{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:53:06Z","timestamp":1780321986631,"version":"3.54.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,16]]},"DOI":"10.7759\/cureus.69498","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:26:46Z","timestamp":1726471606000},"source":"Crossref","is-referenced-by-count":3,"title":["Effects of Platelet-Rich Plasma Injections on Periodontal Health During Accelerated Orthodontic Tooth Movement"],"prefix":"10.7759","author":[{"given":"May","family":"Akel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basima","family":"Yosef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/1305-7456.137651","article-title":"Relationship between orthodontic treatment and gingival health: a retrospective study","volume":"8","author":"Boke F","year":"2014","unstructured":"Boke F, Gazioglu C, Akkaya S, Akkaya M. Relationship between orthodontic treatment and gingival health: a retrospective study. Eur J Dent. 2014, 8:373-80. 10.4103\/1305-7456.137651","journal-title":"Eur J Dent"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.2.145","article-title":"Aspartate aminotransferase activity in gingival crevicular fluid during orthodontic treatment. a controlled short-term longitudinal study","volume":"74","author":"Perinetti G","year":"2003","unstructured":"Perinetti G, Paolantonio M, D'Attilio M, et al.. Aspartate aminotransferase activity in gingival crevicular fluid during orthodontic treatment. a controlled short-term longitudinal study. J Periodontol. 2003, 74:145-52. 10.1902\/jop.2003.74.2.145","journal-title":"J Periodontol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2319\/031512-224.1","article-title":"Interventions for accelerating orthodontic tooth movement: a systematic review","volume":"83","author":"Long H","year":"2013","unstructured":"Long H, Pyakurel U, Wang Y, Liao L, Zhou Y, Lai W. Interventions for accelerating orthodontic tooth movement: a systematic review. Angle Orthod. 2013, 83:164-71. 10.2319\/031512-224.1","journal-title":"Angle Orthod"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.57347","article-title":"Dental and periodontal changes after accelerated correction of lower anterior teeth crowding with periodontally accelerated osteogenic orthodontics (PAOO) procedure: a randomized controlled trial","volume":"16","author":"Alsino HI","year":"2024","unstructured":"Alsino HI, Kheshfeh MN, Hajeer MY, Burhan AS, Alkhouri I, Al-Ibrahim HM, Abou Nassar JN. Dental and periodontal changes after accelerated correction of lower anterior teeth crowding with periodontally accelerated osteogenic orthodontics (PAOO) procedure: a randomized controlled trial. Cureus. 2024, 16:e57347. 10.7759\/cureus.57347","journal-title":"Cureus"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract13060132","article-title":"Patient-reported outcome measures of flapless corticotomy with low-level laser therapy in en masse retraction of upper anterior teeth: a three-arm randomized controlled trial","volume":"13","author":"Mousa MM","year":"2023","unstructured":"Mousa MM, Hajeer MY, Burhan AS, et al.. Patient-reported outcome measures of flapless corticotomy with low-level laser therapy in en masse retraction of upper anterior teeth: a three-arm randomized controlled trial. Clin Pract. 2023, 13:1501-19. 10.3390\/clinpract13060132","journal-title":"Clin Pract"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-021-00331-5","article-title":"Accelerated orthodontic tooth movement: surgical techniques and the regional acceleratory phenomenon","volume":"44","author":"Keser E","year":"2022","unstructured":"Keser E, Naini FB. Accelerated orthodontic tooth movement: surgical techniques and the regional acceleratory phenomenon. Maxillofac Plast Reconstr Surg. 2022, 44:1. 10.1186\/s40902-021-00331-5","journal-title":"Maxillofac Plast Reconstr Surg"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.51779","article-title":"Evaluation of patient-reported outcome measures (PROMs) associated with the acceleration of canine retraction by piezosurgery in comparison with low-level laser therapy: a three-arm randomized controlled clinical trial","volume":"16","author":"Alfailany DT","year":"2024","unstructured":"Alfailany DT, Hajeer MY, Awawdeh MA, et al.. Evaluation of patient-reported outcome measures (PROMs) associated with the acceleration of canine retraction by piezosurgery in comparison with low-level laser therapy: a three-arm randomized controlled clinical trial. Cureus. 2024, 16:e51779. 10.7759\/cureus.51779","journal-title":"Cureus"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000382048","article-title":"Nonsurgical methods for the acceleration of the orthodontic tooth movement","volume":"18","author":"Almpani K","year":"2016","unstructured":"Almpani K, Kantarci A. Nonsurgical methods for the acceleration of the orthodontic tooth movement. Front Oral Biol. 2016, 18:80-91. 10.1159\/000382048","journal-title":"Front Oral Biol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41432-021-0160-8","article-title":"Is platelet-rich plasma able to accelerate orthodontic tooth movement?","volume":"22","author":"Liu L","year":"2021","unstructured":"Liu L, Kuang Q, Zhou J, Long H. Is platelet-rich plasma able to accelerate orthodontic tooth movement?. Evid Based Dent. 2021, 22:36-7. 10.1038\/s41432-021-0160-8","journal-title":"Evid Based Dent"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12146","article-title":"Effect of platelet-rich plasma on orthodontic tooth movement in dogs","volume":"20","author":"Rashid A","year":"2017","unstructured":"Rashid A, ElSharaby FA, Nassef EM, Mehanni S, Mostafa YA. Effect of platelet-rich plasma on orthodontic tooth movement in dogs. Orthod Craniofac Res. 2017, 20:102-10. 10.1111\/ocr.12146","journal-title":"Orthod Craniofac Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2016.05.016","article-title":"Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: a histomorphometric study","volume":"151","author":"G\u00fcle\u00e7 A","year":"2017","unstructured":"G\u00fcle\u00e7 A, Bakkalba\u015f\u0131 B\u00c7, Cumbul A, Uslu \u00dc, Alev B, Yarat A. Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: a histomorphometric study. Am J Orthod Dentofacial Orthop. 2017, 151:92-104. 10.1016\/j.ajodo.2016.05.016","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1043\/0003-3219(1974)044<0127:TEOOTO>2.0.CO;2","article-title":"The effect of orthodontic treatment on the periodontium","volume":"44","author":"Kloehn JS","year":"1974","unstructured":"Kloehn JS, Pfeifer JS. The effect of orthodontic treatment on the periodontium. Angle Orthod. 1974, 44:127-34. 10.1043\/0003-3219(1974)044&lt;0127:TEOOTO&gt;2.0.CO;2","journal-title":"Angle Orthod"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.12.665","article-title":"Orthodontic treatment and periodontal status","volume":"50","author":"Trossello VK","year":"1979","unstructured":"Trossello VK, Gianelly AA. Orthodontic treatment and periodontal status. J Periodontol. 1979, 50:665-71. 10.1902\/jop.1979.50.12.665","journal-title":"J Periodontol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1043\/0003-3219(1972)042<0026:GCAWOT>2.0.CO;2","article-title":"Gingival condition associated with orthodontic treatment","volume":"42","author":"Zachrisson S","year":"1972","unstructured":"Zachrisson S, Zachrisson BU. Gingival condition associated with orthodontic treatment. Angle Orthod. 1972, 42:26-34. 10.1043\/0003-3219(1972)042&lt;0026:GCAWOT&gt;2.0.CO;2","journal-title":"Angle Orthod"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2319\/052823-382.1","article-title":"Salivary and crevicular fluid proinflammatory cytokines and advanced glycation end products in patients with different glycemic levels undergoing fixed orthodontic treatment","volume":"94","author":"Kamran MA","year":"2024","unstructured":"Kamran MA. Salivary and crevicular fluid proinflammatory cytokines and advanced glycation end products in patients with different glycemic levels undergoing fixed orthodontic treatment. Angle Orthod. 2024, 94:233-9. 10.2319\/052823-382.1","journal-title":"Angle Orthod"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2319\/072911-478.1","article-title":"Pentraxin-3 levels in gingival crevicular fluid during orthodontic tooth movement in young and adult patients","volume":"82","author":"Surlin P","year":"2012","unstructured":"Surlin P, Rauten AM, Silosi I, Foia L. Pentraxin-3 levels in gingival crevicular fluid during orthodontic tooth movement in young and adult patients. Angle Orthod. 2012, 82:833-8. 10.2319\/072911-478.1","journal-title":"Angle Orthod"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2319\/111309-641.1","article-title":"Change in dental pulp parameters in response to different modes of orthodontic force application","volume":"80","author":"Veberiene R","year":"2010","unstructured":"Veberiene R, Smailiene D, Baseviciene N, Toleikis A, Machiulskiene V. Change in dental pulp parameters in response to different modes of orthodontic force application. Angle Orthod. 2010, 80:1018-22. 10.2319\/111309-641.1","journal-title":"Angle Orthod"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2319\/082919-562.1","article-title":"Influence of orthodontic appliance type on salivary parameters during treatment","volume":"90","author":"Dallel I","year":"2020","unstructured":"Dallel I, Ben Salem I, Merghni A, et al.. Influence of orthodontic appliance type on salivary parameters during treatment. Angle Orthod. 2020, 90:532-8. 10.2319\/082919-562.1","journal-title":"Angle Orthod"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2006.096","article-title":"Salivary aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase: possible markers in periodontal diseases?","volume":"44","author":"Totan A","year":"2006","unstructured":"Totan A, Greabu M, Totan C, Spinu T. Salivary aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase: possible markers in periodontal diseases?. Clin Chem Lab Med. 2006, 44:612-5. 10.1515\/CCLM.2006.096","journal-title":"Clin Chem Lab Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3923\/jas.2009.1393.1396","article-title":"Preliminary study of aspartate aminotransferase activity in gingival crevicular fluids during orthodontic tooth movement","volume":"9","author":"Rohaya MAW","year":"2009","unstructured":"Rohaya MAW, Hisham Z, Khazlina K. Preliminary study of aspartate aminotransferase activity in gingival crevicular fluids during orthodontic tooth movement. J Appl Sci. 2009, 9:1393-6. 10.3923\/jas.2009.1393.1396","journal-title":"J Appl Sci"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4041\/kjod.2015.45.5.261","article-title":"Aspartate aminotransferase activity in the pulp of teeth treated for 6 months with fixed orthodontic appliances","volume":"45","author":"Veberiene R","year":"2015","unstructured":"Veberiene R, Latkauskiene D, Racinskaite V, Skucaite N, Machiulskiene V. Aspartate aminotransferase activity in the pulp of teeth treated for 6 months with fixed orthodontic appliances. Korean J Orthod. 2015, 45:261-7. 10.4041\/kjod.2015.45.5.261","journal-title":"Korean J Orthod"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2018.01.007","article-title":"Orthodontic tooth movement: the biology and clinical implications","volume":"34","author":"Li Y","year":"2018","unstructured":"Li Y, Jacox LA, Little SH, Ko CC. Orthodontic tooth movement: the biology and clinical implications. Kaohsiung J Med Sci. 2018, 34:207-14. 10.1016\/j.kjms.2018.01.007","journal-title":"Kaohsiung J Med Sci"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/2196-1042-14-42","article-title":"Acceleration of tooth movement during orthodontic treatment--a frontier in orthodontics","volume":"14","author":"Nimeri G","year":"2013","unstructured":"Nimeri G, Kau CH, Abou-Kheir NS, Corona R. Acceleration of tooth movement during orthodontic treatment--a frontier in orthodontics. Prog Orthod. 2013, 14:42. 10.1186\/2196-1042-14-42","journal-title":"Prog Orthod"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000382051","article-title":"Surgical methods for the acceleration of the orthodontic tooth movement","volume":"18","author":"Almpani K","year":"2016","unstructured":"Almpani K, Kantarci A. Surgical methods for the acceleration of the orthodontic tooth movement. Front Oral Biol. 2016, 18:92-101. 10.1159\/000382051","journal-title":"Front Oral Biol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.30574\/wjarr.2023.18.2.0689","article-title":"Relationship between orthodontic tooth movement and periodontal health: a journal review","volume":"18","author":"Wibowo A","year":"2023","unstructured":"Wibowo A, Gautama S, Alida. Relationship between orthodontic tooth movement and periodontal health: a journal review. World J Adv Res Rev. 2023, 18:248-57. 10.30574\/wjarr.2023.18.2.0689","journal-title":"World J Adv Res Rev"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.113374","article-title":"Non-invasive methods of acceleration of orthodontic tooth movement","author":"Patil AK","year":"2024","unstructured":"Patil AK, Jain AV, Naik RD. Non-invasive methods of acceleration of orthodontic tooth movement. Orthodontics - Current Principles and Techniques. Aslan BI (ed): IntechOpen, London, UK; 2024. 10.5772\/intechopen.113374"},{"key":"ref27","article-title":"The effect of orthodontic tooth movement on aspartate aminotransferase activity in gingival crevicular fluid - an in-vivo study","volume":"5","author":"Preet Singh D","year":"2013","unstructured":"Preet Singh D, Singla L, Sobti A. The effect of orthodontic tooth movement on aspartate aminotransferase activity in gingival crevicular fluid - an in-vivo study. Indian J Dent Sci. 2013, 5:p019.","journal-title":"Indian J Dent Sci"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/293759-effects-of-platelet-rich-plasma-injections-on-periodontal-health-during-accelerated-orthodontic-tooth-movement","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:26:52Z","timestamp":1726471612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/293759-effects-of-platelet-rich-plasma-injections-on-periodontal-health-during-accelerated-orthodontic-tooth-movement"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.69498","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,16]]}}}