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Eur Radiol. 2018, 28:1465-75. 10.1007\/s00330-017-5026-2","journal-title":"Eur Radiol"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2272011747","article-title":"Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison","volume":"227","author":"Brown G","year":"2003","unstructured":"Brown G, Richards CJ, Bourne MW, Newcombe RG, Radcliffe AG, Dallimore NS, Williams GT. Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison. Radiology. 2003, 227:371-7. 10.1148\/radiol.2272011747","journal-title":"Radiology"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-023-03893-2","article-title":"Rectal cancer lexicon 2023 revised and updated consensus statement from the Society of Abdominal Radiology Colorectal and Anal Cancer Disease-Focused Panel","volume":"48","author":"Lee S","year":"2023","unstructured":"Lee S, Kassam Z, Baheti AD, et al.. Rectal cancer lexicon 2023 revised and updated consensus statement from the Society of Abdominal Radiology Colorectal and Anal Cancer Disease-Focused Panel. Abdom Radiol (NY). 2023, 48:2792-806. 10.1007\/s00261-023-03893-2","journal-title":"Abdom Radiol (NY)"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4687-9","article-title":"Assessment of clinical complete response after chemoradiation for rectal cancer with digital rectal examination, endoscopy, and MRI: selection for organ-saving treatment","volume":"22","author":"Maas M","year":"2015","unstructured":"Maas M, Lambregts DM, Nelemans PJ, et al.. Assessment of clinical complete response after chemoradiation for rectal cancer with digital rectal examination, endoscopy, and MRI: selection for organ-saving treatment. Ann Surg Oncol. 2015, 22:3873-80. 10.1245\/s10434-015-4687-9","journal-title":"Ann Surg Oncol"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.09.026","article-title":"Timing to achieve the highest rate of pCR after preoperative radiochemotherapy in rectal cancer: a pooled analysis of 3085 patients from 7 randomized trials","volume":"154","author":"Gambacorta MA","year":"2021","unstructured":"Gambacorta MA, Masciocchi C, Chiloiro G, et al.. Timing to achieve the highest rate of pCR after preoperative radiochemotherapy in rectal cancer: a pooled analysis of 3085 patients from 7 randomized trials. Radiother Oncol. 2021, 154:154-60. 10.1016\/j.radonc.2020.09.026","journal-title":"Radiother Oncol"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00004-2","article-title":"Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial","volume":"16","author":"Garcia-Aguilar J","year":"2015","unstructured":"Garcia-Aguilar J, Chow OS, Smith DD, et al.. Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial. Lancet Oncol. 2015, 16:957-66. 10.1016\/S1470-2045(15)00004-2","journal-title":"Lancet Oncol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-021-02440-9","article-title":"T2-weighted, apparent diffusion coefficient and 18F-FDG PET histogram analysis of rectal cancer after preoperative chemoradiotherapy","volume":"25","author":"Crim\u00ec F","year":"2021","unstructured":"Crim\u00ec F, Stramare R, Spolverato G, et al.. T2-weighted, apparent diffusion coefficient and 18F-FDG PET histogram analysis of rectal cancer after preoperative chemoradiotherapy. Tech Coloproctol. 2021, 25:569-77. 10.1007\/s10151-021-02440-9","journal-title":"Tech Coloproctol"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.06.005","article-title":"Early prediction of response by 18F-FDG PET\/CT during preoperative therapy in locally advanced rectal cancer: a systematic review","volume":"40","author":"Maffione AM","year":"2014","unstructured":"Maffione AM, Chondrogiannis S, Capirci C, et al.. Early prediction of response by 18F-FDG PET\/CT during preoperative therapy in locally advanced rectal cancer: a systematic review. Eur J Surg Oncol. 2014, 40:1186-94. 10.1016\/j.ejso.2014.06.005","journal-title":"Eur J Surg Oncol"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-014-0938-2","article-title":"Assessment of response to neoadjuvant radiochemotherapy with F-18 FLT and F-18 FDG PET\/CT in patients with rectal cancer","volume":"29","author":"Rendl G","year":"2015","unstructured":"Rendl G, Rettenbacher L, Holzmannhofer J, et al.. Assessment of response to neoadjuvant radiochemotherapy with F-18 FLT and F-18 FDG PET\/CT in patients with rectal cancer. Ann Nucl Med. 2015, 29:284-94. 10.1007\/s12149-014-0938-2","journal-title":"Ann Nucl Med"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2019.04.22","article-title":"Clinical outcomes of patients with locally advanced rectal cancer with persistent circumferential resection margin invasion after preoperative chemoradiotherapy","volume":"35","author":"Kim CH","year":"2019","unstructured":"Kim CH, Yeom SS, Kwak HD, Lee SY, Ju JK, Kim YJ, Kim HR. Clinical outcomes of patients with locally advanced rectal cancer with persistent circumferential resection margin invasion after preoperative chemoradiotherapy. Ann Coloproctol. 2019, 35:72-82. 10.3393\/ac.2019.04.22","journal-title":"Ann Coloproctol"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2019.04.22.1","article-title":"Oncologic outcomes in patients who undergo neoadjuvant chemoradiotherapy and total mesorectal excision for locally advanced rectal cancer: a 14-year experience in a single institution","volume":"35","author":"Kim MJ","year":"2019","unstructured":"Kim MJ, Jeong SY, Park JW, Ryoo SB, Cho SS, Lee KY, Park KJ. Oncologic outcomes in patients who undergo neoadjuvant chemoradiotherapy and total mesorectal excision for locally advanced rectal cancer: a 14-year experience in a single institution. Ann Coloproctol. 2019, 35:83-93. 10.3393\/ac.2019.04.22.1","journal-title":"Ann Coloproctol"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.2172","article-title":"Lateral nodal features on restaging magnetic resonance imaging associated with lateral local recurrence in low rectal cancer after neoadjuvant chemoradiotherapy or radiotherapy","volume":"154","author":"Ogura A","year":"2019","unstructured":"Ogura A, Konishi T, Beets GL, et al.. Lateral nodal features on restaging magnetic resonance imaging associated with lateral local recurrence in low rectal cancer after neoadjuvant chemoradiotherapy or radiotherapy. JAMA Surg. 2019, 154:e192172. 10.1001\/jamasurg.2019.2172","journal-title":"JAMA Surg"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.10.029","article-title":"EURECCA consensus conference highlights about colon & rectal cancer multidisciplinary management: the radiology experts review","volume":"40","author":"Tudyka V","year":"2014","unstructured":"Tudyka V, Blomqvist L, Beets-Tan RG, et al.. EURECCA consensus conference highlights about colon &amp; rectal cancer multidisciplinary management: the radiology experts review. Eur J Surg Oncol. 2014, 40:469-75. 10.1016\/j.ejso.2013.10.029","journal-title":"Eur J Surg Oncol"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16034","article-title":"Selected stage IV rectal cancer patients managed by the watch-and-wait approach after pelvic radiotherapy: a good alternative to total mesorectal excision surgery?","volume":"24","author":"Custers PA","year":"2022","unstructured":"Custers PA, Hupkens BJ, Grotenhuis BA, Kuhlmann KF, Breukink SO, Beets GL, Melenhorst J. Selected stage IV rectal cancer patients managed by the watch-and-wait approach after pelvic radiotherapy: a good alternative to total mesorectal excision surgery?. Colorectal Dis. 2022, 24:401-10. 10.1111\/codi.16034","journal-title":"Colorectal Dis"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30086-4","article-title":"Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial","volume":"18","author":"Erlandsson J","year":"2017","unstructured":"Erlandsson J, Holm T, Pettersson D, et al.. Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial. Lancet Oncol. 2017, 18:336-346. 10.1016\/S1470-2045(17)30086-4","journal-title":"Lancet Oncol"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.5896","article-title":"Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy","volume":"5","author":"Smith JJ","year":"2019","unstructured":"Smith JJ, Strombom P, Chow OS, et al.. Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy. JAMA Oncol. 2019, 5:e185896. 10.1001\/jamaoncol.2018.5896","journal-title":"JAMA Oncol"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000733","article-title":"Recent trends and overall survival of young versus older adults with stage ii to iii rectal cancer treated with and without surgery in the United States, 2010-2015","volume":"43","author":"Sanford NN","year":"2020","unstructured":"Sanford NN, Dee EC, Ahn C, et al.. 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