{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:50:09Z","timestamp":1779213009369,"version":"3.51.4"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,6]]},"DOI":"10.7759\/cureus.68770","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T09:42:59Z","timestamp":1725615779000},"source":"Crossref","is-referenced-by-count":3,"title":["Dysregulated MicroRNAs in Chronic Lymphocytic Leukemia"],"prefix":"10.7759","author":[{"given":"Oana","family":"Mesaros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefana","family":"Veres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madalina","family":"Onciul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Matei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Jimbu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Neaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihnea","family":"Zdrenghea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.101378","article-title":"The clinical significance of patients' sex in chronic lymphocytic leukemia","volume":"99","author":"Catovsky D","year":"2014","unstructured":"Catovsky D, Wade R, Else M. The clinical significance of patients' sex in chronic lymphocytic leukemia. Haematologica. 2014, 99:1088-94. 10.3324\/haematol.2013.101378","journal-title":"Haematologica"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25595","article-title":"Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment","volume":"94","author":"Hallek M","year":"2019","unstructured":"Hallek M. Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment. Am J Hematol. 2019, 94:1266-87. 10.1002\/ajh.25595","journal-title":"Am J Hematol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.2.448","article-title":"Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: a single institution study of 204 cases","volume":"94","author":"Mauro FR","year":"1999","unstructured":"Mauro FR, Foa R, Giannarelli D, et al.. Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: a single institution study of 204 cases. Blood. 1999, 94:448-54. 10.1182\/blood.V94.2.448","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654","article-title":"Cancer statistics","volume":"71","author":"Siegel RL","year":"2021","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics. CA Cancer J Clin. 2021, 71:7-33. 10.3322\/caac.21654","journal-title":"CA Cancer J Clin"},{"key":"ref5","article-title":"The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL","volume":"8","author":"Matutes E","year":"1994","unstructured":"Matutes E, Owusu-Ankomah K, Morilla R, et al.. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia. 1994, 8:1640-5.","journal-title":"Leukemia"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/108.4.378","article-title":"Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b)","volume":"108","author":"Moreau EJ","year":"1997","unstructured":"Moreau EJ, Matutes E, A'Hern RP, et al.. Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b). Am J Clin Pathol. 1997, 108:378-82. 10.1093\/ajcp\/108.4.378","journal-title":"Am J Clin Pathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247491","article-title":"The contribution of CD200 to the diagnostic accuracy of Matutes score in the diagnosis of chronic lymphocytic leukemia in limited resources laboratories","volume":"16","author":"Jalal SD","year":"2021","unstructured":"Jalal SD. The contribution of CD200 to the diagnostic accuracy of Matutes score in the diagnosis of chronic lymphocytic leukemia in limited resources laboratories. PLoS One. 2021, 16:0247491. 10.1371\/journal.pone.0247491","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2016.02.005","article-title":"Novel mechanisms of regulation of miRNAs in CLL","volume":"2","author":"Balatti V","year":"2016","unstructured":"Balatti V, Acunzo M, Pekarky Y, Croce CM. Novel mechanisms of regulation of miRNAs in CLL. Trends Cancer. 2016, 2:134-43. 10.1016\/j.trecan.2016.02.005","journal-title":"Trends Cancer"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien J","year":"2018","unstructured":"O'Brien J, Hayder H, Zayed Y, Peng C. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne). 2018, 9:402. 10.3389\/fendo.2018.00402","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90529-y","article-title":"elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee RC","year":"1993","unstructured":"Lee RC, Feinbaum RL, Ambros V. The C: elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993, 75:843-54. 10.1016\/0092-8674(93)90529-y","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.07.007","article-title":"The let-7 family of microRNAs","volume":"18","author":"Roush S","year":"2008","unstructured":"Roush S, Slack FJ. The let-7 family of microRNAs. Trends Cell Biol. 2008, 18:505-16. 10.1016\/j.tcb.2008.07.007","journal-title":"Trends Cell Biol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart BJ","year":"2000","unstructured":"Reinhart BJ, Slack FJ, Basson M, et al.. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000, 403:901-6. 10.1038\/35002607","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10. 10.3390\/cells10092415","article-title":"The roles of the let-7 family of microRNAs in the regulation of cancer stemness","volume":"10","author":"Ma Y","year":"2021","unstructured":"Ma Y, Shen N, Wicha MS, Luo M. The roles of the let-7 family of microRNAs in the regulation of cancer stemness. Cells. 2021, 10:10. 10.3390\/cells10092415","journal-title":"Cells"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-018-9808-y","article-title":"Cell cycle regulation of stem cells by microRNAs","volume":"14","author":"Mens MMJ","year":"2018","unstructured":"Mens MMJ, Ghanbari M. Cell cycle regulation of stem cells by microRNAs. Stem Cell Rev Rep. 2018, 14:309-22. 10.1007\/s12015-018-9808-y","journal-title":"Stem Cell Rev Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/biology6030034","article-title":"microRNA signaling in embryo development","volume":"6","author":"Gross N","year":"2017","unstructured":"Gross N, Kropp J, Khatib H. microRNA signaling in embryo development. Biology (Basel). 2017, 6:10.3390\/biology6030034","journal-title":"Biology (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.05.017","article-title":"MicroRNAs in cancer cell death pathways: apoptosis and necroptosis","volume":"139","author":"Shirjang S","year":"2019","unstructured":"Shirjang S, Mansoori B, Asghari S, et al.. MicroRNAs in cancer cell death pathways: apoptosis and necroptosis. Free Radic Biol Med. 2019, 139:1-15. 10.1016\/j.freeradbiomed.2019.05.017","journal-title":"Free Radic Biol Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242606799","article-title":"Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia","volume":"99","author":"Calin GA","year":"2002","unstructured":"Calin GA, Dumitru CD, Shimizu M, et al.. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002, 99:15524-9. 10.1073\/pnas.242606799","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1515\/bmc-2014-0012","article-title":"Update on non-canonical microRNAs","volume":"5","author":"Abdelfattah AM","year":"2014","unstructured":"Abdelfattah AM, Park C, Choi MY. Update on non-canonical microRNAs. Biomol Concepts. 2014, 5:275-87. 10.1515\/bmc-2014-0012","journal-title":"Biomol Concepts"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.11.176","article-title":"miRNAs as potential therapeutic targets for age-related macular degeneration","volume":"4","author":"Wang S","year":"2012","unstructured":"Wang S, Koster KM, He Y, Zhou Q. miRNAs as potential therapeutic targets for age-related macular degeneration. Future Med Chem. 2012, 4:277-87. 10.4155\/fmc.11.176","journal-title":"Future Med Chem"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: microRNA biogenesis pathways and their regulation","volume":"11","author":"Winter J","year":"2009","unstructured":"Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009, 11:228-34. 10.1038\/ncb0309-228","journal-title":"Nat Cell Biol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.058","article-title":"microRNA-223 suppresses the canonical NF-kappaB pathway in basal keratinocytes to dampen neutrophilic inflammation","volume":"22","author":"Zhou W","year":"2018","unstructured":"Zhou W, Pal AS, Hsu AY, et al.. microRNA-223 suppresses the canonical NF-kappaB pathway in basal keratinocytes to dampen neutrophilic inflammation. Cell Rep. 2018, 22:1810-23. 10.1016\/j.celrep.2018.01.058","journal-title":"Cell Rep"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1659","article-title":"The many facets of miR-223 in cancer: Oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response","volume":"12","author":"Favero A","year":"2021","unstructured":"Favero A, Segatto I, Perin T, Belletti B. The many facets of miR-223 in cancer: Oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response. Wiley Interdiscip Rev RNA. 2021, 12:1659. 10.1002\/wrna.1659","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.02.051","article-title":"miRNA-223 at the crossroads of inflammation and cancer","volume":"451","author":"Jeffries J","year":"2019","unstructured":"Jeffries J, Zhou W, Hsu AY, Deng Q. miRNA-223 at the crossroads of inflammation and cancer. Cancer Lett. 2019, 451:136-41. 10.1016\/j.canlet.2019.02.051","journal-title":"Cancer Lett"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-021-09658-x","article-title":"Anti-apoptotic effect of miR-223-3p suppressing PIK3C2A in cardiomyocytes from myocardial infarction rat through regulating PI3K\/AKT signaling pathway","volume":"21","author":"Xiaoyu L","year":"2021","unstructured":"Xiaoyu L, Wei Z, Ming Z, Guowei J. Anti-apoptotic effect of miR-223-3p suppressing PIK3C2A in cardiomyocytes from myocardial infarction rat through regulating PI3K\/AKT signaling pathway. Cardiovasc Toxicol. 2021, 21:669-82. 10.1007\/s12012-021-09658-x","journal-title":"Cardiovasc Toxicol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3401","article-title":"miR-223 reverses the resistance of EGFR-TKIs through IGF1R\/PI3K\/Akt signaling pathway","volume":"48","author":"Han J","year":"2016","unstructured":"Han J, Zhao F, Zhang J, et al.. miR-223 reverses the resistance of EGFR-TKIs through IGF1R\/PI3K\/Akt signaling pathway. Int J Oncol. 2016, 48:1855-67. 10.3892\/ijo.2016.3401","journal-title":"Int J Oncol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.254","article-title":"MicroRNA regulons in tumor microenvironment","volume":"34","author":"Suzuki HI","year":"2015","unstructured":"Suzuki HI, Katsura A, Matsuyama H, Miyazono K. MicroRNA regulons in tumor microenvironment. Oncogene. 2015, 34:3085-94. 10.1038\/onc.2014.254","journal-title":"Oncogene"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-189407","article-title":"microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification","volume":"113","author":"Stamatopoulos B","year":"2009","unstructured":"Stamatopoulos B, Meuleman N, Haibe-Kains B, et al.. microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification. Blood. 2009, 113:5237-45. 10.1182\/blood-2008-11-189407","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1212-2","article-title":"MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL","volume":"15","author":"Rodriguez-Vicente AE","year":"2015","unstructured":"Rodriguez-Vicente AE, Quwaider D, Benito R, et al.. MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL. BMC Cancer. 2015, 15:238. 10.1186\/s12885-015-1212-2","journal-title":"BMC Cancer"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-020-05428-0","article-title":"Evaluation of microRNA-223 and microRNA-125a expression association with STAT3 and Bcl2 genes in blood leukocytes of CLL patients: a case-control study","volume":"14","author":"Davari N","year":"2021","unstructured":"Davari N, Ahmadpour F, Kiani AA, Azadpour M, Asadi ZT. Evaluation of microRNA-223 and microRNA-125a expression association with STAT3 and Bcl2 genes in blood leukocytes of CLL patients: a case-control study. BMC Res Notes. 2021, 14:21. 10.1186\/s13104-020-05428-0","journal-title":"BMC Res Notes"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-018-1000-7","article-title":"Study of microRNA profile as a molecular biomarker in Egyptian chronic lymphocytic leukemia","volume":"35","author":"Farahat NMG","year":"2019","unstructured":"Farahat NMG, Elkaffash D, Alghandour AH, Swelem RS, Abo El-Wafa RAH. Study of microRNA profile as a molecular biomarker in Egyptian chronic lymphocytic leukemia. Indian J Hematol Blood Transfus. 2019, 35:89-99. 10.1007\/s12288-018-1000-7","journal-title":"Indian J Hematol Blood Transfus"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.848199","article-title":"A Systematic Review of Candidate miRNAs, Its Targeted Genes and Pathways in Chronic Myeloid Leukemia-An Integrated Bioinformatical Analysis","volume":"12","author":"Elias MH","year":"2022","unstructured":"Elias MH, Syed Mohamad SF, Abdul Hamid N. A Systematic Review of Candidate miRNAs, Its Targeted Genes and Pathways in Chronic Myeloid Leukemia-An Integrated Bioinformatical Analysis. Front Oncol. 2022, 12:848199. 10.3389\/fonc.2022.848199","journal-title":"Front Oncol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12581","article-title":"Inside the chronic lymphocytic leukemia cell: miRNA and chromosomal aberrations","volume":"25","author":"Grenda A","year":"2022","unstructured":"Grenda A, Filip AA, Wasik-Szczepanek E. Inside the chronic lymphocytic leukemia cell: miRNA and chromosomal aberrations. Mol Med Rep. 2022, 25:10.3892\/mmr.2022.12581","journal-title":"Mol Med Rep"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10. 10.3390\/biomedicines10092121","article-title":"The role of miR-29s in human cancers - an update","author":"Nguyen TTP","year":"2022","unstructured":"Nguyen TTP, Suman KH, Nguyen TB, Nguyen HT, Do DN. The role of miR-29s in human cancers - an update. Biomedicines. 2022, 10. 10.3390\/biomedicines10092121","journal-title":"Biomedicines"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2024.03.001","article-title":"miRNA biology in chronic lymphocytic leukemia","volume":"61","author":"Bayraktar R","year":"2024","unstructured":"Bayraktar R, Fontana B, Calin GA, Nemeth K. miRNA biology in chronic lymphocytic leukemia. Semin Hematol. 2024, 61:181-93. 10.1053\/j.seminhematol.2024.03.001","journal-title":"Semin Hematol"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1186\/2162-3619-3-17","article-title":"Altered expression pattern of miR-29a, miR-29b and the target genes in myeloid leukemia","volume":"3","author":"Xu L","year":"2014","unstructured":"Xu L, Xu Y, Jing Z, et al.. Altered expression pattern of miR-29a, miR-29b and the target genes in myeloid leukemia. Exp Hematol Oncol. 2014, 3:17. 10.1186\/2162-3619-3-17","journal-title":"Exp Hematol Oncol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512471","article-title":"Role of microRNAs in chronic lymphocytic leukemia","volume":"24","author":"Autore F","year":"2023","unstructured":"Autore F, Ramassone A, Stirparo L, et al.. Role of microRNAs in chronic lymphocytic leukemia. Int J Mol Sci. 2023, 24:10.3390\/ijms241512471","journal-title":"Int J Mol Sci"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3613","article-title":"Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181","volume":"66","author":"Pekarsky Y","year":"2006","unstructured":"Pekarsky Y, Santanam U, Cimmino A, et al.. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res. 2006, 66:11590-3. 10.1158\/0008-5472.CAN-06-3613","journal-title":"Cancer Res"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605751","article-title":"The tumour-suppressive miR-29a\/b1 cluster is regulated by CEBPA and blocked in human AML","volume":"103","author":"Eyholzer M","year":"2010","unstructured":"Eyholzer M, Schmid S, Wilkens L, Mueller BU, Pabst T. The tumour-suppressive miR-29a\/b1 cluster is regulated by CEBPA and blocked in human AML. Br J Cancer. 2010, 103:275-84. 10.1038\/sj.bjc.6605751","journal-title":"Br J Cancer"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.09.014","article-title":"MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines","volume":"45","author":"Muniyappa MK","year":"2009","unstructured":"Muniyappa MK, Dowling P, Henry M, et al.. MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines. Eur J Cancer. 2009, 45:3104-18. 10.1016\/j.ejca.2009.09.014","journal-title":"Eur J Cancer"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.01.065","article-title":"The mechanism involved in the loss of PTEN expression in NSCLC tumor cells","volume":"418","author":"Li G","year":"2012","unstructured":"Li G, Zhao J, Peng X, Liang J, Deng X, Chen Y. The mechanism involved in the loss of PTEN expression in NSCLC tumor cells. Biochem Biophys Res Commun. 2012, 418:547-52. 10.1016\/j.bbrc.2012.01.065","journal-title":"Biochem Biophys Res Commun"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1615\/critrevimmunol.2013006858","article-title":"MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and development","volume":"33","author":"Podshivalova K","year":"2013","unstructured":"Podshivalova K, Salomon DR. MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and development. Crit Rev Immunol. 2013, 33:435-76. 10.1615\/critrevimmunol.2013006858","journal-title":"Crit Rev Immunol"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00317","article-title":"T-cell leukemia\/lymphoma 1 (TCL1): an oncogene regulating multiple signaling pathways","volume":"8","author":"Paduano F","year":"2018","unstructured":"Paduano F, Gaudio E, Mensah AA, Pinton S, Bertoni F, Trapasso F. T-cell leukemia\/lymphoma 1 (TCL1): an oncogene regulating multiple signaling pathways. Front Oncol. 2018, 8:317. 10.3389\/fonc.2018.00317","journal-title":"Front Oncol"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1059-5","article-title":"MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer","volume":"38","author":"Zhang L","year":"2019","unstructured":"Zhang L, Liao Y, Tang L. MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer. J Exp Clin Cancer Res. 2019, 38:53. 10.1186\/s13046-019-1059-5","journal-title":"J Exp Clin Cancer Res"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-016-0407-y","article-title":"Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors","volume":"35","author":"Beg MS","year":"2017","unstructured":"Beg MS, Brenner AJ, Sachdev J, et al.. Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors. Invest New Drugs. 2017, 35:180-8. 10.1007\/s10637-016-0407-y","journal-title":"Invest New Drugs"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-845115","article-title":"miR-125a and miR-34a expression predicts Richter syndrome in chronic lymphocytic leukemia patients","volume":"132","author":"Balatti V","year":"2018","unstructured":"Balatti V, Tomasello L, Rassenti LZ, et al.. miR-125a and miR-34a expression predicts Richter syndrome in chronic lymphocytic leukemia patients. Blood. 2018, 132:2179-82. 10.1182\/blood-2018-04-845115","journal-title":"Blood"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-224071","article-title":"Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial","volume":"114","author":"Zenz T","year":"2009","unstructured":"Zenz T, Habe S, Denzel T, et al.. Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial. Blood. 2009, 114:2589-97. 10.1182\/blood-2009-05-224071","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1038\/nature05939","article-title":"A microRNA component of the p53 tumour suppressor network","volume":"447","author":"He L","year":"2007","unstructured":"He L, He X, Lim LP, et al.. A microRNA component of the p53 tumour suppressor network. Nature. 2007, 447:1130-4. 10.1038\/nature05939","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.56","article-title":"The miR-34 family in cancer and apoptosis","volume":"17","author":"Hermeking H","year":"2010","unstructured":"Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010, 17:193-9. 10.1038\/cdd.2009.56","journal-title":"Cell Death Differ"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2232","article-title":"microRNAs join the p53 network - another piece in the tumour-suppression puzzle","volume":"7","author":"He L","year":"2007","unstructured":"He L, He X, Lowe SW, Hannon GJ. microRNAs join the p53 network - another piece in the tumour-suppression puzzle. Nat Rev Cancer. 2007, 7:819-22. 10.1038\/nrc2232","journal-title":"Nat Rev Cancer"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0230-x","article-title":"MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells","volume":"33","author":"Cerna K","year":"2019","unstructured":"Cerna K, Oppelt J, Chochola V, et al.. MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells. Leukemia. 2019, 33:403-14. 10.1038\/s41375-018-0230-x","journal-title":"Leukemia"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.3.1490","article-title":"bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA","volume":"17","author":"Tam W","year":"1997","unstructured":"Tam W, Ben-Yehuda D, Hayward WS. bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA. Mol Cell Biol. 1997, 17:1490-502. 10.1128\/MCB.17.3.1490","journal-title":"Mol Cell Biol"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05121.x","article-title":"MicroRNAs of the immune system: roles in inflammation and cancer","volume":"1183","author":"Davidson-Moncada J","year":"2010","unstructured":"Davidson-Moncada J, Papavasiliou FN, Tam W. MicroRNAs of the immune system: roles in inflammation and cancer. Ann N Y Acad Sci. 2010, 1183:183-94. 10.1111\/j.1749-6632.2009.05121.x","journal-title":"Ann N Y Acad Sci"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139253","article-title":"Requirement of bic\/microRNA-155 for normal immune function","volume":"316","author":"Rodriguez A","year":"2007","unstructured":"Rodriguez A, Vigorito E, Clare S, et al.. Requirement of bic\/microRNA-155 for normal immune function. Science. 2007, 316:608-11. 10.1126\/science.1139253","journal-title":"Science"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610983104","article-title":"CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control","volume":"104","author":"Georgantas RW 3rd","year":"2007","unstructured":"Georgantas RW 3rd, Hildreth R, Morisot S, et al.. CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci U S A. 2007, 104:2750-5. 10.1073\/pnas.0610983104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-559690","article-title":"MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia","volume":"124","author":"Cui B","year":"2014","unstructured":"Cui B, Chen L, Zhang S, et al.. MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. Blood. 2014, 124:546-54. 10.1182\/blood-2014-03-559690","journal-title":"Blood"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-478222","article-title":"Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia","volume":"122","author":"Ferrajoli A","year":"2013","unstructured":"Ferrajoli A, Shanafelt TD, Ivan C, et al.. Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood. 2013, 122:1891-9. 10.1182\/blood-2013-01-478222","journal-title":"Blood"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0272-y","article-title":"RNA-Seq profiling of deregulated miRs in CLL and their impact on clinical outcome","volume":"10","author":"Kaur G","year":"2020","unstructured":"Kaur G, Ruhela V, Rani L, et al.. RNA-Seq profiling of deregulated miRs in CLL and their impact on clinical outcome. Blood Cancer J. 2020, 10:6. 10.1038\/s41408-019-0272-y","journal-title":"Blood Cancer J"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-285064","article-title":"MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia","volume":"117","author":"Vargova K","year":"2011","unstructured":"Vargova K, Curik N, Burda P, et al.. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood. 2011, 117:3816-3825. 10.1182\/blood-2010-05-285064","journal-title":"Blood"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-263889","article-title":"microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival","volume":"116","author":"Rossi S","year":"2010","unstructured":"Rossi S, Shimizu M, Barbarotto E, et al.. microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood. 2010, 116:945-52. 10.1182\/blood-2010-01-263889","journal-title":"Blood"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12420","article-title":"miR-181a\/b therapy in lung cancer: reality or myth?","volume":"13","author":"Braicu C","year":"2019","unstructured":"Braicu C, Gulei D, Cojocneanu R, et al.. miR-181a\/b therapy in lung cancer: reality or myth?. Mol Oncol. 2019, 13:9-25. 10.1002\/1878-0261.12420","journal-title":"Mol Oncol"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062092","article-title":"The pervasive role of the miR-181 family in development, neurodegeneration, and cancer","volume":"21","author":"Indrieri A","year":"2020","unstructured":"Indrieri A, Carrella S, Carotenuto P, Banfi S, Franco B. The pervasive role of the miR-181 family in development, neurodegeneration, and cancer. Int J Mol Sci. 2020, 21:10.3390\/ijms21062092","journal-title":"Int J Mol Sci"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30969","article-title":"The miR-181 family: wide-ranging pathophysiological effects on cell fate and function","volume":"238","author":"Bell-Hensley A","year":"2023","unstructured":"Bell-Hensley A, Das S, McAlinden A. The miR-181 family: wide-ranging pathophysiological effects on cell fate and function. J Cell Physiol. 2023, 238:698-713. 10.1002\/jcp.30969","journal-title":"J Cell Physiol"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs179","article-title":"miR-181a\/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes","volume":"33","author":"Zhu DX","year":"2012","unstructured":"Zhu DX, Zhu W, Fang C, et al.. miR-181a\/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes. Carcinogenesis. 2012, 33:1294-301. 10.1093\/carcin\/bgs179","journal-title":"Carcinogenesis"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-333484","article-title":"miR-181b is a biomarker of disease progression in chronic lymphocytic leukemia","volume":"118","author":"Visone R","year":"2011","unstructured":"Visone R, Veronese A, Rassenti LZ, et al.. miR-181b is a biomarker of disease progression in chronic lymphocytic leukemia. Blood. 2011, 118:3072-9. 10.1182\/blood-2011-01-333484","journal-title":"Blood"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13020257","article-title":"Enhanced expression of miR-181b in B cells of CLL improves the anti-tumor cytotoxic T cell response","volume":"13","author":"Di Marco M","year":"2021","unstructured":"Di Marco M, Veschi S, Lanuti P, et al.. Enhanced expression of miR-181b in B cells of CLL improves the anti-tumor cytotoxic T cell response. Cancers (Basel). 2021, 13:10.3390\/cancers13020257","journal-title":"Cancers (Basel)"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3164","article-title":"Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (review)","volume":"40","author":"Fang LL","year":"2017","unstructured":"Fang LL, Wang XH, Sun BF, et al.. Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (review). Int J Mol Med. 2017, 40:1624-30. 10.3892\/ijmm.2017.3164","journal-title":"Int J Mol Med"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46030120","article-title":"Unraveling the multifaceted role of the miR-17-92 cluster in colorectal cancer: from mechanisms to biomarker potential","volume":"46","author":"Al-Nakhle HH","year":"2024","unstructured":"Al-Nakhle HH. Unraveling the multifaceted role of the miR-17-92 cluster in colorectal cancer: from mechanisms to biomarker potential. Curr Issues Mol Biol. 2024, 46:1832-50. 10.3390\/cimb46030120","journal-title":"Curr Issues Mol Biol"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-03-3773","article-title":"Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma","volume":"64","author":"Ota A","year":"2004","unstructured":"Ota A, Tagawa H, Karnan S, et al.. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res. 2004, 64:3087-95. 10.1158\/0008-5472.can-03-3773","journal-title":"Cancer Res"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.125","article-title":"The miR-17\/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease","volume":"20","author":"Mogilyansky E","year":"2013","unstructured":"Mogilyansky E, Rigoutsos I. The miR-17\/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Differ. 2013, 20:1603-14. 10.1038\/cdd.2013.125","journal-title":"Cell Death Differ"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.019","article-title":"Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters","volume":"132","author":"Ventura A","year":"2008","unstructured":"Ventura A, Young AG, Winslow MM, et al.. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008, 132:875-86. 10.1016\/j.cell.2008.02.019","journal-title":"Cell"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.18632\/genesandcancer.6","article-title":"Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences","volume":"5","author":"Arabi L","year":"2014","unstructured":"Arabi L, Gsponer JR, Smida J, et al.. Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences. Genes Cancer. 2014, 5:56-63. 10.18632\/genesandcancer.6","journal-title":"Genes Cancer"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2022.100647","article-title":"The miR-17-92 cluster: Yin and Yang in human cancers","volume":"33","author":"Zhao W","year":"2022","unstructured":"Zhao W, Gupta A, Krawczyk J, Gupta S. The miR-17-92 cluster: Yin and Yang in human cancers. Cancer Treat Res Commun. 2022, 33:100647. 10.1016\/j.ctarc.2022.100647","journal-title":"Cancer Treat Res Commun"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021705","article-title":"Prognostic value of the miR-17~92 cluster in chronic lymphocytic leukemia","volume":"24","author":"Chocholska S","year":"2023","unstructured":"Chocholska S, Zarobkiewicz M, Szymanska A, Lehman N, Wos J, Bojarska-Junak A. Prognostic value of the miR-17~92 cluster in chronic lymphocytic leukemia. Int J Mol Sci. 2023, 24:10.3390\/ijms24021705","journal-title":"Int J Mol Sci"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0112-x","article-title":"Role of microRNA in chronic lymphocytic leukemia onset and progression","volume":"8","author":"Balatti V","year":"2015","unstructured":"Balatti V, Pekarky Y, Croce CM. Role of microRNA in chronic lymphocytic leukemia onset and progression. J Hematol Oncol. 2015, 8:12. 10.1186\/s13045-015-0112-x","journal-title":"J Hematol Oncol"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S230842","article-title":"Serum Expression of Seven MicroRNAs in Chronic Lymphocytic Leukemia Patients","volume":"11","author":"Farzadfard E","year":"2020","unstructured":"Farzadfard E, Kalantari T, Tamaddon G. Serum Expression of Seven MicroRNAs in Chronic Lymphocytic Leukemia Patients. J Blood Med. 2020, 11:97-102. 10.2147\/JBM.S230842","journal-title":"J Blood Med"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1186\/s43046-021-00097-x","article-title":"Prognostic significance of microRNA 17-92 cluster expression in Egyptian chronic lymphocytic leukemia patients","volume":"33","author":"Khalifa MM","year":"2021","unstructured":"Khalifa MM, Zaki NE, Nazier AA, et al.. Prognostic significance of microRNA 17-92 cluster expression in Egyptian chronic lymphocytic leukemia patients. J Egypt Natl Canc Inst. 2021, 33:37. 10.1186\/s43046-021-00097-x","journal-title":"J Egypt Natl Canc Inst"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2021.22.1.111","article-title":"Diagnostic value of plasma miR-145 and miR-185 as targeting of the APRIL oncogene in the B-cell chronic lymphocytic leukemia","volume":"22","author":"Bagheri M","year":"2021","unstructured":"Bagheri M, Khansarinejad B, Mosayebi G, Moradabadi A, Mondanizadeh M. Diagnostic value of plasma miR-145 and miR-185 as targeting of the APRIL oncogene in the B-cell chronic lymphocytic leukemia. Asian Pac J Cancer Prev. 2021, 22:111-17. 10.31557\/APJCP.2021.22.1.111","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02551-9","article-title":"Functions and underlying mechanisms of miR-650 in human cancers","volume":"22","author":"Su Y","year":"2022","unstructured":"Su Y, Zheng Q, Zhu L, Gu X, Lu J, Li L. Functions and underlying mechanisms of miR-650 in human cancers. Cancer Cell Int. 2022, 22:132. 10.1186\/s12935-022-02551-9","journal-title":"Cancer Cell Int"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-394874","article-title":"MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia","volume":"119","author":"Mraz M","year":"2012","unstructured":"Mraz M, Dolezalova D, Plevova K, et al.. MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. Blood. 2012, 119:2110-13. 10.1182\/blood-2011-11-394874","journal-title":"Blood"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4915-3","article-title":"NDRG2 mRNA levels and miR-28-5p and miR-650 activity in chronic lymphocytic leukemia","volume":"18","author":"Yang YQ","year":"2018","unstructured":"Yang YQ, Tian T, Zhu HY, et al.. NDRG2 mRNA levels and miR-28-5p and miR-650 activity in chronic lymphocytic leukemia. BMC Cancer. 2018, 18:1009. 10.1186\/s12885-018-4915-3","journal-title":"BMC Cancer"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.246","article-title":"Defective DROSHA processing contributes to downregulation of MiR-15\/-16 in chronic lymphocytic leukemia","volume":"28","author":"Allegra D","year":"2014","unstructured":"Allegra D, Bilan V, Garding A, et al.. Defective DROSHA processing contributes to downregulation of MiR-15\/-16 in chronic lymphocytic leukemia. Leukemia. 2014, 28:98-107. 10.1038\/leu.2013.246","journal-title":"Leukemia"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.329","article-title":"The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatment","volume":"2017","author":"Gaidano G","year":"2017","unstructured":"Gaidano G, Rossi D. The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatment. Hematology Am Soc Hematol Educ Program. 2017, 2017:329-37. 10.1182\/asheducation-2017.1.329","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2118752119","article-title":"A large fraction of trisomy 12, 17p(-), and 11q(-) CLL cases carry unidentified microdeletions of miR-15a\/16-1","volume":"119","author":"Pepe F","year":"2022","unstructured":"Pepe F, Rassenti LZ, Pekarsky Y, et al.. A large fraction of trisomy 12, 17p(-), and 11q(-) CLL cases carry unidentified microdeletions of miR-15a\/16-1. Proc Natl Acad Sci U S A. 2022, 119:10.1073\/pnas.2118752119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050995","article-title":"A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia","volume":"353","author":"Calin GA","year":"2005","unstructured":"Calin GA, Ferracin M, Cimmino A, et al.. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005, 353:1793-801. 10.1056\/NEJMoa050995","journal-title":"N Engl J Med"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800121105","article-title":"MiR-15a and miR-16-1 cluster functions in human leukemia","volume":"105","author":"Calin GA","year":"2008","unstructured":"Calin GA, Cimmino A, Fabbri M, et al.. MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A. 2008, 105:5166-71. 10.1073\/pnas.0800121105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708264114","article-title":"MicroRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia","volume":"114","author":"Rassenti LZ","year":"2017","unstructured":"Rassenti LZ, Balatti V, Ghia EM, et al.. MicroRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2017, 114:10731-6. 10.1073\/pnas.1708264114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.157669","article-title":"Role of miR-15a\/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia","volume":"102","author":"Rampazzo E","year":"2017","unstructured":"Rampazzo E, Bojnik E, Trentin L, et al.. Role of miR-15a\/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia. Haematologica. 2017, 102:253-6. 10.3324\/haematol.2016.157669","journal-title":"Haematologica"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2011.58","article-title":"Systemic in vivo lentiviral delivery of miR-15a\/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia","volume":"13","author":"Kasar S","year":"2012","unstructured":"Kasar S, Salerno E, Yuan Y, et al.. Systemic in vivo lentiviral delivery of miR-15a\/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia. Genes Immun. 2012, 13:109-19. 10.1038\/gene.2011.58","journal-title":"Genes Immun"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt412","article-title":"Restoring expression of miR-16: a novel approach to therapy for malignant pleural mesothelioma","volume":"24","author":"Reid G","year":"2013","unstructured":"Reid G, Pel ME, Kirschner MB, et al.. Restoring expression of miR-16: a novel approach to therapy for malignant pleural mesothelioma. Ann Oncol. 2013, 24:3128-35. 10.1093\/annonc\/mdt412","journal-title":"Ann Oncol"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29491","article-title":"Epigenetic silencing of miR-708 enhances NF-kappaB signaling in chronic lymphocytic leukemia","volume":"137","author":"Baer C","year":"2015","unstructured":"Baer C, Oakes CC, Ruppert AS, et al.. Epigenetic silencing of miR-708 enhances NF-kappaB signaling in chronic lymphocytic leukemia. Int J Cancer. 2015, 137:1352-61. 10.1002\/ijc.29491","journal-title":"Int J Cancer"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19772","article-title":"miR-708-5p: a microRNA with emerging roles in cancer","volume":"8","author":"Monteleone NJ","year":"2017","unstructured":"Monteleone NJ, Lutz CS. miR-708-5p: a microRNA with emerging roles in cancer. Oncotarget. 2017, 8:71292-316. 10.18632\/oncotarget.19772","journal-title":"Oncotarget"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317697575","article-title":"MiR- 138: A promising therapeutic target for cancer","volume":"39","author":"Sha HH","year":"2017","unstructured":"Sha HH, Wang DD, Chen D, et al..  MiR- 138: A promising therapeutic target for cancer. Tumour Biol. 2017, 39:1010428317697575. 10.1177\/1010428317697575","journal-title":"Tumour Biol"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1159\/000343349","article-title":"MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer","volume":"31","author":"Zhang H","year":"2013","unstructured":"Zhang H, Zhang H, Zhao M, et al.. MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer. Cell Physiol Biochem. 2013, 31:56-65. 10.1159\/000343349","journal-title":"Cell Physiol Biochem"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018030262","article-title":"Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia","volume":"3","author":"Chartomatsidou E","year":"2019","unstructured":"Chartomatsidou E, Ntoufa S, Kotta K, et al.. Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia. Blood Adv. 2019, 3:1891-6. 10.1182\/bloodadvances.2018030262","journal-title":"Blood Adv"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-586511","article-title":"miRs-138 and-424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL","volume":"125","author":"Berg V","year":"2015","unstructured":"Berg V, Rusch M, Vartak N, et al.. miRs-138 and-424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL. Blood. 2015, 125:2948-2957. 10.1182\/blood-2014-07-586511","journal-title":"Blood"},{"key":"ref96","article-title":"Pivotal role of microRNA-138 in human cancers","volume":"9","author":"Yeh M","year":"2019","unstructured":"Yeh M, Oh CS, Yoo JY, Kaur B, Lee TJ. Pivotal role of microRNA-138 in human cancers. Am J Cancer Res. 2019, 9:1118-1126.","journal-title":"Am J Cancer Res"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-173","article-title":"Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia - implications on constitutive activation of NFkappaB pathway","volume":"12","author":"Wang LQ","year":"2013","unstructured":"Wang LQ, Kwong YL, Kho CS, et al.. Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia - implications on constitutive activation of NFkappaB pathway. Mol Cancer. 2013, 12:173. 10.1186\/1476-4598-12-173","journal-title":"Mol Cancer"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.154077","article-title":"miR-574, miR-499, miR-125b, miR-106a, and miR-9 potentially target TGFBR-1 and TGFBR-2 genes involving in inflammatory response pathway: Potential novel biomarkers for chronic lymphocytic leukemia","volume":"238","author":"Hadi N","year":"2022","unstructured":"Hadi N, Namazi F, Ketabchi F, et al.. miR-574, miR-499, miR-125b, miR-106a, and miR-9 potentially target TGFBR-1 and TGFBR-2 genes involving in inflammatory response pathway: Potential novel biomarkers for chronic lymphocytic leukemia. Pathol Res Pract. 2022, 238:154077. 10.1016\/j.prp.2022.154077","journal-title":"Pathol Res Pract"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00618.x","article-title":"Downregulation of microRNAs-143 and -145 in B-cell malignancies","volume":"98","author":"Akao Y","year":"2007","unstructured":"Akao Y, Nakagawa Y, Kitade Y, Kinoshita T, Naoe T. Downregulation of microRNAs-143 and -145 in B-cell malignancies. Cancer Sci. 2007, 98:1914-20. 10.1111\/j.1349-7006.2007.00618.x","journal-title":"Cancer Sci"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3078","article-title":"Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells","volume":"31","author":"Shen JZ","year":"2014","unstructured":"Shen JZ, Zhang YY, Fu HY, Wu DS, Zhou HR. Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells. Oncol Rep. 2014, 31:2035-2042. 10.3892\/or.2014.3078","journal-title":"Oncol Rep"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.2174\/0929867326666190911114842","article-title":"Role of microRNAs in chronic lymphocytic leukemia pathogenesis","volume":"27","author":"Javandoost E","year":"2020","unstructured":"Javandoost E, Firoozi-Majd E, Rostamian H, Khakpoor-Koosheh M, Mirzaei HR. Role of microRNAs in chronic lymphocytic leukemia pathogenesis. Curr Med Chem. 2020, 27:282-97. 10.2174\/0929867326666190911114842","journal-title":"Curr Med Chem"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2016.04.008","article-title":"MiRNA expression profile of chronic lymphocytic leukemia patients with 13q deletion","volume":"46","author":"Hernandez-Sanchez M","year":"2016","unstructured":"Hernandez-Sanchez M, Rodriguez-Vicente AE, Hernandez JA, et al.. MiRNA expression profile of chronic lymphocytic leukemia patients with 13q deletion. Leuk Res. 2016, 46:30-6. 10.1016\/j.leukres.2016.04.008","journal-title":"Leuk Res"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07982.x","article-title":"A comprehensive evaluation of the prognostic significance of 13q deletions in patients with B-chronic lymphocytic leukaemia","volume":"148","author":"Van Dyke DL","year":"2010","unstructured":"Van Dyke DL, Shanafelt TD, Call TG, et al.. A comprehensive evaluation of the prognostic significance of 13q deletions in patients with B-chronic lymphocytic leukaemia. Br J Haematol. 2010, 148:544-50. 10.1111\/j.1365-2141.2009.07982.x","journal-title":"Br J Haematol"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20885","article-title":"13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia","volume":"50","author":"Dal Bo M","year":"2011","unstructured":"Dal Bo M, Rossi FM, Rossi D, et al.. 13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2011, 50:633-43. 10.1002\/gcc.20885","journal-title":"Genes Chromosomes Cancer"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2703","article-title":"A one-two punch of miR-126\/126* against metastasis","volume":"15","author":"Ren G","year":"2013","unstructured":"Ren G, Kang Y. A one-two punch of miR-126\/126* against metastasis. Nat Cell Biol. 2013, 15:231-233. 10.1038\/ncb2703","journal-title":"Nat Cell Biol"},{"key":"ref106","article-title":"MicroRNA-126 is down-regulated in human esophageal squamous cell carcinoma and inhibits the proliferation and migration in EC109 cell via PI3K\/AKT signaling pathway","volume":"8","author":"Nie ZC","year":"2015","unstructured":"Nie ZC, Weng WH, Shang YS, et al.. MicroRNA-126 is down-regulated in human esophageal squamous cell carcinoma and inhibits the proliferation and migration in EC109 cell via PI3K\/AKT signaling pathway. Int J Clin Exp Pathol. 2015, 8:4745-54.","journal-title":"Int J Clin Exp Pathol"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2384-2-9","article-title":"EGFL7 meets miRNA-126: an angiogenesis alliance","volume":"2","author":"Nikolic I","year":"2010","unstructured":"Nikolic I, Plate KH, Schmidt MHH. EGFL7 meets miRNA-126: an angiogenesis alliance. J Angiogenes Res. 2010, 2:9. 10.1186\/2040-2384-2-9","journal-title":"J Angiogenes Res"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.996","article-title":"The regulation of tumor-suppressive microRNA, miR-126, in chronic lymphocytic leukemia","volume":"6","author":"Guinn D","year":"2017","unstructured":"Guinn D, Lehman A, Fabian C, et al.. The regulation of tumor-suppressive microRNA, miR-126, in chronic lymphocytic leukemia. Cancer Med. 2017, 6:778-87. 10.1002\/cam4.996","journal-title":"Cancer Med"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00015","article-title":"Cytokine targeting by miRNAs in autoimmune diseases","volume":"10","author":"Salvi V","year":"2019","unstructured":"Salvi V, Gianello V, Tiberio L, Sozzani S, Bosisio D. Cytokine targeting by miRNAs in autoimmune diseases. Front Immunol. 2019, 10:15. 10.3389\/fimmu.2019.00015","journal-title":"Front Immunol"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052805","article-title":"miRNAs in cancer (review of literature)","volume":"23","author":"Smolarz B","year":"2022","unstructured":"Smolarz B, Durczynski A, Romanowicz H, Szyllo K, Hogendorf P. miRNAs in cancer (review of literature). Int J Mol Sci. 2022, 23:10.3390\/ijms23052805","journal-title":"Int J Mol Sci"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402272","article-title":"Chronic lymphocytic leukemia: a paradigm of innate immune cross-tolerance","volume":"194","author":"Jurado-Camino T","year":"2015","unstructured":"Jurado-Camino T, Cordoba R, Esteban-Burgos L, et al.. Chronic lymphocytic leukemia: a paradigm of innate immune cross-tolerance. J Immunol. 2015, 194:719-27. 10.4049\/jimmunol.1402272","journal-title":"J Immunol"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-05625-y","article-title":"Prediction of severe infections in chronic lymphocytic leukemia: a simple risk score to stratify patients at diagnosis","volume":"103","author":"Murru R","year":"2024","unstructured":"Murru R, Galitzia A, Barabino L, Presicci R, La Nasa G, Caocci G. Prediction of severe infections in chronic lymphocytic leukemia: a simple risk score to stratify patients at diagnosis. Ann Hematol. 2024, 103:1655-64. 10.1007\/s00277-024-05625-y","journal-title":"Ann Hematol"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005726","article-title":"MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells","volume":"6","author":"Matis S","year":"2022","unstructured":"Matis S, Grazia Recchia A, Colombo M, et al.. MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells. Blood Adv. 2022, 6:5593-612. 10.1182\/bloodadvances.2021005726","journal-title":"Blood Adv"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0398-2","article-title":"A systematic review and network meta-analysis to evaluate the comparative efficacy of interventions for unfit patients with chronic lymphocytic leukemia","volume":"33","author":"Stadler N","year":"2016","unstructured":"Stadler N, Shang A, Bosch F, et al.. A systematic review and network meta-analysis to evaluate the comparative efficacy of interventions for unfit patients with chronic lymphocytic leukemia. Adv Ther. 2016, 33:1814-30. 10.1007\/s12325-016-0398-2","journal-title":"Adv Ther"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-01007-2","article-title":"Expert consensus on the management of chronic lymphocytic leukaemia in Asia","volume":"23","author":"Tse E","year":"2023","unstructured":"Tse E, Kwong YL, Goh YT, et al.. Expert consensus on the management of chronic lymphocytic leukaemia in Asia. Clin Exp Med. 2023, 23:2895-907. 10.1007\/s10238-023-01007-2","journal-title":"Clin Exp Med"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.1946","article-title":"Diagnosis and treatment of chronic lymphocytic leukemia: a review","volume":"329","author":"Shadman M","year":"2023","unstructured":"Shadman M. Diagnosis and treatment of chronic lymphocytic leukemia: a review. JAMA. 2023, 329:918-32. 10.1001\/jama.2023.1946","journal-title":"JAMA"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-123","article-title":"MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia","volume":"9","author":"Ferracin M","year":"2010","unstructured":"Ferracin M, Zagatti B, Rizzotto L, et al.. MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia. Mol Cancer. 2010, 9:123. 10.1186\/1476-4598-9-123","journal-title":"Mol Cancer"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-172254","article-title":"miR-34a as part of the resistance network in chronic lymphocytic leukemia","volume":"113","author":"Zenz T","year":"2009","unstructured":"Zenz T, Mohr J, Eldering E, et al.. miR-34a as part of the resistance network in chronic lymphocytic leukemia. Blood. 2009, 113:3801-08. 10.1182\/blood-2008-08-172254","journal-title":"Blood"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-458695","article-title":"Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients","volume":"121","author":"Dufour A","year":"2013","unstructured":"Dufour A, Palermo G, Zellmeier E, et al.. Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients. Blood. 2013, 121:3650-57. 10.1182\/blood-2012-10-458695","journal-title":"Blood"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.153189","article-title":"miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study","volume":"102","author":"Gagez AL","year":"2017","unstructured":"Gagez AL, Duroux-Richard I, Lepretre S, et al.. miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study. Haematologica. 2017, 102:746-54. 10.3324\/haematol.2016.153189","journal-title":"Haematologica"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/290539-dysregulated-micrornas-in-chronic-lymphocytic-leukemia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T09:43:05Z","timestamp":1725615785000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/290539-dysregulated-micrornas-in-chronic-lymphocytic-leukemia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":120,"URL":"https:\/\/doi.org\/10.7759\/cureus.68770","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,6]]}}}