SL. Immune response in neurological pathology: emerging role of central and peripheral immune crosstalk. Front Immunol. 2021, 12:676621. 10.3389\/fimmu.2021.676621","journal-title":"Front Immunol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210806163352","article-title":"The role of stem cells in the therapy of stroke","volume":"20","author":"Ejma M","year":"2022","unstructured":"Ejma M, Madetko N, Brzecka A, et al.. The role of stem cells in the therapy of stroke. Curr Neuropharmacol. 2022, 20:630-47. 10.2174\/1570159X19666210806163352","journal-title":"Curr Neuropharmacol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123296","article-title":"Neural stem cells: promoting axonal regeneration and spinal cord connectivity","volume":"10","author":"de Freria CM","year":"2021","unstructured":"de Freria CM, Van Niekerk E, Blesch A, Lu P. Neural stem cells: promoting axonal regeneration and spinal cord connectivity. Cells. 2021, 10:3296. 10.3390\/cells10123296","journal-title":"Cells"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-5374.2012.23.009","article-title":"Stem cell therapy in neurodegenerative diseases: from principles to practice","volume":"7","author":"Sakthiswary R","year":"2012","unstructured":"Sakthiswary R, Raymond AA. Stem cell therapy in neurodegenerative diseases: from principles to practice. Neural Regen Res. 2012, 7:1822-31. 10.3969\/j.issn.1673-5374.2012.23.009","journal-title":"Neural Regen Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-023-01344-6","article-title":"The use of stem cells as a potential treatment method for selected neurodegenerative diseases: review","volume":"43","author":"Cecerska-Hery\u0107 E","year":"2023","unstructured":"Cecerska-Hery\u0107 E, P\u0119ka\u0142a M, Serwin N, et al.. The use of stem cells as a potential treatment method for selected neurodegenerative diseases: review. Cell Mol Neurobiol. 2023, 43:2643-73. 10.1007\/s10571-023-01344-6","journal-title":"Cell Mol Neurobiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241814349","article-title":"Advancing spinal cord injury treatment through stem cell therapy: a comprehensive review of cell types, challenges, and emerging technologies in regenerative medicine","volume":"24","author":"Zeng CW","year":"2023","unstructured":"Zeng CW. Advancing spinal cord injury treatment through stem cell therapy: a comprehensive review of cell types, challenges, and emerging technologies in regenerative medicine. Int J Mol Sci. 2023, 24:14349. 10.3390\/ijms241814349","journal-title":"Int J Mol Sci"},{"key":"ref20","article-title":"Stem cell therapy: a promising therapeutic approach for multiple sclerosis","author":"Pourabdolhossein F","year":"2017","unstructured":"Pourabdolhossein F, Hamidabadi HG, Bojnordi MN, Mojaverrostami S. Stem cell therapy: a promising therapeutic approach for multiple sclerosis. Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. Zagon IS, McLaughlin PJ (ed): Codon Publications, Brisbane; 2017."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168363","article-title":"New avenues for the treatment of Huntington\u2019s disease","volume":"22","author":"Kim A","year":"2021","unstructured":"Kim A, Lalonde K, Truesdell A, Gomes Welter P, Brocardo PS, Rosenstock TR, Gil-Mohapel J. New avenues for the treatment of Huntington\u2019s disease. Int J Mol Sci. 2021, 22:8363. 10.3390\/ijms22168363","journal-title":"Int J Mol Sci"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001034","article-title":"Stem cell-based combinatorial therapies for spinal cord injury: a narrative review of current research and future directions","volume":"85","author":"Aderinto N","year":"2023","unstructured":"Aderinto N, Abdulbasit MO, Olatunji D. Stem cell-based combinatorial therapies for spinal cord injury: a narrative review of current research and future directions. Ann Med Surg (Lond). 2023, 85:3943-54. 10.1097\/MS9.0000000000001034","journal-title":"Ann Med Surg (Lond)"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.03.017","article-title":"Advancing cell therapy for neurodegenerative diseases","volume":"30","author":"Temple S","year":"2023","unstructured":"Temple S. Advancing cell therapy for neurodegenerative diseases. Cell Stem Cell. 2023, 30:512-29. 10.1016\/j.stem.2023.03.017","journal-title":"Cell Stem Cell"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042153","article-title":"Regenerative stem cell therapy for neurodegenerative diseases: an overview","volume":"22","author":"Sivandzade F","year":"2021","unstructured":"Sivandzade F, Cucullo L. Regenerative stem cell therapy for neurodegenerative diseases: an overview. Int J Mol Sci. 2021, 22:2153. 10.3390\/ijms22042153","journal-title":"Int J Mol Sci"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13516","article-title":"The next step in translational research: lessons learned from the first preclinical randomized controlled trial","volume":"139","author":"Llovera G","year":"2016","unstructured":"Llovera G, Liesz A. The next step in translational research: lessons learned from the first preclinical randomized controlled trial. J Neurochem. 2016, 139:271-9. 10.1111\/jnc.13516","journal-title":"J Neurochem"},{"key":"ref26","article-title":"Role of stem cells in treatment of neurological disorder","volume":"3","author":"Ul Hassan A","year":"2009","unstructured":"Ul Hassan A, Hassan G, Rasool Z. Role of stem cells in treatment of neurological disorder. Int J Health Sci (Qassim). 2009, 3:227-33.","journal-title":"Int J Health Sci (Qassim)"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0030","article-title":"Immunological considerations for embryonic and induced pluripotent stem cell banking","volume":"366","author":"Taylor CJ","year":"2011","unstructured":"Taylor CJ, Bolton EM, Bradley JA. Immunological considerations for embryonic and induced pluripotent stem cell banking. Philos Trans R Soc Lond B Biol Sci. 2011, 366:2312-22. 10.1098\/rstb.2011.0030","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10070857","article-title":"Assessing tumorigenicity in stem cell-derived therapeutic products: a critical step in safeguarding regenerative medicine","volume":"10","author":"Wang Z","year":"2023","unstructured":"Wang Z. Assessing tumorigenicity in stem cell-derived therapeutic products: a critical step in safeguarding regenerative medicine. Bioengineering. 2023, 10:857. 10.3390\/bioengineering10070857","journal-title":"Bioengineering"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0044","article-title":"Challenges in clinical development of mesenchymal stromal\/stem cells: concise review","volume":"8","author":"Mastrolia I","year":"2019","unstructured":"Mastrolia I, Foppiani EM, Murgia A, et al.. Challenges in clinical development of mesenchymal stromal\/stem cells: concise review. Stem Cells Transl Med. 2019, 8:1135-48. 10.1002\/sctm.19-0044","journal-title":"Stem Cells Transl Med"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00987-y","article-title":"Challenges in the clinical advancement of cell therapies for Parkinson's disease","volume":"7","author":"Skidmore S","year":"2023","unstructured":"Skidmore S, Barker RA. Challenges in the clinical advancement of cell therapies for Parkinson's disease. Nat Biomed Eng. 2023, 7:370-86. 10.1038\/s41551-022-00987-y","journal-title":"Nat Biomed Eng"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.52225\/narra.v3i2.184","article-title":"Application of CRISPR-Cas9 genome editing technology in various fields: a review","volume":"3","author":"Ansori AN","year":"2023","unstructured":"Ansori AN, Antonius Y, Susilo RJ, et al.. Application of CRISPR-Cas9 genome editing technology in various fields: a review. Narra J. 2023, 3:e184. 10.52225\/narra.v3i2.184","journal-title":"Narra J"},{"key":"ref32","article-title":"CRISPR advancements for human health","volume":"121","author":"Davis DJ","year":"2024","unstructured":"Davis DJ, Yeddula SG. CRISPR advancements for human health. Mo Med. 2024, 121:170-6.","journal-title":"Mo Med"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.194","article-title":"3D bioprinting and its innovative approach for biomedical applications","volume":"4","author":"Tripathi S","year":"2023","unstructured":"Tripathi S, Mandal SS, Bauri S, Maiti P. 3D bioprinting and its innovative approach for biomedical applications. MedComm (2020). 2023, 4:e194. 10.1002\/mco2.194","journal-title":"MedComm (2020)"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-018-0530-2","article-title":"3D bioprinting stem cell derived tissues","volume":"11","author":"Tasnim N","year":"2018","unstructured":"Tasnim N, De la Vega L, Anil Kumar S, et al.. 3D bioprinting stem cell derived tissues. Cell Mol Bioeng. 2018, 11:219-40. 10.1007\/s12195-018-0530-2","journal-title":"Cell Mol Bioeng"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3390\/ma12203323","article-title":"Smart hydrogels in tissue engineering and regenerative medicine","volume":"12","author":"Mantha S","year":"2019","unstructured":"Mantha S, Pillai S, Khayambashi P, et al.. Smart hydrogels in tissue engineering and regenerative medicine. Materials. 2019, 12:3323. 10.3390\/ma12203323","journal-title":"Materials"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3892\/br.2017.922","article-title":"Personalized medicine could transform healthcare","volume":"7","author":"Mathur S","year":"2017","unstructured":"Mathur S, Sutton J. Personalized medicine could transform healthcare. Biomed Rep. 2017, 7:3-5. 10.3892\/br.2017.922","journal-title":"Biomed Rep"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093135","article-title":"Regenerative rehabilitation for stroke recovery by inducing synergistic effects of cell therapy and neurorehabilitation on motor function: a narrative review of pre-clinical studies","volume":"21","author":"Ito A","year":"2020","unstructured":"Ito A, Kubo N, Liang N, Aoyama T, Kuroki H. Regenerative rehabilitation for stroke recovery by inducing synergistic effects of cell therapy and neurorehabilitation on motor function: a narrative review of pre-clinical studies. Int J Mol Sci. 2020, 21:3135. 10.3390\/ijms21093135","journal-title":"Int J Mol Sci"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46050255","article-title":"Recent therapeutic gene editing applications to genetic disorders","volume":"46","author":"Deneault E","year":"2024","unstructured":"Deneault E. Recent therapeutic gene editing applications to genetic disorders. Curr Issues Mol Biol. 2024, 46:4147-85. 10.3390\/cimb46050255","journal-title":"Curr Issues Mol Biol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/287721-a-comprehensive-review-of-the-role-of-stem-cells-in-neuroregeneration-potential-therapies-for-neurological-disorders","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T16:50:53Z","timestamp":1724345453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/287721-a-comprehensive-review-of-the-role-of-stem-cells-in-neuroregeneration-potential-therapies-for-neurological-disorders"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":38,"URL":"https:\/\/doi.org\/10.7759\/cureus.67506","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,22]]}}}