{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:56:39Z","timestamp":1783014999159,"version":"3.54.6"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,23]]},"DOI":"10.7759\/cureus.67565","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T10:05:48Z","timestamp":1724407548000},"source":"Crossref","is-referenced-by-count":7,"title":["Pharmacological Insights of Ropivacaine and Clinical Applications: A Narrative Review"],"prefix":"10.7759","author":[{"given":"Shafaque","family":"Maqusood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Madavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol","family":"Bele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambit","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dushyant","family":"Bawiskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.4.5.781","article-title":"Ropivacaine: a pharmacological review","volume":"4","author":"Hansen TG","year":"2004","unstructured":"Hansen TG. Ropivacaine: a pharmacological review. Expert Rev Neurother. 2004, 4:781-91. 10.1586\/14737175.4.5.781","journal-title":"Expert Rev Neurother"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1972.tb00683.x","article-title":"Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds","volume":"31","author":"Aberg G","year":"1972","unstructured":"Aberg G. Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. Acta Pharmacol Toxicol. 1972, 31:273-86. 10.1111\/j.1600-0773.1972.tb00683.x","journal-title":"Acta Pharmacol Toxicol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.049809","article-title":"Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5)","volume":"306","author":"Kindler CH","year":"2003","unstructured":"Kindler CH, Paul M, Zou H, Liu C, Winegar BD, Gray AT, Yost CS. Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5). J Pharmacol Exp Ther. 2003, 306:84-92. 10.1124\/jpet.103.049809","journal-title":"J Pharmacol Exp Ther"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200206000-00023","article-title":"Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physicochemical and stereoselective properties","volume":"96","author":"Graf BM","year":"2002","unstructured":"Graf BM, Abraham I, Eberbach N, Kunst G, Stowe DF, Martin E. Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physicochemical and stereoselective properties. Anesthesiology. 2002, 96:1427-34. 10.1097\/00000542-200206000-00023","journal-title":"Anesthesiology"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.5.507","article-title":"Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers","volume":"78","author":"Knudsen K","year":"1997","unstructured":"Knudsen K, Beckman Suurk\u00fcla M, Blomberg S, Sj\u00f6vall J, Edvardsson N. Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth. 1997, 78:507-14. 10.1093\/bja\/78.5.507","journal-title":"Br J Anaesth"},{"key":"ref6","article-title":"Skin blood flow after intradermal injection of ropivacaine in various concentrations with and without epinephrine evaluated by laser doppler flowmetry","volume":"17","author":"Cederholm I","year":"1992","unstructured":"Cederholm I, Evers H, L\u00f6fstr\u00f6m JB. Skin blood flow after intradermal injection of ropivacaine in various concentrations with and without epinephrine evaluated by laser doppler flowmetry. Reg Anesth. 1992, 17:322-8.","journal-title":"Reg Anesth"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2001.01760.x","article-title":"The effects of ropivacaine hydrochloride on platelet function: an assessment using the platelet function analyser (PFA-100)","volume":"56","author":"Porter J","year":"2001","unstructured":"Porter J, Crowe B, Cahill M, Shorten G. The effects of ropivacaine hydrochloride on platelet function: an assessment using the platelet function analyser (PFA-100). Anaesthesia. 2001, 56:15-8. 10.1046\/j.1365-2044.2001.01760.x","journal-title":"Anaesthesia"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200203000-00046","article-title":"Bacterial growth in ropivacaine hydrochloride","volume":"94","author":"B\u00e1tai I","year":"2002","unstructured":"B\u00e1tai I, Ker\u00e9nyi M, Falvai J, Szab\u00f3 G. Bacterial growth in ropivacaine hydrochloride. Anesth Analg. 2002, 94:729-31; table of contents. 10.1097\/00000539-200203000-00046","journal-title":"Anesth Analg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2165\/00042310-199811070-00005","article-title":"Volatile anaesthetics: know your drug interactions","volume":"11","year":"1998","unstructured":"Volatile anaesthetics. know your drug interactions. Drugs Ther Perspect. 1998, 11:11-4. 10.2165\/00042310-199811070-00005","journal-title":"Drugs Ther Perspect"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197910000-00001","article-title":"Cardiac arrest following regional anesthesia with etidocaine or bupivacaine","volume":"51","author":"Albright GA","year":"1979","unstructured":"Albright GA. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology. 1979, 51:285-7. 10.1097\/00000542-197910000-00001","journal-title":"Anesthesiology"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00775.x","article-title":"A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers","volume":"46","author":"Bardsley H","year":"1998","unstructured":"Bardsley H, Gristwood R, Baker H, Watson N, Nimmo W. A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers. Br J Clin Pharmacol. 1998, 46:245-9. 10.1046\/j.1365-2125.1998.00775.x","journal-title":"Br J Clin Pharmacol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652030-00012","article-title":"Ropivacaine. A review of its pharmacology and therapeutic use in regional anaesthesia","volume":"52","author":"Markham A","year":"1996","unstructured":"Markham A, Faulds D. Ropivacaine. A review of its pharmacology and therapeutic use in regional anaesthesia. Drugs. 1996, 52:429-49. 10.2165\/00003495-199652030-00012","journal-title":"Drugs"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199004000-00022","article-title":"Molecular mechanisms of local anesthesia: a review","volume":"72","author":"Butterworth JF 4th","year":"1990","unstructured":"Butterworth JF 4th, Strichartz GR. Molecular mechanisms of local anesthesia: a review. Anesthesiology. 1990, 72:711-34. 10.1097\/00000542-199004000-00022","journal-title":"Anesthesiology"},{"key":"ref14","article-title":"The effect of continuous lumbar epidural infusion of ropivacaine (0.1%, 0.2%, and 0.3%) and 0.25% bupivacaine on sensory and motor block in volunteers: a double-blind study","volume":"21","author":"Zaric D","year":"1996","unstructured":"Zaric D, Nydahl PA, Philipson L, Samuelsson L, Heierson A, Axelsson K. The effect of continuous lumbar epidural infusion of ropivacaine (0.1%, 0.2%, and 0.3%) and 0.25% bupivacaine on sensory and motor block in volunteers: a double-blind study. Reg Anesth. 1996, 21:14-25.","journal-title":"Reg Anesth"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199805000-00026","article-title":"Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics","volume":"88","author":"Sztark F","year":"1998","unstructured":"Sztark F, Malgat M, Dabadie P, Mazat JP. Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics. Anesthesiology. 1998, 88:1340-9. 10.1097\/00000542-199805000-00026","journal-title":"Anesthesiology"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00192-0","article-title":"Mitochondrial effects of l-ropivacaine, a new local anesthetic","volume":"56","author":"Scutari G","year":"1998","unstructured":"Scutari G, Marian M, Bindoli A, et al.. Mitochondrial effects of l-ropivacaine, a new local anesthetic. Biochem Pharmacol. 1998, 56:1633-37. 10.1016\/S0006-2952(98)00192-0","journal-title":"Biochem Pharmacol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199703000-00025","article-title":"Effects of ropivacaine on a potassium channel (hKv1.5) cloned from human ventricle","volume":"86","author":"Valenzuela C","year":"1997","unstructured":"Valenzuela C, Delp\u00f3n E, Franqueza L, Gay P, Snyders DJ, Tamargo J. Effects of ropivacaine on a potassium channel (hKv1.5) cloned from human ventricle. Anesthesiology. 1997, 86:718-28. 10.1097\/00000542-199703000-00025","journal-title":"Anesthesiology"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199002000-00019","article-title":"Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic","volume":"72","author":"Moller R","year":"1990","unstructured":"Moller R, Covino BG. Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. Anesthesiology. 1990, 72:322-9. 10.1097\/00000542-199002000-00019","journal-title":"Anesthesiology"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4103\/mjdrdypu.mjdrdypu_37_21","article-title":"A comparative study between transversus abdominis block with ropivacaine (0.2%) and fentanyl versus plain ropivacaine (0.2%) for postoperative analgesia in lower abdominal surgeries under general anesthesia","volume":"15","author":"Suryawanshi C","year":"2022","unstructured":"Suryawanshi C, Kabra P, Ravindran D, Singh A. A comparative study between transversus abdominis block with ropivacaine (0.2%) and fentanyl versus plain ropivacaine (0.2%) for postoperative analgesia in lower abdominal surgeries under general anesthesia. Med J Dr Patil Vidyapeeth. 2022, 15:691-95. 10.4103\/mjdrdypu.mjdrdypu_37_21","journal-title":"Med J Dr Patil Vidyapeeth"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijpp.2023.023","article-title":"Levobupivacaine versus ropivacaine in patients undergoing lower abdominal surgeries","volume":"10","author":"Sagar TV","year":"2023","unstructured":"Sagar TV, Byndoor Y. Levobupivacaine versus ropivacaine in patients undergoing lower abdominal surgeries. Indian J Pharm Pharmacol. 2023, 10:111-5. 10.18231\/j.ijpp.2023.023","journal-title":"Indian J Pharm Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.5937\/sjait2206131G","article-title":"The evaluation of the efficacy of 0.25% bupivacaine and 0.5% ropivacaine in ultrasound guided bilateral transversus abdominis plane block for post operative analgesia in lower abdominal surgeries","volume":"44","author":"Gujjar S","year":"2022","unstructured":"Gujjar S, Ghodageri S, Gowrasamudra H, Kurella S. The evaluation of the efficacy of 0.25% bupivacaine and 0.5% ropivacaine in ultrasound guided bilateral transversus abdominis plane block for post operative analgesia in lower abdominal surgeries. Serbian J Anesth Intensive Ther. 2022, 44:131-7. 10.5937\/sjait2206131G","journal-title":"Serbian J Anesth Intensive Ther"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4103\/joacp.JOACP_333_18","article-title":"Continuous preperitoneal infusion of ropivacaine for postoperative analgesia in patients undergoing major abdominal or pelvic surgeries. A prospective controlled randomized study","volume":"36","author":"ElSharkawy RA","year":"2020","unstructured":"ElSharkawy RA, Farahat TE, Abdelwahab K. Continuous preperitoneal infusion of ropivacaine for postoperative analgesia in patients undergoing major abdominal or pelvic surgeries. A prospective controlled randomized study. J Anaesthesiol Clin Pharmacol. 2020, 36:195-200. 10.4103\/joacp.JOACP_333_18","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.18231\/j.sajhp.2022.008","article-title":"Comparision of ropivacaine 0.2% with or without clonidine in epidural labor analgesia: a randomised controlled study","volume":"5","author":"Kanchanamala B","year":"2020","unstructured":"Kanchanamala B, Karthik VJ, Keerthana N, Kokila C. Comparision of ropivacaine 0.2% with or without clonidine in epidural labor analgesia: a randomised controlled study. Southeast Asian J Health Prof. 2020, 5:26-32. 10.18231\/j.sajhp.2022.008","journal-title":"Southeast Asian J Health Prof"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.922611","article-title":"Intrathecal dexmedetomidine combined with ropivacaine in cesarean section: a prospective randomized double-blind controlled study","volume":"9","author":"Zhang Q","year":"2022","unstructured":"Zhang Q, Xia LY, Liang WD, et al.. Intrathecal dexmedetomidine combined with ropivacaine in cesarean section: a prospective randomized double-blind controlled study. Front Med (Lausanne). 2022, 9:922611. 10.3389\/fmed.2022.922611","journal-title":"Front Med (Lausanne)"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2022.101030","article-title":"Effects of labour analgesia with different concentrations of ropivacaine on maternal body temperature and inflammatory factor: a randomised controlled study","volume":"41","author":"Chen X","year":"2022","unstructured":"Chen X, Zhang Y, Ni X, Liu Z. Effects of labour analgesia with different concentrations of ropivacaine on maternal body temperature and inflammatory factor: a randomised controlled study. Anaesth Crit Care Pain Med. 2022, 41:101030. 10.1016\/j.accpm.2022.101030","journal-title":"Anaesth Crit Care Pain Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.23958\/ijirms\/vol04-i02\/546","article-title":"Comparison of ropivacaine 0.2% alone and in combination with fentanyl for caudal anesthesia in paediatric patients","volume":"4","author":"Grewal T","year":"2019","unstructured":"Grewal T, Kaur B, Kumar P, Kaur S. Comparison of ropivacaine 0.2% alone and in combination with fentanyl for caudal anesthesia in paediatric patients. Int J Innov Res Med Sci. 2019, 4:103-7. 10.23958\/ijirms\/vol04-i02\/546","journal-title":"Int J Innov Res Med Sci"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31292","article-title":"Analgesic efficacy of ropivacaine infiltration on early post-tonsillectomy pain in pediatrics","volume":"134","author":"Albazee E","year":"2024","unstructured":"Albazee E, Abdelwahab OA, Abdelaziz A, Magzoub D, Abu-Zaid A. Analgesic efficacy of ropivacaine infiltration on early post-tonsillectomy pain in pediatrics. Laryngoscope. 2024, 134:3018-29. 10.1002\/lary.31292","journal-title":"Laryngoscope"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.2147\/RSRR.S308185","article-title":"Anesthetic implications of robotic-assisted surgery in pediatric patients","volume":"8","author":"Wakimoto M","year":"2021","unstructured":"Wakimoto M, Michalsky M, Nafiu O, Tobias J. Anesthetic implications of robotic-assisted surgery in pediatric patients. Robot Surg. 2021, 8:9-19. 10.2147\/RSRR.S308185","journal-title":"Robot Surg"},{"key":"ref29","article-title":"Implications of dexamethasone and ropivacaine in peripheral nerve blocks","volume":"4","author":"Tow B","year":"2020","unstructured":"Tow B. Implications of dexamethasone and ropivacaine in peripheral nerve blocks. J Hosp Manag Health Policy. 2020, 4:1-10.","journal-title":"J Hosp Manag Health Policy"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet179","article-title":"Dexmedetomidine as adjuvant for peripheral nerve blocks","volume":"111","author":"Kettner SC","year":"2013","unstructured":"Kettner SC. Dexmedetomidine as adjuvant for peripheral nerve blocks. Br J Anaesth. 2013, 111:123. 10.1093\/bja\/aet179","journal-title":"Br J Anaesth"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2007.03.016","article-title":"Continuous peripheral regional analgesia in children [Article in French]","volume":"26","author":"Lacroix F","year":"2007","unstructured":"Lacroix F. Continuous peripheral regional analgesia in children [Article in French]. Ann Fr Anesth Reanim. 2007, 26:554-9. 10.1016\/j.annfar.2007.03.016","journal-title":"Ann Fr Anesth Reanim"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu144","article-title":"Dexamethasone and peripheral nerve blocks: on the nerve or intravenous?","volume":"113","author":"Martinez V","year":"2014","unstructured":"Martinez V, Fletcher D. Dexamethasone and peripheral nerve blocks: on the nerve or intravenous?. Br J Anaesth. 2014, 113:338-40. 10.1093\/bja\/aeu144","journal-title":"Br J Anaesth"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000002466","article-title":"Does liposomal bupivacaine injectable suspension peripheral nerve block further aid in decreasing at-home narcotic utilization in children and adolescents after anterior cruciate ligament reconstruction","volume":"43","author":"Walls HR","year":"2023","unstructured":"Walls HR, Thomas ES, Kain ZN, Schlechter JA. Does liposomal bupivacaine injectable suspension peripheral nerve block further aid in decreasing at-home narcotic utilization in children and adolescents after anterior cruciate ligament reconstruction. J Pediatr Orthop. 2023, 43:511-5. 10.1097\/BPO.0000000000002466","journal-title":"J Pediatr Orthop"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-1237(10)80086-3","article-title":"Verapamil as an adjunct to local anaesthetic for brachial plexus blocks","volume":"66","author":"Lalla RK","year":"2010","unstructured":"Lalla RK, Anant S, Nanda HS. Verapamil as an adjunct to local anaesthetic for brachial plexus blocks. Med J Armed Forces India. 2010, 66:22-4. 10.1016\/S0377-1237(10)80086-3","journal-title":"Med J Armed Forces India"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.7150\/jca.57661","article-title":"Positive impact of intraoperative epidural ropivacaine infusion on oncologic outcomes in pancreatic cancer patients undergoing pancreatectomy: a retrospective cohort study","volume":"12","author":"Chen W","year":"2021","unstructured":"Chen W, Xu Y, Zhang Y, Lou W, Han X. Positive impact of intraoperative epidural ropivacaine infusion on oncologic outcomes in pancreatic cancer patients undergoing pancreatectomy: a retrospective cohort study. J Cancer. 2021, 12:4513-21. 10.7150\/jca.57661","journal-title":"J Cancer"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191912223","article-title":"Cardiac arrest after small doses ropivacaine: local anesthetic systemic toxicity in the course of continuous femoral nerve blockade","volume":"19","author":"Gola W","year":"2022","unstructured":"Gola W, Bialka S, Zajac M, Misiolek H. Cardiac arrest after small doses ropivacaine: local anesthetic systemic toxicity in the course of continuous femoral nerve blockade. Int J Environ Res Public Health. 2022, 19:10.3390\/ijerph191912223","journal-title":"Int J Environ Res Public Health"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/439014","article-title":"Efficacy and safety of ropivacaine addition to intrathecal morphine for pain management in intractable cancer","volume":"2015","author":"Huang Y","year":"2015","unstructured":"Huang Y, Li X, Zhu T, Lin J, Tao G. Efficacy and safety of ropivacaine addition to intrathecal morphine for pain management in intractable cancer. Mediators Inflamm. 2015, 2015:439014. 10.1155\/2015\/439014","journal-title":"Mediators Inflamm"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.36468\/pharmaceutical-sciences.spl.188","article-title":"The impact of intraarticular injection of ropivacaine into knee joint on the postoperative analgesia and local inflammatory response after patellar fracture fixation","volume":"83","author":"Liu C","year":"2021","unstructured":"Liu C, Lu L. The impact of intraarticular injection of ropivacaine into knee joint on the postoperative analgesia and local inflammatory response after patellar fracture fixation. Indian J Pharm Sci. 2021, 83:148-53. 10.36468\/pharmaceutical-sciences.spl.188","journal-title":"Indian J Pharm Sci"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31827d88d8","article-title":"A double-blind randomized trial of wound and intercostal space infiltration with ropivacaine during breast cancer surgery: effects on chronic postoperative pain","volume":"118","author":"Albi-Feldzer A","year":"2013","unstructured":"Albi-Feldzer A, Mouret-Fourme E E, Hamouda S, Motamed C, Dubois PY, Jouanneau L, Jayr C. A double-blind randomized trial of wound and intercostal space infiltration with ropivacaine during breast cancer surgery: effects on chronic postoperative pain. Anesthesiology. 2013, 118:318-26. 10.1097\/ALN.0b013e31827d88d8","journal-title":"Anesthesiology"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000296460.91012.51","article-title":"The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain","volume":"106","author":"Sato C","year":"2008","unstructured":"Sato C, Sakai A, Ikeda Y, Suzuki H, Sakamoto A. The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain. Anesth Analg. 2008, 106:313-20, table of contents. 10.1213\/01.ane.0000296460.91012.51","journal-title":"Anesth Analg"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1159\/000363233","article-title":"Ropivacaine for continuous wound infusion for postoperative pain management: a systematic review and meta-analysis of randomized controlled trials","volume":"53","author":"Raines S","year":"2014","unstructured":"Raines S, Hedlund C, Franzon M, Lillieborg S, Kelleher G, Ahl\u00e9n K. Ropivacaine for continuous wound infusion for postoperative pain management: a systematic review and meta-analysis of randomized controlled trials. Eur Surg Res. 2014, 53:43-60. 10.1159\/000363233","journal-title":"Eur Surg Res"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13410","article-title":"Does intraperitoneal ropivacaine reduce postoperative inflammation? A prospective, double-blind, placebo-controlled pilot study","volume":"63","author":"Hayden J","year":"2019","unstructured":"Hayden J, Gupta A, Th\u00f6rn SE, Thulin P, Block L, Oras J. Does intraperitoneal ropivacaine reduce postoperative inflammation? A prospective, double-blind, placebo-controlled pilot study. Acta Anaesthesiol Scand. 2019, 63:1048-54. 10.1111\/aas.13410","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.01.026","article-title":"Intraperitoneal ropivacaine reduces time interval to initiation of chemotherapy after surgery for advanced ovarian cancer: randomised controlled double-blind pilot study","volume":"124","author":"Hayden JM","year":"2020","unstructured":"Hayden JM, Oras J, Block L, et al.. Intraperitoneal ropivacaine reduces time interval to initiation of chemotherapy after surgery for advanced ovarian cancer: randomised controlled double-blind pilot study. Br J Anaesth. 2020, 124:562-70. 10.1016\/j.bja.2020.01.026","journal-title":"Br J Anaesth"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes495","article-title":"Intraperitoneal nebulization of ropivacaine for pain control after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled trial","volume":"110","author":"Ingelmo PM","year":"2013","unstructured":"Ingelmo PM, Bucciero M, Somaini M, et al.. Intraperitoneal nebulization of ropivacaine for pain control after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled trial. Br J Anaesth. 2013, 110:800-6. 10.1093\/bja\/aes495","journal-title":"Br J Anaesth"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001676","article-title":"Regional anesthesia and cancer recurrence in patients with late-stage cancer: a systematic review and meta-analysis","volume":"134","author":"Zhang YL","year":"2021","unstructured":"Zhang YL, Pei LJ, Sun C, Zhao MY, Che L, Huang YG. Regional anesthesia and cancer recurrence in patients with late-stage cancer: a systematic review and meta-analysis. Chin Med J (Engl). 2021, 134:2403-11. 10.1097\/CM9.0000000000001676","journal-title":"Chin Med J (Engl)"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2020.1857120","article-title":"Ropivacaine inhibits the proliferation and migration of colorectal cancer cells through ITGB1","volume":"12","author":"Wang X","year":"2021","unstructured":"Wang X, Li T. Ropivacaine inhibits the proliferation and migration of colorectal cancer cells through ITGB1. Bioengineered. 2021, 12:44-53. 10.1080\/21655979.2020.1857120","journal-title":"Bioengineered"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16471","article-title":"Ropivacaine inhibits the malignant behavior of lung cancer cells by regulating retinoblastoma-binding protein 4","volume":"11","author":"Jia W","year":"2023","unstructured":"Jia W, Shen J, Wei S, Li C, Shi J, Zhao L, Jia H. Ropivacaine inhibits the malignant behavior of lung cancer cells by regulating retinoblastoma-binding protein 4. PeerJ. 2023, 11:e16471. 10.7717\/peerj.16471","journal-title":"PeerJ"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2022\/56478.16687","article-title":"Ropivacaine: a review on the pharmacological features, therapeutic efficacy and side-effects when used for caudal epidural analgesia","volume":"16","author":"Shankar S","year":"2022","unstructured":"Shankar S, Chakole V. Ropivacaine: a review on the pharmacological features, therapeutic efficacy and side-effects when used for caudal epidural analgesia. J Clin Diagn Res. 2022, 16:8-17. 10.7860\/JCDR\/2022\/56478.16687","journal-title":"J Clin Diagn Res"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-013-1669-6","article-title":"Intravenous lipid rescue and ropivacaine systemic toxicity","volume":"28","author":"Bazerbachi F","year":"2014","unstructured":"Bazerbachi F, Rank K, Chan A. Intravenous lipid rescue and ropivacaine systemic toxicity. J Anesth. 2014, 28:139. 10.1007\/s00540-013-1669-6","journal-title":"J Anesth"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.12890\/2021_002971","article-title":"Ropivacaine: an unusual cause of neuroleptic malignant-like syndrome","volume":"8","author":"Santos M","year":"2021","unstructured":"Santos M, Arroja S, Antunes AL, Mariz J, Teixeira J. Ropivacaine: an unusual cause of neuroleptic malignant-like syndrome. Eur J Case Rep Intern Med. 2021, 8:002971. 10.12890\/2021_002971","journal-title":"Eur J Case Rep Intern Med"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07314.x","article-title":"Immediate allergic cross-reactivity to levobupivacaine and ropivacaine","volume":"68","author":"Calderon AL","year":"2013","unstructured":"Calderon AL, Diot N, Benatir F, et al.. Immediate allergic cross-reactivity to levobupivacaine and ropivacaine. Anaesthesia. 2013, 68:203-5. 10.1111\/j.1365-2044.2012.07314.x","journal-title":"Anaesthesia"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/275722-pharmacological-insights-of-ropivacaine-and-clinical-applications-a-narrative-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T10:05:53Z","timestamp":1724407553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/275722-pharmacological-insights-of-ropivacaine-and-clinical-applications-a-narrative-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":51,"URL":"https:\/\/doi.org\/10.7759\/cureus.67565","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,23]]}}}