{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:19:02Z","timestamp":1790637542524,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,27]]},"DOI":"10.7759\/cureus.67938","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T14:48:26Z","timestamp":1724770106000},"source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Radiofrequency Ablation and Microwave Ablation for the Management of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.7759","author":[{"given":"Tariq M","family":"Shaqran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaber","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahad K","family":"Al-Hunbusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan A","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayadah","family":"Alawaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman M","family":"Diqarshawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakan J","family":"Almokhlef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanoud A","family":"Alfaqih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyuf A","family":"Alhumaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam A","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtesam M","family":"Alzyad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab S","family":"Alwusaybie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashmi M","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaf Jamaan","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-017-9959-0","article-title":"Global epidemiology of hepatocellular carcinoma (HCC epidemiology)","volume":"48","author":"Ozakyol A","year":"2017","unstructured":"Ozakyol A. Global epidemiology of hepatocellular carcinoma (HCC epidemiology). J Gastrointest Cancer. 2017, 48:238-40. 10.1007\/s12029-017-9959-0","journal-title":"J Gastrointest Cancer"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602590","article-title":"Survival rate in patients with hepatocellular carcinoma: a retrospective analysis of 389 patients","volume":"92","author":"Greten TF","year":"2005","unstructured":"Greten TF, Papendorf F, Bleck JS, et al.. Survival rate in patients with hepatocellular carcinoma: a retrospective analysis of 389 patients. Br J Cancer. 2005, 92:1862-8. 10.1038\/sj.bjc.6602590","journal-title":"Br J Cancer"},{"key":"ref3","article-title":"GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012","author":"Edited by Ferlay J","year":"2012","unstructured":"Edited by Ferlay J, Soerjomataram I, Ervik M. GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. International Agency for Research on Cancer, Lyon; 2012."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S442842","article-title":"Treatment patterns and recommendations for improving the management of hepatocellular carcinoma in Saudi Arabia","volume":"11","author":"Alolyan A","year":"2024","unstructured":"Alolyan A, Alshammari K, Arabi M, et al.. Treatment patterns and recommendations for improving the management of hepatocellular carcinoma in Saudi Arabia. J Hepatocell Carcinoma. 2024, 11:349-62. 10.2147\/JHC.S442842","journal-title":"J Hepatocell Carcinoma"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.01.025","article-title":"Diagnosis and staging of hepatocellular carcinoma (HCC): current guidelines","volume":"101","author":"Ayuso C","year":"2018","unstructured":"Ayuso C, Rimola J, Vilana R, et al.. Diagnosis and staging of hepatocellular carcinoma (HCC): current guidelines. Eur J Radiol. 2018, 101:72-81. 10.1016\/j.ejrad.2018.01.025","journal-title":"Eur J Radiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i8.1020","article-title":"Hepatocellular carcinoma: from diagnosis to treatment","volume":"7","author":"Waghray A","year":"2015","unstructured":"Waghray A, Murali AR, Menon KN. Hepatocellular carcinoma: from diagnosis to treatment. World J Hepatol. 2015, 7:1020-9. 10.4254\/wjh.v7.i8.1020","journal-title":"World J Hepatol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i4.477","article-title":"Local ablative treatments for hepatocellular carcinoma: an updated review","volume":"7","author":"Facciorusso A","year":"2016","unstructured":"Facciorusso A, Serviddio G, Muscatiello N. Local ablative treatments for hepatocellular carcinoma: an updated review. World J Gastrointest Pharmacol Ther. 2016, 7:477-89. 10.4292\/wjgpt.v7.i4.477","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2016.01.136","article-title":"Microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: a comparison of efficacy at a single center","volume":"27","author":"Potretzke TA","year":"2016","unstructured":"Potretzke TA, Ziemlewicz TJ, Hinshaw JL, et al.. Microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: a comparison of efficacy at a single center. J Vasc Interv Radiol. 2016, 27:631-8. 10.1016\/j.jvir.2016.01.136","journal-title":"J Vasc Interv Radiol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i8.1054","article-title":"Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma","volume":"7","author":"Poulou LS","year":"2015","unstructured":"Poulou LS, Botsa E, Thanou I, Ziakas PD, Thanos L. Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma. World J Hepatol. 2015, 7:1054-63. 10.4254\/wjh.v7.i8.1054","journal-title":"World J Hepatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-021-00393-0","article-title":"Diagnostic evaluation and ablation treatments assessment in hepatocellular carcinoma","volume":"16","author":"Granata V","year":"2021","unstructured":"Granata V, Grassi R, Fusco R, et al.. Diagnostic evaluation and ablation treatments assessment in hepatocellular carcinoma. Infect Agent Cancer. 2021, 16:53. 10.1186\/s13027-021-00393-0","journal-title":"Infect Agent Cancer"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00136","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"151","author":"Liberati A","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, et al.. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009, 151:W65-94. 10.7326\/0003-4819-151-4-200908180-00136","journal-title":"Ann Intern Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): an R package and Shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness LA","year":"2021","unstructured":"McGuinness LA, Higgins JP. Risk-of-bias VISualization (robvis): an R package and Shiny web app for visualizing risk-of-bias assessments. Res Synth Methods. 2021, 12:55-61. 10.1002\/jrsm.1411","journal-title":"Res Synth Methods"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins JP","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003, 327:557-60. 10.1136\/bmj.327.7414.557","journal-title":"BMJ"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2019.01.34","article-title":"Percutaneous radiofrequency versus microwave ablation for management of hepatocellular carcinoma: a randomized controlled trial","volume":"10","author":"Kamal A","year":"2019","unstructured":"Kamal A, Elmoety AA, Rostom YA, Shater MS, Lashen SA. Percutaneous radiofrequency versus microwave ablation for management of hepatocellular carcinoma: a randomized controlled trial. J Gastrointest Oncol. 2019, 10:562-71. 10.21037\/jgo.2019.01.34","journal-title":"J Gastrointest Oncol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30029-3","article-title":"Efficacy of microwave ablation versus radiofrequency ablation for the treatment of hepatocellular carcinoma in patients with chronic liver disease: a randomised controlled phase 2 trial","volume":"3","author":"Vietti Violi N","year":"2018","unstructured":"Vietti Violi N, Duran R, Guiu B, et al.. Efficacy of microwave ablation versus radiofrequency ablation for the treatment of hepatocellular carcinoma in patients with chronic liver disease: a randomised controlled phase 2 trial. Lancet Gastroenterol Hepatol. 2018, 3:317-25. 10.1016\/S2468-1253(18)30029-3","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312629","article-title":"Percutaneous cooled-probe microwave versus radiofrequency ablation in early-stage hepatocellular carcinoma: a phase III randomised controlled trial","volume":"66","author":"Yu J","year":"2017","unstructured":"Yu J, Yu XL, Han ZY, et al.. Percutaneous cooled-probe microwave versus radiofrequency ablation in early-stage hepatocellular carcinoma: a phase III randomised controlled trial. Gut. 2017, 66:1172-3. 10.1136\/gutjnl-2016-312629","journal-title":"Gut"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3617-4","article-title":"Efficacy and survival analysis of percutaneous radiofrequency versus microwave ablation for hepatocellular carcinoma: an Egyptian multidisciplinary clinic experience","volume":"28","author":"Abdelaziz A","year":"2014","unstructured":"Abdelaziz A, Elbaz T, Shousha HI, Mahmoud S, Ibrahim M, Abdelmaksoud A, Nabeel M. Efficacy and survival analysis of percutaneous radiofrequency versus microwave ablation for hepatocellular carcinoma: an Egyptian multidisciplinary clinic experience. Surg Endosc. 2014, 28:3429-34. 10.1007\/s00464-014-3617-4","journal-title":"Surg Endosc"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-013-0733-9","article-title":"Coagulation areas produced by cool-tip radiofrequency ablation and microwave ablation using a device to decrease back-heating effects: a prospective pilot study","volume":"37","author":"Di Vece F","year":"2014","unstructured":"Di Vece F, Tombesi P, Ermili F, Maraldi C, Sartori S. Coagulation areas produced by cool-tip radiofrequency ablation and microwave ablation using a device to decrease back-heating effects: a prospective pilot study. Cardiovasc Intervent Radiol. 2014, 37:723-9. 10.1007\/s00270-013-0733-9","journal-title":"Cardiovasc Intervent Radiol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2232010775","article-title":"Small hepatocellular carcinoma: comparison of radio-frequency ablation and percutaneous microwave coagulation therapy","volume":"223","author":"Shibata T","year":"2002","unstructured":"Shibata T, Iimuro Y, Yamamoto Y, Maetani Y, Ametani F, Itoh K, Konishi J. Small hepatocellular carcinoma: comparison of radio-frequency ablation and percutaneous microwave coagulation therapy. Radiology. 2002, 223:331-7. 10.1148\/radiol.2232010775","journal-title":"Radiology"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181afde41","article-title":"The accordion severity grading system of surgical complications","volume":"250","author":"Strasberg SM","year":"2009","unstructured":"Strasberg SM, Linehan DC, Hawkins WG. The accordion severity grading system of surgical complications. Ann Surg. 2009, 250:177-86. 10.1097\/SLA.0b013e3181afde41","journal-title":"Ann Surg"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1261782","article-title":"Current tumor ablation technologies: basic science and device review","volume":"27","author":"Saldanha DF","year":"2010","unstructured":"Saldanha DF, Khiatani VL, Carrillo TC, et al.. Current tumor ablation technologies: basic science and device review. Semin Intervent Radiol. 2010, 27:247-54. 10.1055\/s-0030-1261782","journal-title":"Semin Intervent Radiol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.04.025","article-title":"Comparison of two different thermal techniques for the treatment of hepatocellular carcinoma","volume":"82","author":"Ding J","year":"2013","unstructured":"Ding J, Jing X, Liu J, Wang Y, Wang F, Wang Y, Du Z. Comparison of two different thermal techniques for the treatment of hepatocellular carcinoma. Eur J Radiol. 2013, 82:1379-84. 10.1016\/j.ejrad.2013.04.025","journal-title":"Eur J Radiol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11020302","article-title":"A real-world comparative study of microwave and radiofrequency ablation in treatment-na\u00efve and recurrent hepatocellular carcinoma","volume":"11","author":"Lee SK","year":"2022","unstructured":"Lee SK, Chung DJ, Cho SH. A real-world comparative study of microwave and radiofrequency ablation in treatment-na\u00efve and recurrent hepatocellular carcinoma. J Clin Med. 2022, 11:302. 10.3390\/jcm11020302","journal-title":"J Clin Med"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-07610-1","article-title":"Overall survival and local recurrence following RFA, MWA, and cryoablation of very early and early HCC: a systematic review and Bayesian network meta-analysis","volume":"31","author":"Gupta P","year":"2021","unstructured":"Gupta P, Maralakunte M, Kumar-M P, et al.. Overall survival and local recurrence following RFA, MWA, and cryoablation of very early and early HCC: a systematic review and Bayesian network meta-analysis. Eur Radiol. 2021, 31:5400-8. 10.1007\/s00330-020-07610-1","journal-title":"Eur Radiol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022703","article-title":"Radiofrequency ablation versus microwave ablation for early stage hepatocellular carcinoma: a PRISMA-compliant systematic review and meta-analysis","volume":"99","author":"Han J","year":"2020","unstructured":"Han J, Fan YC, Wang K. Radiofrequency ablation versus microwave ablation for early stage hepatocellular carcinoma: a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2020, 99:e22703. 10.1097\/MD.0000000000022703","journal-title":"Medicine (Baltimore)"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5527-2","article-title":"Comparison of laparoscopic microwave to radiofrequency ablation of small hepatocellular carcinoma (\u22643\u00a0cm)","volume":"24","author":"Santambrogio R","year":"2017","unstructured":"Santambrogio R, Chiang J, Barabino M, Meloni FM, Bertolini E, Melchiorre F, Opocher E. Comparison of laparoscopic microwave to radiofrequency ablation of small hepatocellular carcinoma (\u22643\u00a0cm). Ann Surg Oncol. 2017, 24:257-63. 10.1245\/s10434-016-5527-2","journal-title":"Ann Surg Oncol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28020101","article-title":"Higher efficiency of percutaneous microwave (MWA) than radiofrequency ablation (RFA) in achieving complete response in cirrhotic patients with early hepatocellular carcinoma","volume":"28","author":"Gaia S","year":"2021","unstructured":"Gaia S, Ciruolo M, Ribaldone DG, et al.. Higher efficiency of percutaneous microwave (MWA) than radiofrequency ablation (RFA) in achieving complete response in cirrhotic patients with early hepatocellular carcinoma. Curr Oncol. 2021, 28:1034-44. 10.3390\/curroncol28020101","journal-title":"Curr Oncol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2020.01.008","article-title":"Prospective double-blinded randomized controlled trial of Microwave versus RadioFrequency Ablation for hepatocellular carcinoma (McRFA trial)","volume":"22","author":"Chong CC","year":"2020","unstructured":"Chong CC, Lee KF, Cheung SY, et al.. Prospective double-blinded randomized controlled trial of Microwave versus RadioFrequency Ablation for hepatocellular carcinoma (McRFA trial). HPB (Oxford). 2020, 22:1121-7. 10.1016\/j.hpb.2020.01.008","journal-title":"HPB (Oxford)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/288606-comparison-of-radiofrequency-ablation-and-microwave-ablation-for-the-management-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T14:48:29Z","timestamp":1724770109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/288606-comparison-of-radiofrequency-ablation-and-microwave-ablation-for-the-management-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.67938","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,27]]}}}