{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:57:04Z","timestamp":1765961824330},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,16]]},"DOI":"10.7759\/cureus.69513","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T11:12:45Z","timestamp":1726485165000},"source":"Crossref","is-referenced-by-count":1,"title":["A Comparative Study of Skeletal Muscle Relaxant Effects of Thiocolchicoside, Diazepam and Their Combination in Wistar Rats Using the Rotarod Apparatus"],"prefix":"10.7759","author":[{"given":"Akash","family":"Devi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitra","family":"Khanwelkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Essentials of Medical Pharmacology","author":"Tripathi KD","year":"2013","unstructured":"Tripathi KD. Essentials of Medical Pharmacology. Jaypee Brothers Medical Publishers Pvt. Limited, New Delhi; 2013."},{"key":"ref2","article-title":"Muscle fiber contraction and relaxation","author":"Gordon J","year":"2022","unstructured":"Gordon J, Kelly A, James A, et al.. Muscle fiber contraction and relaxation. Anatomy and Physiology. OpenStax, Houston, Texas; 2022. 1:1336."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.21276\/ap.2021.10.1.3","article-title":"Fundamental of a comparative treatment in rheumatoid arthritis: a brief review","volume":"10","author":"Das P","year":"2021","unstructured":"Das P, Likhitha C, Nayak A, Alur A, Prabhu PP. Fundamental of a comparative treatment in rheumatoid arthritis: a brief review. Anna Phytomed. 2021, 10:23-32. 10.21276\/ap.2021.10.1.3","journal-title":"Anna Phytomed"},{"key":"ref4","article-title":"Thiocolchicoside: a review","volume":"4","author":"Kamath A","year":"2013","unstructured":"Kamath A. Thiocolchicoside: a review. DHR Int J Med Sci. 2013, 4:39-45.","journal-title":"DHR Int J Med Sci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.22590","article-title":"Evaluation of the analgesic efficacies of Dexketoprofen Trometamol and Dexketoprofen Trometamol + Thiocolchicoside combinations in the impacted third molar surgery: randomised clinical trial","volume":"24","author":"Cigerim L","year":"2019","unstructured":"Cigerim L, Kaplan V. Evaluation of the analgesic efficacies of Dexketoprofen Trometamol and Dexketoprofen Trometamol + Thiocolchicoside combinations in the impacted third molar surgery: randomised clinical trial. Med Oral Patol Oral Cir Bucal. 2019, 24:e114-22. 10.4317\/medoral.22590","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref6","article-title":"A comparative study of the anti-inflammatory effects of thiocolchicoside, diclofenac, and their combination in Wistar rats using the carrageenan-induced paw edema method","volume":"14","author":"Devi A","year":"2023","unstructured":"Devi A, Khanwelkar CC, Pakale PV, Jadhav SA, Singh H, Singh L. A comparative study of the anti-inflammatory effects of thiocolchicoside, diclofenac, and their combination in Wistar rats using the carrageenan-induced paw edema method. J Pharm Negat Results. 2023, 14:1108-14.","journal-title":"J Pharm Negat Results"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.21276\/ap.2021.10.1.6","article-title":"A Review on Terminalia arjuna(Roxb.) Wight & Arn.: the wonder medicinal plant with prodigious potential in therapeutics","volume":"10","author":"Desai SD","year":"2021","unstructured":"Desai SD, Pai SR, Desai NS. A Review on Terminalia arjuna(Roxb.) Wight & Arn.: the wonder medicinal plant with prodigious potential in therapeutics. Ann Phytomed. 2021, 10:62-73. 10.21276\/ap.2021.10.1.6","journal-title":"Ann Phytomed"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0037","article-title":"Thiocolchicoside exhibits anticancer effects through downregulation of NF-\u03baB pathway and its regulated gene products linked to inflammation and cancer","volume":"3","author":"Reuter S","year":"2010","unstructured":"Reuter S, Prasad S, Phromnoi K, et al.. Thiocolchicoside exhibits anticancer effects through downregulation of NF-\u03baB pathway and its regulated gene products linked to inflammation and cancer. Cancer Prev Res (Phila). 2010, 3:1462-72. 10.1158\/1940-6207.CAPR-10-0037","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref9","unstructured":"European panel recommends restrictions for muscle relaxant. (2013). Accessed. September 20, 2018: https:\/\/www.medscape.com\/viewarticle\/814888?form=fpf."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.54085\/ap.2022.11.1.36","article-title":"Development and evaluation of eugenol-based gel formulation for analgesic and anti-inflammatory action","volume":"11","author":"Ali M","year":"2022","unstructured":"Ali M, Ain S, Kumar B, Ain Q. Development and evaluation of eugenol-based gel formulation for analgesic and anti-inflammatory action. Ann Phytomed. 2022, 11:338-45. 10.54085\/ap.2022.11.1.36","journal-title":"Ann Phytomed"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.21276\/ap.2019.8.2.2","article-title":"Herbs that heal spices: The hoard of natural remedies","volume":"8","author":"Alam A","year":"2019","unstructured":"Alam A. Herbs that heal spices: The hoard of natural remedies. Ann Phytomed. 2019, 8:7-18. 10.21276\/ap.2019.8.2.2","journal-title":"Ann Phytomed"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.18203\/2319-2003.ijbcp20194784","article-title":"A comparative study on safety and efficacy of tolperisone with etodolac and Thiocolchicoside with etodolac in patients of acute low back pain with musculoskeletal spasm","volume":"8","author":"Garg T","year":"2019","unstructured":"Garg T, Yadav VK. A comparative study on safety and efficacy of tolperisone with etodolac and Thiocolchicoside with etodolac in patients of acute low back pain with musculoskeletal spasm. Int J Basic Clin Pharmacol. 2019, 8:2459. 10.18203\/2319-2003.ijbcp20194784","journal-title":"Int J Basic Clin Pharmacol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5606\/tftrd.2022.9744","article-title":"A multi-center, double-blind, randomized parallel-group phase IV study comparing the efficacy and safety of thiocolchicoside ointment versus placebo in patients with chronic mechanical low back pain and an acute muscle spasm","volume":"68","author":"Ketenci A","year":"2022","unstructured":"Ketenci A, Sindel D, T\u00fclay Koca T, et al.. A multi-center, double-blind, randomized parallel-group phase IV study comparing the efficacy and safety of thiocolchicoside ointment versus placebo in patients with chronic mechanical low back pain and an acute muscle spasm. Turk J Phys Med Rehabil. 2022, 68:456-63. 10.5606\/tftrd.2022.9744","journal-title":"Turk J Phys Med Rehabil"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2012.6.2.115","article-title":"Clinical comparative study: efficacy and tolerability of tolperisone and thiocolchicoside in acute low back pain and spinal muscle spasticity","volume":"6","author":"Rao R","year":"2012","unstructured":"Rao R, Panghate A, Chandanwale A, et al.. Clinical comparative study: efficacy and tolerability of tolperisone and thiocolchicoside in acute low back pain and spinal muscle spasticity. Asian Spine J. 2012, 6:115-22. 10.4184\/asj.2012.6.2.115","journal-title":"Asian Spine J"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/2374","article-title":"A Comparative Study of Efficacy and Tolerability of Fixed-Dose Combination of Etoricoxib and Thiocolchicoside versus Thiocolchicoside alone in Patients with Painful Muscle Spasms","volume":"31","author":"Priyanka S","year":"2022","unstructured":"Priyanka S, Manju J, Girish K. A Comparative Study of Efficacy and Tolerability of Fixed-Dose Combination of Etoricoxib and Thiocolchicoside versus Thiocolchicoside alone in Patients with Painful Muscle Spasms. Biomed Pharmacol J. 2022, 31:353-61. 10.13005\/bpj\/2374","journal-title":"Biomed Pharmacol J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5958\/2393-9087.2016.00018.2","article-title":"To compare the efficacy and safety of eperisone with thiocolchicoside in patients with acute lower backache associated with muscle spasm","volume":"3","author":"Rani S","year":"2016","unstructured":"Rani S, Kumar S, Joyti, Vaerma P K, Lamba D, Saini R. To compare the efficacy and safety of eperisone with thiocolchicoside in patients with acute lower backache associated with muscle spasm. Indian J Pharm Pharmacol. 2016, 3:79. 10.5958\/2393-9087.2016.00018.2","journal-title":"Indian J Pharm Pharmacol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.136789","article-title":"To compare the efficacy and safety of fixed dose combination of thiocolchicoside and aceclofenac versus chlorzoxazone, aceclofenac and paracetamol in patients with acute lower backache associated with muscle spasm","volume":"4","author":"Kumar S","year":"2014","unstructured":"Kumar S, Rani S, Siwach R, Verma P. To compare the efficacy and safety of fixed dose combination of thiocolchicoside and aceclofenac versus chlorzoxazone, aceclofenac and paracetamol in patients with acute lower backache associated with muscle spasm. Int J Appl Basic Med Res. 2014, 4:101-5. 10.4103\/2229-516X.136789","journal-title":"Int J Appl Basic Med Res"},{"key":"ref18","article-title":"Development, optimization and evaluation of solid dosage form of Thiocolchicoside by using absorption enhancers","volume":"5","author":"Singh D","year":"2013","unstructured":"Singh D, Sharma PK, Sara UVS. Development, optimization and evaluation of solid dosage form of Thiocolchicoside by using absorption enhancers. Der Pharmacia Lettre. 2013, 5:405-14.","journal-title":"Der Pharmacia Lettre"},{"key":"ref19","unstructured":"Intraperitoneal (IP) injection in rats and mice. (2014). https.\/\/animalcare.ubc.ca\/sites\/default\/files\/documents\/TECH%2010%20IP%20Injections%20in%20the%20Mouse%20and%20Rat.pdf."},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/jps.3030460322","article-title":"A note on a simple apparatus for detecting neurological deficit in rats and mice","volume":"46","author":"Dunham NW","year":"1957","unstructured":"Dunham NW, Miya TS. A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharm Assoc Am Pharm Assoc. 1957, 46:208-9. 10.1002\/jps.3030460322","journal-title":"J Am Pharm Assoc Am Pharm Assoc"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1968.tb09743.x","article-title":"The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod","volume":"20","author":"Jones BJ","year":"1968","unstructured":"Jones BJ, Roberts DJ. The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod. J Pharm Pharmacol. 1968, 20:302-4. 10.1111\/j.2042-7158.1968.tb09743.x","journal-title":"J Pharm Pharmacol"},{"key":"ref22","article-title":"Measuring motor coordination in mice","volume":"29","author":"Deacon RMJ","year":"2013","unstructured":"Deacon RMJ. Measuring motor coordination in mice. J Vis Exp. 2013, 29:2609.","journal-title":"J Vis Exp"},{"key":"ref23","article-title":"Practical Manual of Experimental and Clinical Pharmacology","author":"Medhi B","year":"2017","unstructured":"Medhi B, Prakash A. Practical Manual of Experimental and Clinical Pharmacology. Jaypee Brothers Medical Publishers Pvt. Limited, New Delhi; 2017."},{"key":"ref24","article-title":"Thiocolchicoside as muscle relaxant: a review","volume":"1","author":"Umarkar AR","year":"2011","unstructured":"Umarkar AR, Bavaskar SR, Yewale PN. Thiocolchicoside as muscle relaxant: a review. Int J Pharm Biol. 2011, 1:11-12.","journal-title":"Int J Pharm Biol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.54085\/ap.2022.11.2.81","article-title":"Optimization and comparison of different extraction techniques for colchicine from the seeds of Gloriosa superba L","volume":"11","author":"Sharma S","year":"2022","unstructured":"Sharma S, Sharma YP, Bhardwaj C. Optimization and comparison of different extraction techniques for colchicine from the seeds of Gloriosa superba L. Ann Phytomed. 2022, 11:661-9. 10.54085\/ap.2022.11.2.81","journal-title":"Ann Phytomed"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v12i5.5581","article-title":"Stability-indicating analytical method development and validation of thiocolchicoside and ibuprofen in tablet dosage form by RP-HPLC method","volume":"12","author":"Jadhav Ankush P","year":"2022","unstructured":"Jadhav Ankush P, Datar PA, Kedar TR, et al.. Stability-indicating analytical method development and validation of thiocolchicoside and ibuprofen in tablet dosage form by RP-HPLC method. J Drug Deliv Ther. 2022, 12:103-13. 10.22270\/jddt.v12i5.5581","journal-title":"J Drug Deliv Ther"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.18203\/2319-2003.ijbcp20182103","article-title":"Comparative study of centrally acting skeletal muscle relaxants nitrazepam and thiocolchicoside in Albino mice","volume":"1","author":"Sayana SB","year":"2018","unstructured":"Sayana SB, Sampathirao Y, Munge B, Moorthy S, Burli K. Comparative study of centrally acting skeletal muscle relaxants nitrazepam and thiocolchicoside in Albino mice. Int J Basic Clin Pharmacol. 2018, 1:1182-6. 10.18203\/2319-2003.ijbcp20182103","journal-title":"Int J Basic Clin Pharmacol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/s1297-319x(03)00075-7","article-title":"Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain","volume":"70","author":"T\u00fcz\u00fcn F","year":"2003","unstructured":"T\u00fcz\u00fcn F, \u00dcnalan H, \u00d6ner N, et al.. Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain. Joint Bone Spine. 2003, 70:356-61. 10.1016\/s1297-319x(03)00075-7","journal-title":"Joint Bone Spine"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007659","article-title":"The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness: a real-life study on top-level road cyclists during stage competition","volume":"96","author":"Gervasi M","year":"2017","unstructured":"Gervasi M, Sisti D, Benelli P, et al.. The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness: a real-life study on top-level road cyclists during stage competition. Medicine (Baltimore). 2017, 96:e7659. 10.1097\/MD.0000000000007659","journal-title":"Medicine (Baltimore)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1446","article-title":"Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis","volume":"374","author":"Cashin AG","year":"2021","unstructured":"Cashin AG, Folly T, Bagg MK, et al.. Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis. BMJ. 2021, 374:n1446. 10.1136\/bmj.n1446","journal-title":"BMJ"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/284435-a-comparative-study-of-skeletal-muscle-relaxant-effects-of-thiocolchicoside-diazepam-and-their-combination-in-wistar-rats-using-the-rotarod-apparatus","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T11:12:51Z","timestamp":1726485171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/284435-a-comparative-study-of-skeletal-muscle-relaxant-effects-of-thiocolchicoside-diazepam-and-their-combination-in-wistar-rats-using-the-rotarod-apparatus"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.69513","relation":{},"ISSN":["2168-8184"],"issn-type":[{"type":"print","value":"2168-8184"}],"subject":[],"published":{"date-parts":[[2024,9,16]]}}}